Published in J Biol Chem on February 26, 2010
Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21
Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor. J Cell Biol (2010) 1.90
In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes. Cancer Discov (2015) 1.02
Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomes. J Biol Chem (2010) 1.01
Endosomal acidification by Na+/H+ exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling. Mol Biol Cell (2013) 0.86
Ubiquitination regulates the internalization, endolysosomal sorting, and signaling of the erythropoietin receptor. J Biol Chem (2010) 0.85
Therapeutic Implications of Targeting AKT Signaling in Melanoma. Enzyme Res (2011) 0.85
Endosomal pH in neuronal signaling and synaptic transmission: role of Na(+)/H(+) exchanger NHE5. Front Physiol (2014) 0.80
NRP2 transcriptionally regulates its downstream effector WDFY1. Sci Rep (2016) 0.75
The tomato cell death suppressor Adi3 is restricted to the endosomal system in response to the Pseudomonas syringae effector protein AvrPto. PLoS One (2014) 0.75
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science (2001) 11.22
Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat Cell Biol (2003) 7.74
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem (2001) 7.10
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell (2007) 6.00
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J Clin Invest (2003) 4.79
Derailed endocytosis: an emerging feature of cancer. Nat Rev Cancer (2008) 4.25
Structure, regulation and function of PKB/AKT--a major therapeutic target. Biochim Biophys Acta (2004) 4.11
Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol Cell Biol (2005) 4.00
APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. Cell (2004) 3.95
PI3K/Akt: getting it right matters. Oncogene (2008) 3.91
Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Cell (2006) 3.83
Regulation of membrane traffic by phosphoinositide 3-kinases. J Cell Sci (2006) 3.72
APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol (2006) 3.55
Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr Opin Cell Biol (1999) 3.47
The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development. Cell (2008) 3.37
Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci U S A (2003) 3.03
A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes. Cell (2009) 2.77
Physiological roles of PKB/Akt isoforms in development and disease. Biochem Soc Trans (2007) 2.70
TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2. J Cell Biol (2002) 2.34
Phosphoinositides in membrane traffic. Curr Opin Cell Biol (1999) 1.90
Regulation of receptor tyrosine kinase signaling by endocytic trafficking. Traffic (2001) 1.89
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation. J Biol Chem (2007) 1.80
APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction. Mol Cell Biol (2006) 1.78
Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes. J Cell Sci (2008) 1.70
Negative Regulation of AKT Activation by BRCA1. Cancer Res (2008) 1.34
Plasma membrane domains specialized for clathrin-mediated endocytosis in primary cells. J Biol Chem (2006) 1.31
Tumor necrosis factor-{alpha} decreases Akt protein levels in 3T3-L1 adipocytes via the caspase-dependent ubiquitination of Akt. Endocrinology (2005) 1.22
Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity. J Cell Biol (2006) 1.20
APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex. Mol Cell Endocrinol (2006) 1.18
The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Proc Natl Acad Sci U S A (2006) 1.09
Role of endocytosis in signalling and regulation of G-protein-coupled receptors. Biochem Soc Trans (2001) 1.04
A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda. Biochem J (2006) 1.01
Function of Hrs in endocytic trafficking and signalling. Biochem Soc Trans (2001) 1.00
Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis. EMBO J (2008) 0.93
Neurotransmitter receptor trafficking and the regulation of synaptic strength. Traffic (2001) 0.92
WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta. FEBS J (2007) 0.91
Solving the FYVE domain--PtdIns(3)P puzzle. Nat Struct Biol (2001) 0.81
"One plate/three-reporter" assay format for the detection and validation of yeast two-hybrid interactions. Biotechniques (2004) 0.79
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J Clin Invest (2004) 4.16
Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature (2009) 3.21
Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci U S A (2003) 3.03
The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells. Cell Metab (2012) 2.97
Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone. Mol Cell Biol (2003) 2.95
Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage. J Biol Chem (2007) 2.90
Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc Natl Acad Sci U S A (2008) 2.71
The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev (2010) 2.59
Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c. Nature (2002) 2.51
TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2. J Cell Biol (2002) 2.34
EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton. J Biol Chem (2003) 1.99
Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity. Circulation (2011) 1.97
Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway. Mol Cell Biol (2004) 1.86
Enhanced angiogenesis in obesity and in response to PPARgamma activators through adipocyte VEGF and ANGPTL4 production. Am J Physiol Endocrinol Metab (2008) 1.79
Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes. J Cell Sci (2008) 1.70
A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1. J Biol Chem (2003) 1.65
Sequential roles for phosphatidylinositol 3-phosphate and Rab5 in tethering and fusion of early endosomes via their interaction with EEA1. J Biol Chem (2001) 1.59
Identification of FOXP3-negative regulatory T-like (CD4(+)CD25(+)CD127(low)) cells in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Clin Immunol (2011) 1.57
Insulin stimulates membrane fusion and GLUT4 accumulation in clathrin coats on adipocyte plasma membranes. Mol Cell Biol (2007) 1.50
Structural basis for endosomal targeting by FYVE domains. J Biol Chem (2003) 1.50
What causes the insulin resistance underlying obesity? Curr Opin Endocrinol Diabetes Obes (2012) 1.35
Amphetamine-induced decreases in dopamine transporter surface expression are protein kinase C-independent. Neuropharmacology (2007) 1.33
Plasma membrane domains specialized for clathrin-mediated endocytosis in primary cells. J Biol Chem (2006) 1.31
Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells. J Biol Chem (2005) 1.23
Ian4 is required for mitochondrial integrity and T cell survival. Proc Natl Acad Sci U S A (2003) 1.19
Dopamine transporter endocytic determinants: carboxy terminal residues critical for basal and PKC-stimulated internalization. Mol Cell Neurosci (2008) 1.18
Role of insulin action and cell size on protein expression patterns in adipocytes. J Biol Chem (2004) 1.17
Imbalance between neutrophil elastase and its inhibitor α1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metab (2013) 1.16
The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Proc Natl Acad Sci U S A (2006) 1.09
Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis. Proc Natl Acad Sci U S A (2012) 1.08
Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1). Proc Natl Acad Sci U S A (2010) 1.07
Alternatively Activated M2 Macrophages Improve Autologous Fat Graft Survival in a Mouse Model through Induction of Angiogenesis. Plast Reconstr Surg (2015) 1.07
A role for Hrs in endosomal sorting of ligand-stimulated and unstimulated epidermal growth factor receptor. Exp Cell Res (2004) 1.07
Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma. J Hum Genet (2006) 1.07
Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells. J Biol Chem (2008) 1.05
C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. Cell Metab (2011) 1.03
Evolutionarily conserved structural and functional roles of the FYVE domain. Biochem Soc Symp (2007) 1.00
RNAi-based gene silencing in primary mouse and human adipose tissues. J Lipid Res (2006) 0.98
Dissociation of halted T7 RNA polymerase elongation complexes proceeds via a forward-translocation mechanism. Proc Natl Acad Sci U S A (2007) 0.96
Minimal change nephrotic syndrome associated with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Pediatr Nephrol (2009) 0.92
The first report of adolescent TAFRO syndrome, a unique clinicopathologic variant of multicentric Castleman's disease. BMC Pediatr (2014) 0.91
Essential role of Ca2+/calmodulin in Early Endosome Antigen-1 localization. Mol Biol Cell (2003) 0.91
Regulation of the SHP-2 tyrosine phosphatase by a novel cholesterol- and cell confluence-dependent mechanism. J Biol Chem (2003) 0.91
Photoactivated 3-azioctanol irreversibly desensitizes muscle nicotinic ACh receptors via interactions at alphaE262. Biochemistry (2007) 0.90
Automatic detection of immature platelets for decision making regarding platelet transfusion indications for pediatric patients. Transfus Apher Sci (2008) 0.89
Escherichia coli O26 in feedlot cattle: fecal prevalence, isolation, characterization, and effects of an E. coli O157 vaccine and a direct-fed microbial. Foodborne Pathog Dis (2013) 0.88
Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response. J Biol Chem (2010) 0.88
