RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB-mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN.

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Published in Cancer Res on May 12, 2009

Authors

Seongmi Park1, Dawen Zhao, Kimmo J Hatanpaa, Bruce E Mickey, Debabrata Saha, David A Boothman, Michael D Story, Eric T Wong, Sandeep Burma, Maria-Magdalena Georgescu, Vivek M Rangnekar, Sandili S Chauncey, Amyn A Habib

Author Affiliations

1: Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8813, USA.

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