Nuclear envelope structural defect underlies the main cause of aneuploidy in ovarian carcinogenesis.

PubWeight™: 1.37‹?› | Rank: Top 10%

🔗 View Article (PMID 27875985)

Published in BMC Cell Biol on November 22, 2016

Authors

Callinice D Capo-Chichi1,2,3, Toni M Yeasky1,2, Elizabeth R Smith1,2, Xiang-Xi Xu4,5

Author Affiliations

1: Sylvester Comprehensive Cancer Center/University of Miami, Miami, Florida, 33136, USA.
2: Department of Cell Biology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
3: Institute of Biomedical Sciences, Laboratory of Biochemistry and Molecular Biology, University of Abomey-Calavi, Abomey Calavi, Benin.
4: Sylvester Comprehensive Cancer Center/University of Miami, Miami, Florida, 33136, USA. xxu2@med.miami.edu.
5: Department of Cell Biology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA. xxu2@med.miami.edu.

Articles cited by this

Integrated genomic analyses of ovarian carcinoma. Nature (2011) 47.72

Tumor spectrum analysis in p53-mutant mice. Curr Biol (1994) 16.60

A NEW PROCEDURE FOR STAINING VAGINAL SMEARS. Science (1942) 12.63

Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy. J Cell Biol (1999) 7.65

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol (2009) 6.43

Aneuploidy and cancer. Nature (2004) 5.61

Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science (2008) 5.36

Nuclear structure in cancer cells. Nat Rev Cancer (2004) 5.12

Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev (2007) 4.96

From polyploidy to aneuploidy, genome instability and cancer. Nat Rev Mol Cell Biol (2004) 4.72

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin. Genes Dev (2008) 4.69

Genomic instability in laminopathy-based premature aging. Nat Med (2005) 4.54

Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis. Cell (1990) 4.12

Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature (2005) 4.06

Does aneuploidy cause cancer? Curr Opin Cell Biol (2006) 3.89

Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer Cell (2002) 3.50

Aneuploidy: cells losing their balance. Genetics (2008) 3.48

Karyotypic complexity of the NCI-60 drug-screening panel. Cancer Res (2003) 3.42

Differential timing of nuclear lamin A/C expression in the various organs of the mouse embryo and the young animal: a developmental study. Development (1989) 3.37

Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes. Mol Biol Cell (2000) 3.30

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism. J Cell Biol (2010) 3.28

Lamins A and C but not lamin B1 regulate nuclear mechanics. J Biol Chem (2006) 3.02

Oncogenes and tumour suppressors take on centrosomes. Nat Rev Cancer (2007) 2.87

Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium. Cancer Res (2003) 2.58

Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging. Proc Natl Acad Sci U S A (2007) 2.24

Identification of differentially expressed proteins in ovarian cancer using high-density protein microarrays. Proc Natl Acad Sci U S A (2007) 2.22

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells. Proc Natl Acad Sci U S A (2007) 2.15

The nuclear envelope, muscular dystrophy and gene expression. Trends Cell Biol (2000) 2.06

Catastrophic nuclear envelope collapse in cancer cell micronuclei. Cell (2013) 1.89

Can chromosomal instability initiate tumorigenesis? Semin Cancer Biol (2005) 1.77

MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2003) 1.73

Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S phase. J Cell Biol (1998) 1.50

When 2+2=5: the origins and fates of aneuploid and tetraploid cells. Biochim Biophys Acta (2008) 1.42

The nuclear envelope at a glance. J Cell Sci (2010) 1.38

Lamin A/C is a risk biomarker in colorectal cancer. PLoS One (2008) 1.37

Transient nuclear envelope rupturing during interphase in human cancer cells. Nucleus (2012) 1.36

Mechanisms of chromosome instability in cancers. Crit Rev Oncol Hematol (2006) 1.31

Mutations and aneuploidy: co-conspirators in cancer? Cancer Cell (2003) 1.30

Inactivation of the lamin A/C gene by CpG island promoter hypermethylation in hematologic malignancies, and its association with poor survival in nodal diffuse large B-cell lymphoma. J Clin Oncol (2005) 1.28

Correlation of nuclear morphometry with progression of breast cancer. Cancer (1991) 1.26

Decreased and aberrant nuclear lamin expression in gastrointestinal tract neoplasms. Gut (1999) 1.25

Tetraploidy and tumor development. Cancer Cell (2005) 1.23

The p53 tumor suppressor gene frequently is altered in gynecologic cancers. Am J Obstet Gynecol (1994) 1.16

Phenotypic analysis of ovarian carcinoma: polypeptide expression in benign, borderline and malignant tumors. Int J Cancer (1997) 1.15

Expression of nuclear lamins in human tissues and cancer cell lines and transcription from the promoters of the lamin A/C and B1 genes. Exp Cell Res (1997) 1.06

The protein kinase Akt/PKB regulates both prelamin A degradation and Lmna gene expression. FASEB J (2013) 1.06

Does aneuploidy or mutation start cancer? Science (2005) 1.06

Reduced expression of lamin A/C correlates with poor histological differentiation and prognosis in primary gastric carcinoma. J Exp Clin Cancer Res (2009) 1.06

What can Caenorhabditis elegans tell us about the nuclear envelope? FEBS Lett (2007) 1.05

Lamins as cancer biomarkers. Biochem Soc Trans (2010) 1.04

p300 modulates nuclear morphology in prostate cancer. Cancer Res (2005) 1.04

Nuclear size distinguishes low- from high-grade ovarian serous carcinoma and predicts outcome. Hum Pathol (2005) 1.04

Loss of GATA6 leads to nuclear deformation and aneuploidy in ovarian cancer. Mol Cell Biol (2009) 1.03

Nuclear dreams: the malignant alteration of nuclear architecture. J Cell Biochem (1998) 1.03

Loss of A-type lamin expression compromises nuclear envelope integrity in breast cancer. Chin J Cancer (2011) 1.00

Nuclear envelope irregularity is induced by RET/PTC during interphase. Am J Pathol (2003) 0.98

A comparison of nuclear morphometry and Gleason grade as a predictor of prognosis in stage A2 prostate cancer: a critical analysis. J Urol (1989) 0.98

Repression of nuclear lamin A and C gene expression in human acute lymphoblastic leukemia and non-Hodgkin's lymphoma cells. Leuk Res (1990) 0.98

Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer. BMC Med (2011) 0.97

A lamin-dependent pathway that regulates nuclear organization, cell cycle progression and germ cell development. Novartis Found Symp (2005) 0.97

Interphase phosphorylation of lamin A. J Cell Sci (2014) 0.96

Abnormal A-type lamin organization in a human lung carcinoma cell line. Eur J Cell Biol (1995) 0.93

Preneoplastic alterations in nuclear morphology that accompany loss of tumor suppressor phenotype. J Natl Cancer Inst (1991) 0.87

Tumor formation in p53 mutant ovaries transplanted into wild-type female hosts. Oncogene (2004) 0.87

AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation. Cell Death Differ (2015) 0.86

The prognostic value of nuclear morphometric analysis in serous ovarian carcinoma. Int J Gynecol Cancer (2007) 0.81

Frequency of sister chromatid exchanges and micronuclei monitored over time in patients with early-stage breast cancer: results of an observational study. Cancer Genet Cytogenet (2009) 0.81

Global deletion of Trp53 reverts ovarian tumor phenotype of the germ cell-deficient white spotting variant (Wv) mice. Neoplasia (2015) 0.78

Follicle Depletion Provides a Permissive Environment for Ovarian Carcinogenesis. Mol Cell Biol (2016) 0.76