Published in J Biol Chem on July 28, 2003
Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement. Proc Natl Acad Sci U S A (2008) 2.68
Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy. J Mol Biol (2009) 2.14
Quantification of alpha-synuclein binding to lipid vesicles using fluorescence correlation spectroscopy. Biophys J (2006) 2.05
Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. PLoS One (2008) 1.99
alpha-Synuclein and neuronal cell death. Mol Neurodegener (2009) 1.85
Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One (2008) 1.84
Alpha-synuclein binds large unilamellar vesicles as an extended helix. Biochemistry (2009) 1.73
Effects of curvature and composition on α-synuclein binding to lipid vesicles. Biophys J (2010) 1.71
Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein. Curr Protein Pept Sci (2009) 1.66
Alpha-synuclein structures from fluorescence energy-transfer kinetics: implications for the role of the protein in Parkinson's disease. Proc Natl Acad Sci U S A (2004) 1.60
Cell systems and the toxic mechanism(s) of alpha-synuclein. Exp Neurol (2007) 1.59
Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy. Biochemistry (2010) 1.50
Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases. J Biol Chem (2011) 1.42
Conformational equilibria in monomeric alpha-synuclein at the single-molecule level. PLoS Biol (2008) 1.37
Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation. Proc Natl Acad Sci U S A (2014) 1.31
Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling. Traffic (2008) 1.30
Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain. J Biol Chem (2011) 1.24
Structural characteristics of alpha-synuclein oligomers stabilized by the flavonoid baicalein. J Mol Biol (2008) 1.23
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation. Nat Chem Biol (2015) 1.22
α-Synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling. J Biol Chem (2013) 1.12
Structural intermediates during α-synuclein fibrillogenesis on phospholipid vesicles. J Am Chem Soc (2012) 1.09
Biophysics of α-synuclein membrane interactions. Biochim Biophys Acta (2011) 1.08
Polyunsaturated fatty acids induce alpha-synuclein-related pathogenic changes in neuronal cells. Am J Pathol (2007) 1.08
Curvature dynamics of alpha-synuclein familial Parkinson disease mutants: molecular simulations of the micelle- and bilayer-bound forms. J Biol Chem (2009) 1.08
Depth of α-synuclein in a bilayer determined by fluorescence, neutron reflectometry, and computation. Biophys J (2012) 1.06
Folding and misfolding of alpha-synuclein on membranes. Biochim Biophys Acta (2011) 1.06
Membrane Permeabilization by Oligomeric α-Synuclein: In Search of the Mechanism. PLoS One (2010) 1.05
Tryptophan probes at the alpha-synuclein and membrane interface. J Phys Chem B (2010) 1.05
Gaucher disease and the synucleinopathies. J Biomed Biotechnol (2006) 1.03
Solution conformation, backbone dynamics and lipid interactions of the intrinsically unstructured malaria surface protein MSP2. J Mol Biol (2008) 1.03
CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease. Integr Biol (Camb) (2011) 1.03
Role of endocytic inhibitory drugs on internalization of amyloidogenic light chains by cardiac fibroblasts. Am J Pathol (2006) 1.03
Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease. Mol Neurodegener (2010) 1.00
Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD. Parkinsons Dis (2011) 0.99
Alpha-synuclein function and dysfunction on cellular membranes. Exp Neurobiol (2014) 0.99
Membrane remodeling by α-synuclein and effects on amyloid formation. J Am Chem Soc (2013) 0.99
Role of synucleins in Alzheimer's disease. Neurotox Res (2009) 0.98
Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases. Neurogenetics (2007) 0.98
19F NMR studies of α-synuclein-membrane interactions. Protein Sci (2010) 0.97
Monomeric α-synuclein binds Congo Red micelles in a disordered manner. Biochemistry (2012) 0.95
Phosphatidylethanolamine enhances amyloid fiber-dependent membrane fragmentation. Biochemistry (2012) 0.95
Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease. Hum Mol Genet (2014) 0.95
Specificity and kinetics of alpha-synuclein binding to model membranes determined with fluorescent excited state intramolecular proton transfer (ESIPT) probe. J Biol Chem (2011) 0.94
Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice. Hum Mol Genet (2014) 0.94
Peroxidase mechanism of lipid-dependent cross-linking of synuclein with cytochrome C: protection against apoptosis versus delayed oxidative stress in Parkinson disease. J Biol Chem (2009) 0.94
The influence of vesicle size and composition on alpha-synuclein structure and stability. Biophys J (2009) 0.93
Interaction of α-synuclein with vesicles that mimic mitochondrial membranes. Biochim Biophys Acta (2011) 0.93
Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors. BMC Neurosci (2008) 0.91
α-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity. J Biol Chem (2013) 0.89
Molecular chaperones are nanomachines that catalytically unfold misfolded and alternatively folded proteins. Cell Mol Life Sci (2014) 0.89
Structure and topology of the non-amyloid-beta component fragment of human alpha-synuclein bound to micelles: implications for the aggregation process. Protein Sci (2006) 0.89
Shedding light on protein folding landscapes by single-molecule fluorescence. Chem Soc Rev (2014) 0.89
Adsorption of α-synuclein to supported lipid bilayers: positioning and role of electrostatics. ACS Chem Neurosci (2013) 0.89
Adsorption of alpha-synuclein on lipid bilayers: modulating the structure and stability of protein assemblies. J Phys Chem B (2010) 0.88
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein. Proc Natl Acad Sci U S A (2015) 0.87
Regulation of alpha-synuclein expression in alcohol-preferring and -non preferring rats. J Neurochem (2006) 0.87
Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant α-Synuclein. Sci Rep (2015) 0.86
In parkinsonian substantia nigra, alpha-synuclein is modified by acrolein, a lipid-peroxidation product, and accumulates in the dopamine neurons with inhibition of proteasome activity. J Neural Transm (Vienna) (2007) 0.86
The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes. Acta Neuropathol Commun (2014) 0.85
Transport of phage P22 DNA across the cytoplasmic membrane. J Bacteriol (2008) 0.84
Single-chain fragment variable passive immunotherapies for neurodegenerative diseases. Int J Mol Sci (2013) 0.84
A common landscape for membrane-active peptides. Protein Sci (2013) 0.83
Membrane lipid co-aggregation with α-synuclein fibrils. PLoS One (2013) 0.83
Characterization of a disordered protein during micellation: interactions of α-synuclein with sodium dodecyl sulfate. J Phys Chem B (2012) 0.83
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein. Proc Natl Acad Sci U S A (2016) 0.83
Effect of dioxygen on copper(II) binding to alpha-synuclein. J Inorg Biochem (2009) 0.82
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading. Proc Natl Acad Sci U S A (2016) 0.81
Amyloids of alpha-synuclein affect the structure and dynamics of supported lipid bilayers. Biophys J (2014) 0.81
Molecular details of α-synuclein membrane association revealed by neutrons and photons. J Phys Chem B (2015) 0.80
The interplay between lipids and dopamine on α-synuclein oligomerization and membrane binding. Biosci Rep (2013) 0.79
Molecular chaperones, α-synuclein, and neurodegeneration. Mol Neurobiol (2012) 0.79
Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways. BMC Neurosci (2015) 0.79
Copper(II) enhances membrane-bound α-synuclein helix formation. Metallomics (2011) 0.79
A flash in the pan: dissecting dynamic amyloid intermediates using fluorescence. FEBS Lett (2013) 0.78
Membrane remodeling and mechanics: Experiments and simulations of α-Synuclein. Biochim Biophys Acta (2016) 0.78
Intrinsic and membrane-facilitated α-synuclein oligomerization revealed by label-free detection through solid-state nanopores. Sci Rep (2016) 0.77
Dynamic structural flexibility of α-synuclein. Neurobiol Dis (2015) 0.77
Function and dysfunction of α-synuclein: probing conformational changes and aggregation by single molecule fluorescence. Mol Neurobiol (2012) 0.77
Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption. J Biol Chem (2015) 0.77
Conformational behavior and aggregation of ataxin-3 in SDS. PLoS One (2013) 0.75
Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β. J Biol Chem (2017) 0.75
Heparin-induced amyloid fibrillation of β2 -microglobulin explained by solubility and a supersaturation-dependent conformational phase diagram. Protein Sci (2017) 0.75
Switch region for pathogenic structural change in conformational disease and its prediction. PLoS One (2010) 0.75
Kepler planet-detection mission: introduction and first results. Science (2010) 6.23
High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cancer Discov (2011) 4.78
Conformational constraints for amyloid fibrillation: the importance of being unfolded. Biochim Biophys Acta (2004) 3.69
Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. Science (2013) 3.45
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature (2012) 3.24
Disorder in the nuclear pore complex: the FG repeat regions of nucleoporins are natively unfolded. Proc Natl Acad Sci U S A (2003) 3.07
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med (2015) 3.00
Precise segmental renal artery clamping under the guidance of dual-source computed tomography angiography during laparoscopic partial nephrectomy. Eur Urol (2012) 2.95
