Published in Nat Med on August 17, 2003
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med (2009) 8.45
Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J Exp Med (2005) 7.18
Memory CD8 T-cell differentiation during viral infection. J Virol (2004) 6.75
Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses. J Exp Med (2007) 5.22
Correlates of protection induced by vaccination. Clin Vaccine Immunol (2010) 5.21
Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors. Nature (2008) 3.47
Immunological mechanisms of vaccination. Nat Immunol (2011) 3.35
Diversity in T cell memory: an embarrassment of riches. Immunity (2009) 3.31
Activation phenotype, rather than central- or effector-memory phenotype, predicts the recall efficacy of memory CD8+ T cells. J Exp Med (2007) 3.09
Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox. J Virol (2004) 2.72
A distinct subset of self-renewing human memory CD8+ T cells survives cytotoxic chemotherapy. Immunity (2009) 2.64
Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity. Nat Med (2010) 2.61
Rapid culling of the CD4+ T cell repertoire in the transition from effector to memory. Immunity (2008) 2.56
Memory CD8 T-cell compartment grows in size with immunological experience. Nature (2008) 2.49
Differential contributions of central and effector memory T cells to recall responses. J Exp Med (2005) 2.40
Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome. Science (2015) 2.38
Chemokine receptor expression identifies Pre-T helper (Th)1, Pre-Th2, and nonpolarized cells among human CD4+ central memory T cells. J Exp Med (2004) 2.38
Antiviral CD4+ memory T cells are IL-15 dependent. J Exp Med (2007) 2.29
Reverse vaccinology: developing vaccines in the era of genomics. Immunity (2010) 2.25
Human memory T cells: generation, compartmentalization and homeostasis. Nat Rev Immunol (2013) 2.19
Vaccinia virus H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice. J Virol (2005) 2.18
Distinct time effects of vaccination on long-term proliferative and IFN-gamma-producing T cell memory to smallpox in humans. J Exp Med (2004) 2.08
Superior T memory stem cell persistence supports long-lived T cell memory. J Clin Invest (2013) 2.06
Tissue-resident memory T cells. Immunity (2014) 2.04
Intrinsic properties of immunoglobulin IgG1 isotype-switched B cell receptors promote microclustering and the initiation of signaling. Immunity (2010) 2.01
Generation of effector CD8+ T cells and their conversion to memory T cells. Immunol Rev (2010) 1.85
Redundancy and plasticity of neutralizing antibody responses are cornerstone attributes of the human immune response to the smallpox vaccine. J Virol (2008) 1.77
Contributions of antinucleoprotein IgG to heterosubtypic immunity against influenza virus. J Immunol (2011) 1.74
Comparative immunogenicity and safety of human papillomavirus (HPV)-16/18 vaccine and HPV-6/11/16/18 vaccine: follow-up from months 12-24 in a Phase III randomized study of healthy women aged 18-45 years. Hum Vaccin (2011) 1.73
Mcl-1 is essential for the survival of plasma cells. Nat Immunol (2013) 1.73
Memory CD4 T cells direct protective responses to influenza virus in the lungs through helper-independent mechanisms. J Virol (2010) 1.72
High prevalence of both humoral and cellular immunity to Zaire ebolavirus among rural populations in Gabon. PLoS One (2010) 1.68
Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function. J Virol (2006) 1.62
Protection against lethal vaccinia virus challenge in HLA-A2 transgenic mice by immunization with a single CD8+ T-cell peptide epitope of vaccinia and variola viruses. J Virol (2004) 1.59
Immunological memory after exposure to variola virus, monkeypox virus, and vaccinia virus. J Infect Dis (2007) 1.59
Induction of a virus-specific effector-memory CD4+ T cell response by attenuated SIV infection. J Exp Med (2006) 1.55
The TLR9 ligand CpG promotes the acquisition of Plasmodium falciparum-specific memory B cells in malaria-naive individuals. J Immunol (2009) 1.50
Cowpox virus inhibits the transporter associated with antigen processing to evade T cell recognition. Cell Host Microbe (2009) 1.47
