Published in Immunity on August 01, 2003
The enigma of sepsis. J Clin Invest (2003) 4.32
The role of complement in inflammatory diseases from behind the scenes into the spotlight. Am J Pathol (2007) 3.12
Function, structure and therapeutic potential of complement C5a receptors. Br J Pharmacol (2007) 2.25
Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease. Nature (2009) 2.05
Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. J Exp Med (2006) 1.78
Developmentally regulated IkappaB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation. Proc Natl Acad Sci U S A (2004) 1.64
Novel chemokine responsiveness and mobilization of neutrophils during sepsis. Am J Pathol (2004) 1.42
Trauma: the role of the innate immune system. World J Emerg Surg (2006) 1.37
Ghrelin attenuates sepsis-induced acute lung injury and mortality in rats. Am J Respir Crit Care Med (2007) 1.37
An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction. J Exp Med (2005) 1.29
Effect of IL-10 on neutrophil recruitment and survival after Pseudomonas aeruginosa challenge. Am J Respir Cell Mol Biol (2008) 1.23
Complement and periodontitis. Biochem Pharmacol (2010) 1.20
Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis. FASEB J (2011) 1.19
Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host. Periodontol 2000 (2010) 1.15
A metalloproteinase karilysin present in the majority of Tannerella forsythia isolates inhibits all pathways of the complement system. J Immunol (2012) 1.07
The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis. PLoS One (2008) 1.03
Staphylococcal proteases aid in evasion of the human complement system. J Innate Immun (2013) 1.02
Complement activation product C5a is a selective suppressor of TLR4-induced, but not TLR3-induced, production of IL-27(p28) from macrophages. J Immunol (2012) 1.02
Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a. Mol Immunol (2007) 1.01
MyD88-dependent production of IL-17F is modulated by the anaphylatoxin C5a via the Akt signaling pathway. FASEB J (2011) 1.01
CB2 cannabinoid receptors contribute to bacterial invasion and mortality in polymicrobial sepsis. PLoS One (2009) 0.94
Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium. J Biol Chem (2008) 0.94
Protease-dependent mechanisms of complement evasion by bacterial pathogens. Biol Chem (2012) 0.94
C5aR-antagonist significantly reduces the deleterious effect of a blunt chest trauma on fracture healing. J Orthop Res (2011) 0.88
Dexamethasone suppresses interleukin-22 associated with bacterial infection in vitro and in vivo. Clin Exp Immunol (2009) 0.88
C5a regulates NKT and NK cell functions in sepsis. J Immunol (2011) 0.87
Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin. PLoS One (2012) 0.85
Distinct different contributions of the alternative and classical complement activation pathway for the innate host response during sepsis. J Immunol (2011) 0.84
Persistent neutrophil dysfunction and suppression of acute lung injury in mice following cecal ligation and puncture sepsis. J Innate Immun (2014) 0.84
Beneficial and detrimental effects of plasmin(ogen) during infection and sepsis in mice. PLoS One (2011) 0.83
New insights for C5a and C5a receptors in sepsis. Front Immunol (2012) 0.79
A noninflammatory pathway for pregnancy loss: innate immune activation? J Clin Invest (2004) 0.78
Differential pharmacological behaviour of p38 inhibitors in regulating the LPS-induced TNF-α production in human and rat whole blood in vitro. Inflammation (2011) 0.77
Neutrophil Dysfunction in Sepsis. Chin Med J (Engl) (2016) 0.75
Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds. PLoS One (2017) 0.75
Role of Complement C5 in Experimental Blunt Chest Trauma-Induced Septic Acute Lung Injury (ALI). PLoS One (2016) 0.75
A Metalloproteinase Mirolysin of Tannerella forsythia Inhibits All Pathways of the Complement System. J Immunol (2015) 0.75
Fusion Peptides CPU1 and CPU2 Inhibit Matrix Metalloproteinases and Protect Mice from Endotoxin Shock Within a Strict Time Window. Inflammation (2015) 0.75
Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc (2009) 6.71
Harmful molecular mechanisms in sepsis. Nat Rev Immunol (2008) 6.03
