Published in J Biol Chem on September 22, 2003
Immunobiology of human cytomegalovirus: from bench to bedside. Clin Microbiol Rev (2009) 2.75
The story of human cytomegalovirus and cancer: increasing evidence and open questions. Neoplasia (2009) 1.49
Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Commun Signal (2016) 1.38
Focal adhesion kinase is critical for entry of Kaposi's sarcoma-associated herpesvirus into target cells. J Virol (2006) 1.22
West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of alphavbeta3 integrin. J Virol (2008) 1.19
Human cytomegalovirus-encoded G protein-coupled receptor US28 mediates smooth muscle cell migration through Galpha12. J Virol (2004) 1.11
Epstein-Barr virus-encoded BILF1 is a constitutively active G protein-coupled receptor. J Virol (2005) 1.10
Human cytomegalovirus-regulated paxillin in monocytes links cellular pathogenic motility to the process of viral entry. J Virol (2010) 0.95
The HCMV gH/gL/UL128-131 complex triggers the specific cellular activation required for efficient viral internalization into target monocytes. PLoS Pathog (2013) 0.95
Human cytomegalovirus encoded homologs of cytokines, chemokines and their receptors: roles in immunomodulation. Viruses (2012) 0.94
Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility. PLoS Pathog (2009) 0.94
Heteromerization of human cytomegalovirus encoded chemokine receptors. Biochem Pharmacol (2011) 0.94
Molecular mechanisms deployed by virally encoded G protein-coupled receptors in human diseases. Annu Rev Pharmacol Toxicol (2012) 0.92
Human Cytomegalovirus US28: a functionally selective chemokine binding receptor. Infect Disord Drug Targets (2009) 0.92
The carboxy-terminal tail of human cytomegalovirus (HCMV) US28 regulates both chemokine-independent and chemokine-dependent signaling in HCMV-infected cells. J Virol (2009) 0.91
Cytomegalovirus CC chemokine promotes immune cell migration. J Virol (2012) 0.87
Receptor chimeras demonstrate that the C-terminal domain of the human cytomegalovirus US27 gene product is necessary and sufficient for intracellular receptor localization. Virol J (2012) 0.87
eXamine: exploring annotated modules in networks. BMC Bioinformatics (2014) 0.86
Functional analysis of human cytomegalovirus pUS28 mutants in infected cells. J Gen Virol (2008) 0.85
HCMV pUS28 initiates pro-migratory signaling via activation of Pyk2 kinase. Herpesviridae (2010) 0.85
Desensitization of herpesvirus-encoded G protein-coupled receptors. Life Sci (2007) 0.84
Mouse cytomegalovirus M33 is necessary and sufficient in virus-induced vascular smooth muscle cell migration. J Virol (2005) 0.83
US28 is a potent activator of phospholipase C during HCMV infection of clinically relevant target cells. PLoS One (2012) 0.82
Constitutive β-catenin signaling by the viral chemokine receptor US28. PLoS One (2012) 0.81
Functional characterization of KIN-32, the Caenorhabditis elegans homolog of focal adhesion kinase. Dev Dyn (2008) 0.79
Matricellular protein Cyr61 bridges lysophosphatidic acid and integrin pathways leading to cell migration. J Biol Chem (2013) 0.79
Human Cytomegalovirus Promotes Survival of Infected Monocytes via a Distinct Temporal Regulation of Cellular Bcl-2 Family Proteins. J Virol (2015) 0.78
US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection. Biomol Ther (Seoul) (2017) 0.77
Hijacking GPCRs by viral pathogens and tumor. Biochem Pharmacol (2016) 0.76
Inflammatory breast cancer: high incidence of detection of mixed human cytomegalovirus genotypes associated with disease pathogenesis. Front Oncol (2014) 0.76
Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein. Nat Commun (2017) 0.75
A method for quantifying mechanical properties of tissue following viral infection. PLoS One (2012) 0.75
Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol (2005) 11.74
Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature (2011) 9.61
Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature (2011) 9.30
Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol (2006) 8.52
Duration of antiviral immunity after smallpox vaccination. Nat Med (2003) 7.39
Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge. Nat Med (2009) 7.33
Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J Exp Med (2005) 7.18
