PubRank

Albert J Fornace

Author PubWeight™ 131.04‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 2002 4.88
2 Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nat Genet 2004 3.89
3 Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity. Nat Genet 2002 3.32
4 Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol Cell 2006 2.39
5 Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases. Nat Immunol 2005 2.31
6 Radiation metabolomics. 1. Identification of minimally invasive urine biomarkers for gamma-radiation exposure in mice. Radiat Res 2008 2.27
7 Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint. Cell Cycle 2003 2.10
8 Human in vivo radiation-induced biomarkers: gene expression changes in radiotherapy patients. Cancer Res 2004 2.04
9 Differential responses of stress genes to low dose-rate gamma irradiation. Mol Cancer Res 2003 2.01
10 Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen. Cancer Res 2008 2.01
11 Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation. J Biol Chem 2003 1.97
12 Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53. Cancer Res 2002 1.71
13 p38 MAP kinase's emerging role as a tumor suppressor. Adv Cancer Res 2004 1.64
14 Phosphorylation site interdependence of human p53 post-translational modifications in response to stress. J Biol Chem 2003 1.63
15 UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation. Anal Chem 2008 1.61
16 Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice. Radiat Res 2009 1.59
17 Genomic instability, centrosome amplification, cell cycle checkpoints and Gadd45a. Oncogene 2002 1.59
18 Dual phosphorylation controls Cdc25 phosphatases and mitotic entry. Nat Cell Biol 2003 1.58
19 ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth. Oncogene 2002 1.55
20 Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. Immunity 2002 1.53
21 Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. J Exp Med 2006 1.53
22 The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway. Nat Immunol 2005 1.52
23 Phosphorylation of Xenopus Cdc25C at Ser285 interferes with ability to activate a DNA damage replication checkpoint in pre-midblastula embryos. Cell Cycle 2003 1.48
24 Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis. Proc Natl Acad Sci U S A 2005 1.47
25 p38 and Chk1 kinases: different conductors for the G(2)/M checkpoint symphony. Curr Opin Genet Dev 2002 1.43
26 Stress-specific signatures: expression profiling of p53 wild-type and -null human cells. Oncogene 2005 1.43
27 Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a. Mol Cell Biol 2003 1.38
28 Rapid activation of G2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase. Proc Natl Acad Sci U S A 2001 1.36
29 Comparison of mouse urinary metabolic profiles after exposure to the inflammatory stressors γ radiation and lipopolysaccharide. Radiat Res 2011 1.35
30 Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis. Oncogene 2005 1.34
31 Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response. Cancer Res 2010 1.34
32 Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships. Microbiome 2013 1.32
33 G2/M arrest by 1,25-dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer. J Biol Chem 2003 1.30
34 Functional genomics as a window on radiation stress signaling. Oncogene 2003 1.26
35 MetaboLyzer: a novel statistical workflow for analyzing Postprocessed LC-MS metabolomics data. Anal Chem 2013 1.24
36 Regulation of the Wip1 phosphatase and its effects on the stress response. Front Biosci (Landmark Ed) 2012 1.24
37 Metabolomic analysis in severe childhood pneumonia in the Gambia, West Africa: findings from a pilot study. PLoS One 2010 1.19
38 Senescent growth arrest in mesenchymal stem cells is bypassed by Wip1-mediated downregulation of intrinsic stress signaling pathways. Stem Cells 2009 1.18
39 Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development. Cancer Res 2003 1.17
40 Cytokine-driven cell cycling is mediated through Cdc25A. J Cell Biol 2005 1.15
41 Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse. J Proteome Res 2010 1.13
42 Gadd45a functions as a promoter or suppressor of breast cancer dependent on the oncogenic stress. Cancer Res 2010 1.12
43 Gadd45 in stress signaling, cell cycle control, and apoptosis. Adv Exp Med Biol 2013 1.11
