Published in J Exp Med on August 25, 2003
HLA class I supertypes: a revised and updated classification. BMC Immunol (2008) 3.47
HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium. Diabetes (2010) 1.62
Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition. J Exp Med (2009) 1.45
Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion. J Exp Med (2004) 1.43
Dual, HLA-B27 subtype-dependent conformation of a self-peptide. J Exp Med (2004) 1.31
HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control. J Virol (2011) 1.31
The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation. J Exp Med (2005) 1.28
Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides. Proc Natl Acad Sci U S A (2008) 1.24
Effect of MHC and non-MHC donor/recipient genetic disparity on the outcome of allogeneic HCT. Blood (2012) 1.22
Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface. Proc Natl Acad Sci U S A (2005) 1.20
Detecting site-specific physicochemical selective pressures: applications to the Class I HLA of the human major histocompatibility complex and the SRK of the plant sporophytic self-incompatibility system. J Mol Evol (2005) 1.19
Allelic polymorphism in the T cell receptor and its impact on immune responses. J Exp Med (2010) 1.18
Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition. Proc Natl Acad Sci U S A (2010) 1.13
A shared epitope of the interphotoreceptor retinoid-binding protein recognized by the CD4+ and CD8+ autoreactive T cells. J Immunol (2005) 1.04
HIV control through a single nucleotide on the HLA-B locus. J Virol (2012) 1.00
Comparative molecular dynamics analysis of tapasin-dependent and -independent MHC class I alleles. Protein Sci (2007) 0.99
Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy. Proc Natl Acad Sci U S A (2008) 0.95
A comparative approach linking molecular dynamics of altered peptide ligands and MHC with in vivo immune responses. PLoS One (2010) 0.94
Distinct assembly profiles of HLA-B molecules. J Immunol (2014) 0.89
Therapeutic Vaccine Strategies against Human Papillomavirus. Vaccines (Basel) (2014) 0.89
A single amino-acid polymorphism in pocket A of HLA-A*6602 alters the auxiliary anchors compared with HLA-A*6601 ligands. Immunogenetics (2004) 0.85
Position 156 influences the peptide repertoire and tapasin dependency of human leukocyte antigen B*44 allotypes. Haematologica (2011) 0.84
Predicting alloreactivity in transplantation. J Immunol Res (2014) 0.84
Selector function of MHC I molecules is determined by protein plasticity. Sci Rep (2015) 0.84
Sequence 168 to 177 of interphotoreceptor retinoid-binding protein (IRBP) is an antigenic epitope for autoreactive CD8 T cells in the B10RIII mouse. J Neuroimmunol (2007) 0.83
Increased diversity of the HLA-B40 ligandome by the presentation of peptides phosphorylated at their main anchor residue. Mol Cell Proteomics (2013) 0.83
Purification, crystallization and preliminary X-ray diffraction analysis of the human major histocompatibility antigen HLA-B*2703 complexed with a viral peptide and with a self-peptide. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.83
Preliminary X-ray diffraction analysis of crystals from the recombinantly expressed human major histocompatibility antigen HLA-B*2704 in complex with a viral peptide and with a self-peptide. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.81
Residue 81 confers a restricted C-terminal peptide binding motif in HLA-B*44:09. Immunogenetics (2012) 0.81
KIR-HLA-A and B alleles of the Bw4 epitope against HIV infection in discordant heterosexual couples in Chaco Argentina. Immunology (2013) 0.81
The structure and stability of the monomorphic HLA-G are influenced by the nature of the bound peptide. J Mol Biol (2010) 0.81
The production, purification and crystallization of a soluble form of the nonclassical MHC HLA-G: the essential role of cobalt. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.80
The diversity of the HLA-E-restricted peptide repertoire explains the immunological impact of the Arg107Gly mismatch. Immunogenetics (2015) 0.80
Position 45 influences the peptide binding motif of HLA-B*44:08. Immunogenetics (2011) 0.80
Molecular mechanism of peptide editing in the tapasin-MHC I complex. Sci Rep (2016) 0.80
A molecular basis for the interplay between T cells, viral mutants, and human leukocyte antigen micropolymorphism. J Biol Chem (2014) 0.79
The versatility of the αβ T-cell antigen receptor. Protein Sci (2014) 0.79
Cross-reactive anti-viral T cells increase prior to an episode of viral reactivation post human lung transplantation. PLoS One (2013) 0.78