Coding potential of laboratory and clinical strains of human cytomegalovirus. Proc Natl Acad Sci U S A (2003) 4.37
Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome. J Virol (2004) 4.30
Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling. Science (2004) 3.93
Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation. J Cell Biol (2010) 3.56
Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus. Science (2010) 3.31
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell (2008) 3.31
Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms. Science (2013) 3.27
Immune clearance of highly pathogenic SIV infection. Nature (2013) 3.15
Differential regulation of cell motility and invasion by FAK. J Cell Biol (2003) 3.15
Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol (2002) 2.84
Human papillomavirus, vaccines and women's health: questions and cautions. CMAJ (2007) 2.63
Characterization of the human cytomegalovirus gH/gL/UL128-131 complex that mediates entry into epithelial and endothelial cells. J Virol (2007) 2.53
Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion. J Virol (2006) 2.45
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. J Cell Biol (2008) 2.31
Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery. Blood (2006) 2.13
PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther (2010) 2.10
Consensus on the role of human cytomegalovirus in glioblastoma. Neuro Oncol (2012) 2.02
Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr Opin Cell Biol (2009) 1.99
FAK promotes recruitment of talin to nascent adhesions to control cell motility. J Cell Biol (2012) 1.87
West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis. J Virol (2007) 1.86
VEGF-induced vascular permeability is mediated by FAK. Dev Cell (2012) 1.85
A viral microRNA down-regulates multiple cell cycle genes through mRNA 5'UTRs. PLoS Pathog (2010) 1.82
Granulocyte-colony stimulating factor reactivates human cytomegalovirus in a latently infected humanized mouse model. Cell Host Microbe (2010) 1.77
Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. J Cell Biol (2008) 1.74
FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion. J Cell Biol (2005) 1.70
Direct interaction of focal adhesion kinase with p190RhoGEF. J Biol Chem (2003) 1.67
Rat cytomegalovirus-accelerated transplant vascular sclerosis is reduced with mutation of the chemokine-receptor R33. Am J Transplant (2005) 1.63
A human cytomegalovirus gO-null mutant fails to incorporate gH/gL into the virion envelope and is unable to enter fibroblasts and epithelial and endothelial cells. J Virol (2009) 1.63
The focal adhesion kinase--a regulator of cell migration and invasion. IUBMB Life (2002) 1.55
FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth. EMBO J (2002) 1.55
A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells. J Cell Sci (2009) 1.55
Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway. Cancer Res (2006) 1.55
Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson's disease. Neurobiol Dis (2007) 1.52
Human cytomegalovirus persistence and latency in endothelial cells and macrophages. Curr Opin Microbiol (2002) 1.52
Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis. Cancer Res (2009) 1.44
FERM control of FAK function: implications for cancer therapy. Cell Cycle (2008) 1.43
Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models. Cancer Biol Ther (2010) 1.41
The Src family kinase c-Yes is required for maturation of West Nile virus particles. J Virol (2005) 1.39
High-content assay to identify inhibitors of dengue virus infection. Assay Drug Dev Technol (2010) 1.33
v-Src SH3-enhanced interaction with focal adhesion kinase at beta 1 integrin-containing invadopodia promotes cell invasion. J Biol Chem (2002) 1.31
Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem (2010) 1.31
A novel human cytomegalovirus locus modulates cell type-specific outcomes of infection. PLoS Pathog (2011) 1.30
Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src. Mol Cell Biol (2005) 1.30
FAK promotes organization of fibronectin matrix and fibrillar adhesions. J Cell Sci (2003) 1.28
A cyclooxygenase-2 homologue encoded by rhesus cytomegalovirus is a determinant for endothelial cell tropism. J Virol (2004) 1.28
