Published in J Cell Biol on July 21, 2003
Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis. Mol Biol Cell (2004) 1.93
Rap2A links intestinal cell polarity to brush border formation. Nat Cell Biol (2012) 1.71
Phospholipase D: enzymology, functionality, and chemical modulation. Chem Rev (2011) 1.66
The phospholipase D1 pathway modulates macroautophagy. Nat Commun (2010) 1.56
Insulin-stimulated plasma membrane fusion of Glut4 glucose transporter-containing vesicles is regulated by phospholipase D1. Mol Biol Cell (2005) 1.53
Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits. J Neurosci (2010) 1.49
Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway. J Cell Biol (2011) 1.31
Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane. Mol Biol Cell (2008) 1.30
An effector domain mutant of Arf6 implicates phospholipase D in endosomal membrane recycling. Mol Biol Cell (2005) 1.23
Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis. Future Oncol (2009) 1.17
Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling. Oncogene (2009) 1.14
Phospholipase D in endocytosis and endosomal recycling pathways. Biochim Biophys Acta (2009) 1.12
Phospholipase D2 is required for efficient endocytic recycling of transferrin receptors. Mol Biol Cell (2005) 1.11
Phospholipase signalling networks in cancer. Nat Rev Cancer (2012) 1.10
Kinetic analysis of a mammalian phospholipase D: allosteric modulation by monomeric GTPases, protein kinase C, and polyphosphoinositides. J Biol Chem (2005) 1.10
Phospholipase D signaling: orchestration by PIP2 and small GTPases. Naunyn Schmiedebergs Arch Pharmacol (2007) 1.09
Mammalian phospholipase D physiological and pathological roles. Acta Physiol (Oxf) (2011) 1.06
SCAMP2 interacts with Arf6 and phospholipase D1 and links their function to exocytotic fusion pore formation in PC12 cells. Mol Biol Cell (2005) 1.02
Phospholipase D in the Golgi apparatus. Biochim Biophys Acta (2009) 1.00
The diacylglycerol lipases: structure, regulation and roles in and beyond endocannabinoid signalling. Philos Trans R Soc Lond B Biol Sci (2012) 0.99
Phosphatidic acid is required for the constitutive ruffling and macropinocytosis of phagocytes. Mol Biol Cell (2013) 0.99
Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2. J Biol Chem (2011) 0.98
Dependence of phospholipase D1 multi-monoubiquitination on its enzymatic activity and palmitoylation. J Biol Chem (2010) 0.97
A role for phospholipase D3 in myotube formation. PLoS One (2012) 0.97
Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer. Pharmacol Rev (2014) 0.96
Temporal production of the signaling lipid phosphatidic acid by phospholipase D2 determines the output of extracellular signal-regulated kinase signaling in cancer cells. Mol Cell Biol (2013) 0.95
Role of phospholipase D in parathyroid hormone type 1 receptor signaling and trafficking. Mol Endocrinol (2009) 0.93
Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment. PLoS One (2013) 0.92
Cellular and physiological roles for phospholipase D1 in cancer. J Biol Chem (2014) 0.91
Lipids in Regulated Exocytosis: What are They Doing? Front Endocrinol (Lausanne) (2013) 0.90
A role for Phospholipase D in Drosophila embryonic cellularization. BMC Dev Biol (2006) 0.90
Sphingomyelin synthase 1-generated sphingomyelin plays an important role in transferrin trafficking and cell proliferation. J Biol Chem (2011) 0.90
Phospholipase D family member 4, a transmembrane glycoprotein with no phospholipase D activity, expression in spleen and early postnatal microglia. PLoS One (2010) 0.90
Regulation of phototransduction responsiveness and retinal degeneration by a phospholipase D-generated signaling lipid. J Cell Biol (2005) 0.90
Chemical modulation of glycerolipid signaling and metabolic pathways. Biochim Biophys Acta (2014) 0.89
Novel functions of the phospholipase D2-Phox homology domain in protein kinase Czeta activation. Mol Cell Biol (2005) 0.88
Neurogranin binds to phosphatidic acid and associates to cellular membranes. Biochem J (2007) 0.88
The Coffin-Lowry syndrome-associated protein RSK2 is implicated in calcium-regulated exocytosis through the regulation of PLD1. Proc Natl Acad Sci U S A (2008) 0.88
Physiological and pathophysiological roles for phospholipase D. J Lipid Res (2015) 0.86
Phosphatidic acid regulation of PIPKI is critical for actin cytoskeletal reorganization. J Lipid Res (2012) 0.85
PLD$ is involved in phagocytosis of microglia: expression and localization changes of PLD4 are correlated with activation state of microglia. PLoS One (2011) 0.84
