Published in Mol Cell Biol on August 01, 2003
The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis. Cell (2009) 2.80
Phosphorylation of Par-4 by protein kinase A is critical for apoptosis. Mol Cell Biol (2005) 1.38
Cancer-selective apoptotic effects of extracellular and intracellular Par-4. Oncogene (2010) 1.16
Mechanisms of apoptosis by the tumor suppressor Par-4. J Cell Physiol (2012) 1.13
Prostate apoptosis response 4 (Par-4), a novel substrate of caspase-3 during apoptosis activation. Mol Cell Biol (2011) 1.03
Par-4 binds to topoisomerase 1 and attenuates its DNA relaxation activity. Cancer Res (2008) 1.00
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The Ras effector RASSF2 controls the PAR-4 tumor suppressor. Mol Cell Biol (2010) 0.94
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Prostate apoptosis response-4 is involved in the apoptosis response to docetaxel in MCF-7 breast cancer cells. Int J Oncol (2013) 0.78
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Plant-derived SAC domain of PAR-4 (Prostate Apoptosis Response 4) exhibits growth inhibitory effects in prostate cancer cells. Front Plant Sci (2015) 0.76
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Parasporin-2 from a New Bacillus thuringiensis 4R2 Strain Induces Caspases Activation and Apoptosis in Human Cancer Cells. PLoS One (2015) 0.76
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Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. Cancer Res (2001) 1.46
Oncogenic Ras sensitizes cells to apoptosis by Par-4. J Biol Chem (1999) 1.45
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Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma. Oncogene (1999) 1.38
Apoptosis by Par-4 in cancer and neurodegenerative diseases. Exp Cell Res (2003) 1.34
Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter. J Biol Chem (2003) 1.34
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The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis. Cell (2009) 2.80
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Par-4-dependent apoptosis by the dietary compound withaferin A in prostate cancer cells. Cancer Res (2006) 1.89
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Phosphorylation of Par-4 by protein kinase A is critical for apoptosis. Mol Cell Biol (2005) 1.38
Apoptosis by Par-4 in cancer and neurodegenerative diseases. Exp Cell Res (2003) 1.34
Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter. J Biol Chem (2003) 1.34
Role of tumor necrosis factor-alpha and TRAIL in high-dose radiation-induced bystander signaling in lung adenocarcinoma. Cancer Res (2007) 1.28
Cancer resistance in transgenic mice expressing the SAC module of Par-4. Cancer Res (2007) 1.25
Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells. J Biol Chem (2005) 1.18
Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras. Cancer Res (2007) 1.14
Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth. J Immunol (2007) 1.14
Chemoprevention of pancreatic cancer: characterization of Par-4 and its modulation by 3,3' diindolylmethane (DIM). Pharm Res (2008) 1.13
Mechanisms of apoptosis by the tumor suppressor Par-4. J Cell Physiol (2012) 1.13
A role for interleukin-10 in alcohol-induced liver sensitization to bacterial lipopolysaccharide. Alcohol Clin Exp Res (2002) 1.08
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Accuracy of self-reported tobacco assessments in a head and neck cancer treatment population. Radiother Oncol (2011) 1.07
The phosphoinositide 3-kinase/Akt1/Par-4 axis: a cancer-selective therapeutic target. Cancer Res (2006) 1.06
Novel mechanism of apoptosis resistance in cancer mediated by extracellular PAR-4. Cancer Res (2012) 1.06
Regulation of cancer cell survival by Par-4. Ann N Y Acad Sci (2005) 1.03
The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN. Mol Cancer Ther (2007) 1.03
Large-scale gene profiling of the liver in a mouse model of chronic, intragastric ethanol infusion. J Hepatol (2004) 1.02
Par-4 binds to topoisomerase 1 and attenuates its DNA relaxation activity. Cancer Res (2008) 1.00
Critical role of prostate apoptosis response-4 in determining the sensitivity of pancreatic cancer cells to small-molecule inhibitor-induced apoptosis. Mol Cancer Ther (2008) 1.00
Systemic Par-4 inhibits non-autochthonous tumor growth. Cancer Biol Ther (2011) 0.99
Stokes vector analysis of adaptive optics images of the retina. Opt Lett (2008) 0.98
D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice. Genes Dev (2014) 0.97
Apoptosis and tumor resistance conferred by Par-4. Cancer Biol Ther (2008) 0.95
Par-4 inducible apoptosis in prostate cancer cells. J Cell Biochem (2004) 0.95
Lipopolysaccharide-induced liver apoptosis is increased in interleukin-10 knockout mice. Biochim Biophys Acta (2006) 0.95
In lymphatic cells par-4 sensitizes to apoptosis by down-regulating bcl-2 and promoting disruption of mitochondrial membrane potential and caspase activation. Cancer Res (2002) 0.91
Microarray gene analysis of the liver in a rat model of chronic, voluntary alcohol intake. Alcohol (2004) 0.91
KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells. Cancer Res (2013) 0.90
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A herbal medicine for the treatment of lung cancer. Mol Cell Biochem (2005) 0.81
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Par(-4)oxysm in breast cancer. Cancer Cell (2013) 0.79
The tumor suppressor prostate apoptosis response-4 (Par-4) is regulated by mutant IDH1 and kills glioma stem cells. Acta Neuropathol (2014) 0.79
Molecular therapy intervention prospects in prostate cancer. Curr Pharm Des (2004) 0.78
Exploiting the TSA connections to overcome apoptosis-resistance. Cancer Biol Ther (2005) 0.78
Prostate apoptosis response-4 is involved in the apoptosis response to docetaxel in MCF-7 breast cancer cells. Int J Oncol (2013) 0.78
Association between polymorphisms in FOXP3 and EBI3 genes and the risk for development of allergic rhinitis in Chinese subjects. Hum Immunol (2012) 0.78
Synthesis of the Carbon-Coated Nanoparticle Co9S8 and Its Electrochemical Performance as an Anode Material for Sodium-Ion Batteries. Langmuir (2016) 0.78
Some polymorphisms in Epstein-Barr virus-induced gene 3 modify the risk for chronic rhinosinusitis. Am J Rhinol Allergy (2013) 0.77
Par-4 for molecular therapy of prostate cancer. Curr Drug Targets (2003) 0.76
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Regulation of Par-4 by oncogenic Ras. Methods Enzymol (2006) 0.76
"D" approach to prevent metastasis. Cancer Biol Ther (2007) 0.75
Par-4 prevents breast cancer recurrence. Breast Cancer Res (2013) 0.75
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Cancer-selective apoptosis by tumor suppressor par-4. Adv Exp Med Biol (2014) 0.75
A comparative study on three methods of soil quality evaluation of microtopography in the semi-arid Loess Plateau, China. J Environ Biol (2015) 0.75
Hard Carbon Wrapped Na3V2(PO4)3@C Porous Composite Extending Cycling Lifespan for Sodium-Ion Batteries. ACS Appl Mater Interfaces (2017) 0.75
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