Published in Cell on January 11, 2002
Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature (2010) 9.95
SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton. Mol Cell Biol (2006) 3.39
Nuclear shape, mechanics, and mechanotransduction. Circ Res (2008) 3.12
Orchestrating nuclear envelope disassembly and reassembly during mitosis. Nat Rev Mol Cell Biol (2009) 2.66
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Nup358 integrates nuclear envelope breakdown with kinetochore assembly. J Cell Biol (2003) 2.21
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ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress. Cell (2014) 1.73
Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos. Mol Biol Cell (2002) 1.69
Reorganization of the microtubule array in prophase/prometaphase requires cytoplasmic dynein-dependent microtubule transport. J Cell Biol (2002) 1.68
Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells. Nat Neurosci (2010) 1.66
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Part of Ran is associated with AKAP450 at the centrosome: involvement in microtubule-organizing activity. Mol Biol Cell (2003) 1.57
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Border control at the nucleus: biogenesis and organization of the nuclear membrane and pore complexes. Dev Cell (2009) 1.55
Distinct functional domains within nucleoporins Nup153 and Nup98 mediate transcription-dependent mobility. Mol Biol Cell (2004) 1.54
Nuclear envelope breakdown in starfish oocytes proceeds by partial NPC disassembly followed by a rapidly spreading fenestration of nuclear membranes. J Cell Biol (2003) 1.52
Requirement for Nudel and dynein for assembly of the lamin B spindle matrix. Nat Cell Biol (2009) 1.49
Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration. J Cell Biol (2005) 1.49
Systematic deletion and mitotic localization of the nuclear pore complex proteins of Aspergillus nidulans. Mol Biol Cell (2006) 1.48
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A membranous spindle matrix orchestrates cell division. Nat Rev Mol Cell Biol (2010) 1.39
The nuclear envelope: form and reformation. Curr Opin Cell Biol (2005) 1.37
The nuclear pore complex-associated protein, Mlp2p, binds to the yeast spindle pole body and promotes its efficient assembly. J Cell Biol (2005) 1.33
Lis1 and Ndel1 influence the timing of nuclear envelope breakdown in neural stem cells. J Cell Biol (2008) 1.25
The life cycle of the metazoan nuclear envelope. Curr Opin Cell Biol (2008) 1.24
Role of the endoplasmic reticulum chaperone BiP, SUN domain proteins, and dynein in altering nuclear morphology during human cytomegalovirus infection. J Virol (2010) 1.18
Endoplasmic reticulum positioning and partitioning in mitotic HeLa cells. J Anat (2005) 1.18
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A novel mechanism of nuclear envelope break-down in a fungus: nuclear migration strips off the envelope. EMBO J (2005) 1.15
An in vitro nuclear disassembly system reveals a role for the RanGTPase system and microtubule-dependent steps in nuclear envelope breakdown. J Cell Biol (2007) 1.15
Cytoskeletal influences on nuclear shape in granulocytic HL-60 cells. BMC Cell Biol (2004) 1.14
Dynein recruitment to nuclear pores activates apical nuclear migration and mitotic entry in brain progenitor cells. Cell (2013) 1.13
Dissociation of heterochromatin protein 1 from lamin B receptor induced by human polyomavirus agnoprotein: role in nuclear egress of viral particles. EMBO Rep (2005) 1.10
TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation. Proc Natl Acad Sci U S A (2003) 1.09
Polo-like kinase 1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase. Proc Natl Acad Sci U S A (2010) 1.07
Dynamics of coronavirus replication-transcription complexes. J Virol (2009) 1.07
Nuclear envelope breakdown is coordinated by both Nup358/RanBP2 and Nup153, two nucleoporins with zinc finger modules. Mol Biol Cell (2005) 1.06
Gold-nanoparticle-assisted laser perturbation of chromatin assembly reveals unusual aspects of nuclear architecture within living cells. Biophys J (2007) 1.03
The human cytomegalovirus assembly compartment: a masterpiece of viral manipulation of cellular processes that facilitates assembly and egress. PLoS Pathog (2012) 1.02
The function of spliceosome components in open mitosis. Nucleus (2010) 1.01