Protein kinase Cdelta-mediated phosphorylation of phospholipase D controls integrin-mediated cell spreading. Mol Cell Biol (2010) 0.83
Solution structure of human sorting nexin 22. Protein Sci (2007) 0.83
The hydrophobic amino acids involved in the interdomain association of phospholipase D1 regulate the shuttling of phospholipase D1 from vesicular organelles into the nucleus. Exp Mol Med (2012) 0.79
The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase D. J Biol Chem (2014) 0.79
Biochemical characterization of a Pseudomonas aeruginosa phospholipase D. Biochemistry (2015) 0.78
Phospholipase C and D regulation of Src, calcium release and membrane fusion during Xenopus laevis development. Dev Biol (2015) 0.76
Phospholipase D1-regulated autophagy supplies free fatty acids to counter nutrient stress in cancer cells. Cell Death Dis (2016) 0.75
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science (2002) 18.89
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nat Cell Biol (2001) 4.64
SNAREs are concentrated in cholesterol-dependent clusters that define docking and fusion sites for exocytosis. EMBO J (2001) 4.32
Signal-dependent membrane targeting by pleckstrin homology (PH) domains. Biochem J (2000) 4.26
A regulatory role for ARF6 in receptor-mediated endocytosis. Science (1995) 3.82
Targeting of Golgi-specific pleckstrin homology domains involves both PtdIns 4-kinase-dependent and -independent components. Curr Biol (2002) 3.23
Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization. Curr Biol (1997) 3.22
Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family. J Biol Chem (1995) 3.10
Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity. EMBO J (1997) 2.49
A distinct class of endosome mediates clathrin-independent endocytosis to the Golgi complex. Nat Cell Biol (2002) 2.48
SNARE proteins are highly enriched in lipid rafts in PC12 cells: implications for the spatial control of exocytosis. Proc Natl Acad Sci U S A (2001) 2.48
Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains? Protein Sci (1996) 2.40
The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras. J Biol Chem (2000) 2.33
Phospholipase D: molecular and cell biology of a novel gene family. Biochem J (2000) 2.27
Location, location, location: membrane targeting directed by PX domains. Science (2001) 2.09
Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway. J Biol Chem (1999) 2.02
Phospholipase D stimulates release of nascent secretory vesicles from the trans-Golgi network. J Cell Biol (1997) 1.97
A pleckstrin homology domain specific for phosphatidylinositol 4, 5-bisphosphate (PtdIns-4,5-P2) and fused to green fluorescent protein identifies plasma membrane PtdIns-4,5-P2 as being important in exocytosis. J Biol Chem (2000) 1.76
Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella. Nat Cell Biol (2002) 1.75
Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways. Mol Cell Biol (1998) 1.68
Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells. EMBO J (2001) 1.67
Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation. Curr Biol (1998) 1.62
Identification of a phosphoinositide binding motif that mediates activation of mammalian and yeast phospholipase D isoenzymes. EMBO J (1999) 1.54
Measurement of phospholipase D activity. Anal Biochem (1997) 1.53
Molecular analysis of mammalian phospholipase D2. J Biol Chem (1999) 1.47
Intracellular localization of phospholipase D1 in mammalian cells. Mol Biol Cell (2001) 1.41
Mammalian phospholipase D structure and regulation. Biochim Biophys Acta (1999) 1.41
Phospholipase D regulation and localisation is dependent upon a phosphatidylinositol 4,5-biphosphate-specific PH domain. Curr Biol (2000) 1.30
Phospholipases D1 and D2 regulate different phases of exocytosis in mast cells. J Immunol (2002) 1.27
Structural analysis of human phospholipase D1. J Biol Chem (1999) 1.21
A role for phospholipase D1 in neurotransmitter release. Proc Natl Acad Sci U S A (2001) 1.20
A role for phospholipase D in GLUT4 glucose transporter translocation. J Biol Chem (2000) 1.15
Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor-reversible manner. J Biol Chem (2000) 1.14
Dual requirement for rho and protein kinase C in direct activation of phospholipase D1 through G protein-coupled receptor signaling. Mol Biol Cell (2000) 1.10
Inositol lipids as spatial regulators of membrane traffic. J Membr Biol (2001) 1.06
Phospholipase D1 is phosphorylated and activated by protein kinase C in caveolin-enriched microdomains within the plasma membrane. J Biol Chem (2000) 1.05
