Published in EMBO J on August 15, 2003
Production of gaba (γ - Aminobutyric acid) by microorganisms: a review. Braz J Microbiol (2012) 1.18
Mechanisms of transcription activation exerted by GadX and GadW at the gadA and gadBC gene promoters of the glutamate-based acid resistance system in Escherichia coli. J Bacteriol (2006) 1.10
Escherichia coli acid resistance: pH-sensing, activation by chloride and autoinhibition in GadB. EMBO J (2006) 1.07
Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia. EMBO J (2005) 0.95
The Shigella dysenteriae serotype 1 proteome, profiled in the host intestinal environment, reveals major metabolic modifications and increased expression of invasive proteins. Proteomics (2009) 0.94
Compensations for diminished terminal oxidase activity in Escherichia coli: cytochrome bd-II-mediated respiration and glutamate metabolism. J Biol Chem (2010) 0.93
Expression, immobilization and enzymatic properties of glutamate decarboxylase fused to a cellulose-binding domain. Int J Mol Sci (2011) 0.92
Characterization of the intracellular glutamate decarboxylase system: analysis of its function, transcription, and role in the acid resistance of various strains of Listeria monocytogenes. Appl Environ Microbiol (2012) 0.88
Role of glutamate decarboxylase-like protein 1 (GADL1) in taurine biosynthesis. J Biol Chem (2012) 0.85
PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism. Protein Sci (2011) 0.85
Comparative analysis of different biofactories for the production of a major diabetes autoantigen. Transgenic Res (2013) 0.83
Efficient gamma-aminobutyric acid bioconversion by employing synthetic complex between glutamate decarboxylase and glutamate/GABA antiporter in engineered Escherichia coli. J Ind Microbiol Biotechnol (2013) 0.83
On the catalytic mechanism and stereospecificity of Escherichia coli L-threonine aldolase. FEBS J (2013) 0.82
Mutation of His465 alters the pH-dependent spectroscopic properties of Escherichia coli glutamate decarboxylase and broadens the range of its activity toward more alkaline pH. J Biol Chem (2009) 0.81
Two-step production of gamma-aminobutyric acid from cassava powder using Corynebacterium glutamicum and Lactobacillus plantarum. J Ind Microbiol Biotechnol (2015) 0.80
Transcriptomic analysis of carboxylic acid challenge in Escherichia coli: beyond membrane damage. PLoS One (2014) 0.80
A fluorescence-coupled assay for gamma aminobutyric acid (GABA) reveals metabolic stress-induced modulation of GABA content in neuroendocrine cancer. PLoS One (2014) 0.80
Gamma-aminobutyric acid production using immobilized glutamate decarboxylase followed by downstream processing with cation exchange chromatography. Int J Mol Sci (2013) 0.79
Lactobacillus futsaii CS3, a New GABA-Producing Strain Isolated from Thai Fermented Shrimp (Kung-Som). Indian J Microbiol (2016) 0.79
Integrated bioprocessing for the pH-dependent production of 4-valerolactone from levulinate in Pseudomonas putida KT2440. Appl Environ Microbiol (2009) 0.78
Glutamate decarboxylase-dependent acid resistance in Brucella spp.: distribution and contribution to fitness under extremely acidic conditions. Appl Environ Microbiol (2014) 0.77
Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates. Biosci Rep (2013) 0.77
Discovery of a substrate selectivity motif in amino acid decarboxylases unveils a taurine biosynthesis pathway in prokaryotes. ACS Chem Biol (2013) 0.76
Extracellular expression of glutamate decarboxylase B in Escherichia coli to improve gamma-aminobutyric acid production. AMB Express (2016) 0.75
Common Distribution of gad Operon in Lactobacillus brevis and its GadA Contributes to Efficient GABA Synthesis toward Cytosolic Near-Neutral pH. Front Microbiol (2017) 0.75
Acid evolution deletes amino-acid decarboxylases and reregulates catabolism of Escherichia coli K-12. Appl Environ Microbiol (2017) 0.75
X-Ray Solution Scattering Study of Four Escherichia coli Enzymes Involved in Stationary-Phase Metabolism. PLoS One (2016) 0.75
Role of the virulence plasmid in acid resistance of Shigella flexneri. Sci Rep (2017) 0.75
Activation of the Glutamic Acid-Dependent Acid Resistance System in Escherichia coli BL21(DE3) Leads to Increase of the Fatty Acid Biotransformation Activity. PLoS One (2016) 0.75
