Published in Hepatology on November 01, 2008
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metab Rev (2012) 2.76
Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production. J Biol Chem (2010) 1.41
Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species. Transplant Rev (Orlando) (2012) 1.38
Lysosomal iron mobilization and induction of the mitochondrial permeability transition in acetaminophen-induced toxicity to mouse hepatocytes. Toxicol Sci (2010) 1.15
Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation. Am J Physiol Gastrointest Liver Physiol (2009) 1.02
Mitochondrial permeability transition in rat hepatocytes after anoxia/reoxygenation: role of Ca2+-dependent mitochondrial formation of reactive oxygen species. Am J Physiol Gastrointest Liver Physiol (2012) 1.02
Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria. Mol Interv (2010) 1.00
Translocation of iron from lysosomes to mitochondria during ischemia predisposes to injury after reperfusion in rat hepatocytes. Free Radic Biol Med (2013) 0.97
Enhanced efficacy of photodynamic therapy via a sequential targeting protocol. Photochem Photobiol (2014) 0.97
Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation. Toxicol Sci (2011) 0.91
Ethanol suppresses ureagenesis in rat hepatocytes: role of acetaldehyde. J Biol Chem (2012) 0.91
Lysosomal signaling enhances mitochondria-mediated photodynamic therapy in A431 cancer cells: role of iron. Photochem Photobiol (2012) 0.90
Mitoferrin-2-dependent mitochondrial iron uptake sensitizes human head and neck squamous carcinoma cells to photodynamic therapy. J Biol Chem (2012) 0.89
Innate immune responses to Chlamydia pneumoniae infection: role of TLRs, NLRs, and the inflammasome. Microbes Infect (2012) 0.89
Minocycline and doxycycline, but not other tetracycline-derived compounds, protect liver cells from chemical hypoxia and ischemia/reperfusion injury by inhibition of the mitochondrial calcium uniporter. Toxicol Appl Pharmacol (2013) 0.88
Interleukin-6 directly impairs the erythroid development of human TF-1 erythroleukemic cells. Blood Cells Mol Dis (2013) 0.87
Hepatic reticuloendothelial system cell iron deposition is associated with increased apoptosis in nonalcoholic fatty liver disease. Hepatology (2013) 0.83
Experimental data suggesting that inflammation mediated rat liver mitochondrial dysfunction results from secondary hypoxia rather than from direct effects of inflammatory mediators. Front Physiol (2013) 0.83
Selective autophagy: xenophagy. Methods (2014) 0.83
Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin. J Biol Chem (2014) 0.82
Reactive oxygen species in the normal and acutely injured liver. J Hepatol (2011) 0.82
Signaling From Lysosomes Enhances Mitochondria-Mediated Photodynamic Therapy In Cancer Cells. Proc SPIE Int Soc Opt Eng (2009) 0.81
Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity. Basic Clin Pharmacol Toxicol (2012) 0.81
The presence of multiple cellular defects associated with a novel G50E iron-sulfur cluster scaffold protein (ISCU) mutation leads to development of mitochondrial myopathy. J Biol Chem (2014) 0.80
The roles of mitoferrin-2 in the process of arsenic trioxide-induced cell damage in human gliomas. Eur J Med Res (2014) 0.80
Antioxidant Stress and Anti-Inflammation of PPARα on Warm Hepatic Ischemia-Reperfusion Injury. PPAR Res (2012) 0.79
Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells. Biochem J (2015) 0.76
Iron overload induced death of osteoblasts in vitro: involvement of the mitochondrial apoptotic pathway. PeerJ (2016) 0.75
Carrageenan delays cell cycle progression in human cancer cells in vitro demonstrated by FUCCI imaging. BMC Complement Altern Med (2016) 0.75
Translocation of iron from lysosomes to mitochondria during acetaminophen-induced hepatocellular injury: Protection by starch-desferal and minocycline. Free Radic Biol Med (2016) 0.75
Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress. J Gastroenterol (2016) 0.75
Balancing acts: molecular control of mammalian iron metabolism. Cell (2004) 7.82
Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J (2002) 4.75
Mechanisms of hepatotoxicity. Toxicol Sci (2002) 4.13
Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology (2004) 3.23
Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol (2006) 3.16
Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay. Anal Biochem (1983) 2.85
The Haber-Weiss reaction and mechanisms of toxicity. Toxicology (2000) 2.30
