Nuclear envelope irregularity is induced by RET/PTC during interphase.

PubWeight™: 0.98‹?› | Rank: Top 15%

🔗 View Article (PMC 1868259)

Published in Am J Pathol on September 01, 2003

Authors

Andrew H Fischer1, Panya Taysavang, Sissy M Jhiang

Author Affiliations

1: Department of Pathology, Emory University Hospital, Atlanta, Georgia, USA. Fischa01@ummhc.org

Articles citing this

Nuclear envelope structural defect underlies the main cause of aneuploidy in ovarian carcinogenesis. BMC Cell Biol (2016) 1.37

Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer. Oncologist (2011) 1.27

Loss of A-type lamin expression compromises nuclear envelope integrity in breast cancer. Chin J Cancer (2011) 1.00

Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer. BMC Med (2011) 0.97

The induction of a nucleoplasmic reticulum by prelamin A accumulation requires CTP:phosphocholine cytidylyltransferase-α. J Cell Sci (2012) 0.91

Pleomorphism of the nuclear envelope in breast cancer: a new approach to an old problem. J Cell Mol Med (2007) 0.89

Accurate diagnosis of thyroid follicular lesions from nuclear morphology using supervised learning. Med Image Anal (2014) 0.87

Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model. Oncotarget (2015) 0.84

Promotion of tumor development in prostate cancer by progerin. Cancer Cell Int (2010) 0.82

Frog virus 3 open reading frame 97R localizes to the endoplasmic reticulum and induces nuclear invaginations. J Virol (2013) 0.78

Diagnostic cellular abnormalities in neoplastic and non-neoplastic lesions of the epidermis: a morphological and statistical study. J Cutan Pathol (2013) 0.77

Nuclear assembly as a target for anti-cancer therapies. Nucleus (2014) 0.76

Expression of nuclear membrane proteins in normal, hyperplastic, and neoplastic thyroid epithelial cells. Virchows Arch (2015) 0.75

Articles cited by this

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell (1992) 28.36

Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proc Natl Acad Sci U S A (1997) 7.24

Nuclear membrane dynamics and reassembly in living cells: targeting of an inner nuclear membrane protein in interphase and mitosis. J Cell Biol (1997) 6.57

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature (1996) 6.11

Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science (2002) 5.47

PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell (1990) 3.98

Nuclear envelope breakdown proceeds by microtubule-induced tearing of the lamina. Cell (2002) 3.64

Cytoplasmic dynein as a facilitator of nuclear envelope breakdown. Cell (2002) 3.16

Interphase nuclei of many mammalian cell types contain deep, dynamic, tubular membrane-bound invaginations of the nuclear envelope. J Cell Biol (1997) 2.82

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol Cell Biol (1996) 2.69

Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR. J Biol Chem (1997) 2.58

The nuclear pore complex: a protein machine bridging the nucleus and cytoplasm. Curr Opin Cell Biol (2000) 2.56

A lamin-independent pathway for nuclear envelope assembly. J Cell Biol (1990) 2.55

Disruption of nuclear lamin organization alters the distribution of replication factors and inhibits DNA synthesis. J Cell Biol (1997) 2.41

Nuclear assembly. Annu Rev Cell Dev Biol (1997) 2.33

Nuclear compartments and gene regulation. Curr Opin Genet Dev (1999) 2.30

Dynamics of the nuclear lamina as monitored by GFP-tagged A-type lamins. J Cell Sci (1999) 2.14

The nuclear envelope, muscular dystrophy and gene expression. Trends Cell Biol (2000) 2.06

Visualizing chromosome dynamics with GFP. Trends Cell Biol (2001) 1.91

The dynamic properties and possible functions of nuclear lamins. Int Rev Cytol (1995) 1.87

Searching for a function for nuclear actin. Trends Cell Biol (2000) 1.70

Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export. Mol Cell Biol (2000) 1.64

Disruption of nuclear lamin organization blocks the elongation phase of DNA replication. J Cell Biol (2000) 1.64

Roles of LAP2 proteins in nuclear assembly and DNA replication: truncated LAP2beta proteins alter lamina assembly, envelope formation, nuclear size, and DNA replication efficiency in Xenopus laevis extracts. J Cell Biol (1999) 1.63

Nuclear pore localization and nucleocytoplasmic transport of eIF-5A: evidence for direct interaction with the export receptor CRM1. J Cell Sci (1999) 1.51

Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S phase. J Cell Biol (1998) 1.50

Lamins in disease: why do ubiquitously expressed nuclear envelope proteins give rise to tissue-specific disease phenotypes? J Cell Sci (2001) 1.46

Lamin-binding fragment of LAP2 inhibits increase in nuclear volume during the cell cycle and progression into S phase. J Cell Biol (1997) 1.45