Biochemical and spectroscopic properties of Brucella microti glutamate decarboxylase, a key component of the glutamate-dependent acid resistance system. FEBS Open Bio (2015) 0.75
Functional genomics analysis of free fatty acid production under continuous phosphate limiting conditions. J Ind Microbiol Biotechnol (2016) 0.75
Identification and molecular cloning of glutamate decarboxylase gene from Lactobacillus casei. Mol Biol Res Commun (2015) 0.75
Molecular and proteome analyses highlight the importance of the Cpx envelope stress system for acid stress and cell wall stability in Escherichia coli. Microbiologyopen (2016) 0.75
Purification and characterization of glutamate decarboxylase from Enterococcus raffinosus TCCC11660. J Ind Microbiol Biotechnol (2017) 0.75
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
The Protein Data Bank. Nucleic Acids Res (2000) 187.10
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
The complete genome sequence of Escherichia coli K-12. Science (1997) 84.27
Protein structure comparison by alignment of distance matrices. J Mol Biol (1993) 34.74
Raster3D: photorealistic molecular graphics. Methods Enzymol (1997) 27.30
Reduced surface: an efficient way to compute molecular surfaces. Biopolymers (1996) 10.62
Gastric acid barrier to ingested microorganisms in man: studies in vivo and in vitro. Gut (1972) 4.59
Databases in protein crystallography. Acta Crystallogr D Biol Crystallogr (1998) 4.18
Comparative analysis of extreme acid survival in Salmonella typhimurium, Shigella flexneri, and Escherichia coli. J Bacteriol (1995) 3.92
Mechanisms of acid resistance in enterohemorrhagic Escherichia coli. Appl Environ Microbiol (1996) 3.60
A glutamate-dependent acid resistance gene in Escherichia coli. J Bacteriol (1996) 2.98
Nucleotide sequence of the Escherichia coli cad operon: a system for neutralization of low extracellular pH. J Bacteriol (1992) 2.88
A glutamate decarboxylase system protects Listeria monocytogenes in gastric fluid. Mol Microbiol (2001) 2.63
The response to stationary-phase stress conditions in Escherichia coli: role and regulation of the glutamic acid decarboxylase system. Mol Microbiol (1999) 2.40
Two isoforms of glutamate decarboxylase: why? Trends Pharmacol Sci (1998) 2.40
Specific versus non-specific contacts in protein crystals. Nat Struct Biol (1997) 2.15
Acid- and base-induced proteins during aerobic and anaerobic growth of Escherichia coli revealed by two-dimensional gel electrophoresis. J Bacteriol (1999) 2.14
Escherichia coli has two homologous glutamate decarboxylase genes that map to distinct loci. J Bacteriol (1992) 2.08
Structure, evolution and action of vitamin B6-dependent enzymes. Curr Opin Struct Biol (1998) 2.03
Identification of sigma S-dependent genes associated with the stationary-phase acid-resistance phenotype of Shigella flexneri. Mol Microbiol (1996) 2.02
Functional characterization and regulation of gadX, a gene encoding an AraC/XylS-like transcriptional activator of the Escherichia coli glutamic acid decarboxylase system. J Bacteriol (2002) 1.87
Organic acids: chemistry, antibacterial activity and practical applications. Adv Microb Physiol (1991) 1.78
Glutamic acid decarboxylase. I. Isolation procedures and properties of the enzyme. J Biol Chem (1960) 1.75
Calmodulin binding to glutamate decarboxylase is required for regulation of glutamate and GABA metabolism and normal development in plants. EMBO J (1996) 1.66
Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae. J Biol Chem (2001) 1.54
X-ray structure refinement and comparison of three forms of mitochondrial aspartate aminotransferase. J Mol Biol (1992) 1.49
Activation of a recombinant petunia glutamate decarboxylase by calcium/calmodulin or by a monoclonal antibody which recognizes the calmodulin binding domain. J Biol Chem (1996) 1.40
The conserved, buried aspartic acid in oxidized Escherichia coli thioredoxin has a pKa of 7.5. Its titration produces a related shift in global stability. Biochemistry (1991) 1.38
Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase. Nat Struct Biol (2001) 1.35