SUN proteins facilitate the removal of membranes from chromatin during nuclear envelope breakdown. J Cell Biol (2014) 1.00
Fission yeast Pcp1 links polo kinase-mediated mitotic entry to gamma-tubulin-dependent spindle formation. EMBO J (2009) 1.00
Mitotic lamin disassembly is triggered by lipid-mediated signaling. J Cell Biol (2012) 1.00
Nuclear envelope irregularity is induced by RET/PTC during interphase. Am J Pathol (2003) 0.98
Double duty for nuclear proteins--the price of more open forms of mitosis. Trends Genet (2009) 0.98
Microtubule-nucleus interactions in Dictyostelium discoideum mediated by central motor kinesins. Eukaryot Cell (2009) 0.93
Dynamic rearrangement of nucleoporins during fungal "open" mitosis. Mol Biol Cell (2008) 0.93
Regulation of dynein localization and centrosome positioning by Lis-1 and asunder during Drosophila spermatogenesis. Development (2012) 0.92
Localized accumulation of tubulin during semi-open mitosis in the Caenorhabditis elegans embryo. Mol Biol Cell (2012) 0.92
DNA damage triggers p21WAF1-dependent Emi1 down-regulation that maintains G2 arrest. Mol Biol Cell (2009) 0.91
Parvoviruses cause nuclear envelope breakdown by activating key enzymes of mitosis. PLoS Pathog (2013) 0.90
Mapping of sequences in Pseudorabies virus pUL34 that are required for formation and function of the nuclear egress complex. J Virol (2013) 0.89
Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase. J Cell Sci (2009) 0.89
Cdk1 Activates Pre-mitotic Nuclear Envelope Dynein Recruitment and Apical Nuclear Migration in Neural Stem Cells. Dev Cell (2015) 0.88
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Structural determinants for nuclear envelope localization and function of pseudorabies virus pUL34. J Virol (2011) 0.87
Chromosome shattering: a mitotic catastrophe due to chromosome condensation failure. Eur Biophys J (2009) 0.86
Time-lapse imaging of mitosis after siRNA transfection. J Vis Exp (2010) 0.86
Pre-M phase-promoting factor associates with annulate lamellae in Xenopus oocytes and egg extracts. Mol Biol Cell (2003) 0.85
Remodeling of the Nuclear Envelope and Lamina during Bovine Preimplantation Development and Its Functional Implications. PLoS One (2015) 0.85
The nucleoporin Nup205/NPP-3 is lost near centrosomes at mitotic onset and can modulate the timing of this process in Caenorhabditis elegans embryos. Mol Biol Cell (2012) 0.85
NPP-16/Nup50 function and CDK-1 inactivation are associated with anoxia-induced prophase arrest in Caenorhabditis elegans. Mol Biol Cell (2010) 0.85
Nuclear envelope rupture is induced by actin-based nucleus confinement. J Cell Biol (2016) 0.85
Function and regulation of dynein in mitotic chromosome segregation. Chromosoma (2014) 0.84
Mitotic kinase cascades orchestrating timely disjunction and movement of centrosomes maintain chromosomal stability and prevent cancer. Chromosome Res (2016) 0.84
Nuclear pore disassembly from endoplasmic reticulum membranes promotes Ca2+ signalling competency. J Physiol (2008) 0.84
Temporal control of nuclear envelope assembly by phosphorylation of lamin B receptor. Mol Biol Cell (2011) 0.84
A kinesin-mediated mechanism that couples centrosomes to nuclei. Cell Mol Life Sci (2012) 0.83
Dynein at the nuclear envelope. EMBO Rep (2010) 0.83
Caspase-8 cleaves its substrates from the plasma membrane upon CD95-induced apoptosis. Cell Death Differ (2013) 0.83
Volume regulation and shape bifurcation in the cell nucleus. J Cell Sci (2015) 0.83
The nuclear envelope in the plant cell cycle: structure, function and regulation. Ann Bot (2011) 0.82
Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry. Mol Biol Cell (2012) 0.82
Mitotic phosphorylation of SUN1 loosens its connection with the nuclear lamina while the LINC complex remains intact. Nucleus (2014) 0.82
Functional analysis of centrosomal kinase substrates in Drosophila melanogaster reveals a new function of the nuclear envelope component otefin in cell cycle progression. Mol Cell Biol (2012) 0.82
Multiple requirements of PLK1 during mouse oocyte maturation. PLoS One (2015) 0.81
A molecular dissection of nuclear function. Conference on the dynamic nucleus: questions and implications. EMBO Rep (2003) 0.81
The overexpression of nuclear envelope protein Lap2β induces endoplasmic reticulum reorganisation via membrane stacking. Biol Open (2012) 0.80
