Published in Mol Biol Cell on March 20, 2003
Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis. EMBO J (2005) 1.70
The N-terminal region of IFITM3 modulates its antiviral activity by regulating IFITM3 cellular localization. J Virol (2012) 1.64
The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Proc Natl Acad Sci U S A (2006) 1.09
Immune and inflammatory pathways are involved in inherent bone marrow ossification. Clin Orthop Relat Res (2012) 0.93
Protein kinaseCdelta-calmodulin crosstalk regulates epidermal growth factor receptor exit from early endosomes. Mol Biol Cell (2004) 0.89
Protein kinase Cdelta and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin. Mol Biol Cell (2007) 0.89
Bruton's tyrosine kinase mediates the synergistic signalling between TLR9 and the B cell receptor by regulating calcium and calmodulin. PLoS One (2013) 0.85
Tuberculosis: new aspects of an old disease. Int J Cell Biol (2011) 0.83
Class IA phosphatidylinositol 3-kinase p110α regulates phagosome maturation. PLoS One (2012) 0.81
Perforin enhances the granulysin-induced lysis of Listeria innocua in human dendritic cells. BMC Immunol (2007) 0.80
CMTM7 knockdown increases tumorigenicity of human non-small cell lung cancer cells and EGFR-AKT signaling by reducing Rab5 activation. Oncotarget (2015) 0.75
rab5 controls early endosome fusion in vitro. Cell (1991) 8.31
EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature (1998) 7.92
The Rab5 effector EEA1 is a core component of endosome docking. Nature (1999) 5.78
EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif. J Biol Chem (1995) 5.45
Mycobacterium tuberculosis: here today, and here tomorrow. Nat Rev Mol Cell Biol (2001) 4.91
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nat Cell Biol (2001) 4.64
Calmodulin in action: diversity in target recognition and activation mechanisms. Cell (2002) 3.77
Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin. Nature (2001) 3.67
Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger. J Biol Chem (1996) 3.53
Ca2+/calmodulin signals the completion of docking and triggers a late step of vacuole fusion. Nature (1998) 3.33
Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes. Nat Cell Biol (2001) 3.14
The role of intraorganellar Ca(2+) in late endosome-lysosome heterotypic fusion and in the reformation of lysosomes from hybrid organelles. J Cell Biol (2000) 2.46
PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat Cell Biol (2001) 2.39
SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P. Nat Cell Biol (2001) 2.33
Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes. Curr Biol (1998) 2.15
Multivalent endosome targeting by homodimeric EEA1. Mol Cell (2001) 2.03
Distinct roles for the p110alpha and hVPS34 phosphatidylinositol 3'-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis. J Cell Biol (1998) 1.97
All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate. J Biol Chem (2001) 1.96
Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmannin. J Cell Biol (1996) 1.92
Sequential roles for phosphatidylinositol 3-phosphate and Rab5 in tethering and fusion of early endosomes via their interaction with EEA1. J Biol Chem (2001) 1.59
Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain. J Biol Chem (1996) 1.58
Distinct effects of alpha-SNAP, 14-3-3 proteins, and calmodulin on priming and triggering of regulated exocytosis. J Cell Biol (1995) 1.48
Insulin action on GLUT4 traffic visualized in single 3T3-l1 adipocytes by using ultra-fast microscopy. Mol Biol Cell (2001) 1.36
Relationships between EEA1 binding partners and their role in endosome fusion. J Cell Sci (2001) 1.33
Fusion of endosomes involved in synaptic vesicle recycling. Mol Biol Cell (1999) 1.29
Both calmodulin and the unconventional myosin Myr4 regulate membrane trafficking along the recycling pathway of MDCK cells. Traffic (2000) 1.27
The calmodulin antagonist, W-13, alters transcytosis, recycling, and the morphology of the endocytic pathway in Madin-Darby canine kidney cells. J Biol Chem (1994) 1.24
Phox homology domains specifically bind phosphatidylinositol phosphates. Biochemistry (2001) 1.24