The inner nuclear membrane. J Membr Biol (2000) 1.44

A nuclear export signal in Kap95p is required for both recycling the import factor and interaction with the nucleoporin GLFG repeat regions of Nup116p and Nup100p. J Cell Biol (1997) 1.42

The presence or absence of a vimentin-type intermediate filament network affects the shape of the nucleus in human SW-13 cells. J Cell Sci (1994) 1.36

Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade. Mol Cell Biol (2001) 1.29

RET/PTC oncogene activation is an early event in thyroid carcinogenesis. Oncogene (1995) 1.19

Tetracycline regulated expression of vimentin in fibroblasts derived from vimentin null mice. J Cell Sci (1997) 1.14

Assessment of RET/PTC oncogene activation and clonality in thyroid nodules with incomplete morphological evidence of papillary carcinoma: a search for the early precursors of papillary cancer. Am J Pathol (2002) 1.08

Origin and progression of thyroid epithelial tumours: cellular and molecular mechanisms. Horm Res (1997) 1.06

Xenopus lamin B3 has a direct role in the assembly of a replication competent nucleus: evidence from cell-free egg extracts. J Cell Sci (1995) 1.06

Papillary thyroid carcinoma oncogene (RET/PTC) alters the nuclear envelope and chromatin structure. Am J Pathol (1998) 1.05

Use of nuclear morphometry, gleason histologic scoring, clinical stage, and age to predict disease-free survival among patients with prostate cancer. Cancer (1992) 1.05

Weaving a pattern from disparate threads: lamin function in nuclear assembly and DNA replication. J Cell Sci (1994) 1.04

Chromatin structure in granulocytes. A link between tight compaction and accumulation of a heterochromatin-associated protein (MENT). J Biol Chem (1998) 0.99

In vitro reconstruction of tumour initiation in a human epithelium. Oncogene (1994) 0.97

Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours. Br J Cancer (1993) 0.91

Assessment of nodal involvement and survival analysis in breast cancer patients using image cytometric data: statistical, neural network and fuzzy approaches. Anticancer Res (2002) 0.90

Nuclear envelope organization in papillary thyroid carcinoma. Histol Histopathol (2001) 0.89

Nuclear roundness factor. A predictor of progression in untreated Stage A2 prostate cancer. Cancer (1984) 0.89

Signal transduction pathways activated by RET oncoproteins in PC12 pheochromocytoma cells. J Biol Chem (1998) 0.89

Key role of Shc signaling in the transforming pathway triggered by Ret/ptc2 oncoprotein. Oncogene (2001) 0.87

Ras-associated nuclear structural change appears functionally significant and independent of the mitotic signaling pathway. J Cell Biochem (1998) 0.87

The use of nuclear morphometry in predicting recurrence of transitional cell carcinoma. J Urol (1993) 0.86

Relationship of nuclear invaginations to perinuclear rings composed of intermediate filaments in MIA PaCa-2 and some other cells. Cell Struct Funct (1994) 0.84

Nuclear shape analysis for the assessment of local invasion and metastases in clinically localized prostate carcinoma. Cancer (1994) 0.82

A comparison between histological grade and nuclear morphometry for predicting the clinical outcome of localized renal cell carcinoma. Br J Urol (1996) 0.81

Nuclear morphometry in squamous cell carcinoma (SCC) of the tongue. Eur J Cancer B Oral Oncol (1996) 0.80

Mammalian cell microinjection assay. Methods Enzymol (1995) 0.80

Atypical squamous cells of undetermined significance: A cytohistological study in a colposcopy clinic. Diagn Cytopathol (1999) 0.78

A tense time for the nuclear envelope. Cell (2002) 0.78

Prognostic value of nuclear morphometry in patients with TNM stage T1 ovarian clear cell adenocarcinoma. Br J Cancer (1999) 0.76

Mechanics of nucleocytoplasmic exchanges mediated by vertebrates' nuclear pore complex. Med Hypotheses (2000) 0.76

Morphologic and morphometric features of low grade serous tumours of the ovary. Diagn Cytopathol (1994) 0.76

Articles by these authors

The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties. Nucleic Acids Res (2003) 2.41

Correlation of Na+/I- symporter expression and activity: implications of Na+/I- symporter as an imaging reporter gene. J Nucl Med (2006) 1.58

Expression of sodium iodide symporter in the lacrimal drainage system: implication for the mechanism underlying nasolacrimal duct obstruction in I(131)-treated patients. Ophthal Plast Reconstr Surg (2005) 1.58

Ernest L. Mazzaferri, MD, MACP (1936-2013). Thyroid (2013) 1.39

Hormonal regulation of metastasis-associated protein 3 transcription in breast cancer cells. Mol Endocrinol (2004) 1.12

Efficient delivery of cyclic peptides into mammalian cells with short sequence motifs. ACS Chem Biol (2012) 1.04

