Published in Hepatology on August 01, 2003
Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology (2008) 2.79
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metab Rev (2012) 2.76
Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis. Am J Pathol (2010) 1.91
Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: a critical role for E-selectin. Hepatology (2013) 1.58
Mechanisms of immune-mediated liver injury. Toxicol Sci (2010) 1.48
Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans. Toxicol Appl Pharmacol (2014) 1.46
Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products. Life Sci (2011) 1.46
TRAIL mediates liver injury by the innate immune system in the bile duct-ligated mouse. Hepatology (2008) 1.45
Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species. Transplant Rev (Orlando) (2012) 1.38
Effect of bile duct ligation on bile acid composition in mouse serum and liver. Liver Int (2011) 1.34
Critical role of plasminogen activator inhibitor-1 in cholestatic liver injury and fibrosis. J Pharmacol Exp Ther (2005) 1.33
Novel insight into mechanisms of cholestatic liver injury. World J Gastroenterol (2012) 1.31
Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice. Liver Int (2010) 1.29
Invariant natural killer T cells suppress the neutrophil inflammatory response in a mouse model of cholestatic liver damage. Gastroenterology (2008) 1.25
Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis. Toxicol Appl Pharmacol (2015) 1.13
Upregulation of early growth response factor-1 by bile acids requires mitogen-activated protein kinase signaling. Toxicol Appl Pharmacol (2009) 1.13
Hyper-activated pro-inflammatory CD16 monocytes correlate with the severity of liver injury and fibrosis in patients with chronic hepatitis B. PLoS One (2011) 1.09
Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice. Toxicol Appl Pharmacol (2013) 1.08
Limited role for CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate-induced liver injury. Am J Physiol Gastrointest Liver Physiol (2004) 1.06
Platelet-dependent accumulation of leukocytes in sinusoids mediates hepatocellular damage in bile duct ligation-induced cholestasis. Br J Pharmacol (2007) 1.03
Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation. Am J Physiol Gastrointest Liver Physiol (2009) 1.02
Regulation of wound healing and organ fibrosis by toll-like receptors. Biochim Biophys Acta (2012) 0.99
Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies. Toxicol Sci (2010) 0.94
The BH3-only protein bid does not mediate death-receptor-induced liver injury in obstructive cholestasis. Am J Pathol (2009) 0.92
Experimental obstructive cholestasis: the wound-like inflammatory liver response. Fibrogenesis Tissue Repair (2008) 0.91
Osteopontin is an initial mediator of inflammation and liver injury during obstructive cholestasis after bile duct ligation in mice. Toxicol Lett (2013) 0.89
Experimental models of hepatotoxicity related to acute liver failure. Toxicol Appl Pharmacol (2015) 0.88
Neutrophil depletion blocks early collagen degradation in repairing cholestatic rat livers. Am J Pathol (2010) 0.88
Lithocholic acid feeding results in direct hepato-toxicity independent of neutrophil function in mice. Toxicol Lett (2014) 0.88
The traditional ayurvedic medicine, Eugenia jambolana (Jamun fruit), decreases liver inflammation, injury and fibrosis during cholestasis. Liver Int (2011) 0.88
The antifibrinolytic drug tranexamic acid reduces liver injury and fibrosis in a mouse model of chronic bile duct injury. J Pharmacol Exp Ther (2014) 0.87
IL-17A synergistically enhances bile acid-induced inflammation during obstructive cholestasis. Am J Pathol (2013) 0.86
Oxidized low-density-lipoprotein accumulation is associated with liver fibrosis in experimental cholestasis. Clinics (Sao Paulo) (2008) 0.86
The role of anesthetic drugs in liver apoptosis. Hepat Mon (2013) 0.86
Biliary obstruction results in PD-1-dependent liver T cell dysfunction and acute inflammation mediated by Th17 cells and neutrophils. J Leukoc Biol (2013) 0.85
Rapamycin ameliorates inflammation and fibrosis in the early phase of cirrhotic portal hypertension in rats through inhibition of mTORC1 but not mTORC2. PLoS One (2014) 0.85
Simvastatin protects against cholestasis-induced liver injury. Br J Pharmacol (2008) 0.85
Protective effect of intermittent clamping of the portal triad in the rat liver on liver ischemia-reperfusion injury. Hepat Mon (2011) 0.84
Laser capture microdissection and genetic analysis of carbon-labeled Kupffer cells. World J Gastroenterol (2009) 0.83
Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice. Toxicol Appl Pharmacol (2010) 0.83
Cyclopamine attenuates acute warm ischemia reperfusion injury in cholestatic rat liver: hope for marginal livers. Mol Pharm (2011) 0.83
Drug disposition alterations in liver disease: extrahepatic effects in cholestasis and nonalcoholic steatohepatitis. Expert Opin Drug Metab Toxicol (2014) 0.81
Differential DNA methylation analysis of breast cancer reveals the impact of immune signaling in radiation therapy. Int J Cancer (2014) 0.81
Effects of combined anisodamine and neostigmine treatment on the inflammatory response and liver regeneration of obstructive jaundice rats after hepatectomy. Biomed Res Int (2014) 0.81
Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis. Front Biosci (Landmark Ed) (2009) 0.81
Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response. JCI Insight (2017) 0.79
Benzene metabolite 1,2,4-benzenetriol induces halogenated DNA and tyrosines representing halogenative stress in the HL-60 human myeloid cell line. Environ Health Perspect (2011) 0.78
Role of matrix metalloproteinases in cholestasis and hepatic ischemia/reperfusion injury: A review. World J Gastroenterol (2015) 0.78
Epigallocatechin 3-gallate ameliorates bile duct ligation induced liver injury in mice by modulation of mitochondrial oxidative stress and inflammation. PLoS One (2015) 0.78
Targeting extracellular cyclophilins ameliorates disease progression in experimental biliary atresia. Mol Med (2015) 0.77
Liver fibrosis and mechanisms of the protective action of medicinal plants targeting inflammation and the immune response. Int J Inflam (2015) 0.77
Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential. Redox Biol (2016) 0.77
Dose-dependent effects of alpha-naphthylisothiocyanate disconnect biliary fibrosis from hepatocellular necrosis. J Biochem Mol Toxicol (2016) 0.77
Histone preconditioning protects against obstructive jaundice-induced liver injury in rats. Exp Ther Med (2014) 0.77
Therapeutic targets for cholestatic liver injury. Expert Opin Ther Targets (2015) 0.76
Xenobiotic and Endobiotic Mediated Interactions Between the Cytochrome P450 System and the Inflammatory Response in the Liver. Adv Pharmacol (2015) 0.76
Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis. Oncotarget (2016) 0.76
Fatty acid-binding protein 5 limits the anti-inflammatory response in murine macrophages. Mol Immunol (2015) 0.76
The protective or damaging effect of Tumor necrosis factor-α in acute liver injury is concentration-dependent. Cell Biosci (2016) 0.75
Sterile inflammation in acute liver injury: myth or mystery? Expert Rev Gastroenterol Hepatol (2015) 0.75
P-selectin glycoprotein ligand-1-mediated leukocyte recruitment regulates hepatocellular damage in acute obstructive cholestasis in mice. Inflamm Res (2009) 0.75
Hormesis in Cholestatic Liver Disease; Preconditioning with Low Bile Acid Concentrations Protects against Bile Acid-Induced Toxicity. PLoS One (2016) 0.75
Inhibition of PAR-4 and P2Y12 receptor-mediated platelet activation produces distinct hepatic pathologies in experimental xenobiotic-induced cholestatic liver disease. Toxicology (2016) 0.75
Role of the Inflammasome in Acetaminophen-induced Liver Injury and Acute Liver Failure. J Hepatol (2016) 0.75
Immunological basis in the pathogenesis of intrahepatic cholestasis of pregnancy. Expert Rev Clin Immunol (2015) 0.75
Acetaminophen hepatotoxicity and sterile inflammation: The mechanism of protection of Chlorogenic acid. Chem Biol Interact (2015) 0.75
Critical Factors in the Assessment of Cholestatic Liver Injury In Vitro. Methods Mol Biol (2015) 0.75
Up-regulation of nerve growth factor in cholestatic livers and its hepatoprotective role against oxidative stress. PLoS One (2014) 0.75
Ly6C(hi) Monocytes and Their Macrophage Descendants Regulate Neutrophil Function and Clearance in Acetaminophen-Induced Liver Injury. Front Immunol (2017) 0.75
Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury. Inflamm Cell Signal (2017) 0.75
alpha-melanocyte-stimulating hormone gene transfer attenuates inflammation after bile duct ligation in the rat. Dig Dis Sci (2007) 0.75
CD18 deficiency improves liver injury in the MCD model of steatohepatitis. PLoS One (2017) 0.75
The Impact of Sterile Inflammation in Acute Liver Injury. J Clin Transl Res (2017) 0.75
Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. J Hepatol (2012) 3.15
Intracellular signaling mechanisms of acetaminophen-induced liver cell death. Toxicol Sci (2005) 3.12
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology (2004) 2.92
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. J Clin Invest (2012) 2.65
Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis? Toxicol Sci (2002) 2.42
Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J Pharmacol Exp Ther (2005) 2.41
The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity. Toxicol Lett (2003) 2.19
Activation of autophagy protects against acetaminophen-induced hepatotoxicity. Hepatology (2011) 2.15
Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine. Hepatology (2010) 2.15
Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine. Toxicol Sci (2004) 2.07
Role of neutrophils in the pathogenesis of acute inflammatory liver injury. Toxicol Pathol (2007) 1.99
Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury. Toxicol Sci (2006) 1.94
Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis. Am J Pathol (2010) 1.91
Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts. Am J Pathol (2009) 1.87
HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity. Hepatology (2011) 1.86
c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol (2010) 1.84
Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione. J Pharmacol Exp Ther (2002) 1.73
Bile acids trigger cholemic nephropathy in common bile-duct-ligated mice. Hepatology (2013) 1.71
Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity. J Pharmacol Exp Ther (2007) 1.70
A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis. Am J Pathol (2007) 1.70
Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm Res (2013) 1.62