Molecular docking analysis of 2009-H1N1 and 2004-H5N1 influenza virus HLA-B*4405-restricted HA epitope candidates: implications for TCR cross-recognition and vaccine development. BMC Bioinformatics (2013) 0.78
Soluble HLA technology as a strategy to evaluate the impact of HLA mismatches. J Immunol Res (2014) 0.78
Zooming into the binding groove of HLA molecules: which positions and which substitutions change peptide binding most? Immunogenetics (2015) 0.78
The same major histocompatibility complex polymorphism involved in control of HIV influences peptide binding in the mouse H-2Ld system. J Biol Chem (2013) 0.77
Proofreading of Peptide-MHC Complexes through Dynamic Multivalent Interactions. Front Immunol (2017) 0.76
The cellular redox environment alters antigen presentation. J Biol Chem (2014) 0.76
Peptide-binding motif of HLA-A*6603. Immunogenetics (2004) 0.76
Partial Dissociation of Truncated Peptides Influences the Structural Dynamics of the MHCI Binding Groove. Front Immunol (2017) 0.75
A Micropolymorphism Altering the Residue Triad 97/114/156 Determines the Relative Levels of Tapasin Independence and Distinct Peptide Profiles for HLA-A(*)24 Allotypes. J Immunol Res (2014) 0.75
Cross-Reactivity of TCR Repertoire: Current Concepts, Challenges, and Implication for Allotransplantation. Front Immunol (2016) 0.75
Assessment of the amino acid substitution in HLA-B*5719 for allorecognition. Tissue Antigens (2009) 0.75
MFPred: Rapid and accurate prediction of protein-peptide recognition multispecificity using self-consistent mean field theory. PLoS Comput Biol (2017) 0.75
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63
Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis (1999) 45.01
The finer things in X-ray diffraction data collection. Acta Crystallogr D Biol Crystallogr (1999) 19.10
Common west African HLA antigens are associated with protection from severe malaria. Nature (1991) 9.43
Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism. Immunogenetics (1999) 4.88
Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution. J Mol Biol (1991) 4.44
Specificity pockets for the side chains of peptide antigens in HLA-Aw68. Nature (1989) 4.34
The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation. Nature (1991) 3.84
Population biology of antigen presentation by MHC class I molecules. Science (1996) 3.58
Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense. Science (2002) 2.61
Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus. J Exp Med (1994) 2.47
Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat Immunol (2001) 2.34
Murine major histocompatibility complex class-I mutants: molecular analysis and structure-function implications. Annu Rev Immunol (1986) 2.29
The HLA-A,B "negative" mutant cell line C1R expresses a novel HLA-B35 allele, which also has a point mutation in the translation initiation codon. J Immunol (1992) 2.27
An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: implications for graft-versus-host disease. J Exp Med (1994) 2.02
Evidence that multiple residues on both the alpha-helices of the class I MHC molecule are simultaneously recognized by the T cell receptor. Cell (1988) 1.77
Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice. Immunity (2000) 1.77
On the nature of peptides involved in T cell alloreactivity. J Exp Med (1991) 1.75
Differential transport requirements of HLA and H-2 class I glycoproteins. Immunogenetics (1989) 1.67
CD8 CTL from genital herpes simplex lesions: recognition of viral tegument and immediate early proteins and lysis of infected cutaneous cells. J Immunol (2001) 1.60
T cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility complex antigen. J Exp Med (1995) 1.56
Polymorphism in the alpha 1 helix of the HLA-B heavy chain can have an overriding influence on peptide-binding specificity. J Immunol (1997) 1.52
Cytotoxic T lymphocyte response and viral load in hepatitis C virus infection. Hepatology (1997) 1.40
Bone marrow-allograft rejection by T lymphocytes recognizing a single amino acid difference in HLA-B44. N Engl J Med (1990) 1.38
HLA B44-restricted cytotoxic T lymphocytes recognizing an epitope on hepatitis C virus nucleocapsid protein. Hepatology (1993) 1.36
Overlap in the repertoires of peptides bound in vivo by a group of related class I HLA-B allotypes. Curr Biol (1995) 1.31
Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53. Immunity (1996) 1.27
Quantitative and qualitative influences of tapasin on the class I peptide repertoire. J Immunol (2001) 1.27
Alloreactive T cells discriminate among a diverse set of endogenous peptides. Proc Natl Acad Sci U S A (1991) 1.25
Identification of the peptide binding motif for HLA-B44, one of the most common HLA-B alleles in the Caucasian population. Biochemistry (1995) 1.20