44 Chemical inhibition of Wip1 phosphatase contributes to suppression of tumorigenesis. Cancer Biol Ther 2005 1.09
45 Boolean relationships among genes responsive to ionizing radiation in the NCI 60 ACDS. Bioinformatics 2004 1.08
46 Development of urinary biomarkers for internal exposure by cesium-137 using a metabolomics approach in mice. Radiat Res 2013 1.08
47 Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact. Nat Rev Drug Discov 2010 1.08
48 t4 workshop report: Pathways of Toxicity. ALTEX 2013 1.06
49 p38 Mitogen-activated protein kinase inhibitor protects the epidermis against the acute damaging effects of ultraviolet irradiation by blocking apoptosis and inflammatory responses. J Invest Dermatol 2004 1.06
50 Enhanced intestinal tumor multiplicity and grade in vivo after HZE exposure: mouse models for space radiation risk estimates. Radiat Environ Biophys 2010 1.05
51 UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model. J Proteome Res 2011 1.05
52 Activating p38 MAPK: new tricks for an old kinase. Cell Cycle 2005 1.05
53 A functional role for p38 MAPK in modulating mitotic transit in the absence of stress. J Biol Chem 2007 1.04
54 Detection of Radiation-Exposure Biomarkers by Differential Mobility Prefiltered Mass Spectrometry (DMS-MS). Int J Mass Spectrom 2010 1.04
55 Heavy ion radiation exposure triggered higher intestinal tumor frequency and greater β-catenin activation than γ radiation in APC(Min/+) mice. PLoS One 2013 1.03
56 Exposure to heavy ion radiation induces persistent oxidative stress in mouse intestine. PLoS One 2012 1.03
57 Surrogate tissue analysis: monitoring toxicant exposure and health status of inaccessible tissues through the analysis of accessible tissues and cells. Toxicol Appl Pharmacol 2004 1.02
58 The effect of low dose rate on metabolomic response to radiation in mice. Radiat Environ Biophys 2014 1.00
59 Functional genomics of UV radiation responses in human cells. Mutat Res 2004 0.99
60 Nuclear factor-kappaB (NF-kappaB) is a novel positive transcriptional regulator of the oncogenic Wip1 phosphatase. J Biol Chem 2009 0.99
61 Casein kinase 2- and protein kinase A-regulated adenomatous polyposis coli and beta-catenin cellular localization is dependent on p38 MAPK. J Biol Chem 2005 0.99
62 Gadd45a regulates matrix metalloproteinases by suppressing DeltaNp63alpha and beta-catenin via p38 MAP kinase and APC complex activation. Oncogene 2004 0.99
63 Characterization and interlaboratory comparison of a gene expression signature for differentiating genotoxic mechanisms. Toxicol Sci 2009 0.99
64 Gadd34 requirement for normal hemoglobin synthesis. Mol Cell Biol 2006 0.99
65 Development of a metabolomic radiation signature in urine from patients undergoing total body irradiation. Radiat Res 2014 0.98
66 Metabolomic and lipidomic analysis of serum from mice exposed to an internal emitter, cesium-137, using a shotgun LC-MS(E) approach. J Proteome Res 2014 0.98
67 G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin. J Biol Chem 2006 0.98
68 Inhibition of the ATR/Chk1 pathway induces a p38-dependent S-phase delay in mouse embryonic stem cells. Cell Cycle 2005 0.97
69 Monitoring human radiation exposure by gene expression profiling: possibilities and pitfalls. Health Phys 2003 0.95
70 Gadd34 functional domains involved in growth suppression and apoptosis. Oncogene 2003 0.95
71 Gadd45alpha regulates p38-dependent dendritic cell cytokine production and Th1 differentiation. J Immunol 2007 0.89
72 Gadd45a: an elusive yet attractive candidate gene in pancreatic cancer. Clin Cancer Res 2002 0.88
73 Accelerated hematopoietic toxicity by high energy (56)Fe radiation. Int J Radiat Biol 2011 0.88
74 Exposure to ionizing radiation causes long-term increase in serum estradiol and activation of PI3K-Akt signaling pathway in mouse mammary gland. Int J Radiat Oncol Biol Phys 2012 0.87
75 Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure. J Biol Chem 2004 0.86
76 Tumor susceptibility and apoptosis defect in a mouse strain expressing a human p53 transgene. Cancer Res 2006 0.86
77 Zap70 functions to maintain stemness of mouse embryonic stem cells by negatively regulating Jak1/Stat3/c-Myc signaling. Stem Cells 2010 0.85
78 Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production. Aging (Albany NY) 2013 0.85
