Published in EMBO J on July 15, 2003
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The signal recognition particle binds to protein L23 at the peptide exit of the Escherichia coli ribosome. RNA (2003) 1.59
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SRbeta coordinates signal sequence release from SRP with ribosome binding to the translocon. EMBO J (2001) 1.25
The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane. J Cell Biol (1995) 1.23
Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh. J Mol Biol (2002) 1.21
Crystal structure of SRP19 in complex with the S domain of SRP RNA and its implication for the assembly of the signal recognition particle. Mol Cell (2002) 1.18
Crystal structure of an early protein-RNA assembly complex of the signal recognition particle. Science (2001) 1.15
The crystal structure of the conserved GTPase of SRP54 from the archaeon Acidianus ambivalens and its comparison with related structures suggests a model for the SRP-SRP receptor complex. Structure (2000) 1.14
Structure of the phylogenetically most conserved domain of SRP RNA. RNA (1999) 1.14
The N-domain of the signal recognition particle 54-kDa subunit promotes efficient signal sequence binding. Eur J Biochem (1997) 1.14
Visualizing induced fit in early assembly of the human signal recognition particle. Nat Struct Biol (2001) 1.14
An amino-terminal domain containing hydrophobic and hydrophilic sequences binds the signal recognition particle receptor alpha subunit to the beta subunit on the endoplasmic reticulum membrane. J Biol Chem (1995) 1.12
Crystal structure of the conserved subdomain of human protein SRP54M at 2.1 A resolution: evidence for the mechanism of signal peptide binding. J Mol Biol (1999) 1.12
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The crystal structure of the signal recognition particle Alu RNA binding heterodimer, SRP9/14. EMBO J (1997) 0.98
Towards the structure of the mammalian signal recognition particle. Curr Opin Struct Biol (2002) 0.97
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Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution. Nature (2009) 2.82
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Insights into egg coat assembly and egg-sperm interaction from the X-ray structure of full-length ZP3. Cell (2010) 1.91
Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats. Nature (2008) 1.85
Crystal structure of Prp8 reveals active site cavity of the spliceosome. Nature (2013) 1.85
Recognition of a signal peptide by the signal recognition particle. Nature (2010) 1.77
A supramolecular assembly formed by influenza A virus genomic RNA segments. Nucleic Acids Res (2011) 1.65
Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation. Mol Cell Biol (2002) 1.61
Structure-based drug design targeting an inactive RNA conformation: exploiting the flexibility of HIV-1 TAR RNA. J Mol Biol (2004) 1.29
The structure and biochemical properties of the human spliceosomal protein U1C. J Mol Biol (2004) 1.23
Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders. J Med Chem (2010) 1.23
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An in vitro network of intermolecular interactions between viral RNA segments of an avian H5N2 influenza A virus: comparison with a human H3N2 virus. Nucleic Acids Res (2012) 1.10
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The molecular basis of sex: linking yeast to human. Mol Biol Evol (2011) 1.01
Critical role of segment-specific packaging signals in genetic reassortment of influenza A viruses. Proc Natl Acad Sci U S A (2013) 1.00
Protein-induced conformational changes of RNA during the assembly of human signal recognition particle. J Mol Biol (2006) 1.00
The crystal structure of JNK2 reveals conformational flexibility in the MAP kinase insert and indicates its involvement in the regulation of catalytic activity. J Mol Biol (2008) 1.00
Structural characterization of fish egg vitelline envelope proteins by mass spectrometry. Biochemistry (2004) 1.00
Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavage. Biochem Biophys Res Commun (2008) 0.99
Interaction network linking the human H3N2 influenza A virus genomic RNA segments. Vaccine (2012) 0.98
Crystal structures of IL-2-inducible T cell kinase complexed with inhibitors: insights into rational drug design and activity regulation. Chem Biol Drug Des (2010) 0.98
