Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements.

PubWeight™: 1.32‹?› | Rank: Top 10%

🔗 View Article (PMC 3616639)

Published in Nat Med on November 07, 2012

Authors

Andrew J Holland1, Don W Cleveland

Author Affiliations

1: Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. a1holland@ucsd.edu

Articles citing this

The MLL recombinome of acute leukemias in 2013. Leukemia (2013) 2.55

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing. Nat Cell Biol (2016) 1.76

Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements. Genes Dev (2013) 1.61

Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation. Nat Chem Biol (2016) 1.45

Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging. Cell Stem Cell (2015) 1.42

Is non-homologous end-joining really an inherently error-prone process? PLoS Genet (2014) 1.37

Whole-genome sequencing identifies genomic heterogeneity at a nucleotide and chromosomal level in bladder cancer. Proc Natl Acad Sci U S A (2014) 1.14

The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing. Asian J Androl (2013) 1.11

Chromothripsis-like patterns are recurring but heterogeneously distributed features in a survey of 22,347 cancer genome screens. BMC Genomics (2014) 1.08

Structural variation mutagenesis of the human genome: Impact on disease and evolution. Environ Mol Mutagen (2015) 1.00

Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer. Front Oncol (2013) 0.96

Human Structural Variation: Mechanisms of Chromosome Rearrangements. Trends Genet (2015) 0.93

In vivo CaspaseTracker biosensor system for detecting anastasis and non-apoptotic caspase activity. Sci Rep (2015) 0.92

ShatterProof: operational detection and quantification of chromothripsis. BMC Bioinformatics (2014) 0.91

Evidence of Selection against Complex Mitotic-Origin Aneuploidy during Preimplantation Development. PLoS Genet (2015) 0.90

Replication stress in early S phase generates apparent micronuclei and chromosome rearrangement in fission yeast. Mol Biol Cell (2015) 0.89

Causes of genome instability: the effect of low dose chemical exposures in modern society. Carcinogenesis (2015) 0.86

Deciphering the Code of the Cancer Genome: Mechanisms of Chromosome Rearrangement. Trends Cancer (2015) 0.86

Systems biology of cancer: entropy, disorder, and selection-driven evolution to independence, invasion and "swarm intelligence". Cancer Metastasis Rev (2013) 0.86

Structural variation discovery in the cancer genome using next generation sequencing: computational solutions and perspectives. Oncotarget (2015) 0.85

Gene fusions by chromothripsis of chromosome 5q in the VCaP prostate cancer cell line. Hum Genet (2013) 0.84

The cytokinesis-blocked micronucleus assay as a strong predictor of lung cancer: extension of a lung cancer risk prediction model. Cancer Epidemiol Biomarkers Prev (2014) 0.83

Chromothripsis-like chromosomal rearrangements induced by ionizing radiation using proton microbeam irradiation system. Oncotarget (2016) 0.80

Complex structural rearrangement features suggesting chromoanagenesis mechanism in a case of 1p36 deletion syndrome. Mol Genet Genomics (2014) 0.80

Multicolour FISH analysis of ionising radiation induced micronucleus formation in human lymphocytes. Mutagenesis (2014) 0.79

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining. Nat Cell Biol (2016) 0.79

Strategies for tracking anastasis, a cell survival phenomenon that reverses apoptosis. J Vis Exp (2015) 0.77

The shock of being united and symphiliosis. Another lesson from plants? Cell Cycle (2014) 0.77

Chromoanasynthetic Genomic Rearrangement Identified in a N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Screen in Caenorhabditis elegans. G3 (Bethesda) (2015) 0.77

Mechanisms for Complex Chromosomal Insertions. PLoS Genet (2016) 0.76

Defining the diverse spectrum of inversions, complex structural variation, and chromothripsis in the morbid human genome. Genome Biol (2017) 0.75