Long-lived poxvirus immunity, robust CD4 help, and better persistence of CD4 than CD8 T cells. J Virol (2004) 1.46
Memory CD4 T cells that express CXCR5 provide accelerated help to B cells. J Immunol (2011) 1.43
A protein-based smallpox vaccine protects mice from vaccinia and ectromelia virus challenges when given as a prime and single boost. Vaccine (2006) 1.43
Quantitation of rare memory B cell populations by two independent and complementary approaches. J Immunol Methods (2006) 1.41
Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates. J Immunol (2010) 1.41
Gender effects on humoral immune responses to smallpox vaccine. Vaccine (2009) 1.39
Multiple myeloma cancer stem cells. J Clin Oncol (2008) 1.39
Antibody persistence and T-cell balance: two key factors confronting HIV vaccine development. Proc Natl Acad Sci U S A (2014) 1.39
Antibody to dengue 1 detected more than 60 years after infection. Viral Immunol (2007) 1.38
An attenuated LC16m8 smallpox vaccine: analysis of full-genome sequence and induction of immune protection. J Virol (2005) 1.37
Regulation of antinucleoprotein IgG by systemic vaccination and its effect on influenza virus clearance. J Virol (2011) 1.35
OX40 drives protective vaccinia virus-specific CD8 T cells. J Immunol (2008) 1.33
Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans. Vaccine (2011) 1.32
Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories. J Immunol (2014) 1.31
How can HIV-type-1-Env immunogenicity be improved to facilitate antibody-based vaccine development? AIDS Res Hum Retroviruses (2011) 1.30
CD4 memory T cells: what are they and what can they do? Semin Immunol (2009) 1.29
Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice. J Exp Med (2007) 1.28
Cooperativity between CD8+ T cells, non-neutralizing antibodies, and alveolar macrophages is important for heterosubtypic influenza virus immunity. PLoS Pathog (2013) 1.28
ACAM2000: the new smallpox vaccine for United States Strategic National Stockpile. Drug Des Devel Ther (2010) 1.27
An extremely diverse CD4 response to vaccinia virus in humans is revealed by proteome-wide T-cell profiling. J Virol (2008) 1.27
Development of a new hydrogen peroxide–based vaccine platform. Nat Med (2012) 1.24
Pulmonary immunity and immunopathology: lessons from respiratory syncytial virus. Expert Rev Vaccines (2008) 1.23
Smallpox vaccines: targets of protective immunity. Immunol Rev (2011) 1.21
Interferon function is not required for recovery from a secondary poxvirus infection. Proc Natl Acad Sci U S A (2005) 1.21
Monkeypox-induced immunity and failure of childhood smallpox vaccination to provide complete protection. Clin Vaccine Immunol (2007) 1.20
Human CD4+ T cell epitopes from vaccinia virus induced by vaccination or infection. PLoS Pathog (2007) 1.20
The orthopoxvirus type I IFN binding protein is essential for virulence and an effective target for vaccination. J Exp Med (2008) 1.19
Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans. J Immunol (2014) 1.18
Induction and function of virus-specific CD4+ T cell responses. Virology (2011) 1.18
Diversity in the acute CD8 T cell response to vaccinia virus in humans. J Immunol (2005) 1.16
Memory CD4 T cells: generation, reactivation and re-assignment. Immunology (2010) 1.16
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. Hum Genet (2012) 1.15
Age-related changes in CD8 T cell homeostasis and immunity to infection. Semin Immunol (2012) 1.14
Human T-cell responses to vaccinia virus envelope proteins. J Virol (2006) 1.14
Comparison of smallpox outbreak control strategies using a spatial metapopulation model. Epidemiol Infect (2007) 1.13
Immunity from smallpox vaccine persists for decades: a longitudinal study. Am J Med (2008) 1.11
How might infant and paediatric immune responses influence malaria vaccine efficacy? Parasite Immunol (2009) 1.11
The immunology of smallpox vaccines. Curr Opin Immunol (2009) 1.10
Response surface methodology to determine optimal cytokine responses in human peripheral blood mononuclear cells after smallpox vaccination. J Immunol Methods (2008) 1.09
