The ins and outs of fibronectin matrix assembly.

The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol (2010) 4.72

Assembly of fibronectin extracellular matrix. Annu Rev Cell Dev Biol (2010) 2.86

Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Dev Cell (2009) 2.41

Cadherin adhesion, tissue tension, and noncanonical Wnt signaling regulate fibronectin matrix organization. Dev Cell (2009) 2.32

Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans. Dev Cell (2009) 2.03

Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells. Proc Natl Acad Sci U S A (2011) 2.01

Force-dependent chemical kinetics of disulfide bond reduction observed with single-molecule techniques. Proc Natl Acad Sci U S A (2006) 1.95

Fibronectins, their fibrillogenesis, and in vivo functions. Cold Spring Harb Perspect Biol (2011) 1.84

The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol (2007) 1.81

Fibronectins in vascular morphogenesis. Angiogenesis (2009) 1.66

Galectin binding to Mgat5-modified N-glycans regulates fibronectin matrix remodeling in tumor cells. Mol Cell Biol (2006) 1.57

Micropatterning of poly(ethylene glycol) diacrylate hydrogels with biomolecules to regulate and guide endothelial morphogenesis. Tissue Eng Part A (2009) 1.57

Integrin beta4 regulates migratory behavior of keratinocytes by determining laminin-332 organization. J Biol Chem (2006) 1.55

Interaction of endosialin/TEM1 with extracellular matrix proteins mediates cell adhesion and migration. Proc Natl Acad Sci U S A (2007) 1.54

Fibronectin matrix assembly regulates alpha5beta1-mediated cell cohesion. Mol Biol Cell (2004) 1.51

The neovasculature homing motif NGR: more than meets the eye. Blood (2008) 1.46

Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development. Development (2010) 1.42

Plasma and cellular fibronectin: distinct and independent functions during tissue repair. Fibrogenesis Tissue Repair (2011) 1.41

Assay to mechanically tune and optically probe fibrillar fibronectin conformations from fully relaxed to breakage. Matrix Biol (2008) 1.38

Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Dev Biol (2007) 1.38

Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis. EMBO J (2010) 1.36

Metastatic outgrowth encompasses COL-I, FN1, and POSTN up-regulation and assembly to fibrillar networks regulating cell adhesion, migration, and growth. Am J Pathol (2010) 1.31

The N-terminal 70-kDa fragment of fibronectin binds to cell surface fibronectin assembly sites in the absence of intact fibronectin. Matrix Biol (2006) 1.26

Tropomyosin isoform expression regulates the transition of adhesions to determine cell speed and direction. Mol Cell Biol (2009) 1.26

Mechanochemistry: one bond at a time. ACS Nano (2009) 1.26

On multiscale approaches to three-dimensional modelling of morphogenesis. J R Soc Interface (2005) 1.26

The extracellular matrix and blood vessel formation: not just a scaffold. J Cell Mol Med (2007) 1.25

The Rac activator Tiam1 is required for (alpha)3(beta)1-mediated laminin-5 deposition, cell spreading, and cell migration. J Cell Biol (2005) 1.23

Live imaging of cell protrusive activity, and extracellular matrix assembly and remodeling during morphogenesis in the frog, Xenopus laevis. Dev Dyn (2008) 1.22

CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling. J Cell Biol (2007) 1.21

The physical state of fibronectin matrix differentially regulates morphogenetic movements in vivo. Dev Biol (2008) 1.19

Enhancement of thrombogenesis by plasma fibronectin cross-linked to fibrin and assembled in platelet thrombi. Blood (2006) 1.15

Bone regeneration with low dose BMP-2 amplified by biomimetic supramolecular nanofibers within collagen scaffolds. Biomaterials (2012) 1.15

Laminin deposition in the extracellular matrix: a complex picture emerges. J Cell Sci (2009) 1.14

Syndecan-1 in breast cancer stroma fibroblasts regulates extracellular matrix fiber organization and carcinoma cell motility. Am J Pathol (2010) 1.13

Intestinal adenomagenesis involves core molecular signatures of the epithelial-mesenchymal transition. J Mol Histol (2008) 1.12

Fibronectin binds and enhances the activity of bone morphogenetic protein 1. J Biol Chem (2009) 1.11

Cell-matrix interactions in dermal repair and scarring. Fibrogenesis Tissue Repair (2010) 1.11

Senescent peritoneal mesothelial cells promote ovarian cancer cell adhesion: the role of oxidative stress-induced fibronectin. Am J Pathol (2009) 1.08

Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism. J Cell Physiol (2010) 1.07

The mechanism of lens placode formation: a case of matrix-mediated morphogenesis. Dev Biol (2011) 1.04