Endogenous human cytomegalovirus gB is presented efficiently by MHC class II molecules to CD4+ CTL. J Exp Med (2005) 1.26
Human cytomegalovirus secretome contains factors that induce angiogenesis and wound healing. J Virol (2008) 1.23
The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis. J Biol Chem (2003) 1.20
Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression. Clin Exp Metastasis (2012) 1.20
West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of alphavbeta3 integrin. J Virol (2008) 1.19
Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival. J Biol Chem (2009) 1.18
Cytomegalovirus-mediated upregulation of chemokine expression correlates with the acceleration of chronic rejection in rat heart transplants. J Virol (2003) 1.18
Human cytomegalovirus attenuates interleukin-1beta and tumor necrosis factor alpha proinflammatory signaling by inhibition of NF-kappaB activation. J Virol (2006) 1.17
Acceleration of allograft failure by cytomegalovirus. Curr Opin Immunol (2007) 1.13
Human cytomegalovirus-encoded G protein-coupled receptor US28 mediates smooth muscle cell migration through Galpha12. J Virol (2004) 1.11
Constitutively active Gq/11-coupled receptors enable signaling by co-expressed G(i/o)-coupled receptors. J Biol Chem (2003) 1.10
Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection. J Virol (2006) 1.10
Elimination of donor-specific alloreactivity prevents cytomegalovirus-accelerated chronic rejection in rat small bowel and heart transplants. Transplantation (2002) 1.08
Tracking superparamagnetic iron oxide labeled monocytes in brain by high-field magnetic resonance imaging. J Neurosci Res (2003) 1.08
Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function. J Cell Biol (2014) 1.07
Retrieval of human cytomegalovirus glycoprotein B from cell surface is not required for virus envelopment in astrocytoma cells. J Virol (2002) 1.07
Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer. Nat Commun (2011) 1.06
Rat cytomegalovirus gene expression in cardiac allograft recipients is tissue specific and does not parallel the profiles detected in vitro. J Virol (2007) 1.05
Chikungunya virus infection results in higher and persistent viral replication in aged rhesus macaques due to defects in anti-viral immunity. PLoS Negl Trop Dis (2013) 1.04
BST2/Tetherin enhances entry of human cytomegalovirus. PLoS Pathog (2011) 1.04
West nile virus capsid degradation of claudin proteins disrupts epithelial barrier function. J Virol (2009) 1.03
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression. J Cell Biol (2012) 1.02
The human cytomegalovirus-encoded chemokine receptor US28 induces caspase-dependent apoptosis. FEBS J (2005) 1.01
The rat cytomegalovirus R33-encoded G protein-coupled receptor signals in a constitutive fashion. J Virol (2002) 1.00
EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1. PLoS One (2012) 1.00
Human cytomegalovirus tropism for endothelial cells: not all endothelial cells are created equal. J Virol (2006) 1.00
P58(IPK): a novel "CIHD" member of the host innate defense response against pathogenic virus infection. PLoS Pathog (2009) 0.99
Inhibition of dengue virus infections in cell cultures and in AG129 mice by a small interfering RNA targeting a highly conserved sequence. J Virol (2011) 0.98
FAK nuclear export signal sequences. FEBS Lett (2008) 0.98
Cortactin as a target for FAK in the regulation of focal adhesion dynamics. PLoS One (2012) 0.97
Quantitative 1H magnetic resonance spectroscopic imaging determines therapeutic immunization efficacy in an animal model of Parkinson's disease. J Neurosci (2005) 0.97
Synthesis and structure-activity relationship of the first nonpeptidergic inverse agonists for the human cytomegalovirus encoded chemokine receptor US28. J Med Chem (2005) 0.96
Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells. J Cell Sci (2012) 0.96
Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization. Am J Pathol (2007) 0.96
p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase. Cancer Res (2011) 0.96
Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells. J Cell Biol (2011) 0.95
Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility. PLoS Pathog (2009) 0.94