79 Modulation of fatty acid and bile acid metabolism by peroxisome proliferator-activated receptor α protects against alcoholic liver disease. Alcohol Clin Exp Res 2014 0.84
80 Metabolic phenotyping reveals a lipid mediator response to ionizing radiation. J Proteome Res 2014 0.84
81 High-energy particle-induced tumorigenesis throughout the gastrointestinal tract. Radiat Res 2014 0.84
82 Toxicogenomics: overview and potential applications for the study of non-covalent DNA interacting chemicals. Mutat Res 2007 0.84
83 The dark side of light: the damaging effects of UV rays and the protective efforts of MAP kinase signaling in the epidermis. DNA Repair (Amst) 2004 0.82
84 Neural tube development requires the cooperation of p53- and Gadd45a-associated pathways. Birth Defects Res A Clin Mol Teratol 2006 0.82
85 Metabolomic profiling of urine samples from mice exposed to protons reveals radiation quality and dose specific differences. Radiat Res 2015 0.81
86 Sex-dependent differences in intestinal tumorigenesis induced in Apc1638N/+ mice by exposure to γ rays. Int J Radiat Oncol Biol Phys 2012 0.81
87 Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland. Radiat Oncol 2012 0.81
88 Generation of cancerous neural stem cells forming glial tumor by oncogenic stimulation. Stem Cell Rev 2012 0.80
89 Inactivation of gadd45a sensitizes epithelial cancer cells to ionizing radiation in vivo resulting in prolonged survival. Cancer Res 2008 0.80
90 Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells. Am J Physiol Renal Physiol 2006 0.80
91 Genetic toxicity assessment: employing the best science for human safety evaluation Part VII: Why not start with a single test: a transformational alternative to genotoxicity hazard and risk assessment. Toxicol Sci 2007 0.80
92 Loss of Gadd45a does not modify the pulmonary response to oxidative stress. Am J Physiol Lung Cell Mol Physiol 2005 0.80
93 p16Ink4a suppression of lung adenocarcinoma by Bmi-1 in the presence of p38 activation. J Thorac Oncol 2011 0.79
94 Identifying radiation exposure biomarkers from mouse blood transcriptome. Int J Bioinform Res Appl 2013 0.79
95 Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response. Radiat Oncol 2012 0.79
96 Chemotherapeutic targeting of p53. Cancer Biol Ther 2002 0.78
97 Microarray approaches for analysis of cell cycle regulatory genes. Methods Mol Biol 2004 0.78
98 Differential mobility spectrometry with nanospray ion source as a compact detector for small organics and inorganics. Int J Ion Mobil Spectrom 2013 0.78
99 Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival. Food Chem Toxicol 2013 0.78
100 Comparative analysis of the genetic structure and chromosomal mapping of the murine Gadd45g/CR6 gene. DNA Cell Biol 2003 0.78
101 Radioprotective effects of ON 01210.Na upon oral administration. J Radiat Res 2012 0.78
102 Exome Sequencing of Normal and Isogenic Transformed Human Colonic Epithelial Cells (HCECs) Reveals Novel Genes Potentially Involved in the Early Stages of Colorectal Tumorigenesis. BMC Genomics 2015 0.78
103 Relative biological effectiveness of 12C and 28Si radiation in C57BL/6J mice. Radiat Environ Biophys 2012 0.77
104 Distinct serum metabolomics profiles associated with malignant progression in the KrasG12D mouse model of pancreatic ductal adenocarcinoma. BMC Genomics 2015 0.77
105 Understanding gas phase modifier interactions in rapid analysis by differential mobility-tandem mass spectrometry. J Am Soc Mass Spectrom 2014 0.76
106 Wip1 abrogation decreases intestinal tumor frequency in APC(Min/+) mice irrespective of radiation quality. Radiat Res 2014 0.76
107 PPARβ/δ modulates ethanol-induced hepatic effects by decreasing pyridoxal kinase activity. Toxicology 2013 0.76
108 Editorial comment: mutation research special issue on stress responses. Mutat Res 2005 0.75
109 Erratum: Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function. Sci Rep 2016 0.75
110 Wip1-expressing feeder cells retain pluripotency of co-cultured mouse embryonic stem cells under leukemia inhibitory factor-deprivated condition. Arch Pharm Res 2010 0.75
111 Microarray approaches for analysis of tumor suppressor gene function. Methods Mol Biol 2003 0.75
112 A serum small molecule biosignature of radiation exposure from total body irradiated patients. J Proteome Res 2017 0.75