PubRank

Markus G Grütter

Author PubWeight™ 100.60‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature 2011 6.29
2 High-affinity binders selected from designed ankyrin repeat protein libraries. Nat Biotechnol 2004 3.34
3 Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLoS Biol 2007 2.89
4 The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J Biol Chem 2002 2.75
5 NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain. Structure 2003 2.15
6 Insights into the regulatory mechanism for caspase-8 activation. Mol Cell 2003 2.01
7 Designed to be stable: crystal structure of a consensus ankyrin repeat protein. Proc Natl Acad Sci U S A 2003 1.98
8 Inhibition of caspase-2 by a designed ankyrin repeat protein: specificity, structure, and inhibition mechanism. Structure 2007 1.93
9 Allosteric inhibition of aminoglycoside phosphotransferase by a designed ankyrin repeat protein. Structure 2005 1.75
10 Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun 2003 1.74
11 Crystal structure of the multidrug exporter MexB from Pseudomonas aeruginosa. J Mol Biol 2009 1.69
12 Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation. Nat Struct Mol Biol 2012 1.66
13 Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. Proc Natl Acad Sci U S A 2012 1.66
14 Crystal structure and functional analysis of Escherichia coli glutamate decarboxylase. EMBO J 2003 1.50
15 Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters. Proc Natl Acad Sci U S A 2013 1.46
16 Structural basis of chaperone-subunit complex recognition by the type 1 pilus assembly platform FimD. EMBO J 2005 1.42
17 Structure of the PRYSPRY-domain: implications for autoinflammatory diseases. FEBS Lett 2005 1.36
18 Structural basis and kinetics of inter- and intramolecular disulfide exchange in the redox catalyst DsbD. EMBO J 2004 1.32
19 Precision is essential for efficient catalysis in an evolved Kemp eliminase. Nature 2013 1.28
20 Intracellular kinase inhibitors selected from combinatorial libraries of designed ankyrin repeat proteins. J Biol Chem 2005 1.17
21 Structural and biochemical studies on procaspase-8: new insights on initiator caspase activation. Structure 2009 1.16
22 Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency. Proc Natl Acad Sci U S A 2009 1.15
23 Chaperone-assisted crystallography with DARPins. Structure 2008 1.14
24 Infinite kinetic stability against dissociation of supramolecular protein complexes through donor strand complementation. Structure 2008 1.12
25 DsbL and DsbI form a specific dithiol oxidase system for periplasmic arylsulfate sulfotransferase in uropathogenic Escherichia coli. J Mol Biol 2008 1.10
26 Vacuolar protein sorting: two different functional states of the AAA-ATPase Vps4p. J Mol Biol 2008 1.09
27 Structural basis and kinetics of DsbD-dependent cytochrome c maturation. Structure 2005 1.08
28 Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis. J Mol Biol 2006 1.08
29 Escherichia coli acid resistance: pH-sensing, activation by chloride and autoinhibition in GadB. EMBO J 2006 1.07
30 Structure of rabbit-muscle glyceraldehyde-3-phosphate dehydrogenase. Acta Crystallogr D Biol Crystallogr 2003 1.05
31 Structure-activity studies in a family of beta-hairpin protein epitope mimetic inhibitors of the p53-HDM2 protein-protein interaction. Chembiochem 2006 1.04
32 Fire and death: the pyrin domain joins the death-domain superfamily. C R Biol 2004 1.03
33 Crystal structure of the ternary FimC-FimF(t)-FimD(N) complex indicates conserved pilus chaperone-subunit complex recognition by the usher FimD. FEBS Lett 2008 1.03
34 The crystal structure of human pyrin b30.2 domain: implications for mutations associated with familial Mediterranean fever. J Mol Biol 2009 1.02
35 Structural determinants for improved stability of designed ankyrin repeat proteins with a redesigned C-capping module. J Mol Biol 2010 1.02
36 Stabilizing ionic interactions in a full-consensus ankyrin repeat protein. J Mol Biol 2007 0.99
37 The crystal structure of Helicobacter cysteine-rich protein C at 2.0 A resolution: similar peptide-binding sites in TPR and SEL1-like repeat proteins. J Mol Biol 2004 0.99
38 Structure and oligomeric state of the mammalian tumour-associated antigen UK114. Acta Crystallogr D Biol Crystallogr 2003 0.98
39 An invariant surface patch on the TRIM5alpha PRYSPRY domain is required for retroviral restriction but dispensable for capsid binding. J Virol 2009 0.98
40 Structure and zymogen activation of caspases. Biophys Chem 2002 0.98
41 Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10. J Med Chem 2006 0.97
42 Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: A basis for the design of specific inhibitors. Structure 2006 0.95
43 Structural and functional insights into the assembly of type 1 pili from Escherichia coli. Microbes Infect 2006 0.95
44 Crystal structure of a consensus-designed ankyrin repeat protein: implications for stability. Proteins 2006 0.94
45 Quality control of disulfide bond formation in pilus subunits by the chaperone FimC. Nat Chem Biol 2012 0.94
46 Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism. Structure 2010 0.94
47 Crystallization of the NADH-oxidizing domain of the Na+-translocating NADH:ubiquinone oxidoreductase from Vibrio cholerae. Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 0.92
48 Exploring the S4 and S1 prime subsite specificities in caspase-3 with aza-peptide epoxide inhibitors. Biochemistry 2006 0.92
49 Crystal structure of the anti-His tag antibody 3D5 single-chain fragment complexed to its antigen. J Mol Biol 2002 0.92