Mitotic defects lead to pervasive aneuploidy and accompany loss of RB1 activity in mouse LmnaDhe dermal fibroblasts. PLoS One (2011) 0.80
Centrosome maturation requires YB-1 to regulate dynamic instability of microtubules for nucleus reassembly. Sci Rep (2015) 0.79
Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Mol Biol Cell (2013) 0.79
Divergence of mitotic strategies in fission yeasts. Nucleus (2012) 0.79
Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope. Cell Res (2013) 0.78
The different function of single phosphorylation sites of Drosophila melanogaster lamin Dm and lamin C. PLoS One (2012) 0.78
Uncovering buffered pleiotropy: a genome-scale screen for mel-28 genetic interactors in Caenorhabditis elegans. G3 (Bethesda) (2014) 0.78
Signatures of mutational processes in human cancer. Nature (2013) 21.63
International network of cancer genome projects. Nature (2010) 20.35
Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature (2010) 9.95
Systemic spread is an early step in breast cancer. Cancer Cell (2008) 7.91
The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nat Biotechnol (2010) 7.08
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell (2009) 6.89
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. Cell (2012) 6.07
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
High-throughput RNAi screening by time-lapse imaging of live human cells. Nat Methods (2006) 4.86
From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression. Proc Natl Acad Sci U S A (2003) 4.79
Dissecting the genomic complexity underlying medulloblastoma. Nature (2012) 4.77
Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science (2010) 4.69
Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling. Mol Cell (2003) 4.67
The quantitative proteome of a human cell line. Mol Syst Biol (2011) 4.57
Customized oligonucleotide microarray gene expression-based classification of neuroblastoma patients outperforms current clinical risk stratification. J Clin Oncol (2006) 4.35
Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes. PLoS Biol (2005) 4.33
Visualization of image data from cells to organisms. Nat Methods (2010) 3.66
Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation. Nat Cell Biol (2006) 3.66
Mapping the dynamic organization of the nuclear pore complex inside single living cells. Nat Cell Biol (2004) 3.62
Roles of polo-like kinase 1 in the assembly of functional mitotic spindles. Curr Biol (2004) 3.29
Global chromosome positions are transmitted through mitosis in mammalian cells. Cell (2003) 3.27
Automatic identification of subcellular phenotypes on human cell arrays. Genome Res (2004) 3.25
Distinct functions of condensin I and II in mitotic chromosome assembly. J Cell Sci (2004) 3.14
Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit. Nat Struct Mol Biol (2007) 3.13
High-throughput fluorescence microscopy for systems biology. Nat Rev Mol Cell Biol (2006) 3.08
Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer. Cancer Cell (2013) 3.08
Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles. Proc Natl Acad Sci U S A (2002) 3.05
Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Cell Host Microbe (2011) 3.05
Self-organization of MTOCs replaces centrosome function during acentrosomal spindle assembly in live mouse oocytes. Cell (2007) 2.99
CellCognition: time-resolved phenotype annotation in high-throughput live cell imaging. Nat Methods (2010) 2.93
Complete kinetochore tracking reveals error-prone homologous chromosome biorientation in mammalian oocytes. Cell (2011) 2.89
Molecular crowding affects diffusion and binding of nuclear proteins in heterochromatin and reveals the fractal organization of chromatin. EMBO J (2009) 2.78
Condensin I stabilizes chromosomes mechanically through a dynamic interaction in live cells. Curr Biol (2006) 2.69
The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis. Mol Biol Cell (2004) 2.63
Live-cell imaging reveals a stable cohesin-chromatin interaction after but not before DNA replication. Curr Biol (2006) 2.47
A contractile nuclear actin network drives chromosome congression in oocytes. Nature (2005) 2.45
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nat Genet (2013) 2.42
Omic data from evolved E. coli are consistent with computed optimal growth from genome-scale models. Mol Syst Biol (2010) 2.41