Characterization of natural peptide ligands for HLA-B*4402 and -B*4403: implications for peptide involvement in allorecognition of a single amino acid change in the HLA-B44 heavy chain. Tissue Antigens (1994) 1.19
HLA-A2 subtypes are functionally distinct in peptide binding and presentation. J Exp Med (1995) 1.14
HLA-B27 subtypes differentially associated with disease exhibit subtle structural alterations. J Biol Chem (2002) 1.13
Decamer-like conformation of a nona-peptide bound to HLA-B*3501 due to non-standard positioning of the C terminus. J Mol Biol (1999) 1.10
A tyrosinase nonapeptide presented by HLA-B44 is recognized on a human melanoma by autologous cytolytic T lymphocytes. Eur J Immunol (1996) 1.08
Differential association of HLA-B*2705 and B*2709 to ankylosing spondylitis correlates with limited peptide subsets but not with altered cell surface stability. J Biol Chem (2002) 1.07
Herpes simplex virus type 2-specific CD8 cytotoxic T lymphocyte cross-reactivity against prevalent HLA class I alleles. Blood (2002) 1.06
HLA-B27 and the pathogenesis of spondyloarthritis. Tissue Antigens (2002) 1.05
Identification of a dominant self-ligand bound to three HLA B44 alleles and the preliminary crystallographic analysis of recombinant forms of each complex. FEBS Lett (2002) 1.02
Recognition of a B cell leukemia-associated minor histocompatibility antigen by CTL. J Immunol (1997) 0.97
Identification by site-directed mutagenesis of amino acid residues contributing to serologic and CTL-defined epitope differences between HLA-A2.1 and HLA-A2.3. J Immunol (1988) 0.96
HLA-B15 peptide ligands are preferentially anchored at their C termini. J Immunol (1999) 0.96
Analysis of mutant HLA-A2 molecules. Differential effects on peptide binding and CTL recognition. J Immunol (1994) 0.96
The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity. Immunity (2001) 0.95
HLA-B44-directed cytotoxic T cells associated with acute graft-versus-host disease following unrelated bone marrow transplantation. Bone Marrow Transplant (1994) 0.94
Alloreactivity: allogeneic presentation of endogenous peptide or direct recognition of MHC polymorphism? A review. Tissue Antigens (1990) 0.93
MHC polymorphism can enrich the T cell repertoire of the species by shifts in intrathymic selection. J Immunol (2000) 0.92
Hierarchy of Epstein-Barr virus-specific cytotoxic T-cell responses in individuals carrying different subtypes of an HLA allele: implications for epitope-based antiviral vaccines. J Virol (1997) 0.90
Saturation mutagenesis of a major histocompatibility complex protein domain: identification of a single conserved amino acid important for allorecognition. Proc Natl Acad Sci U S A (1988) 0.90
The peptide binding specificity of HLA-B27 subtypes. Immunogenetics (1994) 0.89
A peptide encoded by the human MAGE3 gene and presented by HLA-B44 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE3. Immunogenetics (1996) 0.89
Peptide-presenting similarities among functionally distant HLA-B27 subtypes revealed by alloreactive T lymphocytes of unusual specificity. J Immunol (1992) 0.87
HLA B44-restricted cytotoxic T lymphocyte responses to the peptides of HCV nucleoprotein residues 81-100 in patients with chronic hepatitis C. J Gastroenterol (1995) 0.86
Human leukocyte antigen phenotype imposes complex constraints on the antigen-specific cytotoxic T lymphocyte repertoire. Eur J Immunol (1997) 0.86
Differences in the recognition by CTL of peptides presented by the HLA-B*4402 and the HLA-B*4403 molecules which differ by a single amino acid. Tissue Antigens (1999) 0.84
Identification of HLA-B44 subtypes associated with extended MHC haplotypes. Immunogenetics (1987) 0.83
Characterization of antigenic peptides presented by HLA-B44 molecules on tumor cells expressing the gene MAGE-3. Int J Cancer (1996) 0.82
HLA-B44 subtypes and the chance of finding HLA compatible donor/recipient pairs for bone marrow transplantation: a haplotype study of 303 Italian families. Tissue Antigens (1997) 0.82
High T cell epitope sharing between two HLA-B27 subtypes (B*2705 and B*2709) differentially associated to ankylosing spondylitis. J Immunol (1999) 0.81
The use of post-source decay in matrix-assisted laser desorption/ionisation mass spectrometry to delineate T cell determinants. J Immunol Methods (2001) 0.81
Changes in the repertoire of peptides bound to HLA-B27 subtypes and to site-specific mutants inside and outside pocket B. J Exp Med (1993) 0.80
The World Wide Web as a graphical user interface to program macros for molecular graphics, molecular modeling, and structure-based drug design. J Mol Graph (1996) 0.80
HLA-B44-restricted minor antigen. Transplantation (1995) 0.78