DNA/MVA HIV-1/AIDS vaccine elicits long-lived vaccinia virus-specific immunity and confers protection against a lethal monkeypox challenge. Virology (2007) 1.09
Evolving concepts of specificity in immune reactions. Proc Natl Acad Sci U S A (2010) 1.09
Highly differentiated, resting gn-specific memory CD8+ T cells persist years after infection by andes hantavirus. PLoS Pathog (2010) 1.08
Genome-wide genetic associations with IFNγ response to smallpox vaccine. Hum Genet (2012) 1.08
Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens. Future Microbiol (2010) 1.07
Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques. J Immunol (2011) 1.07
Characterization of hepatitis E-specific cell-mediated immune response using IFN-gamma ELISPOT assay. J Immunol Methods (2007) 1.06
Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory. Proc Natl Acad Sci U S A (2014) 1.06
Memory T follicular helper CD4 T cells. Front Immunol (2015) 1.06
Recombinant Modified Vaccinia Ankara (MVA) effectively boosts DNA-primed HIV-specific immune responses in humans despite pre-existing vaccinia immunity. Vaccine (2009) 1.05
Generation and characterization of a large panel of murine monoclonal antibodies against vaccinia virus. Virology (2010) 1.05
Immune memory and aging: an infinite or finite resource? Curr Opin Immunol (2010) 1.05
Genetically retargeting CD8+ lymphocyte subsets for cancer immunotherapy. Curr Opin Immunol (2011) 1.04
Statistical approach to estimate vaccinia-specific neutralizing antibody titers using a high-throughput assay. Clin Vaccine Immunol (2009) 1.04
The Future of Smallpox Vaccination: is MVA the key? Med Immunol (2005) 1.04
Immunogenicity profile of a 3.75-μg hemagglutinin pandemic rH5N1 split virion AS03A-adjuvanted vaccine in elderly persons: a randomized trial. J Infect Dis (2011) 1.03
A novel, killed-virus nasal vaccinia virus vaccine. Clin Vaccine Immunol (2007) 1.03
Development of smallpox vaccine candidates with integrated interleukin-15 that demonstrate superior immunogenicity, efficacy, and safety in mice. J Virol (2007) 1.02
The combination of immunosuppression and carrier cells significantly enhances the efficacy of oncolytic poxvirus in the pre-immunized host. Gene Ther (2010) 1.02
Wanted, dead or alive: new viral vaccines. Antiviral Res (2009) 1.02
Division-linked generation of death-intermediates regulates the numerical stability of memory CD8 T cells. Proc Natl Acad Sci U S A (2012) 1.01
Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature (2011) 9.30
Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge. Nat Med (2009) 7.33
Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J Exp Med (2005) 7.18
Duration of humoral immunity to common viral and vaccine antigens. N Engl J Med (2007) 6.13
Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol (2010) 5.55
Coding potential of laboratory and clinical strains of human cytomegalovirus. Proc Natl Acad Sci U S A (2003) 4.37
Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome. J Virol (2004) 4.30
The many important facets of T-cell repertoire diversity. Nat Rev Immunol (2004) 3.83
Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus. Science (2010) 3.31
Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms. Science (2013) 3.27
Immune clearance of highly pathogenic SIV infection. Nature (2013) 3.15
Differential regulation of cell motility and invasion by FAK. J Cell Biol (2003) 3.15
Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report. J Allergy Clin Immunol (2010) 2.98
Multiple diagnostic techniques identify previously vaccinated individuals with protective immunity against monkeypox. Nat Med (2005) 2.57
Immunity and immunological memory following smallpox vaccination. Immunol Rev (2006) 2.57
Characterization of the human cytomegalovirus gH/gL/UL128-131 complex that mediates entry into epithelial and endothelial cells. J Virol (2007) 2.53
Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion. J Virol (2006) 2.45
IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates. J Clin Invest (2006) 2.41
New paradigms for HIV/AIDS vaccine development. Annu Rev Med (2011) 2.21
Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum. J Allergy Clin Immunol (2009) 2.20
Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery. Blood (2006) 2.13
Mechanisms that determine plasma cell lifespan and the duration of humoral immunity. Immunol Rev (2010) 1.99
Cell cycle status affects coxsackievirus replication, persistence, and reactivation in vitro. J Virol (2002) 1.92
West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis. J Virol (2007) 1.86
Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines. Nat Med (2012) 1.86
A viral microRNA down-regulates multiple cell cycle genes through mRNA 5'UTRs. PLoS Pathog (2010) 1.82
Complete sequence and genomic analysis of rhesus cytomegalovirus. J Virol (2003) 1.79
Tight junction defects in patients with atopic dermatitis. J Allergy Clin Immunol (2010) 1.77
Granulocyte-colony stimulating factor reactivates human cytomegalovirus in a latently infected humanized mouse model. Cell Host Microbe (2010) 1.77
Protective immunity following vaccination: how is it defined? Hum Vaccin (2008) 1.70
Consensus conference on pediatric atopic dermatitis. J Am Acad Dermatol (2003) 1.68
Rat cytomegalovirus-accelerated transplant vascular sclerosis is reduced with mutation of the chemokine-receptor R33. Am J Transplant (2005) 1.63
A human cytomegalovirus gO-null mutant fails to incorporate gH/gL into the virion envelope and is unable to enter fibroblasts and epithelial and endothelial cells. J Virol (2009) 1.63
How do viral infections predispose patients to bacterial infections? Curr Opin Infect Dis (2004) 1.60
Contributions of humoral and cellular immunity to vaccine-induced protection in humans. Virology (2011) 1.53
Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson's disease. Neurobiol Dis (2007) 1.52
Human cytomegalovirus persistence and latency in endothelial cells and macrophages. Curr Opin Microbiol (2002) 1.52
Cowpox virus inhibits the transporter associated with antigen processing to evade T cell recognition. Cell Host Microbe (2009) 1.47
Adult eczema prevalence and associations with asthma and other health and demographic factors: a US population-based study. J Allergy Clin Immunol (2013) 1.43
Immunodominance in virus-induced CD8(+) T-cell responses is dramatically modified by DNA immunization and is regulated by gamma interferon. J Virol (2002) 1.42
Quantitation of rare memory B cell populations by two independent and complementary approaches. J Immunol Methods (2006) 1.41
Reversion of methicillin-resistant Staphylococcus aureus skin infections to methicillin-susceptible isolates. JAMA Dermatol (2013) 1.40
The Src family kinase c-Yes is required for maturation of West Nile virus particles. J Virol (2005) 1.39
Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A (2012) 1.38
Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum. J Allergy Clin Immunol (2010) 1.38
High-content assay to identify inhibitors of dengue virus infection. Assay Drug Dev Technol (2010) 1.33
Cytokine-mediated programmed proliferation of virus-specific CD8(+) memory T cells. Immunity (2012) 1.31
A novel human cytomegalovirus locus modulates cell type-specific outcomes of infection. PLoS Pathog (2011) 1.30
Activation of virus-specific CD8+ T cells by lipopolysaccharide-induced IL-12 and IL-18. J Immunol (2004) 1.30
Atopic dermatitis and asthma: parallels in the evolution of treatment. Pediatrics (2003) 1.30
FAK promotes organization of fibronectin matrix and fibrillar adhesions. J Cell Sci (2003) 1.28
A cyclooxygenase-2 homologue encoded by rhesus cytomegalovirus is a determinant for endothelial cell tropism. J Virol (2004) 1.28
Endogenous human cytomegalovirus gB is presented efficiently by MHC class II molecules to CD4+ CTL. J Exp Med (2005) 1.26
Development of a new hydrogen peroxide–based vaccine platform. Nat Med (2012) 1.24
Human cytomegalovirus secretome contains factors that induce angiogenesis and wound healing. J Virol (2008) 1.23
Kaposi sarcoma-associated herpesvirus (KSHV) induces heme oxygenase-1 expression and activity in KSHV-infected endothelial cells. Blood (2004) 1.23