Reactive oxygen species, but not Ca2+ overloading, trigger pH- and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia-reperfusion. Am J Physiol Heart Circ Physiol (2006) 2.08
The transferrin receptor: role in health and disease. Int J Biochem Cell Biol (1999) 2.02
Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide. Biochem J (1995) 1.98
E5531, a pure endotoxin antagonist of high potency. Science (1995) 1.88
Function and regulation of transferrin and ferritin. Semin Hematol (1998) 1.84
Bax inhibition protects against free fatty acid-induced lysosomal permeabilization. Am J Physiol Gastrointest Liver Physiol (2006) 1.66
Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species. Am J Physiol (1997) 1.61
Mitochondrial permeability transition in pH-dependent reperfusion injury to rat hepatocytes. Am J Physiol (1997) 1.58
Inhibition of mitochondrial calcium ion transport by an oxo-bridged dinuclear ruthenium ammine complex. Biochemistry (1991) 1.53
Iron-induced mitochondrial permeability transition in cultured hepatocytes. J Hepatol (2004) 1.53
Ferric iron and superoxide ions are required for the killing of cultured hepatocytes by hydrogen peroxide. Evidence for the participation of hydroxyl radicals formed by an iron-catalyzed Haber-Weiss reaction. J Biol Chem (1985) 1.52
Mitochondria as a source of reactive oxygen species during reductive stress in rat hepatocytes. Am J Physiol (1993) 1.49
Tumor necrosis factor-alpha-associated lysosomal permeabilization is cathepsin B dependent. Am J Physiol Gastrointest Liver Physiol (2002) 1.47
Role of the mitochondrial permeability transition in apoptotic and necrotic death after ischemia/reperfusion injury to hepatocytes. Curr Mol Med (2003) 1.47
Human NRAMP2/DMT1, which mediates iron transport across endosomal membranes, is localized to late endosomes and lysosomes in HEp-2 cells. J Biol Chem (2000) 1.46
Intralysosomal iron chelation protects against oxidative stress-induced cellular damage. FEBS J (2006) 1.43
Intralysosomal iron: a major determinant of oxidant-induced cell death. Free Radic Biol Med (2003) 1.33
Prevention of oxidant-induced cell death by lysosomotropic iron chelators. Free Radic Biol Med (2003) 1.31
Signaling role of intracellular iron in NF-kappaB activation. J Biol Chem (2003) 1.30
Cellular injury induced by oxidative stress is mediated through lysosomal damage. Free Radic Biol Med (1995) 1.30
Mitochondrial dysfunction in neurodegenerative diseases associated with copper imbalance. Neurochem Res (2004) 1.29
Autophagy, ageing and apoptosis: the role of oxidative stress and lysosomal iron. Arch Biochem Biophys (2007) 1.28
Iron and copper toxicity in diseases of aging, particularly atherosclerosis and Alzheimer's disease. Exp Biol Med (Maywood) (2007) 1.28
Iron Imports. II. Iron uptake at the apical membrane in the intestine. Am J Physiol Gastrointest Liver Physiol (2005) 1.27
Iron toxicity and chelation therapy. Int J Hematol (2002) 1.27
Transport of iron and other transition metals into cells as revealed by a fluorescent probe. Am J Physiol (1995) 1.24
Energy-dependent accumulation of iron by isolated rat liver mitochondria. Requirement of reducing equivalents and evidence for a unidirectional flux of Fe(II) across the inner membrane. J Biol Chem (1975) 1.24
Design of clinically useful iron(III)-selective chelators. Med Res Rev (2002) 1.21
A novel cytotoxicity screening assay using a multiwell fluorescence scanner. Toxicol Appl Pharmacol (1992) 1.20
Iron accumulation in alcoholic liver diseases. Alcohol Clin Exp Res (2005) 1.14
Progression of subcellular changes during chemical hypoxia to cultured rat hepatocytes: a laser scanning confocal microscopic study. Hepatology (1995) 1.13
Superoxide dismutase and catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen. Biochem Biophys Res Commun (1987) 1.12
Iron activates NF-kappaB in Kupffer cells. Am J Physiol Gastrointest Liver Physiol (2002) 1.10
Chemistry and structure activity relationships of bafilomycin A1, a potent and selective inhibitor of the vacuolar H+-ATPase. Curr Med Chem (1999) 1.07
Oxidative stress-mediated hepatotoxicity of iron and copper: role of Kupffer cells. Biometals (2003) 1.05
Alcohol, iron-associated oxidative stress, and cancer. Alcohol (2005) 0.96
Iron-dependent vs. iron-independent cold-induced injury to cultured rat hepatocytes: a comparative study in physiological media and organ preservation solutions. Cryobiology (2006) 0.96
Iron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death. J Hepatol (2007) 0.96
Cold-induced apoptosis of rat liver cells in University of Wisconsin solution: the central role of chelatable iron. Hepatology (2002) 0.90
