Mitochondrial sources of H2O2 generation play a key role in flow-mediated dilation in human coronary resistance arteries.

PubWeight™: 2.31‹?› | Rank: Top 2%

🔗 View Article (PMID 12919951)

Published in Circ Res on August 14, 2003

Authors

Yanping Liu1, Hongtao Zhao, Hongwei Li, B Kalyanaraman, Alfred C Nicolosi, David D Gutterman

Author Affiliations

1: Department of Internal Medicine, Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, Wis 53226, USA. ypliu@mcw.edu

Articles citing this

(truncated to the top 100)

Measurement of reactive oxygen species in cardiovascular studies. Hypertension (2007) 3.17

Cross talk between mitochondria and NADPH oxidases. Free Radic Biol Med (2011) 2.63

Inflammation and endothelial dysfunction during aging: role of NF-kappaB. J Appl Physiol (1985) (2008) 2.40

Mitochondria-derived reactive oxygen species dilate cerebral arteries by activating Ca2+ sparks. Circ Res (2005) 2.29

Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications. Rev Endocr Metab Disord (2010) 2.19

Chemistry and antihypertensive effects of tempol and other nitroxides. Pharmacol Rev (2008) 1.91

Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption. Hypertension (2012) 1.79

Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition. Am J Physiol Heart Circ Physiol (2005) 1.76

TNF-alpha dilates cerebral arteries via NAD(P)H oxidase-dependent Ca2+ spark activation. Am J Physiol Cell Physiol (2005) 1.70

Peroxynitrite disrupts endothelial caveolae leading to eNOS uncoupling and diminished flow-mediated dilation in coronary arterioles of diabetic patients. Diabetes (2013) 1.61

Endothelium-dependent smooth muscle hyperpolarization: do gap junctions provide a unifying hypothesis? Br J Pharmacol (2004) 1.61

Oxidative stress as a mediator of cardiovascular disease. Oxid Med Cell Longev (2010) 1.58

Reactive oxygen species in health and disease. J Biomed Biotechnol (2012) 1.52

Cardiac mitochondria and reactive oxygen species generation. Circ Res (2014) 1.51

H2O2 is the transferrable factor mediating flow-induced dilation in human coronary arterioles. Circ Res (2011) 1.49

Elevated oxidative stress and endothelial dysfunction in right coronary artery of right ventricular hypertrophy. J Appl Physiol (1985) (2011) 1.43

Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation. Circ Res (2015) 1.42

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers. J Hematol Oncol (2013) 1.42

Cyclic stretch, reactive oxygen species, and vascular remodeling. Antioxid Redox Signal (2009) 1.38

Mitochondrial reactive oxygen species: a double edged sword in ischemia/reperfusion vs preconditioning. Redox Biol (2014) 1.37

Hydrogen peroxide inhibits cytochrome p450 epoxygenases: interaction between two endothelium-derived hyperpolarizing factors. Circ Res (2007) 1.36

Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells. Am J Pathol (2006) 1.33

A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potential. Free Radic Biol Med (2009) 1.31

Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension. Antioxid Redox Signal (2013) 1.26

Regulation of endothelial function by mitochondrial reactive oxygen species. Antioxid Redox Signal (2011) 1.25

Oxidative risk for atherothrombotic cardiovascular disease. Free Radic Biol Med (2009) 1.24

Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling. Am J Physiol Heart Circ Physiol (2011) 1.20

Role of reactive oxygen and nitrogen species in the vascular responses to inflammation. Free Radic Biol Med (2011) 1.17

NAD(P)H oxidase-derived peroxide mediates elevated basal and impaired flow-induced NO production in SHR mesenteric arteries in vivo. Am J Physiol Heart Circ Physiol (2008) 1.14

Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopus. Am J Physiol Heart Circ Physiol (2009) 1.13

ROS-induced ROS release in vascular biology: redox-redox signaling. Am J Physiol Heart Circ Physiol (2011) 1.11

NO-mediated regulation of NAD(P)H oxidase by laminar shear stress in human endothelial cells. J Physiol (2006) 1.11

MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries. J Exp Med (2008) 1.09

Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol (2008) 1.08

Diversity in mechanisms of endothelium-dependent vasodilation in health and disease. Microcirculation (2013) 1.07

Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells. J Pharmacol Exp Ther (2009) 1.05

Oxidative stress as an underlying contributor in the development of chronic complications in diabetes mellitus. Int J Mol Sci (2013) 1.04

Role of mitochondrial oxidative stress in hypertension. Am J Physiol Heart Circ Physiol (2013) 1.04

Bradykinin-induced dilation of human coronary arterioles requires NADPH oxidase-derived reactive oxygen species. Arterioscler Thromb Vasc Biol (2009) 1.04

Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications. J Biomed Sci (2014) 1.04

Hydrogen peroxide as an endothelium-derived hyperpolarizing factor. Pflugers Arch (2010) 1.04

Disturbed-flow-mediated vascular reactive oxygen species induce endothelial dysfunction. Circ J (2011) 1.03

Hemodynamic forces, vascular oxidative stress, and regulation of BMP-2/4 expression. Antioxid Redox Signal (2009) 1.02

Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite. Am J Physiol Cell Physiol (2008) 1.02

Reactive oxygen species and dopamine receptor function in essential hypertension. Clin Exp Hypertens (2009) 1.02

Endothelial cytoskeletal elements are critical for flow-mediated dilation in human coronary arterioles. Med Biol Eng Comput (2008) 1.01

Vascular control in humans: focus on the coronary microcirculation. Basic Res Cardiol (2009) 1.01

Interactions between A(2A) adenosine receptors, hydrogen peroxide, and KATP channels in coronary reactive hyperemia. Am J Physiol Heart Circ Physiol (2013) 1.00

Depletion of intracellular Ca2+ stores enhances flow-induced vascular dilatation in rat small mesenteric artery. Br J Pharmacol (2006) 0.99

Gene and protein responses of human monocytes to extracellular cysteine redox potential. Toxicol Sci (2009) 0.99

15-Lipoxygenase-1-enhanced Src-Janus kinase 2-signal transducer and activator of transcription 3 stimulation and monocyte chemoattractant protein-1 expression require redox-sensitive activation of epidermal growth factor receptor in vascular wall remodeling. J Biol Chem (2011) 0.98

Local production of O2- by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: cADPR-mediated Ca2+ regulation. Cell Signal (2007) 0.98

Mitochondrial-mediated suppression of ROS production upon exposure of neurons to lethal stress: mitochondrial targeted preconditioning. Adv Drug Deliv Rev (2008) 0.97

Impaired myocardial perfusion reserve and fibrosis in Friedreich ataxia: a mitochondrial cardiomyopathy with metabolic syndrome. Eur Heart J (2010) 0.97

Ceramide changes the mediator of flow-induced vasodilation from nitric oxide to hydrogen peroxide in the human microcirculation. Circ Res (2014) 0.96

Flow-induced dilation is mediated by Akt-dependent activation of endothelial nitric oxide synthase-derived hydrogen peroxide in mouse cerebral arteries. Stroke (2009) 0.93

Critical role of endothelial hydrogen peroxide in post-ischemic neovascularization. PLoS One (2013) 0.92

Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes. Circ Res (2016) 0.92

Oxidative mechanisms and atherothrombotic cardiovascular disease. Drug Discov Today Ther Strateg (2008) 0.90

Endogenous hydrogen peroxide in paraventricular nucleus mediating cardiac sympathetic afferent reflex and regulating sympathetic activity. Pflugers Arch (2007) 0.90

Vascular TRP channels: performing under pressure and going with the flow. Physiology (Bethesda) (2014) 0.89

Vein graft failure. J Vasc Surg (2013) 0.88

An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles. Am J Physiol Heart Circ Physiol (2014) 0.88

Age and exercise training alter signaling through reactive oxygen species in the endothelium of skeletal muscle arterioles. J Appl Physiol (1985) (2013) 0.87

Abnormal nitric oxide production in aged rat mesenteric arteries is mediated by NAD(P)H oxidase-derived peroxide. Am J Physiol Heart Circ Physiol (2009) 0.87

Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress. Am J Physiol Heart Circ Physiol (2013) 0.86