Antibodies to cell surface proteins redirect intracellular trafficking pathways. Exp Mol Pathol (2011) 0.86
Phosphorylation of FAR-RED ELONGATED HYPOCOTYL1 is a key mechanism defining signaling dynamics of phytochrome A under red and far-red light in Arabidopsis. Plant Cell (2012) 0.85
Longitudinal emergence and distribution of Escherichia coli O157 genotypes in a beef feedlot. Appl Environ Microbiol (2006) 0.84
Minimal residual disease monitoring in neuroblastoma patients based on the expression of a set of real-time RT-PCR markers in tumor-initiating cells. Oncol Rep (2013) 0.84
CD14 deficiency impacts glucose homeostasis in mice through altered adrenal tone. PLoS One (2012) 0.83
Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking. Orphanet J Rare Dis (2014) 0.83
Analysis of histone modification around the CpG island region of the p15 gene in acute myeloblastic leukemia. Leuk Res (2006) 0.81
Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region. Proc Natl Acad Sci U S A (2013) 0.81
Rab15 expression correlates with retinoic acid-induced differentiation of neuroblastoma cells. Oncol Rep (2011) 0.81
Development of the Japanese version of the Minneapolis-Manchester Quality of Life Survey of Health - Adolescent Form (MMQL-AF) and investigation of its reliability and validity. Health Qual Life Outcomes (2014) 0.81
Characterization of the protein dimerization domain responsible for assembly of functional selenodeiodinases. J Biol Chem (2005) 0.81
Ubiquitin-interacting motifs confer full catalytic activity, but not ubiquitin chain substrate specificity, to deubiquitinating enzyme USP37. J Biol Chem (2013) 0.81
Electron microscopy of wet tissues: a case study in renal pathology. Toxicol Pathol (2004) 0.80
High level of ezrin mRNA expression in an osteosarcoma biopsy sample with lung metastasis. J Pediatr Hematol Oncol (2007) 0.79
FLNA p.V528M substitution is neither associated with bilateral periventricular nodular heterotopia nor with macrothrombocytopenia. J Hum Genet (2010) 0.79
Current cat ownership may be associated with the lower prevalence of atopic dermatitis, allergic rhinitis, and Japanese cedar pollinosis in schoolchildren in Himeji, Japan. Pediatr Allergy Immunol (2006) 0.79
Congenital cardiovascular malformations are complicated in neuroblastomas identified by mass screening but not by clinical examination in Japan. J Pediatr (2006) 0.78
Human adipose tissue expansion in pregnancy is impaired in gestational diabetes mellitus. Diabetologia (2015) 0.78
Bone marrow magnetic resonance imaging of the clivus in pediatric leukemia patients and normal controls. Jpn J Radiol (2015) 0.78
Association of genetic polymorphisms with hepatotoxicity in patients with childhood acute lymphoblastic leukemia or lymphoma. Pediatr Hematol Oncol (2010) 0.77
Persistent detection of a novel MLL-SACM1L rearrangement in the absence of leukemia. Leuk Res (2010) 0.77
Rab15 alternative splicing is altered in spheres of neuroblastoma cells. Oncol Rep (2012) 0.77
Identification of the key residues responsible for the assembly of selenodeiodinases. J Biol Chem (2006) 0.77
Tensions rise and blood flows over dysfunctional fat. Circulation (2011) 0.77
Transient macrothrombocytopenia associated with maternal-neonatal HPA-21bw incompatibility. Thromb Res (2013) 0.76
Mapping ubiquitin modifications reveals new functions for the yeast nuclear pore complex. Cell Logist (2012) 0.76
Time-resolved ultrastructural detection of phosphatidylinositol 3-phosphate. J Histochem Cytochem (2010) 0.76
Hematopoietic stem cell transplantation for patients with acute lymphoblastic leukemia and Down syndrome. Pediatr Blood Cancer (2014) 0.76
Long-term follow-up of children with refractory immune thrombocytopenia treated with rituximab. Int J Hematol (2014) 0.76
Epigallocatechin gallate inhibits sphere formation of neuroblastoma BE(2)-C cells. Environ Health Prev Med (2011) 0.75
Application of electrolyte analysis of pleural effusion to diagnosis of drowning. Leg Med (Tokyo) (2012) 0.75
The emergence of CD20-/CD19- tumor cells after rituximab therapy for Epstein-Barr virus-associated post-transplant lymphoproliferative disorder complicated with hemophagocytic lymphohistiocytosis. Eur J Pediatr (2013) 0.75
Raising future forensic pathologists (second report): results of a preliminary interview survey. Hokkaido Igaku Zasshi (2012) 0.75
Correction: The Dkk3 gene encodes a vital intracellular regulator of cell proliferation. PLoS One (2017) 0.75
Place of death of pediatric cancer patients in a single institute during 7 years. Kobe J Med Sci (2012) 0.75
Utility of multiplex PCR in detecting the causative pathogens for pediatric febrile neutropenia. Kobe J Med Sci (2011) 0.75