Complex Chromosomal Rearrangements in B-Cell Lymphoma: Evidence of Chromoanagenesis? A Case Report. Neoplasia (2016) 0.75

Molecular signature of anastasis for reversal of apoptosis. F1000Res (2017) 0.75

Mesenchymal stromal cells of osteosarcoma patients do not show evidence of neoplastic changes during long-term culture. Clin Sarcoma Res (2015) 0.75

The Growing Complexity of the Monosomy 1p36 Syndrome. Mol Syndromol (2016) 0.75

Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair. Nucleic Acids Res (2014) 0.75

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila. J Vis Exp (2016) 0.75

Computational approaches for the identification of cancer genes and pathways. Wiley Interdiscip Rev Syst Biol Med (2016) 0.75

[Molecular characterization of osteosarcomas]. Pathologe (2013) 0.75

Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis. Trends Cell Biol (2017) 0.75

Of Simple and Complex Genome Rearrangements, Chromothripsis, Chromoanasynthesis, and Chromosome Chaos. Mol Syndromol (2017) 0.75

Articles cited by this

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med (2012) 44.56

Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet (2008) 43.63

Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell (2011) 16.72

Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature (2009) 13.45

Cell-cycle checkpoints and cancer. Nature (2004) 13.19

Genetic instability in colorectal cancers. Nature (1997) 12.51

The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature (2010) 12.43

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature (2012) 9.89

The impact of translocations and gene fusions on cancer causation. Nat Rev Cancer (2007) 9.81

A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders. Cell (2007) 9.81

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem (2010) 9.80

A mechanism linking extra centrosomes to chromosomal instability. Nature (2009) 9.45

Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs. Cancer Cell (2008) 6.62

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol (2009) 6.43

A microhomology-mediated break-induced replication model for the origin of human copy number variation. PLoS Genet (2009) 6.39

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. Cell (2012) 6.07

Mammalian cell fusion: studies on the regulation of DNA synthesis and mitosis. Nature (1970) 5.90

DNA breaks and chromosome pulverization from errors in mitosis. Nature (2012) 5.19

Examining the link between chromosomal instability and aneuploidy in human cells. J Cell Biol (2008) 4.95

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes. Nature (2012) 4.53

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature (2004) 4.35

Mammalian cell fusion: induction of premature chromosome condensation in interphase nuclei. Nature (1970) 4.21

Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature (2012) 4.13

Causes and consequences of aneuploidy in cancer. Nat Rev Genet (2012) 4.08

Intratumor heterogeneity: seeing the wood for the trees. Sci Transl Med (2012) 3.38

Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PLoS One (2009) 3.36

Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. Science (2011) 3.29

Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangements. Cell (2011) 3.03

Constitutional chromothripsis rearrangements involve clustered double-stranded DNA breaks and nonhomologous repair mechanisms. Cell Rep (2012) 2.67

Complex reorganization and predominant non-homologous repair following chromosomal breakage in karyotypically balanced germline rearrangements and transgenic integration. Nat Genet (2012) 2.45

Chromothripsis as a mechanism driving complex de novo structural rearrangements in the germline. Hum Mol Genet (2011) 2.43

CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability. Cancer Res (2005) 2.19

Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer. Genome Biol (2011) 2.11

The importance of circular DNA in mammalian gene amplification. Cancer Res (1989) 2.07

Chromothripsis identifies a rare and aggressive entity among newly diagnosed multiple myeloma patients. Blood (2011) 1.97

Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep (2012) 1.81

Resolution of anaphase bridges in cancer cells. Chromosoma (2004) 1.72

DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis. Mol Cell Biol (1997) 1.51

Chromothripsis and human disease: piecing together the shattering process. Cell (2012) 1.30

Cell survival, DNA damage, and oncogenic transformation after a transient and reversible apoptotic response. Mol Biol Cell (2012) 1.25

Genetic activities in micronuclei: is the DNA entrapped in micronuclei lost for the cell? Mutat Res (2010) 1.20