Role of caspases in acetaminophen-induced liver injury. Life Sci (2005) 1.62
24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology (2006) 1.54
Mechanisms of immune-mediated liver injury. Toxicol Sci (2010) 1.48
Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications. Toxicol Appl Pharmacol (2013) 1.46
Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury. Free Radic Res (2010) 1.45
Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. Toxicol Appl Pharmacol (2012) 1.45
Apoptosis and necrosis in liver disease. Liver Int (2004) 1.41
Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice. Hepatology (2013) 1.41
Functional importance of ICAM-1 in the mechanism of neutrophil-induced liver injury in bile duct-ligated mice. Am J Physiol Gastrointest Liver Physiol (2003) 1.40
Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury. Toxicol Appl Pharmacol (2010) 1.38
Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury. Toxicol Sci (2012) 1.38
Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity. Toxicol Appl Pharmacol (2006) 1.37
Effect of bile duct ligation on bile acid composition in mouse serum and liver. Liver Int (2011) 1.34
Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury. Hepatology (2008) 1.31
Novel insight into mechanisms of cholestatic liver injury. World J Gastroenterol (2012) 1.31
Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice. Am J Pathol (2006) 1.30
Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice. Liver Int (2010) 1.29
Parkin and mitofusins reciprocally regulate mitophagy and mitochondrial spheroid formation. J Biol Chem (2012) 1.25
Scavenging peroxynitrite with glutathione promotes regeneration and enhances survival during acetaminophen-induced liver injury in mice. J Pharmacol Exp Ther (2003) 1.25
NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia. Am J Physiol Gastrointest Liver Physiol (2004) 1.23
The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity. Toxicol Appl Pharmacol (2011) 1.23
Generation of hypochlorite-modified proteins by neutrophils during ischemia-reperfusion injury in rat liver: attenuation by ischemic preconditioning. Am J Physiol Gastrointest Liver Physiol (2005) 1.22
Oxidative stress and the pathogenesis of cholestasis. Semin Liver Dis (2010) 1.22
Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury. Toxicol Appl Pharmacol (2011) 1.21
Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity. Toxicol Sci (2011) 1.16
Serum glutamate dehydrogenase--biomarker for liver cell death or mitochondrial dysfunction? Toxicol Sci (2013) 1.15
Lysosomal iron mobilization and induction of the mitochondrial permeability transition in acetaminophen-induced toxicity to mouse hepatocytes. Toxicol Sci (2010) 1.15
Pathophysiological relevance of neutrophils in acetaminophen hepatotoxicity. Hepatology (2013) 1.14
Reduced oncotic necrosis in Fas receptor-deficient C57BL/6J-lpr mice after bile duct ligation. Hepatology (2004) 1.13
Plasminogen activator inhibitor-1 limits liver injury and facilitates regeneration after acetaminophen overdose. Toxicol Sci (2008) 1.11
Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress. Free Radic Res (2003) 1.10
Role of heme oxygenase 1 in TNF/TNF receptor-mediated apoptosis after hepatic ischemia/reperfusion in rats. Shock 39: 380-388, 2013. Shock (2013) 1.09
Role of lipid peroxidation as a mechanism of liver injury after acetaminophen overdose in mice. Toxicol Sci (2003) 1.09
Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice. Toxicol Appl Pharmacol (2013) 1.08
Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans. Arch Toxicol (2013) 1.08
Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome. Hepatology (2014) 1.07
Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation. Toxicol Sci (2012) 1.05
The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes. Toxicol Sci (2010) 1.05
Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation. Am J Physiol Gastrointest Liver Physiol (2009) 1.02
Acetaminophen-induced inhibition of Fas receptor-mediated liver cell apoptosis: mitochondrial dysfunction versus glutathione depletion. Toxicol Appl Pharmacol (2002) 1.02
Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients. Expert Opin Drug Metab Toxicol (2014) 1.02
Inflammation in response to hepatocellular apoptosis. Hepatology (2002) 1.01
Mechanism of protection by metallothionein against acetaminophen hepatotoxicity. Toxicol Appl Pharmacol (2009) 1.00
Hepatic neutrophil infiltration in the pathogenesis of alcohol-induced liver injury. Toxicol Mech Methods (2007) 0.98
Innate immunity and acetaminophen-induced liver injury: why so many controversies? Hepatology (2008) 0.98
Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver. Redox Biol (2013) 0.97
Biomarkers distinguish apoptotic and necrotic cell death during hepatic ischemia/reperfusion injury in mice. Liver Transpl (2014) 0.96
No evidence for caspase-dependent apoptosis in acetaminophen hepatotoxicity. Hepatology (2010) 0.95
Neutrophil depletion protects against murine acetaminophen hepatotoxicity: another perspective. Hepatology (2007) 0.95
The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation. Toxicol Appl Pharmacol (2013) 0.95
Reduced inflammatory response and increased microcirculatory disturbances during hepatic ischemia-reperfusion injury in steatotic livers of ob/ob mice. Am J Physiol Gastrointest Liver Physiol (2007) 0.94