Fatty acylation of phospholipase D1 on cysteine residues 240 and 241 determines localization on intracellular membranes. J Biol Chem (1999) 1.03
Loss of receptor regulation by a phospholipase D1 mutant unresponsive to protein kinase C. EMBO J (1999) 1.03
Immunolocalisation of phospholipase D1 on tubular vesicular membranes of endocytic and secretory origin. Eur J Cell Biol (2001) 0.94
G-protein-coupled receptor regulation of phospholipase D. Methods Enzymol (2002) 0.91
PKN regulates phospholipase D1 through direct interaction. J Biol Chem (2001) 0.84
Endosomal localization of phospholipase D 1a and 1b is defined by the C-termini of the proteins, and is independent of activity. Biochem J (2001) 0.83
Regulation of phospholipase D1 activity by Rho GTPases. Methods Enzymol (2000) 0.82
Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos. Nat Cell Biol (2007) 3.68
Vital Signs: HIV diagnosis, care, and treatment among persons living with HIV--United States, 2011. MMWR Morb Mortal Wkly Rep (2014) 3.60
CFTR regulates phagosome acidification in macrophages and alters bactericidal activity. Nat Cell Biol (2006) 3.60
A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis. Nat Cell Biol (2006) 3.56
Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev (2011) 2.97
Genome sequence of foxtail millet (Setaria italica) provides insights into grass evolution and biofuel potential. Nat Biotechnol (2012) 2.82
piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling. Dev Cell (2011) 2.73
Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat. Nature (2013) 2.70
5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol Pharmacol (2008) 2.24
Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Science (2009) 2.23
Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis. Cell Metab (2011) 2.08
Phospholipase D. Biochem Cell Biol (2004) 2.06
Scrib controls Cdc42 localization and activity to promote cell polarization during astrocyte migration. Curr Biol (2006) 2.03
Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4. Nat Genet (2002) 2.00
Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis. Mol Biol Cell (2004) 1.93
Mammalian Scribble forms a tight complex with the betaPIX exchange factor. Curr Biol (2004) 1.89
Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis. Sci Signal (2012) 1.86
3' end cDNA amplification using classic RACE. Nat Protoc (2006) 1.85
Structural basis of substrate discrimination and integrin binding by autotaxin. Nat Struct Mol Biol (2011) 1.81
Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proc Natl Acad Sci U S A (2010) 1.80
Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis. J Biol Chem (2009) 1.78
Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people. J Clin Endocrinol Metab (2007) 1.77
Familial risk and clustering of nasopharyngeal carcinoma in Guangdong, China. Cancer (2004) 1.77
5' end cDNA amplification using classic RACE. Nat Protoc (2006) 1.77
Coplanar polychlorinated biphenyls impair glucose homeostasis in lean C57BL/6 mice and mitigate beneficial effects of weight loss on glucose homeostasis in obese mice. Environ Health Perspect (2012) 1.73
Krüppel-like factor 6 regulates mitochondrial function in the kidney. J Clin Invest (2015) 1.72
IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling. Nat Commun (2013) 1.71
Phospholipase D1 production of phosphatidic acid at the plasma membrane promotes exocytosis of large dense-core granules at a late stage. J Biol Chem (2007) 1.69
Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions. Biochem J (2005) 1.67
PLD1 and ERK2 regulate cytosolic lipid droplet formation. J Cell Sci (2006) 1.67
Proteasome function is regulated by cyclic AMP-dependent protein kinase through phosphorylation of Rpt6. J Biol Chem (2007) 1.66
SNARE-catalyzed fusion events are regulated by Syntaxin1A-lipid interactions. Mol Biol Cell (2007) 1.62
PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1. Curr Biol (2003) 1.62
Cytosolic lipid droplets increase in size by microtubule-dependent complex formation. Arterioscler Thromb Vasc Biol (2005) 1.62
Sexual risk behaviour and viral suppression among HIV-infected adults receiving medical care in the United States. AIDS (2014) 1.61
Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature (2013) 1.61
Roles for lipid phosphate phosphatases in regulation of cellular signaling. Biochim Biophys Acta (2002) 1.59
Regulated exocytosis in neuroendocrine cells: a role for subplasmalemmal Cdc42/N-WASP-induced actin filaments. Mol Biol Cell (2003) 1.58