Cancer genomes evolve by pulverizing single chromosomes. Cell (2011) 1.20

DNA lesions sequestered in micronuclei induce a local defective-damage response. DNA Repair (Amst) (2009) 1.09

Transient hypermutability, chromothripsis and replication-based mechanisms in the generation of concurrent clustered mutations. Mutat Res (2012) 1.05

Poly-gene fusion transcripts and chromothripsis in prostate cancer. Genes Chromosomes Cancer (2012) 1.05

Cancer: When catastrophe strikes a cell. Nature (2011) 1.01

DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells. J Biol Chem (2011) 0.97

Mechanisms of MLL gene rearrangement: site-specific DNA cleavage within the breakpoint cluster region is independent of chromosomal context. Hum Mol Genet (2001) 0.93

The phenomenon of premature chromosome condensation: its relevance to basic and applied research. Humangenetik (1974) 0.89

Nuclear envelope defects impede a proper response to micronuclear DNA lesions. Mutat Res (2011) 0.87

Articles by these authors

(truncated to the top 100)

Onset and progression in inherited ALS determined by motor neurons and microglia. Science (2006) 9.42

ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron (2006) 7.82

On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer (2005) 7.53

Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci (2004) 6.99

The human CENP-A centromeric nucleosome-associated complex. Nat Cell Biol (2006) 6.85

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol (2009) 6.43

Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell (2006) 6.37

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nat Neurosci (2011) 6.01

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci (2008) 5.89

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. Hum Mol Genet (2010) 5.75

Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J Cell Biol (2009) 5.65

Rethinking ALS: the FUS about TDP-43. Cell (2009) 4.71

Propagation of centromeric chromatin requires exit from mitosis. J Cell Biol (2007) 4.60

Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis. Neuron (2012) 4.48

A standardized kinesin nomenclature. J Cell Biol (2004) 4.43

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A (2002) 4.37

Structural determinants for generating centromeric chromatin. Nature (2004) 4.25

Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP. Cell (2009) 4.22

Does aneuploidy cause cancer? Curr Opin Cell Biol (2006) 3.89

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat Neurosci (2008) 3.78

Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death. Cancer Cell (2005) 3.69

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint. Proc Natl Acad Sci U S A (2004) 3.69

Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing. Curr Biol (2004) 3.65

Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis. Neuron (2013) 3.63

Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding. Dev Cell (2009) 3.36

Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations. Neuron (2002) 3.31

Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev Cell (2002) 3.23

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J Cell Biol (2003) 3.15

Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nat Neurosci (2002) 3.09

Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease. Nat Neurosci (2007) 3.02

Antisense oligonucleotide therapy for neurodegenerative disease. J Clin Invest (2006) 3.00

Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration. Proc Natl Acad Sci U S A (2013) 2.95

Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria. Neuron (2004) 2.94

Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. Nat Neurosci (2012) 2.93

Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression. Cell (2012) 2.83

Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domain. Mol Cell (2007) 2.76

Epigenetic centromere propagation and the nature of CENP-a nucleosomes. Cell (2011) 2.74

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. Nat Neurosci (2013) 2.71

ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS. Proc Natl Acad Sci U S A (2010) 2.65

Understanding the role of TDP-43 and FUS/TLS in ALS and beyond. Curr Opin Neurobiol (2011) 2.48

Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1. Cell (2003) 2.47

Cep152 interacts with Plk4 and is required for centriole duplication. J Cell Biol (2010) 2.45

ZW10 links mitotic checkpoint signaling to the structural kinetochore. J Cell Biol (2005) 2.36

Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria. Proc Natl Acad Sci U S A (2008) 2.35

Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2007) 2.25

An epigenetic mark generated by the incorporation of CENP-A into centromeric nucleosomes. Proc Natl Acad Sci U S A (2007) 2.23

