Published in Nat Med on May 21, 2006
Complement: a key system for immune surveillance and homeostasis. Nat Immunol (2010) 10.37
Harmful molecular mechanisms in sepsis. Nat Rev Immunol (2008) 6.03
Modulation of the antitumor immune response by complement. Nat Immunol (2008) 4.53
Complement regulators and inhibitory proteins. Nat Rev Immunol (2009) 4.46
Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity (2008) 3.36
Thrombomodulin mutations in atypical hemolytic-uremic syndrome. N Engl J Med (2009) 3.24
The role of complement in inflammatory diseases from behind the scenes into the spotlight. Am J Pathol (2007) 3.12
Identification of a central role for complement in osteoarthritis. Nat Med (2011) 3.11
The role of the anaphylatoxins in health and disease. Mol Immunol (2009) 2.95
The role of saliva in tick feeding. Front Biosci (Landmark Ed) (2009) 2.73
Molecular intercommunication between the complement and coagulation systems. J Immunol (2010) 2.12
Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis. Blood (2010) 2.08
STEC-HUS, atypical HUS and TTP are all diseases of complement activation. Nat Rev Nephrol (2012) 1.89
The development of atypical hemolytic uremic syndrome depends on complement C5. J Am Soc Nephrol (2010) 1.88
Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. Invest Ophthalmol Vis Sci (2009) 1.86
The complement system. Cell Tissue Res (2010) 1.86
The broad antibacterial activity of the natural antibody repertoire is due to polyreactive antibodies. Cell Host Microbe (2007) 1.69
NK-cell activation and antibody-dependent cellular cytotoxicity induced by rituximab-coated target cells is inhibited by the C3b component of complement. Blood (2007) 1.69
Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins. Periodontol 2000 (2010) 1.65
Interaction between the coagulation and complement system. Adv Exp Med Biol (2008) 1.65
Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome. J Exp Med (2008) 1.64
The alternative complement pathway revisited. J Cell Mol Med (2008) 1.62
Porphyromonas gingivalis-host interactions: open war or intelligent guerilla tactics? Microbes Infect (2009) 1.61
An early complement-dependent and TLR-4-independent phase in the pathogenesis of ethanol-induced liver injury in mice. Hepatology (2009) 1.60
Intravascular immunity: the host-pathogen encounter in blood vessels. Nat Rev Immunol (2009) 1.60
Mechanisms of immune complex-mediated neutrophil recruitment and tissue injury. Circulation (2009) 1.56
Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis. Blood (2010) 1.56
Complement System Part I - Molecular Mechanisms of Activation and Regulation. Front Immunol (2015) 1.52
Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice. Gastroenterology (2007) 1.50
The complement cascade: Yin-Yang in neuroinflammation--neuro-protection and -degeneration. J Neurochem (2008) 1.48
Interactions between coagulation and complement--their role in inflammation. Semin Immunopathol (2011) 1.46
Simultaneous activation of complement and coagulation by MBL-associated serine protease 2. PLoS One (2007) 1.42
C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. J Exp Med (2008) 1.38
New insights of an old defense system: structure, function, and clinical relevance of the complement system. Mol Med (2010) 1.37
Inducible innate resistance of lung epithelium to infection. Annu Rev Physiol (2010) 1.34
Role of C3, C5 and anaphylatoxin receptors in acute lung injury and in sepsis. Adv Exp Med Biol (2012) 1.34
Complement and viral pathogenesis. Virology (2011) 1.32
The harmful role of c5a on innate immunity in sepsis. J Innate Immun (2010) 1.31
Anti-inflammatory effects of β2 adrenergic receptor agonists in experimental acute lung injury. FASEB J (2012) 1.31
Complement--tapping into new sites and effector systems. Nat Rev Immunol (2014) 1.30
Anaphylatoxin C5a creates a favorable microenvironment for lung cancer progression. J Immunol (2012) 1.30
Functions of the complement components C3 and C5 during sepsis. FASEB J (2008) 1.30
Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury. FASEB J (2013) 1.26
Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studies. Ann Rheum Dis (2007) 1.26
Complement activation triggered by chondroitin sulfate released by thrombin receptor-activated platelets. J Thromb Haemost (2008) 1.26
Complexity of complement activation in sepsis. J Cell Mol Med (2008) 1.26
Eculizumab treatment efficiently prevents C5 cleavage without C5a generation in vivo. Blood (2015) 1.25
Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice. J Neuroinflammation (2007) 1.24
Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex. Circ Res (2009) 1.23
Recent developments in low molecular weight complement inhibitors. Mol Immunol (2009) 1.23
Acute lung injury induced by lipopolysaccharide is independent of complement activation. J Immunol (2008) 1.22
Complement inhibition in cancer therapy. Semin Immunol (2013) 1.20
Gelatinase contributes to the pathogenesis of endocarditis caused by Enterococcus faecalis. Infect Immun (2010) 1.20
Evidence for non-traditional activation of complement factor C3 during murine liver regeneration. Mol Immunol (2008) 1.19
Neuroprotection in stroke by complement inhibition and immunoglobulin therapy. Neuroscience (2008) 1.16