Three-dimensional culture regulates Raf-1 expression to modulate fibronectin matrix assembly. Mol Biol Cell (2006) 0.99

Angioinhibitory action of NK4 involves impaired extracellular assembly of fibronectin mediated by perlecan-NK4 association. J Biol Chem (2009) 0.97

PAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the alphavbeta5 and alpha5beta1 integrins. J Cell Sci (2008) 0.96

Syntaxin 6, a regulator of the protein trafficking machinery and a target of the p53 family, is required for cell adhesion and survival. J Biol Chem (2008) 0.96

Actin cytoskeleton in myofibroblast differentiation: ultrastructure defining form and driving function. Transl Res (2011) 0.96

Mislocalized scaffolding by the Na-H exchanger NHE1 dominantly inhibits fibronectin production and TGF-beta activation. Mol Biol Cell (2009) 0.95

Cooperative binding and activation of fibronectin by a bacterial surface protein. J Biol Chem (2010) 0.95

Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces. Hepatology (2015) 0.94

Evolution of complexity in the integrin adhesome. J Cell Biol (2009) 0.94

Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation. Dev Biol (2014) 0.94

Matrix control of scarring. Cell Mol Life Sci (2011) 0.93

Dynamic 3D cell rearrangements guided by a fibronectin matrix underlie somitogenesis. PLoS One (2009) 0.93

Alcohol promotes breast cancer cell invasion by regulating the Nm23-ITGA5 pathway. J Exp Clin Cancer Res (2011) 0.93

Nanoscale features of fibronectin fibrillogenesis depend on protein-substrate interaction and cytoskeleton structure. Biophys J (2004) 0.93

Fibronectin-α4β1 interactions in hepatic cold ischemia and reperfusion injury: regulation of MMP-9 and MT1-MMP via the p38 MAPK pathway. Am J Transplant (2012) 0.92

Fibronectin-alpha4beta1 integrin interactions regulate metalloproteinase-9 expression in steatotic liver ischemia and reperfusion injury. Am J Pathol (2007) 0.91

Fibronectin: functional character and role in alcoholic liver disease. World J Gastroenterol (2011) 0.89

Cellular fibronectin expression in human trabecular meshwork and induction by transforming growth factor-β2. Invest Ophthalmol Vis Sci (2013) 0.88

Current concepts of extracellular matrix. J Orthop Sci (2006) 0.88

FGF2-induced effects on transcriptome associated with regeneration competence in adult human fibroblasts. BMC Genomics (2013) 0.88

Mechanical stretch and shear flow induced reorganization and recruitment of fibronectin in fibroblasts. Sci Rep (2011) 0.88

Skin wound healing and scarring: fetal wounds and regenerative restitution. Birth Defects Res C Embryo Today (2012) 0.87

Leupaxin is similar to paxillin in focal adhesion targeting and tyrosine phosphorylation but has distinct roles in cell adhesion and spreading. Cell Adh Migr (2011) 0.87

An angiogenic role for the α5β1 integrin in promoting endothelial cell proliferation during cerebral hypoxia. Exp Neurol (2012) 0.87

Extra-domain B in oncofetal fibronectin structurally promotes fibrillar head-to-tail dimerization of extracellular matrix protein. J Biol Chem (2012) 0.87

iso-DGR sequences do not mediate binding of fibronectin N-terminal modules to adherent fibronectin-null fibroblasts. J Biol Chem (2010) 0.87

ECM protein nanofibers and nanostructures engineered using surface-initiated assembly. J Vis Exp (2014) 0.86

Relative sialylation and fucosylation of synovial and plasma fibronectins in relation to the progression and activity of rheumatoid arthritis. Glycoconj J (2007) 0.85

Inadequate activation of the GTPase RhoA contributes to the lack of fibronectin matrix assembly in von Hippel-Lindau protein-defective renal cancer cells. J Biol Chem (2008) 0.85

Novel chemo-sensitizing agent, ERW1227B, impairs cellular motility and enhances cell death in glioblastomas. J Neurooncol (2010) 0.85

Extracellular molecules involved in cancer cell invasion. Cancers (Basel) (2015) 0.85

Fibronectin fibril pattern displays the force balance of cell-matrix adhesion. Eur Biophys J (2005) 0.84

Conditional knockout of fibronectin abrogates mouse mammary gland lobuloalveolar differentiation. Dev Biol (2010) 0.84

Coordinate regulation of fibronectin matrix assembly by the plasminogen activator system and vitronectin in human osteosarcoma cells. Cancer Cell Int (2006) 0.83

Development and fibronectin signaling requirements of the zebrafish interrenal vessel. PLoS One (2012) 0.81

Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells. PLoS One (2014) 0.81

A dual role for caveolin-1 in the regulation of fibronectin matrix assembly by uPAR. J Cell Sci (2008) 0.81

