Published in Nature on July 29, 2004
Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. Mol Cell Biol (2005) 4.80
Propagation of centromeric chromatin requires exit from mitosis. J Cell Biol (2007) 4.60
The life and miracles of kinetochores. EMBO J (2009) 4.59
Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP. Cell (2009) 4.22
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What controls nucleosome positions? Trends Genet (2009) 3.15
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Dual recognition of CENP-A nucleosomes is required for centromere assembly. J Cell Biol (2010) 2.79
Epigenetic centromere propagation and the nature of CENP-a nucleosomes. Cell (2011) 2.74
Histone H3 variants and their potential role in indexing mammalian genomes: the "H3 barcode hypothesis". Proc Natl Acad Sci U S A (2006) 2.68
CENP-A confers a reduction in height on octameric nucleosomes. Nat Struct Mol Biol (2013) 2.64
Centromere identity is specified by a single centromeric nucleosome in budding yeast. Proc Natl Acad Sci U S A (2007) 2.58
The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres. Nature (2010) 2.55
Inactivation of a human kinetochore by specific targeting of chromatin modifiers. Dev Cell (2008) 2.50
Fission yeast Scm3 mediates stable assembly of Cnp1/CENP-A into centromeric chromatin. Mol Cell (2009) 2.49
Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N. Nat Cell Biol (2009) 2.48
A super-resolution map of the vertebrate kinetochore. Proc Natl Acad Sci U S A (2010) 2.36
In vitro centromere and kinetochore assembly on defined chromatin templates. Nature (2011) 2.34
An epigenetic mark generated by the incorporation of CENP-A into centromeric nucleosomes. Proc Natl Acad Sci U S A (2007) 2.23
HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore. J Cell Biol (2011) 2.20
Cell-cycle-dependent structural transitions in the human CENP-A nucleosome in vivo. Cell (2012) 2.11
HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres. Proc Natl Acad Sci U S A (2010) 2.09
CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1. Mol Cell Biol (2005) 2.00
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Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3. Nature (2011) 1.99
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Vibrio cholerae toxin-coregulated pilus structure analyzed by hydrogen/deuterium exchange mass spectrometry. Structure (2008) 1.92
Recognition of the centromere-specific histone Cse4 by the chaperone Scm3. Proc Natl Acad Sci U S A (2011) 1.87
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An E3 ubiquitin ligase prevents ectopic localization of the centromeric histone H3 variant via the centromere targeting domain. Mol Cell (2010) 1.78
The ABCs of CENPs. Chromosoma (2011) 1.72
Human centromeric chromatin is a dynamic chromosomal domain that can spread over noncentromeric DNA. Proc Natl Acad Sci U S A (2006) 1.72
Loading of Arabidopsis centromeric histone CENH3 occurs mainly during G2 and requires the presence of the histone fold domain. Plant Cell (2006) 1.72
Tetrameric organization of vertebrate centromeric nucleosomes. Proc Natl Acad Sci U S A (2010) 1.69
Active establishment of centromeric CENP-A chromatin by RSF complex. J Cell Biol (2009) 1.69
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The octamer is the major form of CENP-A nucleosomes at human centromeres. Nat Struct Mol Biol (2013) 1.59
Single-molecule imaging of DNA curtains reveals intrinsic energy landscapes for nucleosome deposition. Nat Struct Mol Biol (2009) 1.58
A two-step mechanism for epigenetic specification of centromere identity and function. Nat Cell Biol (2013) 1.52
Loss of centromeric histone H3 (CENH3) from centromeres precedes uniparental chromosome elimination in interspecific barley hybrids. Proc Natl Acad Sci U S A (2011) 1.50
Co-evolving CENP-A and CAL1 Domains Mediate Centromeric CENP-A Deposition across Drosophila Species. Dev Cell (2016) 1.50
Double-strand DNA breaks recruit the centromeric histone CENP-A. Proc Natl Acad Sci U S A (2009) 1.47
Structure and Scm3-mediated assembly of budding yeast centromeric nucleosomes. Nat Commun (2011) 1.46
Histone H1 is essential for mitotic chromosome architecture and segregation in Xenopus laevis egg extracts. J Cell Biol (2005) 1.43
HJURP uses distinct CENP-A surfaces to recognize and to stabilize CENP-A/histone H4 for centromere assembly. Dev Cell (2012) 1.41
Functions of the centromere and kinetochore in chromosome segregation. Curr Opin Cell Biol (2013) 1.41
Assembly of Drosophila centromeric nucleosomes requires CID dimerization. Mol Cell (2011) 1.39
Pericentromeric regions of soybean (Glycine max L. Merr.) chromosomes consist of retroelements and tandemly repeated DNA and are structurally and evolutionarily labile. Genetics (2005) 1.38