Isolation, overexpression, and biochemical characterization of the two isoforms of glutamic acid decarboxylase from Escherichia coli. Protein Expr Purif (1996) 1.32
Crystal structure of a NifS-like protein from Thermotoga maritima: implications for iron sulphur cluster assembly. J Mol Biol (2000) 1.23
Refinement and comparisons of the crystal structures of pig cytosolic aspartate aminotransferase and its complex with 2-methylaspartate. J Biol Chem (1997) 1.20
Glutamic acid decarboxylase. II. The spectrum of the enzyme. J Biol Chem (1960) 1.11
Two isoforms of glutamate decarboxylase in Arabidopsis are regulated by calcium/calmodulin and differ in organ distribution. Plant Mol Biol (1998) 0.99
pH jump studies of glutamate decarboxylase. Evidence for a pH-dependent conformation change. J Biol Chem (1974) 0.92
Contribution of Lys276 to the conformational flexibility of the active site of glutamate decarboxylase from Escherichia coli. Eur J Biochem (2002) 0.85
Crystallization and preliminary X-ray analysis of the beta-isoform of glutamate decarboxylase from Escherichia coli. Acta Crystallogr D Biol Crystallogr (1998) 0.81
Quaternary structure of glutamate decarboxylase of Escherichia coli as revealed by electron microscopy. J Mol Biol (1971) 0.80
[Study of the quaternary structure of glutamate carboxylase from Escherichia coli]. Mol Biol (Mosk) (1995) 0.80
TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature (2011) 6.29
High-affinity binders selected from designed ankyrin repeat protein libraries. Nat Biotechnol (2004) 3.34
Histone methylation by PRC2 is inhibited by active chromatin marks. Mol Cell (2011) 3.14
Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLoS Biol (2007) 2.89
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J Biol Chem (2002) 2.75
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation. Cell (2011) 2.16
NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain. Structure (2003) 2.15
Insights into the regulatory mechanism for caspase-8 activation. Mol Cell (2003) 2.01
Designed to be stable: crystal structure of a consensus ankyrin repeat protein. Proc Natl Acad Sci U S A (2003) 1.98
Inhibition of caspase-2 by a designed ankyrin repeat protein: specificity, structure, and inhibition mechanism. Structure (2007) 1.93
Functional characterization and regulation of gadX, a gene encoding an AraC/XylS-like transcriptional activator of the Escherichia coli glutamic acid decarboxylase system. J Bacteriol (2002) 1.87
Allosteric inhibition of aminoglycoside phosphotransferase by a designed ankyrin repeat protein. Structure (2005) 1.75
Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun (2003) 1.74
Crystal structure of the multidrug exporter MexB from Pseudomonas aeruginosa. J Mol Biol (2009) 1.69
Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation. Nat Struct Mol Biol (2012) 1.66
Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. Proc Natl Acad Sci U S A (2012) 1.66
Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters. Proc Natl Acad Sci U S A (2013) 1.46
Structural basis of chaperone-subunit complex recognition by the type 1 pilus assembly platform FimD. EMBO J (2005) 1.42
Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin. J Biol Chem (2003) 1.40
Pyridoxal 5'-phosphate enzymes as targets for therapeutic agents. Curr Med Chem (2007) 1.36
Structure of the PRYSPRY-domain: implications for autoinflammatory diseases. FEBS Lett (2005) 1.36
GadX/GadW-dependent regulation of the Escherichia coli acid fitness island: transcriptional control at the gadY-gadW divergent promoters and identification of four novel 42 bp GadX/GadW-specific binding sites. Mol Microbiol (2008) 1.34
Structural basis and kinetics of inter- and intramolecular disulfide exchange in the redox catalyst DsbD. EMBO J (2004) 1.32
Precision is essential for efficient catalysis in an evolved Kemp eliminase. Nature (2013) 1.28
Intracellular kinase inhibitors selected from combinatorial libraries of designed ankyrin repeat proteins. J Biol Chem (2005) 1.17
Structural and biochemical studies on procaspase-8: new insights on initiator caspase activation. Structure (2009) 1.16
PyMod: sequence similarity searches, multiple sequence-structure alignments, and homology modeling within PyMOL. BMC Bioinformatics (2012) 1.16
Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency. Proc Natl Acad Sci U S A (2009) 1.15
Chaperone-assisted crystallography with DARPins. Structure (2008) 1.14
Structure and mechanism of Escherichia coli pyridoxine 5'-phosphate oxidase. Biochim Biophys Acta (2003) 1.13
Comparative structural analysis of psychrophilic and meso- and thermophilic enzymes. Proteins (2002) 1.13
Infinite kinetic stability against dissociation of supramolecular protein complexes through donor strand complementation. Structure (2008) 1.12
Mechanisms of transcription activation exerted by GadX and GadW at the gadA and gadBC gene promoters of the glutamate-based acid resistance system in Escherichia coli. J Bacteriol (2006) 1.10
DsbL and DsbI form a specific dithiol oxidase system for periplasmic arylsulfate sulfotransferase in uropathogenic Escherichia coli. J Mol Biol (2008) 1.10
Vacuolar protein sorting: two different functional states of the AAA-ATPase Vps4p. J Mol Biol (2008) 1.09
Structural basis and kinetics of DsbD-dependent cytochrome c maturation. Structure (2005) 1.08
Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis. J Mol Biol (2006) 1.08
Antagonistic role of H-NS and GadX in the regulation of the glutamate decarboxylase-dependent acid resistance system in Escherichia coli. J Biol Chem (2005) 1.07
Escherichia coli acid resistance: pH-sensing, activation by chloride and autoinhibition in GadB. EMBO J (2006) 1.07
Structure of rabbit-muscle glyceraldehyde-3-phosphate dehydrogenase. Acta Crystallogr D Biol Crystallogr (2003) 1.05
Structure-activity studies in a family of beta-hairpin protein epitope mimetic inhibitors of the p53-HDM2 protein-protein interaction. Chembiochem (2006) 1.04
Fire and death: the pyrin domain joins the death-domain superfamily. C R Biol (2004) 1.03
Crystal structure of the ternary FimC-FimF(t)-FimD(N) complex indicates conserved pilus chaperone-subunit complex recognition by the usher FimD. FEBS Lett (2008) 1.03
The crystal structure of human pyrin b30.2 domain: implications for mutations associated with familial Mediterranean fever. J Mol Biol (2009) 1.02
Structural determinants for improved stability of designed ankyrin repeat proteins with a redesigned C-capping module. J Mol Biol (2010) 1.02
Identification by virtual screening and in vitro testing of human DOPA decarboxylase inhibitors. PLoS One (2012) 1.00
Stabilizing ionic interactions in a full-consensus ankyrin repeat protein. J Mol Biol (2007) 0.99
The crystal structure of Helicobacter cysteine-rich protein C at 2.0 A resolution: similar peptide-binding sites in TPR and SEL1-like repeat proteins. J Mol Biol (2004) 0.99
Structure and oligomeric state of the mammalian tumour-associated antigen UK114. Acta Crystallogr D Biol Crystallogr (2003) 0.98
Structure and zymogen activation of caspases. Biophys Chem (2002) 0.98
An invariant surface patch on the TRIM5alpha PRYSPRY domain is required for retroviral restriction but dispensable for capsid binding. J Virol (2009) 0.98
Evolutionarily conserved regions and hydrophobic contacts at the superfamily level: The case of the fold-type I, pyridoxal-5'-phosphate-dependent enzymes. Protein Sci (2004) 0.98
Rif1 and Rif2 shape telomere function and architecture through multivalent Rap1 interactions. Cell (2013) 0.97
Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10. J Med Chem (2006) 0.97
Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development. Mol Cell Biol (2012) 0.97
In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed. Eur J Med Chem (2011) 0.97
Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: A basis for the design of specific inhibitors. Structure (2006) 0.95
Structural and functional insights into the assembly of type 1 pili from Escherichia coli. Microbes Infect (2006) 0.95
Crystal structure of a consensus-designed ankyrin repeat protein: implications for stability. Proteins (2006) 0.94
Quality control of disulfide bond formation in pilus subunits by the chaperone FimC. Nat Chem Biol (2012) 0.94
Coping with low pH: molecular strategies in neutralophilic bacteria. FEMS Microbiol Rev (2014) 0.94
Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism. Structure (2010) 0.94
Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O-fucosylation. EMBO J (2012) 0.94
Crystal structure of the anti-His tag antibody 3D5 single-chain fragment complexed to its antigen. J Mol Biol (2002) 0.92
Crystallization of the NADH-oxidizing domain of the Na+-translocating NADH:ubiquinone oxidoreductase from Vibrio cholerae. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.92
Exploring the S4 and S1 prime subsite specificities in caspase-3 with aza-peptide epoxide inhibitors. Biochemistry (2006) 0.92
Evidence for a novel domain of bacterial outer membrane ushers. Proteins (2006) 0.91
A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions. Proc Natl Acad Sci U S A (2008) 0.91
A common structural basis for pH- and calmodulin-mediated regulation in plant glutamate decarboxylase. J Mol Biol (2009) 0.91
Improvement in prediction of solvent accessibility by probability profiles. Protein Eng (2003) 0.90
Comparison of the crystal structures of the human manganese superoxide dismutase and the homologous Aspergillus fumigatus allergen at 2-A resolution. J Immunol (2002) 0.90
Structural adaptation to low temperatures--analysis of the subunit interface of oligomeric psychrophilic enzymes. FEBS J (2007) 0.90
Identification of a basic surface area of the FADD death effector domain critical for apoptotic signaling. FEBS Lett (2002) 0.89
Opportunities for structure-based design of protease-directed drugs. Curr Opin Struct Biol (2006) 0.89
High-resolution structures of Escherichia coli cDsbD in different redox states: A combined crystallographic, biochemical and computational study. J Mol Biol (2006) 0.88
Designed ankyrin repeat protein binders for the crystallization of AcrB: plasticity of the dominant interface. J Struct Biol (2011) 0.88
Asymmetry in the homodimeric ABC transporter MsbA recognized by a DARPin. J Biol Chem (2012) 0.87
Threonine aldolase and alanine racemase: novel examples of convergent evolution in the superfamily of vitamin B6-dependent enzymes. Biochim Biophys Acta (2003) 0.87
Design, construction, and characterization of a second-generation DARP in library with reduced hydrophobicity. Protein Sci (2013) 0.87
New concepts and aids to facilitate crystallization. Curr Opin Struct Biol (2013) 0.87
Catalytic and thermodynamic properties of tetrahydromethanopterin-dependent serine hydroxymethyltransferase from Methanococcus jannaschii. J Biol Chem (2003) 0.87
Transcription of the Listeria monocytogenes fri gene is growth-phase dependent and is repressed directly by Fur, the ferric uptake regulator. Gene (2008) 0.87
The expression of the dodecameric ferritin in Listeria spp. is induced by iron limitation and stationary growth phase. Gene (2002) 0.86
Structural adaptation of serine hydroxymethyltransferase to low temperatures. Int J Biol Macromol (2009) 0.85
CRK: an evolutionary approach for distinguishing biologically relevant interfaces from crystal contacts. Proteins (2010) 0.85
CAMPO, SCR_FIND and CHC_FIND: a suite of web tools for computational structural biology. Nucleic Acids Res (2005) 0.85
Contribution of Lys276 to the conformational flexibility of the active site of glutamate decarboxylase from Escherichia coli. Eur J Biochem (2002) 0.85
The mechanism of addition of pyridoxal 5'-phosphate to Escherichia coli apo-serine hydroxymethyltransferase. Biochem J (2007) 0.85
The glutamic acid decarboxylase system of the new species Brucella microti contributes to its acid resistance and to oral infection of mice. J Infect Dis (2012) 0.83
HIV-1 protease inhibition potential of functionalized polyoxometalates. Bioorg Med Chem Lett (2010) 0.83
Structure-based optimization of designed Armadillo-repeat proteins. Protein Sci (2012) 0.83
Metal-free MIRAS phasing: structure of apo-S100A3. Acta Crystallogr D Biol Crystallogr (2002) 0.83
Structure of ACC synthase inactivated by the mechanism-based inhibitor L-vinylglycine. FEBS Lett (2005) 0.82
Molecular dynamics study of the stabilities of consensus designed ankyrin repeat proteins. Proteins (2006) 0.82
Dimerization of Sir3 via its C-terminal winged helix domain is essential for yeast heterochromatin formation. EMBO J (2013) 0.82