Kidney volume and functional outcomes in autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol (2012) 2.78
Cre-mediated recombination in cell lineages that express the progesterone receptor. Genesis (2005) 2.67
Differential genome-wide profiling of tandem 3' UTRs among human breast cancer and normal cells by high-throughput sequencing. Genome Res (2011) 2.61
Retinal degeneration 12 (rd12): a new, spontaneously arising mouse model for human Leber congenital amaurosis (LCA). Mol Vis (2005) 2.55
Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake. Circ Res (2005) 2.49
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proc Natl Acad Sci U S A (2013) 2.49
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell (2013) 2.38
Size-dependent immunogenicity: therapeutic and protective properties of nano-vaccines against tumors. J Immunol (2004) 2.33
FIT interacts with AtbHLH38 and AtbHLH39 in regulating iron uptake gene expression for iron homeostasis in Arabidopsis. Cell Res (2008) 2.33
Exposure to schistosome eggs protects mice from TNBS-induced colitis. Am J Physiol Gastrointest Liver Physiol (2002) 2.28
Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer. Genome Res (2012) 2.27
Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis. Mol Ther (2005) 2.27
Subintimal angioplasty for below-the-ankle arterial occlusions in diabetic patients with chronic critical limb ischemia. J Endovasc Ther (2009) 2.22
Emerging role for autophagy in the removal of aggresomes in Schwann cells. J Neurosci (2003) 2.21
Seroprevalence of Toxoplasma gondii infection in dairy goats in Shaanxi Province, Northwestern China. Parasit Vectors (2011) 2.19
A novel transgenic mouse model reveals deregulation of the ubiquitin-proteasome system in the heart by doxorubicin. FASEB J (2005) 2.13
Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins. J Biol Chem (2002) 2.07
The Arabidopsis histidine phosphotransfer proteins are redundant positive regulators of cytokinin signaling. Plant Cell (2006) 2.06
Potential bridges for HIV infection to men who have sex with men in Guangzhou, China. AIDS Behav (2006) 2.06
Decoupling suspension controller based on magnetic flux feedback. ScientificWorldJournal (2013) 2.03
Tumor susceptibility of Rassf1a knockout mice. Cancer Res (2005) 2.03
The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils. J Biol Chem (2004) 2.02
The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein. J Biol Chem (2001) 1.99
Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer. J Clin Oncol (2010) 1.95
PRL-3 and PRL-1 promote cell migration, invasion, and metastasis. Cancer Res (2003) 1.94
Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts. Cardiovasc Res (2010) 1.93
Improvement of the survival of human autologous fat transplantation by using VEGF-transfected adipose-derived stem cells. Plast Reconstr Surg (2009) 1.93
A general model for amyloid fibril assembly based on morphological studies using atomic force microscopy. Biophys J (2003) 1.93
Rifampicin inhibits alpha-synuclein fibrillation and disaggregates fibrils. Chem Biol (2004) 1.91
Brain cannabinoid CB₂ receptors modulate cocaine's actions in mice. Nat Neurosci (2011) 1.88
Catalytic domain of PRL-3 plays an essential role in tumor metastasis: formation of PRL-3 tumors inside the blood vessels. Cancer Biol Ther (2004) 1.84
The post-stishovite phase transition in hydrous alumina-bearing SiO2 in the lower mantle of the earth. Proc Natl Acad Sci U S A (2007) 1.80
The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein. J Mol Biol (2005) 1.74
Role of Escherichia coli O157:H7 virulence factors in colonization at the bovine terminal rectal mucosa. Infect Immun (2006) 1.72
Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from alpha-synuclein in vitro. Biochemistry (2002) 1.71
Retracted Application and implementation of selective tissue microdissection and proteomic profiling in neurological disease. Neurosurgery (2009) 1.69
AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation. Invest Ophthalmol Vis Sci (2008) 1.68
Design of efficient thermally activated delayed fluorescence materials for pure blue organic light emitting diodes. J Am Chem Soc (2012) 1.68
The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse. Dev Biol (2009) 1.67
Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-beta structure. Proc Natl Acad Sci U S A (2003) 1.67
Proteome analysis of microdissected formalin-fixed and paraffin-embedded tissue specimens. J Histochem Cytochem (2007) 1.66
Automated clinical reminders for primary care providers in the care of CKD: a small cluster-randomized controlled trial. Am J Kidney Dis (2011) 1.66
Lipid binding inhibits alpha-synuclein fibril formation. J Biol Chem (2003) 1.64