Endothelium-derived hyperpolarizing factor and vascular function. Cardiol Res Pract (2011) 0.86

Reactive oxygen species cause endothelial dysfunction in chronic flow overload. J Appl Physiol (1985) (2010) 0.86

The Human Microcirculation: Regulation of Flow and Beyond. Circ Res (2016) 0.86

Regulation of the human coronary microcirculation. J Mol Cell Cardiol (2011) 0.85

Redox regulation of endothelial cell fate. Cell Mol Life Sci (2014) 0.84

Emerging roles of mitochondria ROS in atherosclerotic lesions: causation or association? J Atheroscler Thromb (2014) 0.84

Acute exertion elicits a H2O2-dependent vasodilator mechanism in the microvasculature of exercise-trained but not sedentary adults. Hypertension (2014) 0.83

Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association. Circ Res (2016) 0.83

The Role of Mitochondrial Reactive Oxygen Species in Cardiovascular Injury and Protective Strategies. Oxid Med Cell Longev (2016) 0.83

Renovascular hypertension leads to DNA damage and apoptosis in bone marrow cells. DNA Cell Biol (2013) 0.82

Impact of age on the vasodilatory function of human skeletal muscle feed arteries. Am J Physiol Heart Circ Physiol (2015) 0.81

The vascular renin-angiotensin system contributes to blunted vasodilation induced by transient high pressure in human adipose microvessels. Am J Physiol Heart Circ Physiol (2014) 0.81

Fluid Mechanical Forces and Endothelial Mitochondria: A Bioengineering Perspective. Cell Mol Bioeng (2014) 0.81

Mouse models for preeclampsia: disruption of redox-regulated signaling. Reprod Biol Endocrinol (2009) 0.81

Inwardly-rectifying K(+) channels are major contributors to flow-induced vasodilation in resistance arteries. J Physiol (2016) 0.80

Increased superoxide leads to decreased flow-induced dilation in resistance arteries of Mn-SOD-deficient mice. Am J Physiol Heart Circ Physiol (2005) 0.80

Overexpressing superoxide dismutase 2 induces a supernormal cardiac function by enhancing redox-dependent mitochondrial function and metabolic dilation. J Mol Cell Cardiol (2015) 0.80

Advanced age protects microvascular endothelium from aberrant Ca(2+) influx and cell death induced by hydrogen peroxide. J Physiol (2015) 0.80

Exercise and vascular function: how much is too much? Can J Physiol Pharmacol (2014) 0.78

Effect of hydrogen peroxide and superoxide anions on cytosolic Ca2+: comparison of endothelial cells from large-sized and small-sized arteries. PLoS One (2011) 0.78

Oxidation by trace Cu2+ ions underlies the ability of ascorbate to induce vascular dysfunction in the rat perfused mesentery. Eur J Pharmacol (2009) 0.78

Endothelium-Derived Hyperpolarization and Coronary Vasodilation: Diverse and Integrated Roles of Epoxyeicosatrienoic Acids, Hydrogen Peroxide, and Gap Junctions. Microcirculation (2016) 0.78

Tocopherol induced angiogenesis in placental vascular network in late pregnant ewes. Reprod Biol Endocrinol (2010) 0.77

Vascular Actions of Angiotensin 1-7 in the Human Microcirculation: Novel Role for Telomerase. Arterioscler Thromb Vasc Biol (2016) 0.77

Time-related alteration in flow- (shear stress-) mediated remodeling in resistance arteries from spontaneously hypertensive rats. Int J Hypertens (2014) 0.76

Regulation of exercise blood flow: Role of free radicals. Free Radic Biol Med (2016) 0.76

Ceramide signaling in the coronary microcirculation: a double-edged sword? Circ Res (2014) 0.76

Hydrogen peroxide elicits constriction of skeletal muscle arterioles by activating the arachidonic acid pathway. PLoS One (2014) 0.76

Peripheral vascular function, oxygen delivery and utilization: the impact of oxidative stress in aging and heart failure with reduced ejection fraction. Heart Fail Rev (2016) 0.75

Diverse Functions of Endothelial NO Synthases System: NO and EDH. J Cardiovasc Pharmacol (2016) 0.75