Nanolitre-scale crystallization using acoustic liquid-transfer technology. Acta Crystallogr D Biol Crystallogr (2012) 0.97
Mg2+ dependency of HIV-1 reverse transcription, inhibition by nucleoside analogues and resistance. Nucleic Acids Res (2006) 0.96
Bruton's tyrosine kinase inhibitors: approaches to potent and selective inhibition, preclinical and clinical evaluation for inflammatory diseases and B cell malignancies. J Med Chem (2012) 0.95
β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J Med Chem (2013) 0.95
Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation. Acta Crystallogr D Biol Crystallogr (2013) 0.95
Secondary structure of the 3' terminus of hepatitis C virus minus-strand RNA. J Virol (2002) 0.94
The A-rich RNA sequences of HIV-1 pol are important for the synthesis of viral cDNA. Nucleic Acids Res (2008) 0.92
Structural insights for design of potent spleen tyrosine kinase inhibitors from crystallographic analysis of three inhibitor complexes. Chem Biol Drug Des (2009) 0.92
A structural view of egg coat architecture and function in fertilization. Biol Reprod (2011) 0.91
Egg-sperm interactions at fertilization in mammals. Eur J Obstet Gynecol Reprod Biol (2004) 0.90
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Recent aspects of mammalian fertilization research. Mol Cell Endocrinol (2005) 0.86
Evolution of the voltage sensor domain of the voltage-sensitive phosphoinositide phosphatase VSP/TPTE suggests a role as a proton channel in eutherian mammals. Mol Biol Evol (2012) 0.86
Polypeptide encoded by mouse ZP3 exon-7 is necessary and sufficient for binding of mouse sperm in vitro. J Cell Physiol (2006) 0.85
Tracking down the ZP domain: From the mammalian zona pellucida to the molluscan vitelline envelope. Semin Reprod Med (2006) 0.85
Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones. Acta Crystallogr D Biol Crystallogr (2013) 0.84
Mass spectrometric evidence that proteolytic processing of rainbow trout egg vitelline envelope proteins takes place on the egg. J Biol Chem (2005) 0.84
Identification of the RNA binding regions of SRP68/72 and SRP72 by systematic mutagenesis of human SRP RNA. RNA Biol (2007) 0.83
The relationships between consumer liking, sensory and chemical attributes of Vitis vinifera L. cv. Pinotage wines elaborated with different Oenococcus oeni starter cultures. J Sci Food Agric (2013) 0.83
Charge separation induces conformational changes in the photosynthetic reaction centre of purple bacteria. Acta Crystallogr D Biol Crystallogr (2002) 0.82
Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors. J Med Chem (2013) 0.81
3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models. J Med Chem (2012) 0.81
8-Modified-2'-deoxyadenosine analogues induce delayed polymerization arrest during HIV-1 reverse transcription. PLoS One (2011) 0.81
The structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold. J Mol Biol (2011) 0.80
Discovery of a novel series of 4-quinolone JNK inhibitors. Bioorg Med Chem Lett (2012) 0.80
Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors. Bioorg Med Chem Lett (2013) 0.79
Using ovality to predict nonmutagenic, orally efficacious pyridazine amides as cell specific spleen tyrosine kinase inhibitors. J Med Chem (2014) 0.79
Identification of potent and selective cathepsin S inhibitors containing different central cyclic scaffolds. J Med Chem (2013) 0.78
Structure-based drug design of RN486, a potent and selective Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of rheumatoid arthritis. J Med Chem (2014) 0.78
Rational design of highly selective spleen tyrosine kinase inhibitors. J Med Chem (2012) 0.78
Crystallization of RNA-protein complexes. Methods Mol Biol (2007) 0.78
A protein.protein interaction platform involved in recruitment of GLD-3 to the FBF.fem-3 mRNA complex. J Mol Biol (2012) 0.78
3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: design and development to a highly selective lead. Bioorg Med Chem Lett (2011) 0.77
Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinome. Bioorg Med Chem Lett (2013) 0.76
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The structure of XIAP BIR2: understanding the selectivity of the BIR domains. Acta Crystallogr D Biol Crystallogr (2013) 0.76
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A pyrophosphatase activity associated with purified HIV-1 particles. Biochimie (2012) 0.75
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