Allosteric inhibition of complement function by a staphylococcal immune evasion protein. Proc Natl Acad Sci U S A (2010) 1.37
Biphasic incorporation of centromeric histone CENP-A in fission yeast. Mol Biol Cell (2007) 1.36
Proteolysis restricts localization of CID, the centromere-specific histone H3 variant of Drosophila, to centromeres. Nucleic Acids Res (2006) 1.35
Two distinct pathways responsible for the loading of CENP-A to centromeres in the fission yeast cell cycle. Philos Trans R Soc Lond B Biol Sci (2005) 1.34
Replacement of histone H3 with CENP-A directs global nucleosome array condensation and loosening of nucleosome superhelical termini. Proc Natl Acad Sci U S A (2011) 1.33
Biophysical characterization of the centromere-specific nucleosome from budding yeast. J Biol Chem (2010) 1.29
The quantitative architecture of centromeric chromatin. Elife (2014) 1.26
CENP-A: the key player behind centromere identity, propagation, and kinetochore assembly. Chromosoma (2012) 1.24
Probing the (H3-H4)2 histone tetramer structure using pulsed EPR spectroscopy combined with site-directed spin labelling. Nucleic Acids Res (2009) 1.20
PAS domain allostery and light-induced conformational changes in photoactive yellow protein upon I2 intermediate formation, probed with enhanced hydrogen/deuterium exchange mass spectrometry. J Mol Biol (2006) 1.17
The budding yeast point centromere associates with two Cse4 molecules during mitosis. Curr Biol (2013) 1.15
Epigenetic centromere specification directs aurora B accumulation but is insufficient to efficiently correct mitotic errors. J Cell Biol (2010) 1.13
The rapidly evolving centromere-specific histone has stringent functional requirements in Arabidopsis thaliana. Genetics (2010) 1.13
Histone variant H2A.Z regulates centromere silencing and chromosome segregation in fission yeast. J Biol Chem (2009) 1.11
The molecular basis for centromere identity and function. Nat Rev Mol Cell Biol (2015) 1.10
Assembly in G1 phase and long-term stability are unique intrinsic features of CENP-A nucleosomes. Mol Biol Cell (2013) 1.10
Adaptive evolution of foundation kinetochore proteins in primates. Mol Biol Evol (2010) 1.09
Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere. Science (2015) 1.09
Transcriptional coactivator PC4, a chromatin-associated protein, induces chromatin condensation. Mol Cell Biol (2006) 1.09
Premitotic assembly of human CENPs -T and -W switches centromeric chromatin to a mitotic state. PLoS Biol (2011) 1.09
Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y. J Cell Biol (2010) 1.08
Visualization of diffuse centromeres with centromere-specific histone H3 in the holocentric plant Luzula nivea. Plant Cell (2005) 1.07
DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function. Dev Cell (2015) 1.06
Probing DNA- and ATP-mediated conformational changes in the MutS family of mispair recognition proteins using deuterium exchange mass spectrometry. J Biol Chem (2010) 1.05
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Sequence-dependent variations associated with H2A/H2B depletion of nucleosomes. Biophys J (2007) 1.05
A high-resolution map of nucleosome positioning on a fission yeast centromere. Genome Res (2008) 1.04
Focus on the centre: the role of chromatin on the regulation of centromere identity and function. EMBO J (2009) 1.04
Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function. J Cell Sci (2012) 1.03
Both tails and the centromere targeting domain of CENP-A are required for centromere establishment. J Cell Biol (2015) 1.01
Chromatin environment of histone variant H3.3 revealed by quantitative imaging and genome-scale chromatin and DNA immunoprecipitation. Mol Biol Cell (2010) 1.01
Scm3 is a centromeric nucleosome assembly factor. J Biol Chem (2011) 1.01
Structure, assembly and reading of centromeric chromatin. Curr Opin Genet Dev (2011) 1.01
Chaperone Nap1 shields histone surfaces used in a nucleosome and can put H2A-H2B in an unconventional tetrameric form. Mol Cell (2013) 1.00
Molecular underpinnings of centromere identity and maintenance. Trends Biochem Sci (2012) 0.99
Putting CENP-A in its place. Cell Mol Life Sci (2012) 0.99
PICH: a DNA translocase specially adapted for processing anaphase bridge DNA. Mol Cell (2013) 0.98
Centromeric histone H3 is essential for vegetative cell division and for DNA elimination during conjugation in Tetrahymena thermophila. Mol Cell Biol (2006) 0.98
Down the rabbit hole of centromere assembly and dynamics. Curr Opin Cell Biol (2010) 0.97
Maize centromeres expand and adopt a uniform size in the genetic background of oat. Genome Res (2013) 0.97