Confocal imaging of Ca2+, pH, electrical potential, and membrane permeability in single living cells. Methods Enzymol (1999) 0.90
Iron intake and regulation: implications for iron deficiency and iron overload. Alcohol (2003) 0.88
Chelation and determination of labile iron in primary hepatocytes by pyridinone fluorescent probes. Biochem J (2006) 0.87
Oxidative damage of mitochondria induced by Fe(II)citrate is potentiated by Ca2+ and includes lipid peroxidation and alterations in membrane proteins. Arch Biochem Biophys (1994) 0.87
Iron regulation of hepatic macrophage TNFalpha expression. Free Radic Biol Med (2002) 0.86
The role of lysosomes in the heart. Adv Myocardiol (1980) 0.81
TPEN attenuates hepatic apoptotic ischemia/ reperfusion injury and remote early cardiac dysfunction. Apoptosis (2005) 0.79
Rusty notions of cell injury. J Hepatol (2004) 0.78
Oxygen radical generation by microsomes: role of iron and implications for alcohol metabolism and toxicity. Free Radic Biol Med (1989) 0.78
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys (2007) 8.24
Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of an open-label randomised controlled trial. Lancet Oncol (2010) 5.51
Mechanisms of hepatotoxicity. Toxicol Sci (2002) 4.13
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest (2004) 3.92
NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest (2003) 3.69
Apoptosis and necrosis in the liver: a tale of two deaths? Hepatology (2006) 3.52
Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury. Gastroenterology (2003) 3.21
Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. J Hepatol (2012) 3.15
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology (2004) 2.92
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. J Clin Invest (2012) 2.65
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J Cell Biol (2011) 2.64
Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochem Biophys Res Commun (2003) 2.58
Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis? Toxicol Sci (2002) 2.42
Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J Pharmacol Exp Ther (2005) 2.41
Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes. Autophagy (2006) 2.37
Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver. Hepatology (2002) 2.34
Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition. Hepatology (2008) 2.22
Activation of autophagy protects against acetaminophen-induced hepatotoxicity. Hepatology (2011) 2.15
Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine. Hepatology (2010) 2.15
Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function? FEBS Lett (2002) 2.08
Reactive oxygen species, but not Ca2+ overloading, trigger pH- and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia-reperfusion. Am J Physiol Heart Circ Physiol (2006) 2.08
Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine. Toxicol Sci (2004) 2.07
Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Antioxid Redox Signal (2002) 2.03
Role of mitochondrial permeability transition pores in mitochondrial autophagy. Int J Biochem Cell Biol (2004) 2.01
Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice. Hepatology (2003) 2.00
Role of neutrophils in the pathogenesis of acute inflammatory liver injury. Toxicol Pathol (2007) 1.99
Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice. Gastroenterology (2011) 1.96
Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811. Mol Pharmacol (2002) 1.95
Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury. Toxicol Sci (2006) 1.94
Gastric adenocarcinoma of fundic gland type (chief cell predominant type): proposal for a new entity of gastric adenocarcinoma. Am J Surg Pathol (2010) 1.93
Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis. Am J Pathol (2010) 1.91
Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts. Am J Pathol (2009) 1.87
Cyclophilin D as a drug target. Curr Med Chem (2003) 1.87
HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity. Hepatology (2011) 1.86
c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol (2010) 1.84
Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways. Hepatology (2008) 1.82
Functions of autophagy in normal and diseased liver. Autophagy (2013) 1.81
Mitophagy selectively degrades individual damaged mitochondria after photoirradiation. Antioxid Redox Signal (2011) 1.79
Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. FASEB J (2004) 1.76
Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione. J Pharmacol Exp Ther (2002) 1.73
Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology (2004) 1.73
Bile acids trigger cholemic nephropathy in common bile-duct-ligated mice. Hepatology (2013) 1.71
Pioglitazone promotes survival and prevents hepatic regeneration failure after partial hepatectomy in obese and diabetic KK-A(y) mice. Hepatology (2009) 1.71
Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity. J Pharmacol Exp Ther (2007) 1.70
A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis. Am J Pathol (2007) 1.70
Large Brunner's gland hyperplasia treated with modified endoscopic submucosal dissection. Dig Dis Sci (2006) 1.66
Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel disease. Gastroenterology (2005) 1.66
Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes. Gastroenterology (2003) 1.63
Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm Res (2013) 1.62
Newly developed antibiotic combination therapy for ulcerative colitis: a double-blind placebo-controlled multicenter trial. Am J Gastroenterol (2010) 1.61
Loss of autophagy promotes murine acetaminophen hepatotoxicity. J Gastroenterol (2011) 1.61
Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese. PLoS One (2012) 1.56
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nat Chem Biol (2012) 1.55
24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology (2006) 1.54
Alteration of sensory neurons and spinal response to an experimental osteoarthritis pain model. Arthritis Rheum (2010) 1.51
Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling. Cell Metab (2012) 1.50
Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology (2012) 1.49
Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes. Autophagy (2009) 1.49
Pancreatic-duct-lavage cytology in candidates for surgical resection of branch-duct intraductal papillary mucinous neoplasm of the pancreas: should the International Consensus Guidelines be revised? Gastrointest Endosc (2008) 1.48
Mechanisms of immune-mediated liver injury. Toxicol Sci (2010) 1.48
Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications. Toxicol Appl Pharmacol (2013) 1.46
Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury. Free Radic Res (2010) 1.45
Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. Toxicol Appl Pharmacol (2012) 1.45
Multiple carcinoid tumors of the small intestine preoperatively diagnosed by double-balloon endoscopy. Med Sci Monit (2012) 1.44
Pancreatic duct lavage cytology with the cell block method for discriminating benign and malignant branch-duct type intraductal papillary mucinous neoplasms. Gastrointest Endosc (2013) 1.42
Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice. Hepatology (2013) 1.41
Modified dose difference method for comparing dose distributions. J Appl Clin Med Phys (2012) 1.41
Discrimination of depolarized from polarized mitochondria by confocal fluorescence resonance energy transfer. Arch Biochem Biophys (2004) 1.40
Functional importance of ICAM-1 in the mechanism of neutrophil-induced liver injury in bile duct-ligated mice. Am J Physiol Gastrointest Liver Physiol (2003) 1.40
Endoscopic submucosal dissection of large colorectal tumors by using a novel spring-action S-O clip for traction (with video). Gastrointest Endosc (2009) 1.38
Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury. Toxicol Appl Pharmacol (2010) 1.38
Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury. Toxicol Sci (2012) 1.38
MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis. Gene (2011) 1.38
Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity. Toxicol Appl Pharmacol (2006) 1.37
SMAD and p38 MAPK signaling pathways independently regulate alpha1(I) collagen gene expression in unstimulated and transforming growth factor-beta-stimulated hepatic stellate cells. J Biol Chem (2005) 1.36
Effect of bile duct ligation on bile acid composition in mouse serum and liver. Liver Int (2011) 1.34
Liver diseases and metabolic syndrome. J Gastroenterol (2008) 1.33
Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation. Am J Physiol Cell Physiol (2010) 1.32
Different metastatic pattern according to the KRAS mutational status and site-specific discordance of KRAS status in patients with colorectal cancer. BMC Cancer (2012) 1.31
Novel insight into mechanisms of cholestatic liver injury. World J Gastroenterol (2012) 1.31
Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice. Am J Pathol (2006) 1.30
Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice. Liver Int (2010) 1.29
Preoperative chemoradiation using oral capecitabine in locally advanced rectal cancer. Int J Radiat Oncol Biol Phys (2002) 1.29