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science (2002) 8.27
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev (2002) 7.08
Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science (2005) 5.49
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat Genet (2006) 5.36
CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor. Nature (2007) 5.31
Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha. Cell (2002) 4.92
Linear ubiquitination prevents inflammation and regulates immune signalling. Nature (2011) 4.85
Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells. Nat Immunol (2009) 4.51
Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition. Nat Med (2009) 4.03
Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. Nat Genet (2010) 3.99
In-frame deletion in a novel centrosomal/ciliary protein CEP290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse. Hum Mol Genet (2006) 3.90
MR1 presents microbial vitamin B metabolites to MAIT cells. Nature (2012) 3.71
Cadherin 23 is a component of the tip link in hair-cell stereocilia. Nature (2004) 3.69
Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation. J Exp Med (2007) 3.66
AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP. Nature (2006) 3.65
Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin. Nat Genet (2005) 3.55
Protein composition of catalytically active human telomerase from immortal cells. Science (2007) 3.53
A common fold mediates vertebrate defense and bacterial attack. Science (2007) 3.43
A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity. Immunity (2003) 3.41
Different patterns of peripheral migration by memory CD4+ and CD8+ T cells. Nature (2011) 3.38
The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors. Mol Cell (2003) 3.20
Germline-encoded recognition of diverse glycolipids by natural killer T cells. Nat Immunol (2007) 3.19
Structural determinants of T-cell receptor bias in immunity. Nat Rev Immunol (2006) 3.01
Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria. Neuron (2004) 2.94
Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'. Nat Immunol (2007) 2.78
More than one reason to rethink the use of peptides in vaccine design. Nat Rev Drug Discov (2007) 2.68
Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptors. Immunity (2009) 2.61
A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule. Nat Immunol (2007) 2.55
Standard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trials. Lancet (2012) 2.54
T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide. Nat Immunol (2005) 2.52
Transcriptome-wide studies of merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival. J Clin Oncol (2011) 2.52
Cone-like morphological, molecular, and electrophysiological features of the photoreceptors of the Nrl knockout mouse. Invest Ophthalmol Vis Sci (2005) 2.51
Immune self-reactivity triggered by drug-modified HLA-peptide repertoire. Nature (2012) 2.46
Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations. Nat Immunol (2005) 2.44
Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors. Nat Immunol (2011) 2.42
The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor. Blood (2005) 2.41
Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice. J Clin Invest (2008) 2.40
Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection. Nature (2013) 2.38
The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition. Nat Immunol (2005) 2.38
The power of social networking in medicine. Nat Biotechnol (2009) 2.37
The molecular basis of TCR germline bias for MHC is surprisingly simple. Nat Immunol (2009) 2.34
Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection. J Infect Dis (2007) 2.33
Autoreactive T cells in healthy individuals. J Immunol (2004) 2.29
Progression of armed CTL from draining lymph node to spleen shortly after localized infection with herpes simplex virus 1. J Immunol (2002) 2.29
Neutrophils ameliorate lung injury and the development of severe disease during influenza infection. J Immunol (2009) 2.28
T cell allorecognition via molecular mimicry. Immunity (2009) 2.25
Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. J Clin Invest (2008) 2.24
The 2.0-A crystal structure of eqFP611, a far red fluorescent protein from the sea anemone Entacmaea quadricolor. J Biol Chem (2003) 2.23
Structure of the insulin receptor ectodomain reveals a folded-over conformation. Nature (2006) 2.22
Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant. Proc Natl Acad Sci U S A (2004) 2.15
Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin. Nature (2008) 2.11
A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells. Immunity (2011) 2.11
The shaping of T cell receptor recognition by self-tolerance. Immunity (2009) 2.06