Accelerated alpha-synuclein fibrillation in crowded milieu. FEBS Lett (2002) 1.64
Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells. Mol Cell (2012) 1.63
Protein kinase g positively regulates proteasome-mediated degradation of misfolded proteins. Circulation (2013) 1.62
Characterization of the osteoblast-specific transmembrane protein IFITM5 and analysis of IFITM5-deficient mice. J Bone Miner Metab (2010) 1.61
A novel LacZ reporter mouse reveals complex regulation of the progesterone receptor promoter during mammary gland development. Mol Endocrinol (2002) 1.61
Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance. Clin Cancer Res (2010) 1.55
Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the Chinese: significant linkage to chromosome 6q21-q23 and chromosome 1q21-q24. Diabetes (2004) 1.54
An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus. J Immunol (2002) 1.52
von Hippel-Lindau disease-associated hemangioblastomas are derived from embryologic multipotent cells. PLoS Med (2007) 1.52
Conformational behavior and aggregation of alpha-synuclein in organic solvents: modeling the effects of membranes. Biochemistry (2003) 1.51
Cesarean section reduces perinatal transmission of hepatitis B virus infection from hepatitis B surface antigen-positive women to their infants. Clin Gastroenterol Hepatol (2013) 1.51
Alcohol-induced adipogenesis in bone and marrow: a possible mechanism for osteonecrosis. Clin Orthop Relat Res (2003) 1.49
Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants. Blood (2007) 1.49
PCBP1 suppresses the translation of metastasis-associated PRL-3 phosphatase. Cancer Cell (2010) 1.48
Anti-tumorigenicity of dietary α-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites. Mol Nutr Food Res (2012) 1.48
Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion. J Cell Biol (2002) 1.48
The effect of macromolecular crowding on protein aggregation and amyloid fibril formation. J Mol Recognit (2004) 1.48
Retrograde transdorsal-to-plantar or transplantar-to-dorsal intraluminal re-entry following unsuccessful subintimal angioplasty for below-the-ankle arterial occlusion. J Endovasc Ther (2010) 1.47
Cloning and functional analysis of a novel DREB1/CBF transcription factor involved in cold-responsive gene expression in Zea mays L. Plant Cell Physiol (2004) 1.46
Discovery of novel secreted virulence factors from Salmonella enterica serovar Typhimurium by proteomic analysis of culture supernatants. Infect Immun (2010) 1.44
Surface-catalyzed amyloid fibril formation. J Biol Chem (2002) 1.43
Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degeneration. Neurobiol Dis (2006) 1.43
Involvement of MicroRNA-133a in the Development of Arteriosclerosis Obliterans of the Lower Extremities via RhoA Targeting. J Atheroscler Thromb (2014) 1.42
Experimental and clinical observations of 99mTc-MIBI uptake correlate with P-glycoprotein expression in lung cancer. Nucl Med Commun (2007) 1.41
PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis. J Clin Invest (2009) 1.41
GM1 specifically interacts with alpha-synuclein and inhibits fibrillation. Biochemistry (2007) 1.40
Parkinson's disease patients with pain suffer from more severe non-motor symptoms. Neurol Sci (2014) 1.40
Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases. Free Radic Biol Med (2004) 1.40
Complete DiGeorge syndrome: development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases. J Allergy Clin Immunol (2004) 1.39
Gold-nanocrystal-enhanced bioluminescent nanocapsules. ACS Nano (2014) 1.39
Partially folded intermediates in insulin fibrillation. Biochemistry (2003) 1.38
Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells. Immunity (2004) 1.37
Isolation, diversity, and antimicrobial activity of rare actinobacteria from medicinal plants of tropical rain forests in Xishuangbanna, China. Appl Environ Microbiol (2009) 1.36
Cerebral angiogenesis and expression of angiogenic factors in aging rats after exercise. Curr Neurovasc Res (2006) 1.36
Type-B response regulators display overlapping expression patterns in Arabidopsis. Plant Physiol (2004) 1.35
Role of protein-water interactions and electrostatics in alpha-synuclein fibril formation. Biochemistry (2004) 1.35
Hemangioblastomas share protein expression with embryonal hemangioblast progenitor cell. Cancer Res (2006) 1.34
Nuclear localization of alpha-synuclein and its interaction with histones. Biochemistry (2003) 1.33
Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing. Mod Pathol (2012) 1.32
Difference in risk behaviors and STD prevalence between street-based and establishment-based FSWs in Guangdong Province, China. AIDS Behav (2012) 1.30
FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway. Blood (2012) 1.29