Group testing for pathway analysis improves comparability of different microarray datasets. Bioinformatics (2006) 2.37
Cross-platform analysis of cancer microarray data improves gene expression based classification of phenotypes. BMC Bioinformatics (2005) 2.36
A new model for asymmetric spindle positioning in mouse oocytes. Curr Biol (2008) 2.32
Transport through the Golgi apparatus by rapid partitioning within a two-phase membrane system. Cell (2008) 2.30
Systematic kinetic analysis of mitotic dis- and reassembly of the nuclear pore in living cells. J Cell Biol (2008) 2.30
Argonaute--a database for gene regulation by mammalian microRNAs. Nucleic Acids Res (2006) 2.26
The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development. J Cell Biol (2012) 2.18
Regulation of sister chromatid cohesion between chromosome arms. Curr Biol (2004) 2.16
NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization. J Cell Biol (2003) 2.13
Reverse transfection on cell arrays for high content screening microscopy. Nat Protoc (2007) 2.09
Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. Nat Genet (2012) 2.07
Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer. Cancer Cell (2005) 2.03
Maximal chromosome compaction occurs by axial shortening in anaphase and depends on Aurora kinase. Nat Cell Biol (2007) 2.00
Visualizing telomere dynamics in living mammalian cells using PNA probes. EMBO J (2003) 1.99
Quantitative kinetic analysis of nucleolar breakdown and reassembly during mitosis in live human cells. J Cell Biol (2004) 1.98
Resolution of chiasmata in oocytes requires separase-mediated proteolysis. Cell (2006) 1.96
Dissecting the contribution of diffusion and interactions to the mobility of nuclear proteins. Biophys J (2005) 1.94
Remodelling the walls of the nucleus. Nat Rev Mol Cell Biol (2002) 1.92
Wapl is an essential regulator of chromatin structure and chromosome segregation. Nature (2013) 1.92
Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway. Nat Cell Biol (2012) 1.88
Large-scale in silico modeling of metabolic interactions between cell types in the human brain. Nat Biotechnol (2010) 1.85
Nuclear pore scaffold structure analyzed by super-resolution microscopy and particle averaging. Science (2013) 1.80
CCM2 mediates death signaling by the TrkA receptor tyrosine kinase. Neuron (2009) 1.79
GOPET: a tool for automated predictions of Gene Ontology terms. BMC Bioinformatics (2006) 1.75
Dynamics of HIV-1 assembly and release. PLoS Pathog (2009) 1.67
Microarray-based copy number and expression profiling in dedifferentiated and pleomorphic liposarcoma. Cancer Res (2002) 1.64
Nuclear pore complex assembly through the cell cycle: regulation and membrane organization. FEBS Lett (2008) 1.63
Prediction of clinical outcome and biological characterization of neuroblastoma by expression profiling. Oncogene (2005) 1.62
Etiology-dependent molecular mechanisms in human hepatocarcinogenesis. Hepatology (2008) 1.62
LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly. J Cell Sci (2004) 1.61
Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus. Nat Cell Biol (2002) 1.60
Micropilot: automation of fluorescence microscopy-based imaging for systems biology. Nat Methods (2011) 1.59
Dynamics within the CD95 death-inducing signaling complex decide life and death of cells. Mol Syst Biol (2010) 1.57
Integration of activating and inhibitory receptor signaling by regulated phosphorylation of Vav1 in immune cells. Sci Signal (2011) 1.57
LambdaN-GFP: an RNA reporter system for live-cell imaging. Nat Methods (2007) 1.56
Analysis of CD95 threshold signaling: triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling. J Biol Chem (2007) 1.55
Genome-wide transcriptional analysis of the human cell cycle identifies genes differentially regulated in normal and cancer cells. Proc Natl Acad Sci U S A (2008) 1.53
Nuclear envelope breakdown in starfish oocytes proceeds by partial NPC disassembly followed by a rapidly spreading fenestration of nuclear membranes. J Cell Biol (2003) 1.52
Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy. BMC Biol (2011) 1.51
A highly standardized, robust, and cost-effective method for genome-wide transcriptome analysis of peripheral blood applicable to large-scale clinical trials. Genomics (2006) 1.51