Calmodulin regulates endosome fusion. J Biol Chem (1997) 1.24
Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A (2001) 1.16
Regulation of endosome fusion. Mol Membr Biol (1999) 1.14
Imaging Ca2+ concentration changes at the secretory vesicle surface with a recombinant targeted cameleon. Curr Biol (1999) 1.02
Role of calmodulin in platelet aggregation. Structure-activity relationship of calmodulin antagonists. J Clin Invest (1982) 1.02
Calcium regulation of exocytosis in PC12 cells. J Biol Chem (2001) 0.95
Calcium-binding proteins and secretion. Cell Calcium (1986) 0.92
A 115 kDa calmodulin-binding protein is located in rat liver endosome fractions. Biochem J (1988) 0.89
Alteration of calmodulin-protein interactions by a monoclonal antibody to calmodulin. Biochim Biophys Acta (1994) 0.78
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol (2008) 8.43
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J Clin Invest (2004) 4.16
The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells. Cell Metab (2012) 2.97
Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone. Mol Cell Biol (2003) 2.95
Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage. J Biol Chem (2007) 2.90
Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc Natl Acad Sci U S A (2008) 2.71
Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. J Clin Invest (2005) 2.69
Visualization of single molecules of mRNA in situ. Methods Enzymol (2003) 2.62
The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev (2010) 2.59
TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2. J Cell Biol (2002) 2.34
EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton. J Biol Chem (2003) 1.99
Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity. Circulation (2011) 1.97
Stimulation of neural regeneration in the mouse retina. Proc Natl Acad Sci U S A (2008) 1.95
Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway. Mol Cell Biol (2004) 1.86
Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC. EMBO Mol Med (2009) 1.80
Enhanced angiogenesis in obesity and in response to PPARgamma activators through adipocyte VEGF and ANGPTL4 production. Am J Physiol Endocrinol Metab (2008) 1.79
An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport. Proc Natl Acad Sci U S A (2006) 1.78
Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes. J Cell Sci (2008) 1.70
Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules. EMBO J (2003) 1.64
A phosphatidylinositol 3-kinase-independent insulin signaling pathway to N-WASP/Arp2/3/F-actin required for GLUT4 glucose transporter recycling. J Biol Chem (2001) 1.60
Sequential roles for phosphatidylinositol 3-phosphate and Rab5 in tethering and fusion of early endosomes via their interaction with EEA1. J Biol Chem (2001) 1.59
Insulin stimulates membrane fusion and GLUT4 accumulation in clathrin coats on adipocyte plasma membranes. Mol Cell Biol (2007) 1.50
Structural basis for endosomal targeting by FYVE domains. J Biol Chem (2003) 1.50
Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2. J Biol Chem (2007) 1.35
What causes the insulin resistance underlying obesity? Curr Opin Endocrinol Diabetes Obes (2012) 1.35
The p40phox and p47phox PX domains of NADPH oxidase target cell membranes via direct and indirect recruitment by phosphoinositides. J Biol Chem (2001) 1.34
Phosphatidylinositol-4,5-bisphosphate-rich plasma membrane patches organize active zones of endocytosis and ruffling in cultured adipocytes. Mol Cell Biol (2004) 1.32
Plasma membrane domains specialized for clathrin-mediated endocytosis in primary cells. J Biol Chem (2006) 1.31
Ian4 is required for mitochondrial integrity and T cell survival. Proc Natl Acad Sci U S A (2003) 1.19
Role of insulin action and cell size on protein expression patterns in adipocytes. J Biol Chem (2004) 1.17
Baf60c is a component of the neural progenitor-specific BAF complex in developing retina. Dev Dyn (2008) 1.12
NeuroD1 regulates expression of thyroid hormone receptor 2 and cone opsins in the developing mouse retina. J Neurosci (2008) 1.12
Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes. Biochem J (2008) 1.10