50 Evidence for a novel domain of bacterial outer membrane ushers. Proteins 2006 0.91
51 A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions. Proc Natl Acad Sci U S A 2008 0.91
52 A common structural basis for pH- and calmodulin-mediated regulation in plant glutamate decarboxylase. J Mol Biol 2009 0.91
53 Comparison of the crystal structures of the human manganese superoxide dismutase and the homologous Aspergillus fumigatus allergen at 2-A resolution. J Immunol 2002 0.90
54 Identification of a basic surface area of the FADD death effector domain critical for apoptotic signaling. FEBS Lett 2002 0.89
55 Opportunities for structure-based design of protease-directed drugs. Curr Opin Struct Biol 2006 0.89
56 High-resolution structures of Escherichia coli cDsbD in different redox states: A combined crystallographic, biochemical and computational study. J Mol Biol 2006 0.88
57 Designed ankyrin repeat protein binders for the crystallization of AcrB: plasticity of the dominant interface. J Struct Biol 2011 0.88
58 Design, construction, and characterization of a second-generation DARP in library with reduced hydrophobicity. Protein Sci 2013 0.87
59 Asymmetry in the homodimeric ABC transporter MsbA recognized by a DARPin. J Biol Chem 2012 0.87
60 New concepts and aids to facilitate crystallization. Curr Opin Struct Biol 2013 0.87
61 CRK: an evolutionary approach for distinguishing biologically relevant interfaces from crystal contacts. Proteins 2010 0.85
62 Structure-based optimization of designed Armadillo-repeat proteins. Protein Sci 2012 0.83
63 HIV-1 protease inhibition potential of functionalized polyoxometalates. Bioorg Med Chem Lett 2010 0.83
64 Metal-free MIRAS phasing: structure of apo-S100A3. Acta Crystallogr D Biol Crystallogr 2002 0.83
65 Molecular dynamics study of the stabilities of consensus designed ankyrin repeat proteins. Proteins 2006 0.82
66 Structure of ACC synthase inactivated by the mechanism-based inhibitor L-vinylglycine. FEBS Lett 2005 0.82
67 Tuning the drug efflux activity of an ABC transporter in vivo by in vitro selected DARPin binders. PLoS One 2012 0.82
68 Specific inhibition of caspase-3 by a competitive DARPin: molecular mimicry between native and designed inhibitors. Structure 2013 0.81
69 NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22. J Clin Invest 2016 0.81
70 Structural model of human GAD65: prediction and interpretation of biochemical and immunogenic features. Proteins 2005 0.81
71 Chimeric hERG channels containing a tetramerization domain are functional and stable. Biochemistry 2013 0.81
72 Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe. Chem Biol 2010 0.81
73 Isolation of a small-molecule inhibitor of the antiapoptotic protein Bcl-xL from a DNA-encoded chemical library. ChemMedChem 2010 0.81
74 Structure and substrate-induced conformational changes of the secondary citrate/sodium symporter CitS revealed by electron crystallography. Structure 2013 0.80
75 Generation of an antibody toolbox to characterize hERG. Biochem Biophys Res Commun 2012 0.80
76 Amino acid dimorphism and parasite immune evasion: cellular immune responses to a promiscuous epitope of Plasmodium falciparum merozoite surface protein 1 displaying dimorphic amino acid polymorphism are highly constrained. Eur J Immunol 2002 0.80
77 Structure of the recombinant antibody Fab fragment f3p4. Acta Crystallogr D Biol Crystallogr 2008 0.80
78 The structure of Bradyrhizobium japonicum transcription factor FixK2 unveils sites of DNA binding and oxidation. J Biol Chem 2013 0.80
79 Apple 1-aminocyclopropane-1-carboxylate synthase in complex with the inhibitor L-aminoethoxyvinylglycine. Evidence for a ketimine intermediate. J Biol Chem 2002 0.80
80 Structural basis for reduced activity of 1-aminocyclopropane-1-carboxylate synthase affected by a mutation linked to andromonoecy. FEBS Lett 2010 0.80
81 A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders. PLoS One 2011 0.79
82 Determination of the minimal functional ligand-binding domain of the GABAB1b receptor. Biochem J 2005 0.79
83 Autoproteolytic and catalytic mechanisms for the β-aminopeptidase BapA--a member of the Ntn hydrolase family. Structure 2012 0.79
84 In silico identification and crystal structure validation of caspase-3 inhibitors without a P1 aspartic acid moiety. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 0.78
85 Human caspases in vitro: expression, purification and kinetic characterization. Protein Expr Purif 2012 0.78
86 Structure of 1-aminocyclopropane-1-carboxylate synthase in complex with an amino-oxy analogue of the substrate: implications for substrate binding. Biochim Biophys Acta 2003 0.77
87 Unusual structural features revealed by the solution NMR structure of the NLRC5 caspase recruitment domain. Biochemistry 2014 0.76
88 Specific targeting of human caspases using designed ankyrin repeat proteins. Biol Chem 2014 0.75
89 Structural analysis of mycobacterial and murine hsp60 epitopes in complex with the class I MHC molecule H-2Db. FEBS Lett 2003 0.75
90 Projection structure of the secondary citrate/sodium symporter CitS at 6 Å resolution by electron crystallography. J Mol Biol 2012 0.75
91 Crystal structures of BapA complexes with β-lactam-derived inhibitors illustrate substrate specificity and enantioselectivity of β-aminopeptidases. Chembiochem 2012 0.75
92 NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22. J Clin Invest 2016 0.75
93 The critical structural role of a highly conserved histidine residue in group II amino acid decarboxylases. FEBS Lett 2003 0.75