Voluntary aerobic exercise increases arterial resilience and mitochondrial health with aging in mice. Aging (Albany NY) (2016) 0.75

Mitochondrial Dysfunction Contributes to Hypertensive Target Organ Damage: Lessons from an Animal Model of Human Disease. Oxid Med Cell Longev (2016) 0.75

Acute supplementation of N-acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise. Physiol Rep (2016) 0.75

Depolarization of mitochondria in neurons promotes activation of nitric oxide synthase and generation of nitric oxide. Am J Physiol Heart Circ Physiol (2016) 0.75

Articles by these authors

Executive summary: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 5.88

Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide. Free Radic Biol Med (2003) 5.14

Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. Proc Natl Acad Sci U S A (1998) 4.94

Oxidation of polycyclic aromatic hydrocarbons and dibenzo[p]-dioxins by Phanerochaete chrysosporium ligninase. J Biol Chem (1986) 4.10

Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence. Proc Natl Acad Sci U S A (2005) 3.85

Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing. Proc Natl Acad Sci U S A (2004) 3.85

MIRA-assisted microarray analysis, a new technology for the determination of DNA methylation patterns, identifies frequent methylation of homeodomain-containing genes in lung cancer cells. Cancer Res (2006) 3.66

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives. J Biol Chem (1994) 3.64

Methodology for the development of antithrombotic therapy and prevention of thrombosis guidelines: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 3.14

Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma. PLoS One (2011) 3.10

The ligninase of Phanerochaete chrysosporium generates cation radicals from methoxybenzenes. J Biol Chem (1985) 3.08

Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide. Free Radic Biol Med (2005) 2.80

MicroRNA-214 suppresses osteogenic differentiation of C2C12 myoblast cells by targeting Osterix. Bone (2013) 2.79

Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants. Arterioscler Thromb Vasc Biol (2002) 2.53

Primary and secondary prevention of cardiovascular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 2.50

Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: another inconvenient truth. Free Radic Biol Med (2010) 2.32

Mitochondrial reactive oxygen species-mediated signaling in endothelial cells. Am J Physiol Heart Circ Physiol (2007) 2.24

Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms. intermediacy of H(2)O(2)- and p53-dependent pathways. J Biol Chem (2004) 2.21

Ligninase of Phanerochaete chrysosporium. Mechanism of its degradation of the non-phenolic arylglycerol beta-aryl ether substructure of lignin. Biochem J (1986) 2.21

Association of the beta2-adrenergic receptor gene with essential hypertension in the non-Han Chinese Yi minority human population. J Hypertens (2006) 2.16

Role for hydrogen peroxide in flow-induced dilation of human coronary arterioles. Circ Res (2003) 2.09

Mechanism of nitric oxide release from S-nitrosothiols. J Biol Chem (1996) 2.02

Diabetes mellitus impairs vasodilation to hypoxia in human coronary arterioles: reduced activity of ATP-sensitive potassium channels. Circ Res (2003) 2.01

Mechanism of oxidative C alpha-C beta cleavage of a lignin model dimer by Phanerochaete chrysosporium ligninase. Stoichiometry and involvement of free radicals. J Biol Chem (1985) 1.96

The confounding effects of light, sonication, and Mn(III)TBAP on quantitation of superoxide using hydroethidine. Free Radic Biol Med (2006) 1.83

The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest (2008) 1.82

Comparison of lignin peroxidase, horseradish peroxidase and laccase in the oxidation of methoxybenzenes. Biochem J (1990) 1.78

Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species. J Biol Chem (2000) 1.78

Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition. Am J Physiol Heart Circ Physiol (2005) 1.76

TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress. Am J Physiol Heart Circ Physiol (2009) 1.76

Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin. Biochemistry (1997) 1.76

Measuring FMD in the brachial artery: how important is QRS gating? J Appl Physiol (1985) (2010) 1.75

CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators. Mol Cell (2003) 1.75

Direct oxidation of boronates by peroxynitrite: mechanism and implications in fluorescence imaging of peroxynitrite. Free Radic Biol Med (2009) 1.72