The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning. Development (2003) 1.57
The phospholipase D1 pathway modulates macroautophagy. Nat Commun (2010) 1.56
Exocytosis in neuroendocrine cells: new tasks for actin. Biochim Biophys Acta (2006) 1.56
Differences in therapeutic indexes of combination metronomic chemotherapy and an anti-VEGFR-2 antibody in multidrug-resistant human breast cancer xenografts. Clin Cancer Res (2002) 1.56
Insulin-stimulated plasma membrane fusion of Glut4 glucose transporter-containing vesicles is regulated by phospholipase D1. Mol Biol Cell (2005) 1.53
Asymmetric phospholipid distribution drives in vitro reconstituted SNARE-dependent membrane fusion. Proc Natl Acad Sci U S A (2006) 1.51
A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance. Nat Cell Biol (2008) 1.50
Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1. Sci Signal (2010) 1.49
S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release. Blood (2012) 1.47
Clinical and behavioral characteristics of adults receiving medical care for HIV infection --- Medical Monitoring Project, United States, 2007. MMWR Surveill Summ (2011) 1.42
Design of expression vectors for RNA interference based on miRNAs and RNA splicing. FEBS J (2006) 1.37
Behavioral and clinical characteristics of persons receiving medical care for HIV infection - Medical Monitoring Project, United States, 2009. MMWR Surveill Summ (2014) 1.36
Structural modulation of gut microbiota in life-long calorie-restricted mice. Nat Commun (2013) 1.36
Roles of lysophosphatidic acid in cardiovascular physiology and disease. Biochim Biophys Acta (2008) 1.34
SH2B regulation of growth, metabolism, and longevity in both insects and mammals. Cell Metab (2010) 1.34
CLC-3 channels modulate excitatory synaptic transmission in hippocampal neurons. Neuron (2006) 1.33
Calcium-regulated exocytosis of dense-core vesicles requires the activation of ADP-ribosylation factor (ARF)6 by ARF nucleotide binding site opener at the plasma membrane. J Cell Biol (2002) 1.33
Annexin 2 promotes the formation of lipid microdomains required for calcium-regulated exocytosis of dense-core vesicles. Mol Biol Cell (2005) 1.32
Isolation of circulating epithelial and tumor progenitor cells with an invasive phenotype from breast cancer patients. Int J Cancer (2010) 1.31
Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. Cancer Res (2012) 1.31
Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway. J Cell Biol (2011) 1.31
Haploinsufficiency of utrophin gene worsens skeletal muscle inflammation and fibrosis in mdx mice. J Neurol Sci (2007) 1.31
Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells. J Virol (2003) 1.29
Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors. J Med Chem (2010) 1.28
Phospholipases D1 and D2 regulate different phases of exocytosis in mast cells. J Immunol (2002) 1.27
Therapeutic potential of autotaxin/lysophospholipase d inhibitors. Curr Drug Targets (2008) 1.27
COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells. Nucleic Acids Res (2005) 1.26
A role for nephrin, a renal protein, in vertebrate skeletal muscle cell fusion. Proc Natl Acad Sci U S A (2009) 1.26
Intersectin-1L nucleotide exchange factor regulates secretory granule exocytosis by activating Cdc42. EMBO J (2006) 1.26
Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARgamma by cyclic phosphatidic acid. Mol Cell (2010) 1.23
Lipid phosphate phosphatase 3 enables efficient thymic egress. J Exp Med (2011) 1.23
Dominant-negative loss of PPARgamma function enhances smooth muscle cell proliferation, migration, and vascular remodeling. Arterioscler Thromb Vasc Biol (2009) 1.23
The potential for phospholipase D as a new therapeutic target. Expert Opin Ther Targets (2007) 1.23
Frenolicins C-G, pyranonaphthoquinones from Streptomyces sp. RM-4-15. J Nat Prod (2013) 1.23
Dual role for phosphoinositides in regulation of yeast and mammalian phospholipase D enzymes. J Cell Biol (2002) 1.22
Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J Exp Med (2005) 1.22
Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice. Mol Endocrinol (2012) 1.21
Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure. Circ Res (2008) 1.20
Coupling actin and membrane dynamics during calcium-regulated exocytosis: a role for Rho and ARF GTPases. Biochim Biophys Acta (2004) 1.20
Endogenous ARF6 interacts with Rac1 upon angiotensin II stimulation to regulate membrane ruffling and cell migration. Mol Biol Cell (2006) 1.20
Dynamics and function of phospholipase D and phosphatidic acid during phagocytosis. Traffic (2006) 1.19