An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS. Nat Med (2007) 2.20

Aneuploidy: instigator and inhibitor of tumorigenesis. Cancer Res (2007) 2.12

Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling. J Cell Biol (2005) 2.11

Catalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20. Mol Cell (2013) 2.06

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability. J Cell Biol (2010) 2.05

The seeds of neurodegeneration: prion-like spreading in ALS. Cell (2011) 2.03

Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. J Cell Biol (2003) 2.02

Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E. Cell (2010) 2.00

Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2006) 1.97

CENP-A-containing nucleosomes: easier disassembly versus exclusive centromeric localization. J Mol Biol (2007) 1.93

Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metab (2012) 1.92

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest (2009) 1.86

Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proc Natl Acad Sci U S A (2008) 1.84

Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep (2012) 1.81

Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons. Proc Natl Acad Sci U S A (2007) 1.79

CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether. J Cell Biol (2008) 1.77

Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells. Genes Dev (2010) 1.66

Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS. Neuron (2010) 1.65

A two-step mechanism for epigenetic specification of centromere identity and function. Nat Cell Biol (2013) 1.52

Enhancing mitochondrial calcium buffering capacity reduces aggregation of misfolded SOD1 and motor neuron cell death without extending survival in mouse models of inherited amyotrophic lateral sclerosis. J Neurosci (2013) 1.51

Medicine. Treating neurodegenerative diseases with antibiotics. Science (2005) 1.51

Prion-like spread of protein aggregates in neurodegeneration. J Exp Med (2012) 1.49

Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F. EMBO J (2005) 1.48

NuMA after 30 years: the matrix revisited. Trends Cell Biol (2010) 1.48

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43. Proc Natl Acad Sci U S A (2013) 1.48

Double-strand DNA breaks recruit the centromeric histone CENP-A. Proc Natl Acad Sci U S A (2009) 1.47

Requirements for NuMA in maintenance and establishment of mammalian spindle poles. J Cell Biol (2009) 1.47

Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death. Proc Natl Acad Sci U S A (2008) 1.45

Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. J Biol Chem (2004) 1.44

Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis. Ann Neurol (2005) 1.44

Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS. Proc Natl Acad Sci U S A (2013) 1.44

Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes. PLoS One (2008) 1.43

Misregulated RNA processing in amyotrophic lateral sclerosis. Brain Res (2012) 1.42

NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth. J Cell Biol (2003) 1.41

The role of aneuploidy in promoting and suppressing tumors. J Cell Biol (2009) 1.39

Therapeutic AAV9-mediated suppression of mutant SOD1 slows disease progression and extends survival in models of inherited ALS. Mol Ther (2013) 1.36

Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS. PLoS One (2008) 1.34

Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells. Proc Natl Acad Sci U S A (2012) 1.33

Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice. Proc Natl Acad Sci U S A (2009) 1.33

Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors. Proc Natl Acad Sci U S A (2013) 1.28

Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation. PLoS One (2009) 1.27

ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import. Proc Natl Acad Sci U S A (2010) 1.26

A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J Cell Biol (2010) 1.25

The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle. Genes Dev (2012) 1.23

Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension. Proc Natl Acad Sci U S A (2012) 1.23

Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS. Proc Natl Acad Sci U S A (2005) 1.19

The aneuploidy paradox in cell growth and tumorigenesis. Cancer Cell (2008) 1.19

Modest loss of peripheral axons, muscle atrophy and formation of brain inclusions in mice with targeted deletion of gigaxonin exon 1. J Neurochem (2008) 1.18

C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Proc Natl Acad Sci U S A (2013) 1.17

Elevation of the Hsp70 chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis. J Neurochem (2005) 1.16

Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A. Hum Mol Genet (2007) 1.16

Cell biology: nondisjunction, aneuploidy and tetraploidy. Nature (2006) 1.15

Slow axonal transport: fast motors in the slow lane. Curr Opin Cell Biol (2002) 1.14

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice. Proc Natl Acad Sci U S A (2014) 1.14