PubRank

Don W Cleveland

Author PubWeight™ 302.89‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Onset and progression in inherited ALS determined by motor neurons and microglia. Science 2006 9.42
2 ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron 2006 7.82
3 On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer 2005 7.53
4 Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci 2004 6.99
5 The human CENP-A centromeric nucleosome-associated complex. Nat Cell Biol 2006 6.85
6 Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol 2009 6.43
7 Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell 2006 6.37
8 Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nat Neurosci 2011 6.01
9 Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci 2008 5.89
10 TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. Hum Mol Genet 2010 5.75
11 Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J Cell Biol 2009 5.65
12 Rethinking ALS: the FUS about TDP-43. Cell 2009 4.71
13 Propagation of centromeric chromatin requires exit from mitosis. J Cell Biol 2007 4.60
14 Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis. Neuron 2012 4.48
15 A standardized kinesin nomenclature. J Cell Biol 2004 4.43
16 Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A 2002 4.37
17 Structural determinants for generating centromeric chromatin. Nature 2004 4.25
18 Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP. Cell 2009 4.22
19 Does aneuploidy cause cancer? Curr Opin Cell Biol 2006 3.89
20 ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat Neurosci 2008 3.78
21 Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death. Cancer Cell 2005 3.69
22 Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint. Proc Natl Acad Sci U S A 2004 3.69
23 Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing. Curr Biol 2004 3.65
24 Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis. Neuron 2013 3.63
25 Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding. Dev Cell 2009 3.36
26 Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations. Neuron 2002 3.31
27 Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev Cell 2002 3.23
28 Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J Cell Biol 2003 3.15
29 Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nat Neurosci 2002 3.09
30 Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease. Nat Neurosci 2007 3.02
31 Antisense oligonucleotide therapy for neurodegenerative disease. J Clin Invest 2006 3.00
32 Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration. Proc Natl Acad Sci U S A 2013 2.95
33 Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria. Neuron 2004 2.94
34 Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. Nat Neurosci 2012 2.93
35 Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression. Cell 2012 2.83
36 Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domain. Mol Cell 2007 2.76
37 Epigenetic centromere propagation and the nature of CENP-a nucleosomes. Cell 2011 2.74
38 Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. Nat Neurosci 2013 2.71
39 ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS. Proc Natl Acad Sci U S A 2010 2.65
40 Understanding the role of TDP-43 and FUS/TLS in ALS and beyond. Curr Opin Neurobiol 2011 2.48
41 Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1. Cell 2003 2.47
42 Cep152 interacts with Plk4 and is required for centriole duplication. J Cell Biol 2010 2.45
43 ZW10 links mitotic checkpoint signaling to the structural kinetochore. J Cell Biol 2005 2.36
44 Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria. Proc Natl Acad Sci U S A 2008 2.35
45 Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A 2007 2.25
46 An epigenetic mark generated by the incorporation of CENP-A into centromeric nucleosomes. Proc Natl Acad Sci U S A 2007 2.23
47 An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS. Nat Med 2007 2.20
48 Aneuploidy: instigator and inhibitor of tumorigenesis. Cancer Res 2007 2.12
49 Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling. J Cell Biol 2005 2.11
50 Catalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20. Mol Cell 2013 2.06
51 Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability. J Cell Biol 2010 2.05
52 The seeds of neurodegeneration: prion-like spreading in ALS. Cell 2011 2.03
53 Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. J Cell Biol 2003 2.02
54 Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E. Cell 2010 2.00
55 Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A 2006 1.97
56 CENP-A-containing nucleosomes: easier disassembly versus exclusive centromeric localization. J Mol Biol 2007 1.93
57 Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metab 2012 1.92
58 Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest 2009 1.86
59 Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proc Natl Acad Sci U S A 2008 1.84
60 Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep 2012 1.81
61 Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons. Proc Natl Acad Sci U S A 2007 1.79
62 CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether. J Cell Biol 2008 1.77
63 Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells. Genes Dev 2010 1.66
64 Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS. Neuron 2010 1.65
65 A two-step mechanism for epigenetic specification of centromere identity and function. Nat Cell Biol 2013 1.52
66 Enhancing mitochondrial calcium buffering capacity reduces aggregation of misfolded SOD1 and motor neuron cell death without extending survival in mouse models of inherited amyotrophic lateral sclerosis. J Neurosci 2013 1.51
67 Medicine. Treating neurodegenerative diseases with antibiotics. Science 2005 1.51
68 Prion-like spread of protein aggregates in neurodegeneration. J Exp Med 2012 1.49
69 Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F. EMBO J 2005 1.48
70 NuMA after 30 years: the matrix revisited. Trends Cell Biol 2010 1.48
71 ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43. Proc Natl Acad Sci U S A 2013 1.48
72 Double-strand DNA breaks recruit the centromeric histone CENP-A. Proc Natl Acad Sci U S A 2009 1.47
73 Requirements for NuMA in maintenance and establishment of mammalian spindle poles. J Cell Biol 2009 1.47