Synergistic coactivator function by coactivator-associated arginine methyltransferase (CARM) 1 and beta-catenin with two different classes of DNA-binding transcriptional activators. J Biol Chem (2002) 1.71

PARP1 ADP-ribosylates lysine residues of the core histone tails. Nucleic Acids Res (2010) 1.64

Introduction to the ninth edition: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 1.63

Moderate cardiac-selective overexpression of angiotensin II type 2 receptor protects cardiac functions from ischaemic injury. Exp Physiol (2011) 1.61

Lignin peroxidase oxidation of Mn2+ in the presence of veratryl alcohol, malonic or oxalic acid, and oxygen. Biochemistry (1990) 1.60

HPLC study of oxidation products of hydroethidine in chemical and biological systems: ramifications in superoxide measurements. Free Radic Biol Med (2008) 1.60

Synthesis and biochemical applications of a solid cyclic nitrone spin trap: a relatively superior trap for detecting superoxide anions and glutathiyl radicals. Free Radic Biol Med (2001) 1.59

The mechanism of flow-induced dilation in human adipose arterioles involves hydrogen peroxide during CAD. Am J Physiol Heart Circ Physiol (2006) 1.55

RNA silencing: a conserved antiviral immunity of plants and animals. Virus Res (2004) 1.54

L-4F, an apolipoprotein A-1 mimetic, dramatically improves vasodilation in hypercholesterolemia and sickle cell disease. Circulation (2003) 1.53

Transient receptor potential vanilloid type 4-deficient mice exhibit impaired endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo. Hypertension (2009) 1.51

H2O2 is the transferrable factor mediating flow-induced dilation in human coronary arterioles. Circ Res (2011) 1.49

Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase. J Biol Chem (1999) 1.49

Peroxynitrite inhibits Ca2+-activated K+ channel activity in smooth muscle of human coronary arterioles. Circ Res (2002) 1.49

Mitochondrial aconitase is a source of hydroxyl radical. An electron spin resonance investigation. J Biol Chem (2000) 1.47

Pirfenidone attenuates cardiac fibrosis in a mouse model of TAC-induced left ventricular remodeling by suppressing NLRP3 inflammasome formation. Cardiology (2013) 1.46

Mechanistic similarities between oxidation of hydroethidine by Fremy's salt and superoxide: stopped-flow optical and EPR studies. Free Radic Biol Med (2005) 1.45

The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications. Free Radic Res (2003) 1.45

The role of glutathione in the transport and catabolism of nitric oxide. FEBS Lett (1996) 1.45

Acquired microvascular dysfunction in inflammatory bowel disease: Loss of nitric oxide-mediated vasodilation. Gastroenterology (2003) 1.44

Epidemiology, mechanisms, and risks: American College of Chest Physicians guidelines for the prevention and management of postoperative atrial fibrillation after cardiac surgery. Chest (2005) 1.42

Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with type 2 diabetes. Transl Res (2010) 1.40

Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis. J Biol Chem (2004) 1.39

Spin traps: in vitro toxicity and stability of radical adducts. Free Radic Biol Med (2003) 1.38

Oxidative stress-induced iron signaling is responsible for peroxide-dependent oxidation of dichlorodihydrofluorescein in endothelial cells: role of transferrin receptor-dependent iron uptake in apoptosis. Circ Res (2003) 1.38

First, do no harm: less training ≠ quality care. Am J Crit Care (2012) 1.38

Hydrogen peroxide inhibits cytochrome p450 epoxygenases: interaction between two endothelium-derived hyperpolarizing factors. Circ Res (2007) 1.36

Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: identification of homo- and heterodimers. Free Radic Biol Med (2007) 1.34

Nitric oxide inhibition of lipoxygenase-dependent liposome and low-density lipoprotein oxidation: termination of radical chain propagation reactions and formation of nitrogen-containing oxidized lipid derivatives. Arch Biochem Biophys (1995) 1.34

Doxorubicin-induced apoptosis is associated with increased transcription of endothelial nitric-oxide synthase. Effect of antiapoptotic antioxidants and calcium. J Biol Chem (2001) 1.32

Biochemical characterization of human S-nitrosohemoglobin. Effects on oxygen binding and transnitrosation. J Biol Chem (1999) 1.31