Generation of C5a in the absence of C3: a new complement activation pathway. Nat Med (2006) 5.26
Novel strategies for the treatment of sepsis. Nat Med (2003) 5.14
The NLR gene family: a standard nomenclature. Immunity (2008) 4.77
Role of C5a in inflammatory responses. Annu Rev Immunol (2005) 4.38
The enigma of sepsis. J Clin Invest (2003) 4.32
Functional roles for C5a receptors in sepsis. Nat Med (2008) 3.33
The disconnect between animal models of sepsis and human sepsis. J Leukoc Biol (2006) 3.11
Adverse functions of IL-17A in experimental sepsis. FASEB J (2008) 2.60
Phagocyte-derived catecholamines enhance acute inflammatory injury. Nature (2007) 2.56
CCAAT/enhancer-binding protein δ is a critical mediator of lipopolysaccharide-induced acute lung injury. Am J Pathol (2012) 2.12
Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression. J Immunol (2003) 2.00
The complement system. Cell Tissue Res (2010) 1.86
Increased C5a receptor expression in sepsis. J Clin Invest (2002) 1.79
Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-alpha mRNA. J Biol Chem (2006) 1.75
Generation of C5a by phagocytic cells. Am J Pathol (2002) 1.72
Role of oxidants in lung injury during sepsis. Antioxid Redox Signal (2007) 1.71
Changes and regulation of the C5a receptor on neutrophils during septic shock in humans. J Immunol (2013) 1.57
Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages. J Cell Sci (2012) 1.57
Evidence for a functional role of the second C5a receptor C5L2. FASEB J (2005) 1.53
Expression and function of C5a receptor in mouse microvascular endothelial cells. J Immunol (2002) 1.53
Role of nitric oxide in acute lung inflammation: lessons learned from the inducible nitric oxide synthase knockout mouse. Crit Care Med (2002) 1.51
Evaluation of endotoxin models for the study of sepsis. Shock (2005) 1.47
Interactions between coagulation and complement--their role in inflammation. Semin Immunopathol (2011) 1.46
Complement-induced impairment of innate immunity during sepsis. J Immunol (2002) 1.44
Protection of innate immunity by C5aR antagonist in septic mice. FASEB J (2002) 1.44
Novel chemokine responsiveness and mobilization of neutrophils during sepsis. Am J Pathol (2004) 1.42
Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis. FASEB J (2003) 1.42
Regulatory effects of iNOS on acute lung inflammatory responses in mice. Am J Pathol (2003) 1.42
Harmful and protective roles of neutrophils in sepsis. Shock (2005) 1.41
High-fat diet decreases cancellous bone mass but has no effect on cortical bone mass in the tibia in mice. Bone (2009) 1.41
Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality. Blood (2011) 1.39
C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. J Exp Med (2008) 1.38
Humanizing the mouse: in defense of murine models of critical illness. Am J Respir Crit Care Med (2013) 1.36
Mediators and regulation of neutrophil accumulation in inflammatory responses in lung: insights from the IgG immune complex model. Free Radic Biol Med (2002) 1.35
The inflammatory response in sepsis. Trends Immunol (2012) 1.34
C5a-induced gene expression in human umbilical vein endothelial cells. Am J Pathol (2004) 1.34
Role of C3, C5 and anaphylatoxin receptors in acute lung injury and in sepsis. Adv Exp Med Biol (2012) 1.34
Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis. Am J Pathol (2002) 1.33
Relationship of acute lung inflammatory injury to Fas/FasL system. Am J Pathol (2005) 1.33
Regulatory effects of estrogen on acute lung inflammation in mice. Am J Physiol Cell Physiol (2005) 1.32
Alveolar epithelial type II cells activate alveolar macrophages and mitigate P. Aeruginosa infection. PLoS One (2009) 1.31
C5a receptor and thymocyte apoptosis in sepsis. FASEB J (2002) 1.31
Elevated inflammatory response in caveolin-1-deficient mice with Pseudomonas aeruginosa infection is mediated by STAT3 protein and nuclear factor kappaB (NF-kappaB). J Biol Chem (2011) 1.31
Anti-inflammatory effects of β2 adrenergic receptor agonists in experimental acute lung injury. FASEB J (2012) 1.31
Functions of the complement components C3 and C5 during sepsis. FASEB J (2008) 1.30