74 Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death. Proc Natl Acad Sci U S A 2008 1.45
75 Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. J Biol Chem 2004 1.44
76 Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis. Ann Neurol 2005 1.44
77 Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS. Proc Natl Acad Sci U S A 2013 1.44
78 Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes. PLoS One 2008 1.43
79 Misregulated RNA processing in amyotrophic lateral sclerosis. Brain Res 2012 1.42
80 NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth. J Cell Biol 2003 1.41
81 The role of aneuploidy in promoting and suppressing tumors. J Cell Biol 2009 1.39
82 Therapeutic AAV9-mediated suppression of mutant SOD1 slows disease progression and extends survival in models of inherited ALS. Mol Ther 2013 1.36
83 Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS. PLoS One 2008 1.34
84 Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells. Proc Natl Acad Sci U S A 2012 1.33
85 Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice. Proc Natl Acad Sci U S A 2009 1.33
86 Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements. Nat Med 2012 1.32
87 Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors. Proc Natl Acad Sci U S A 2013 1.28
88 Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation. PLoS One 2009 1.27
89 ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import. Proc Natl Acad Sci U S A 2010 1.26
90 A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J Cell Biol 2010 1.25
91 Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension. Proc Natl Acad Sci U S A 2012 1.23
92 The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle. Genes Dev 2012 1.23
93 Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS. Proc Natl Acad Sci U S A 2005 1.19
94 The aneuploidy paradox in cell growth and tumorigenesis. Cancer Cell 2008 1.19
95 Modest loss of peripheral axons, muscle atrophy and formation of brain inclusions in mice with targeted deletion of gigaxonin exon 1. J Neurochem 2008 1.18
96 C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Proc Natl Acad Sci U S A 2013 1.17
97 Elevation of the Hsp70 chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis. J Neurochem 2005 1.16
98 Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A. Hum Mol Genet 2007 1.16
99 Cell biology: nondisjunction, aneuploidy and tetraploidy. Nature 2006 1.15
100 Slow axonal transport: fast motors in the slow lane. Curr Opin Cell Biol 2002 1.14
101 Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice. Proc Natl Acad Sci U S A 2014 1.14
102 Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation. PLoS One 2012 1.13
103 Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport. J Cell Biol 2002 1.11
104 The neuroprotective factor Wlds does not attenuate mutant SOD1-mediated motor neuron disease. Neuromolecular Med 2004 1.10
105 High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. J Biol Chem 2001 1.07
106 Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset. PLoS One 2011 1.07
107 Centrosomes, chromosome instability (CIN) and aneuploidy. Curr Opin Cell Biol 2012 1.04
108 Progressive spinal axonal degeneration and slowness in ALS2-deficient mice. Ann Neurol 2006 1.04
109 Phosphorylation of highly conserved neurofilament medium KSP repeats is not required for myelin-dependent radial axonal growth. J Neurosci 2009 1.04
110 Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease. Proc Natl Acad Sci U S A 2003 1.03
111 Cancer. Aneuploidy drives a mutator phenotype in cancer. Science 2011 1.01
112 Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F. J Cell Sci 2010 1.01
113 Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis. Mol Biol Cell 2012 0.99
114 Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases. J Neuroimmunol 2006 0.96
115 Revisiting oxidative damage in ALS: microglia, Nox, and mutant SOD1. J Clin Invest 2008 0.95
116 Neurodegeneration: An expansion in ALS genetics. Nature 2010 0.94
117 Centriole duplication: A lesson in self-control. Cell Cycle 2010 0.92
118 In vivo quantitative studies of dynamic intracellular processes using fluorescence correlation spectroscopy. Biophys J 2006 0.92
119 Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism. Hum Genet 2014 0.92
120 Motor neuron disease: The curious ways of ALS. Nature 2008 0.92
121 Novel missense mutation in ALS2 gene results in infantile ascending hereditary spastic paralysis. Ann Neurol 2006 0.91
122 Replicating centromeric chromatin: spatial and temporal control of CENP-A assembly. Exp Cell Res 2012 0.89
123 VEGF: multitasking in ALS. Nat Neurosci 2005 0.89
124 Low rates of aneuploidy promote tumorigenesis while high rates of aneuploidy cause cell death and tumor suppression. Cell Oncol 2008 0.86
125 Mutations in neurofilament genes are not a significant primary cause of non-SOD1-mediated amyotrophic lateral sclerosis. Neurobiol Dis 2005 0.84
126 RCADiA: simple automation platform for comparative multidimensional protein identification technology. Anal Chem 2007 0.83
127 Gene therapy for ALS delivers. Trends Neurosci 2004 0.83
128 Beyond genetics: surprising determinants of cell fate in antitumor drugs. Cancer Cell 2008 0.80
129 How to survive aneuploidy. Cell 2010 0.80
130 Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint". Science 2007 0.80
131 The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation. J Clin Invest 2012 0.79
132 Intercellular miscommunication in polyglutamine pathogenesis. Nat Neurosci 2006 0.78
133 CENP-A and the CENP nomenclature: response to Talbert and Henikoff. Trends Genet 2013 0.77
134 Reply to Woodruff et al.: C1q and C3-dependent complement pathway activation does not contribute to disease in SOD1 mutant ALS mice. Proc Natl Acad Sci U S A 2014 0.76
135 Has gene therapy for ALS arrived? Nat Med 2003 0.76
136 TDP-43 toxicity and the usefulness of junk. Nat Genet 2012 0.75
137 Multiclassifier proteomics to define complexes yields new chromosomal proteins. Dev Cell 2010 0.75
138 Determinants of rapid disease progression in ALS. Neurology 2005 0.75
139 Amyotrophic lateral sclerosis and gene therapy. Nat Clin Pract Neurol 2006 0.75