Detection of superoxide anion using an isotopically labeled nitrone spin trap: potential biological applications. FEBS Lett (2000) 1.29

Characterization of sulfur-centered radical intermediates formed during the oxidation of thiols and sulfite by peroxynitrite. ESR-spin trapping and oxygen uptake studies. J Biol Chem (1996) 1.28

S-Nitrosoglutathione as a substrate for gamma-glutamyl transpeptidase. Biochem J (1997) 1.28

Oxidative stress and potassium channel function. Clin Exp Pharmacol Physiol (2002) 1.28

Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q. Biophys J (2009) 1.28

Beyond vasodilatation: non-vasomotor roles of epoxyeicosatrienoic acids in the cardiovascular system. Trends Pharmacol Sci (2006) 1.28

Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor. FEBS Lett (1993) 1.27

H2O2-induced dilation in human coronary arterioles: role of protein kinase G dimerization and large-conductance Ca2+-activated K+ channel activation. Circ Res (2011) 1.27

Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature. Am J Physiol Heart Circ Physiol (2006) 1.26

Nitric oxide inhibits H2O2-induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A (2003) 1.26

Regulation of endothelial function by mitochondrial reactive oxygen species. Antioxid Redox Signal (2011) 1.25

Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxide. J Biol Chem (2004) 1.24

Superoxide anion formation from lucigenin: an electron spin resonance spin-trapping study. FEBS Lett (1997) 1.23

Bicarbonate enhances peroxidase activity of Cu,Zn-superoxide dismutase. Role of carbonate anion radical and scavenging of carbonate anion radical by metalloporphyrin antioxidant enzyme mimetics. J Biol Chem (2001) 1.22

Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease. Am J Physiol Heart Circ Physiol (2005) 1.22

The reductive metabolism of metronidazole and ronidazole by aerobic liver microsomes. Mol Pharmacol (1980) 1.21

Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: role of mitochondrial reactive oxygen species and calcium. Biochem J (2005) 1.20

Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling. Am J Physiol Heart Circ Physiol (2011) 1.20

Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells: role of oxidant-induced iron signaling in apoptosis. J Biol Chem (2002) 1.20

Acute exposure to low glucose rapidly induces endothelial dysfunction and mitochondrial oxidative stress: role for AMP kinase. Arterioscler Thromb Vasc Biol (2011) 1.20

Macrophage migration inhibitory factor: an intracellular inhibitor of angiotensin II-induced increases in neuronal activity. J Neurosci (2004) 1.20

Inhibition of low-density lipoprotein oxidation by nitric oxide. Potential role in atherogenesis. FEBS Lett (1993) 1.19

A direct electron spin resonance and spin-trapping investigation of peroxyl free radical formation by hematin/hydroperoxide systems. J Biol Chem (1983) 1.18

RNA-Seq analyses generate comprehensive transcriptomic landscape and reveal complex transcript patterns in hepatocellular carcinoma. PLoS One (2011) 1.18

Peroxynitrite reversibly inhibits Ca(2+)-activated K(+) channels in rat cerebral artery smooth muscle cells. Am J Physiol Heart Circ Physiol (2000) 1.17

Effects of angiotensin type 2 receptor overexpression in the rostral ventrolateral medulla on blood pressure and urine excretion in normal rats. Hypertension (2007) 1.17

The effect of exertional hypertension evoked by weight lifting on vascular endothelial function. J Am Coll Cardiol (2006) 1.17

Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical. Free Radic Biol Med (2001) 1.15

Human microvascular dysfunction and apoptotic injury induced by AL amyloidosis light chain proteins. Am J Physiol Heart Circ Physiol (2011) 1.14

Elevated glucose impairs cAMP-mediated dilation by reducing Kv channel activity in rat small coronary smooth muscle cells. Am J Physiol Heart Circ Physiol (2003) 1.14

Protein tyrosine nitration in hydrophilic and hydrophobic environments. Amino Acids (2006) 1.13

Upregulation of immunoproteasomes by nitric oxide: potential antioxidative mechanism in endothelial cells. Free Radic Biol Med (2005) 1.13