Requirement of focal adhesion kinase in branching tubulogenesis. J Biomed Sci (2009) 0.80

The laminin alpha-1 chain derived peptide, AG73, increases fibronectin levels in breast and melanoma cancer cells. Clin Exp Metastasis (2008) 0.80

Cell-material interactions on biphasic polyurethane matrix. J Biomed Mater Res A (2012) 0.80

Nano-stenciled RGD-gold patterns that inhibit focal contact maturation induce lamellipodia formation in fibroblasts. PLoS One (2011) 0.80

Interplay of mechanical and binding properties of Fibronectin type I. Theor Chem Acc (2010) 0.79

αV-integrins are required for mechanotransduction in MDCK epithelial cells. PLoS One (2013) 0.79

Human apolipoprotein(a) kringle V inhibits ischemia-induced retinal neovascularization via suppression of fibronectin-mediated angiogenesis. Diabetes (2012) 0.79

Functional cooperation of spns2 and fibronectin in cardiac and lower jaw development. Biol Open (2013) 0.79

Expression of cellular fibronectin mRNA in adult periodontitis and peri-implantitis: a real-time polymerase chain reaction study. Int J Oral Sci (2013) 0.77

Biopolymers and supramolecular polymers as biomaterials for biomedical applications. MRS Bull (2015) 0.77

The shed ectodomain of type XIII collagen associates with the fibrillar fibronectin matrix and may interfere with its assembly in vitro. Biochem J (2006) 0.77

Fluorescently tagged laminin subunits facilitate analyses of the properties, assembly and processing of laminins in live and fixed lung epithelial cells and keratinocytes. Matrix Biol (2008) 0.76

Combined effect of insulin-like growth factor-1 and CC chemokine ligand 2 on angiogenic events in endothelial cells. PLoS One (2015) 0.76

Theory of the origin, evolution, and nature of life. Life (Basel) (2011) 0.76

Regulation of matrix remodelling phenotype in gingival fibroblasts by substratum topography. J Cell Mol Med (2015) 0.76

The monoclonal antibody SM5-1 recognizes a fibronectin variant which is widely expressed in melanoma. BMC Cancer (2006) 0.76

Fibronectin molecular status determination useful to differentiate between rheumatoid arthritis and systemic lupus erythematosus patients. Rheumatol Int (2012) 0.75

Syndecan-1-Induced ECM Fiber Alignment Requires Integrin αvβ3 and Syndecan-1 Ectodomain and Heparan Sulfate Chains. PLoS One (2016) 0.75

Engineering of Self-Assembled Fibronectin Matrix Protein and Its Effects on Mesenchymal Stem Cells. Int J Mol Sci (2015) 0.75

Biomarkers Discovery for Colorectal Cancer: A Review on Tumor Endothelial Markers as Perspective Candidates. Dis Markers (2016) 0.75

Hepatic congestion leads to fibrosis: findings in a newly developed murine model. Hepatology (2015) 0.75

α5β1 integrin mediates pulmonary epithelial cyst formation. Dev Dyn (2017) 0.75

Fibronectin fibrillogenesis, a cell-mediated matrix assembly process. Matrix Biol (2005) 3.62

Assembly of fibronectin extracellular matrix. Annu Rev Cell Dev Biol (2010) 2.86

Tissue repair and the dynamics of the extracellular matrix. Int J Biochem Cell Biol (2004) 2.59

Fibronectin expression modulates mammary epithelial cell proliferation during acinar differentiation. Cancer Res (2008) 1.81

Stimulatory effects of a three-dimensional microenvironment on cell-mediated fibronectin fibrillogenesis. J Cell Sci (2005) 1.52

Talin loss-of-function uncovers roles in cell contractility and migration in C. elegans. J Cell Sci (2003) 1.51

Meet the tenascins: multifunctional and mysterious. J Biol Chem (2005) 1.50

A systematic RNA interference screen reveals a cell migration gene network in C. elegans. J Cell Sci (2006) 1.32

Distinct activation states of alpha5beta1 integrin show differential binding to RGD and synergy domains of fibronectin. Biochemistry (2002) 1.29

Tenascin-C modulates matrix contraction via focal adhesion kinase- and Rho-mediated signaling pathways. Mol Biol Cell (2002) 1.27

Accessibility to the fibronectin synergy site in a 3D matrix regulates engagement of alpha5beta1 versus alphavbeta3 integrin receptors. Cell Commun Adhes (2006) 1.21

Coregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4. Mol Biol Cell (2004) 1.16

Fibronectin and stem cell differentiation - lessons from chondrogenesis. J Cell Sci (2012) 1.15

Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors. Genes Dev (2007) 1.15

Fibroblast migration on fibronectin requires three distinct functional domains. J Invest Dermatol (2003) 1.09

A novel mode of cell detachment from fibrillar fibronectin matrix under shear. J Cell Sci (2009) 1.08

Modulation of cell-fibronectin matrix interactions during tissue repair. J Investig Dermatol Symp Proc (2006) 1.07

Regulatory role for SRC and phosphatidylinositol 3-kinase in initiation of fibronectin matrix assembly. J Biol Chem (2002) 1.05

Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30. Mol Endocrinol (2009) 1.05

Temporal and spatial regulation of integrins during development. Curr Opin Cell Biol (2008) 1.03

Analysis of fibronectin matrix assembly. Curr Protoc Cell Biol (2004) 1.02

Elastic fibers: building bridges between cells and their matrix. Curr Biol (2002) 1.01

Fibronectin fragmentation promotes alpha4beta1 integrin-mediated contraction of a fibrin-fibronectin provisional matrix. Exp Cell Res (2005) 1.01

Endogenous production of fibronectin is required for self-renewal of cultured mouse embryonic stem cells. Exp Cell Res (2012) 0.99

Self-assembled monolayers of alpha,omega-diphosphonic acids on Ti enable complete or spatially controlled surface derivatization. Langmuir (2004) 0.97

Requirements for sulfate transport and the diastrophic dysplasia sulfate transporter in fibronectin matrix assembly. J Cell Biol (2007) 0.97

Role of material-driven fibronectin fibrillogenesis in cell differentiation. Biomaterials (2010) 0.96

Continuous requirement for pp60-Src and phospho-paxillin during fibronectin matrix assembly by transformed cells. J Cell Physiol (2007) 0.93

Easy and efficient bonding of biomolecules to an oxide surface of silicon. Langmuir (2004) 0.92

Connections between integrins and Rac GTPase pathways control gonad formation and function in C. elegans. Biochim Biophys Acta (2005) 0.90

Probing the conformation of the fibronectin III1-2 domain by fluorescence resonance energy transfer. J Biol Chem (2008) 0.90

Defined extracellular matrix components are necessary for definitive endoderm induction. Stem Cells (2013) 0.89

A shared mechanism of adhesion modulation for tenascin-C and fibulin-1. Mol Biol Cell (2008) 0.88

Regulation of matrix assembly through rigidity-dependent fibronectin conformational changes. J Biol Chem (2013) 0.88

Gonad morphogenesis and distal tip cell migration in the Caenorhabditis elegans hermaphrodite. Wiley Interdiscip Rev Dev Biol (2013) 0.86

High-yield activation of scaffold polymer surfaces to attach cell adhesion molecules. J Am Chem Soc (2007) 0.82

Ligand density and integrin repertoire regulate cellular response to LPA. Matrix Biol (2006) 0.81

The talin wags the dog: new insights into integrin activation. Trends Cell Biol (2004) 0.81

A Simple Nanoscale Interface Directs Alignment of a Confluent Cell Layer on Oxide and Polymer Surfaces. J Mater Chem B Mater Biol Med (2013) 0.80

Engineered cell-adhesive nanoparticles nucleate extracellular matrix assembly. Tissue Eng (2007) 0.80

Functional characterization of KIN-32, the Caenorhabditis elegans homolog of focal adhesion kinase. Dev Dyn (2008) 0.79

Preparation and analysis of synthetic multicomponent extracellular matrix. Methods Cell Biol (2002) 0.79

mig-38, a novel gene that regulates distal tip cell turning during gonadogenesis in C. elegans hermaphrodites. Dev Biol (2012) 0.79

Organogenesis: cutting to the chase. Curr Biol (2004) 0.78

Albumin-derived nanocarriers: substrates for enhanced cell adhesive ligand display and cell motility. Biomaterials (2006) 0.76

Cell-to-cell contact and extracellular matrix. Curr Opin Cell Biol (2008) 0.76

Analysis of cell migration using Caenorhabditis elegans as a model system. Methods Mol Biol (2011) 0.76

Adenoviral-mediated expression and local deposition of recombinant tenascin-C perturbs cell-dependent matrix contraction. J Surg Res (2006) 0.76

Surface derivatization strategy for combinatorial analysis of cell response to mixtures of protein domains. Langmuir (2011) 0.75

Transcriptionally regulated cell adhesion network dictates distal tip cell directionality. Dev Dyn (2014) 0.75

α Integrin cytoplasmic tails have tissue-specific roles during C. elegans development. Int J Dev Biol (2014) 0.75

Nanomaterials can dynamically steer cell responses to biological ligands. Small (2010) 0.75

Tightening the connections between cadherins and fibronectin matrix. Dev Cell (2009) 0.75