At the right place at the right time: novel CENP-A binding proteins shed light on centromere assembly. Chromosoma (2009) 0.97
Centromeres Off the Hook: Massive Changes in Centromere Size and Structure Following Duplication of CenH3 Gene in Fabeae Species. Mol Biol Evol (2015) 0.96
Phylogenetic analysis of fungal centromere H3 proteins. Genetics (2006) 0.96
Using hydrogen/deuterium exchange mass spectrometry to define the specific interactions of the phospholipase A2 superfamily with lipid substrates, inhibitors, and membranes. J Biol Chem (2012) 0.96
Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes. PLoS Genet (2010) 0.95
Functional centromeres in soybean include two distinct tandem repeats and a retrotransposon. Chromosome Res (2010) 0.93
A cell-free system for functional centromere and kinetochore assembly. Nat Protoc (2012) 0.93
CENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere. Dev Cell (2015) 0.92
A centromeric DNA sequence colocalized with a centromere-specific histone H3 in tobacco. Chromosoma (2008) 0.92
Onset and progression in inherited ALS determined by motor neurons and microglia. Science (2006) 9.42
Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 a resolution. J Mol Biol (2002) 8.42
ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron (2006) 7.82
On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer (2005) 7.53
Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci (2004) 6.99
The human CENP-A centromeric nucleosome-associated complex. Nat Cell Biol (2006) 6.85
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol (2009) 6.43
Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell (2006) 6.37
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nat Neurosci (2011) 6.01
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci (2008) 5.89
TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. Hum Mol Genet (2010) 5.75
Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J Cell Biol (2009) 5.65
Rethinking ALS: the FUS about TDP-43. Cell (2009) 4.71
Propagation of centromeric chromatin requires exit from mitosis. J Cell Biol (2007) 4.60
Reconstitution of nucleosome core particles from recombinant histones and DNA. Methods Enzymol (2004) 4.57
Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis. Neuron (2012) 4.48
A standardized kinesin nomenclature. J Cell Biol (2004) 4.43
Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A (2002) 4.37
Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP. Cell (2009) 4.22
Does aneuploidy cause cancer? Curr Opin Cell Biol (2006) 3.89
ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat Neurosci (2008) 3.78
Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death. Cancer Cell (2005) 3.69
Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint. Proc Natl Acad Sci U S A (2004) 3.69
Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing. Curr Biol (2004) 3.65
Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis. Neuron (2013) 3.63
The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA. Science (2006) 3.46
Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding. Dev Cell (2009) 3.36
Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations. Neuron (2002) 3.31
Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev Cell (2002) 3.23
Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J Cell Biol (2003) 3.15
Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nat Neurosci (2002) 3.09
Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease. Nat Neurosci (2007) 3.02
Antisense oligonucleotide therapy for neurodegenerative disease. J Clin Invest (2006) 3.00
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration. Proc Natl Acad Sci U S A (2013) 2.95
Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria. Neuron (2004) 2.94
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. Nat Neurosci (2012) 2.93
Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression. Cell (2012) 2.83
Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domain. Mol Cell (2007) 2.76
Epigenetic centromere propagation and the nature of CENP-a nucleosomes. Cell (2011) 2.74
Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. Nat Neurosci (2013) 2.71
The histone chaperone Nap1 promotes nucleosome assembly by eliminating nonnucleosomal histone DNA interactions. Mol Cell (2010) 2.69
ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS. Proc Natl Acad Sci U S A (2010) 2.65
H2A.Z alters the nucleosome surface to promote HP1alpha-mediated chromatin fiber folding. Mol Cell (2004) 2.63
The essential histone variant H2A.Z regulates the equilibrium between different chromatin conformational states. Nat Struct Biol (2002) 2.63
Understanding the role of TDP-43 and FUS/TLS in ALS and beyond. Curr Opin Neurobiol (2011) 2.48
Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1. Cell (2003) 2.47
Cep152 interacts with Plk4 and is required for centriole duplication. J Cell Biol (2010) 2.45
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor. Nature (2011) 2.43
ZW10 links mitotic checkpoint signaling to the structural kinetochore. J Cell Biol (2005) 2.36
Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria. Proc Natl Acad Sci U S A (2008) 2.35
A new fluorescence resonance energy transfer approach demonstrates that the histone variant H2AZ stabilizes the histone octamer within the nucleosome. J Biol Chem (2004) 2.33
Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2007) 2.25
An epigenetic mark generated by the incorporation of CENP-A into centromeric nucleosomes. Proc Natl Acad Sci U S A (2007) 2.23
An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS. Nat Med (2007) 2.20
HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore. J Cell Biol (2011) 2.20
The structure of nucleosome assembly protein 1. Proc Natl Acad Sci U S A (2006) 2.13
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Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling. J Cell Biol (2005) 2.11
Histone chaperones in nucleosome eviction and histone exchange. Curr Opin Struct Biol (2008) 2.09
Protein structure change studied by hydrogen-deuterium exchange, functional labeling, and mass spectrometry. Proc Natl Acad Sci U S A (2003) 2.09
Crystal structures of histone Sin mutant nucleosomes reveal altered protein-DNA interactions. EMBO J (2004) 2.08
Nucleosome assembly protein 1 exchanges histone H2A-H2B dimers and assists nucleosome sliding. J Biol Chem (2004) 2.08
Catalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20. Mol Cell (2013) 2.06
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Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex. Proc Natl Acad Sci U S A (2011) 2.03
Modest stabilization by most hydrogen-bonded side-chain interactions in membrane proteins. Nature (2008) 2.03
Cdk activity couples epigenetic centromere inheritance to cell cycle progression. Dev Cell (2011) 2.02
Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. J Cell Biol (2003) 2.02
Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E. Cell (2010) 2.00
Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2006) 1.97
A charged and contoured surface on the nucleosome regulates chromatin compaction. Nat Struct Mol Biol (2007) 1.95
Histone chaperones and nucleosome assembly. Curr Opin Struct Biol (2003) 1.94
CENP-A-containing nucleosomes: easier disassembly versus exclusive centromeric localization. J Mol Biol (2007) 1.93
Vibrio cholerae toxin-coregulated pilus structure analyzed by hydrogen/deuterium exchange mass spectrometry. Structure (2008) 1.92
Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metab (2012) 1.92
The core histone N-terminal tail domains function independently and additively during salt-dependent oligomerization of nucleosomal arrays. J Biol Chem (2005) 1.91
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest (2009) 1.86
Structural characterization of the histone variant macroH2A. Mol Cell Biol (2005) 1.85
Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proc Natl Acad Sci U S A (2008) 1.84
Nucleosome-binding affinity as a primary determinant of the nuclear mobility of the pioneer transcription factor FoxA. Genes Dev (2009) 1.82
Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep (2012) 1.81
Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons. Proc Natl Acad Sci U S A (2007) 1.79
CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether. J Cell Biol (2008) 1.77
The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure. Nat Struct Mol Biol (2008) 1.73
Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS. Proc Natl Acad Sci U S A (2004) 1.70
Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA. EMBO J (2004) 1.67
Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells. Genes Dev (2010) 1.66
Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS. Neuron (2010) 1.65
Structure and properties of alpha-synuclein and other amyloids determined at the amino acid level. Proc Natl Acad Sci U S A (2005) 1.65
Structure and function of nucleosome assembly proteins. Biochem Cell Biol (2006) 1.64
Histone chaperone FACT coordinates nucleosome interaction through multiple synergistic binding events. J Biol Chem (2011) 1.63
Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands. J Mol Biol (2003) 1.63
Preferential binding of the histone (H3-H4)2 tetramer by NAP1 is mediated by the amino-terminal histone tails. J Biol Chem (2003) 1.56
Nucleosome accessibility governed by the dimer/tetramer interface. Nucleic Acids Res (2010) 1.55