Nasolacrimal drainage system obstruction from radioactive iodine therapy for thyroid carcinoma. J Clin Endocrinol Metab (2002) 1.03

Inhibition of heat shock protein 90, a novel RET/PTC1-associated protein, increases radioiodide accumulation in thyroid cells. J Biol Chem (2004) 1.01

Signaling through 3',5'-cyclic adenosine monophosphate and phosphoinositide-3 kinase induces sodium/iodide symporter expression in breast cancer. J Clin Endocrinol Metab (2004) 0.99

PI3K activation is associated with intracellular sodium/iodide symporter protein expression in breast cancer. BMC Cancer (2007) 0.96

Modulation of sodium/iodide symporter expression in the salivary gland. Thyroid (2013) 0.96

Caveolin-1 and caveolin-2,together with three bone morphogenetic protein-related genes, may encode novel tumor suppressors down-regulated in sporadic follicular thyroid carcinogenesis. Cancer Res (2003) 0.95

MEK signaling modulates sodium iodide symporter at multiple levels and in a paradoxical manner. Endocr Relat Cancer (2007) 0.94

Imaging of metastatic pulmonary tumors following NIS gene transfer using single photon emission computed tomography. Cancer Gene Ther (2004) 0.93

Identification of in vivo phosphorylation sites and their functional significance in the sodium iodide symporter. J Biol Chem (2007) 0.89

Cell surface targeting accounts for the difference in iodide uptake activity between human Na+/I- symporter and rat Na+/I- symporter. J Clin Endocrinol Metab (2005) 0.87

Single photon emission computed tomography imaging for temporal dynamics of thyroidal and salivary radionuclide accumulation in 17-allyamino-17-demothoxygeldanamycin-treated thyroid cancer mouse model. Endocr Relat Cancer (2010) 0.85

The roles of phosphotyrosines-294, -404, and -451 in RET/PTC1-induced thyroid tumor formation. Oncogene (2002) 0.83

Modulation of sodium iodide symporter expression and function by LY294002, Akti-1/2 and Rapamycin in thyroid cells. Endocr Relat Cancer (2012) 0.83

In vivo expression and function of the sodium iodide symporter following gene transfer in the MATLyLu rat model of metastatic prostate cancer. Prostate (2002) 0.82

Microarray analysis of genes associated with cell surface NIS protein levels in breast cancer. BMC Res Notes (2011) 0.82

Micro-single-photon emission computed tomography image acquisition and quantification of sodium-iodide symporter-mediated radionuclide accumulation in mouse thyroid and salivary glands. Thyroid (2012) 0.81

Application of the Cre/loxP system to enhance thyroid-targeted expression of sodium/iodide symporter. J Clin Endocrinol Metab (2004) 0.81

Three-axis rapid steering of optically propelled micro/nanoparticles. Rev Sci Instrum (2009) 0.80

Creation and characterization of a doxycycline-inducible mouse model of thyroid-targeted RET/PTC1 oncogene and luciferase reporter gene coexpression. Thyroid (2007) 0.78

Variable expression of coxsackie-adenovirus receptor in thyroid tumors: implications for adenoviral gene therapy. Thyroid (2005) 0.78

Apigenin in combination with Akt inhibition significantly enhances thyrotropin-stimulated radioiodide accumulation in thyroid cells. Thyroid (2014) 0.77

MEK inhibition leads to lysosome-mediated Na+/I- symporter protein degradation in human breast cancer cells. Endocr Relat Cancer (2013) 0.77

Modulation of sodium iodide symporter in thyroid cancer. Horm Cancer (2014) 0.77

Forskolin, 8-Br-3',5'-cyclic adenosine 5'-monophosphate, and catalytic protein kinase A expression in the nucleus increase radioiodide uptake and sodium/iodide symporter protein levels in RET/PTC1-expressing cells. J Clin Endocrinol Metab (2004) 0.77

Real-time visual sensing system achieving high-speed 3D particle tracking with nanometer resolution. Appl Opt (2013) 0.76

Effect of exogenous human sodium iodide symporter expression on growth of MATLyLu cells. Thyroid (2003) 0.76

High frequency of loss of heterozygosity in imprinted, compared with nonimprinted, genomic regions in follicular thyroid carcinomas and atypical adenomas. J Clin Endocrinol Metab (2005) 0.75

Prospects for small interfering RNA therapeutics in thyroid cancer. Thyroid (2010) 0.75

Two-axis probing system for atomic force microscopy. Rev Sci Instrum (2008) 0.75

Cloning of the 5'-flanking region of mouse sodium/iodide symporter and identification of a thyroid-specific and TSH-responsive enhancer. Thyroid (2004) 0.75

Modeling and calibrating nonlinearity and crosstalk in back focal plane interferometry for three-dimensional position detection. Opt Lett (2017) 0.75