C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria. PLoS One (2009) 1.16
Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome. Blood (2010) 1.15
The absence of serum IgM enhances the susceptibility of mice to pulmonary challenge with Cryptococcus neoformans. J Immunol (2010) 1.15
Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host. Periodontol 2000 (2010) 1.15
Polytrauma--pathophysiology and management principles. Langenbecks Arch Surg (2008) 1.14
C5a and TNF-alpha up-regulate the expression of tissue factor in intra-alveolar neutrophils of patients with the acute respiratory distress syndrome. J Immunol (2008) 1.13
Complement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm. Circulation (2009) 1.13
Complement activation, regulation, and molecular basis for complement-related diseases. EMBO J (2015) 1.12
Complement activation in the injured central nervous system: another dual-edged sword? J Neuroinflammation (2012) 1.11
Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain. Blood (2008) 1.11
The role of complement in tumor growth. Adv Exp Med Biol (2014) 1.11
Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot. Immunology (2009) 1.10
Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation. BMC Neurosci (2006) 1.09
Pathophysiology of the systemic inflammatory response after major accidental trauma. Scand J Trauma Resusc Emerg Med (2009) 1.08
Relative contributions of dectin-1 and complement to immune responses to particulate β-glucans. J Immunol (2012) 1.07
Staphylococcus aureus secretes coagulase and von Willebrand factor binding protein to modify the coagulation cascade and establish host infections. J Innate Immun (2012) 1.07
Generation of anaphylatoxins by human beta-tryptase from C3, C4, and C5. J Immunol (2008) 1.05
Molecular mechanisms of inflammation and tissue injury after major trauma--is complement the "bad guy"? J Biomed Sci (2011) 1.04
Fc gamma RIII and Fc gamma RIV are indispensable for acute glomerular inflammation induced by switch variant monoclonal antibodies. J Immunol (2008) 1.04
Regulation of tissue inflammation by thrombin-activatable carboxypeptidase B (or TAFI). Mol Immunol (2008) 1.03
Defect in early lung defence against Pseudomonas aeruginosa in DBA/2 mice is associated with acute inflammatory lung injury and reduced bactericidal activity in naive macrophages. Microbiology (2007) 1.03
Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease. J Neuroinflammation (2011) 1.02
Innate immunity activation on biomaterial surfaces: a mechanistic model and coping strategies. Adv Drug Deliv Rev (2011) 1.01
Mannose-binding lectin-associated serine protease-1 is a significant contributor to coagulation in a murine model of occlusive thrombosis. J Immunol (2011) 1.01
Deficiency in complement C1q improves histological and functional locomotor outcome after spinal cord injury. J Neurosci (2008) 1.01
Versatility of the complement system in neuroinflammation, neurodegeneration and brain homeostasis. Front Cell Neurosci (2014) 1.01
Complement gene expression and regulation in mouse retina and retinal pigment epithelium/choroid. Mol Vis (2011) 0.98
Opposing roles for complement component C5a in tumor progression and the tumor microenvironment. J Immunol (2012) 0.98
The emerging role of neutrophils in thrombosis-the journey of TF through NETs. Front Immunol (2012) 0.98
Neutrophil extracellular traps can activate alternative complement pathways. Clin Exp Immunol (2015) 0.98
New developments in C5a receptor signaling. Cell Health Cytoskelet (2012) 0.97
Cytokine storm in a mouse model of IgG-mediated hemolytic transfusion reactions. Blood (2008) 0.97
Early complementopathy after multiple injuries in humans. Shock (2012) 0.97
Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice. PLoS One (2011) 0.97
Complement activation pathways in murine immune complex-induced arthritis and in C3a and C5a generation in vitro. Clin Exp Immunol (2009) 0.97
Inhibition of neutrophil exocytosis ameliorates acute lung injury in rats. Shock (2013) 0.97
Phosphoinositide 3-kinases gamma and delta, linkers of coordinate C5a receptor-Fcgamma receptor activation and immune complex-induced inflammation. J Biol Chem (2008) 0.96
Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice. J Immunol (2014) 0.96
Complement C3 plays an essential role in the control of opportunistic fungal infections. Infect Immun (2009) 0.96
Role for terminal complement activation in amyotrophic lateral sclerosis disease progression. Proc Natl Acad Sci U S A (2013) 0.96
The role of the complement system in metabolic organs and metabolic diseases. Semin Immunol (2013) 0.95
CD4+ T cells and complement independently mediate graft ischemia in the rejection of mouse orthotopic tracheal transplants. Circ Res (2011) 0.94
Complement: a key system for immune surveillance and homeostasis. Nat Immunol (2010) 10.37
The classical complement cascade mediates CNS synapse elimination. Cell (2007) 9.06
Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc (2009) 6.71
Harmful molecular mechanisms in sepsis. Nat Rev Immunol (2008) 6.03
Novel strategies for the treatment of sepsis. Nat Med (2003) 5.14
Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host Microbe (2011) 5.06
The NLR gene family: a standard nomenclature. Immunity (2008) 4.77