The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Proc Natl Acad Sci U S A (2006) 1.09
Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis. Proc Natl Acad Sci U S A (2012) 1.08
Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1). Proc Natl Acad Sci U S A (2010) 1.07
Alternatively Activated M2 Macrophages Improve Autologous Fat Graft Survival in a Mouse Model through Induction of Angiogenesis. Plast Reconstr Surg (2015) 1.07
Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells. J Biol Chem (2008) 1.05
Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity. Mol Cell Biol (2009) 1.05
Glucan particles for selective delivery of siRNA to phagocytic cells in mice. Biochem J (2011) 1.03
Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning. J Neurosci (2009) 1.02
Regulation of fat specific protein 27 by isoproterenol and TNF-α to control lipolysis in murine adipocytes. J Lipid Res (2010) 1.01
Evolutionarily conserved structural and functional roles of the FYVE domain. Biochem Soc Symp (2007) 1.00
Neuropilin-2 regulates α6β1 integrin in the formation of focal adhesions and signaling. J Cell Sci (2012) 0.98
RNAi-based gene silencing in primary mouse and human adipose tissues. J Lipid Res (2006) 0.98
Identification of Map4k4 as a novel suppressor of skeletal muscle differentiation. Mol Cell Biol (2012) 0.96
Map4k4 negatively regulates peroxisome proliferator-activated receptor (PPAR) gamma protein translation by suppressing the mammalian target of rapamycin (mTOR) signaling pathway in cultured adipocytes. J Biol Chem (2009) 0.94
A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes. J Biol Chem (2010) 0.93
Visual evoked potentials with CRT and LCD monitors: when newer is not better. Neurology (2009) 0.92
Identification of the lipid droplet targeting domain of the Cidea protein. J Lipid Res (2010) 0.92
Regulation of the SHP-2 tyrosine phosphatase by a novel cholesterol- and cell confluence-dependent mechanism. J Biol Chem (2003) 0.91
Isoform-specific regulation of Akt signaling by the endosomal protein WDFY2. J Biol Chem (2010) 0.89
A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells. PLoS One (2010) 0.89
Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response. J Biol Chem (2010) 0.88
Antibodies to cell surface proteins redirect intracellular trafficking pathways. Exp Mol Pathol (2011) 0.86
Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2alpha. J Biol Chem (2005) 0.84
Notch signaling plays a key role in cardiac cell differentiation. Mech Dev (2006) 0.84
Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues. Mol Cell Biol (2015) 0.84
CD14 deficiency impacts glucose homeostasis in mice through altered adrenal tone. PLoS One (2012) 0.83
Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking. Orphanet J Rare Dis (2014) 0.83
Protein kinase Cα and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog. Mol Cell Neurosci (2012) 0.81
Estimates of the years-of-life-lost due to the top nine causes of death in rural areas of major states in India in 1995. Natl Med J India (2002) 0.80
Molecular insights into Rab7-mediated endosomal recruitment of core retromer: deciphering the role of Vps26 and Vps35. Traffic (2014) 0.80
Human adipose tissue expansion in pregnancy is impaired in gestational diabetes mellitus. Diabetologia (2015) 0.78
The Association Between Social Skills and Mental Health in School-Aged Children with Autism Spectrum Disorder, With and Without Intellectual Disability. J Autism Dev Disord (2015) 0.78
Tensions rise and blood flows over dysfunctional fat. Circulation (2011) 0.77
Time-resolved ultrastructural detection of phosphatidylinositol 3-phosphate. J Histochem Cytochem (2010) 0.76
Designing an Internationally Accessible Web-Based Questionnaire to Discover Risk Factors for Amyotrophic Lateral Sclerosis: A Case-Control Study. JMIR Res Protoc (2015) 0.75
Redesign of portable suction equipment cases: an engineering approach to a disinfection problem. Am J Infect Control (2006) 0.75
Monovalent polio immunisation--a strategy for India. J Indian Med Assoc (2005) 0.75