Evolution of the response to levodopa during the first 4 years of therapy. Ann Neurol (2002) 1.23
Association of gammaA/gamma' fibrinogen levels and coronary artery disease. Thromb Haemost (2002) 1.21
Murine cytomegalovirus interference with antigen presentation has little effect on the size or the effector memory phenotype of the CD8 T cell response. J Immunol (2004) 1.20
Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response. J Allergy Clin Immunol (2011) 1.19
West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of alphavbeta3 integrin. J Virol (2008) 1.19
Cytomegalovirus-mediated upregulation of chemokine expression correlates with the acceleration of chronic rejection in rat heart transplants. J Virol (2003) 1.18
Human cytomegalovirus attenuates interleukin-1beta and tumor necrosis factor alpha proinflammatory signaling by inhibition of NF-kappaB activation. J Virol (2006) 1.17
Human cytomegalovirus chemokine receptor US28-induced smooth muscle cell migration is mediated by focal adhesion kinase and Src. J Biol Chem (2003) 1.15
Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report. Nutr Res (2011) 1.14
Acceleration of allograft failure by cytomegalovirus. Curr Opin Immunol (2007) 1.13
The rapidity with which virus-specific CD8+ T cells initiate IFN-gamma synthesis increases markedly over the course of infection and correlates with immunodominance. J Immunol (2004) 1.12
Human cytomegalovirus-encoded G protein-coupled receptor US28 mediates smooth muscle cell migration through Galpha12. J Virol (2004) 1.11
Regulation of innate and adaptive immune responses by the related cytokines IL-12, IL-23, and IL-27. Arch Immunol Ther Exp (Warsz) (2006) 1.11
Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection. J Virol (2006) 1.10
Cowpox virus evades CTL recognition and inhibits the intracellular transport of MHC class I molecules. J Immunol (2007) 1.09
Elimination of donor-specific alloreactivity prevents cytomegalovirus-accelerated chronic rejection in rat small bowel and heart transplants. Transplantation (2002) 1.08
A pilot study of emollient therapy for the primary prevention of atopic dermatitis. J Am Acad Dermatol (2010) 1.08
Tracking superparamagnetic iron oxide labeled monocytes in brain by high-field magnetic resonance imaging. J Neurosci Res (2003) 1.08
Retrieval of human cytomegalovirus glycoprotein B from cell surface is not required for virus envelopment in astrocytoma cells. J Virol (2002) 1.07
Rat cytomegalovirus gene expression in cardiac allograft recipients is tissue specific and does not parallel the profiles detected in vitro. J Virol (2007) 1.05
BST2/Tetherin enhances entry of human cytomegalovirus. PLoS Pathog (2011) 1.04
Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines. Blood (2004) 1.04
West nile virus capsid degradation of claudin proteins disrupts epithelial barrier function. J Virol (2009) 1.03
Wanted, dead or alive: new viral vaccines. Antiviral Res (2009) 1.02
Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis. J Allergy Clin Immunol (2011) 1.01
The dopamine transporter: importance in Parkinson's disease. Ann Neurol (2004) 1.01
Analysis of rhesus rhadinovirus microRNAs expressed in virus-induced tumors from infected rhesus macaques. Virology (2010) 1.00
Human cytomegalovirus tropism for endothelial cells: not all endothelial cells are created equal. J Virol (2006) 1.00
P58(IPK): a novel "CIHD" member of the host innate defense response against pathogenic virus infection. PLoS Pathog (2009) 0.99
Inhibition of dengue virus infections in cell cultures and in AG129 mice by a small interfering RNA targeting a highly conserved sequence. J Virol (2011) 0.98
A hydrogen peroxide-inactivated virus vaccine elicits humoral and cellular immunity and protects against lethal West Nile virus infection in aged mice. J Virol (2012) 0.98
The safety assessment of fragrance materials. Regul Toxicol Pharmacol (2003) 0.98
Quantitative 1H magnetic resonance spectroscopic imaging determines therapeutic immunization efficacy in an animal model of Parkinson's disease. J Neurosci (2005) 0.97