Modulation of the antitumor immune response by complement. Nat Immunol (2008) 4.53
Role of C5a in inflammatory responses. Annu Rev Immunol (2005) 4.38
The enigma of sepsis. J Clin Invest (2003) 4.32
Membranoproliferative glomerulonephritis type II (dense deposit disease): an update. J Am Soc Nephrol (2005) 3.57
Navigated total knee replacement. A meta-analysis. J Bone Joint Surg Am (2007) 3.39
Functional roles for C5a receptors in sepsis. Nat Med (2008) 3.33
Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci U S A (2006) 3.25
Complement-targeted therapeutics. Nat Biotechnol (2007) 3.24
Structure of C3b reveals conformational changes that underlie complement activity. Nature (2006) 3.22
The role of complement in inflammatory diseases from behind the scenes into the spotlight. Am J Pathol (2007) 3.12
The disconnect between animal models of sepsis and human sepsis. J Leukoc Biol (2006) 3.11
New approaches to the treatment of dense deposit disease. J Am Soc Nephrol (2007) 3.02
The treatment of displaced intra-articular distal radius fractures in elderly patients. Dtsch Arztebl Int (2014) 2.98
Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice. Proc Natl Acad Sci U S A (2002) 2.76
Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood (2007) 2.72
Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation. Blood (2002) 2.62
Adverse functions of IL-17A in experimental sepsis. FASEB J (2008) 2.60
Phagocyte-derived catecholamines enhance acute inflammatory injury. Nature (2007) 2.56
Structure of complement fragment C3b-factor H and implications for host protection by complement regulators. Nat Immunol (2009) 2.54
Complement and coagulation: strangers or partners in crime? Trends Immunol (2007) 2.48
Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest (2003) 2.39
The proinflammatory mediators C3a and C5a are essential for liver regeneration. J Exp Med (2003) 2.38
A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor, IkappaBalpha. Hepatology (2005) 2.18
A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. J Clin Invest (2006) 2.15
A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways. J Immunol (2006) 2.13
Molecular intercommunication between the complement and coagulation systems. J Immunol (2010) 2.12
Complement in immune and inflammatory disorders: pathophysiological mechanisms. J Immunol (2013) 2.10
The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo. J Exp Med (2005) 2.09
Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis. Blood (2010) 2.08
Microbial manipulation of receptor crosstalk in innate immunity. Nat Rev Immunol (2011) 2.01
Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression. J Immunol (2003) 2.00
Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor. Nat Immunol (2009) 1.98
A structural basis for complement inhibition by Staphylococcus aureus. Nat Immunol (2007) 1.95
Microbial hijacking of complement-toll-like receptor crosstalk. Sci Signal (2010) 1.91
The complement system. Cell Tissue Res (2010) 1.86
Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circ Res (2012) 1.85
Crosstalk pathways between Toll-like receptors and the complement system. Trends Immunol (2010) 1.83
Increased C5a receptor expression in sepsis. J Clin Invest (2002) 1.79
Cardiopulmonary, histological, and inflammatory alterations after lung contusion in a novel mouse model of blunt chest trauma. Shock (2003) 1.78
A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A (2007) 1.74
Generation of C5a by phagocytic cells. Am J Pathol (2002) 1.72
Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin. J Med Chem (2006) 1.72
Role of oxidants in lung injury during sepsis. Antioxid Redox Signal (2007) 1.71
Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition. J Biol Chem (2007) 1.71
Complement: a novel factor in basal and ischemia-induced neurogenesis. EMBO J (2006) 1.70
Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1. Blood (2003) 1.68
The role of complement in biomaterial-induced inflammation. Mol Immunol (2006) 1.67
Compstatin: a complement inhibitor on its way to clinical application. Adv Exp Med Biol (2008) 1.66
Pulmonary contusion causes impairment of macrophage and lymphocyte immune functions and increases mortality associated with a subsequent septic challenge. Crit Care Med (2005) 1.65
Interaction between the coagulation and complement system. Adv Exp Med Biol (2008) 1.65
The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss. J Immunol (2010) 1.64
Complement in immune and inflammatory disorders: therapeutic interventions. J Immunol (2013) 1.64
Inhibition of complement activation by a secreted Staphylococcus aureus protein. J Infect Dis (2004) 1.62
Structures of C3b in complex with factors B and D give insight into complement convertase formation. Science (2010) 1.59
Antibodies against the extracellular enveloped virus B5R protein are mainly responsible for the EEV neutralizing capacity of vaccinia immune globulin. Virology (2004) 1.58
Complement activation and the resulting placental vascular insufficiency drives fetal growth restriction associated with placental malaria. Cell Host Microbe (2013) 1.57
Changes and regulation of the C5a receptor on neutrophils during septic shock in humans. J Immunol (2013) 1.57
Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis. Blood (2010) 1.56