Published in Biochem Biophys Res Commun on September 12, 2003
An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis. Immunity (2013) 1.35
IL-17-induced NF-kappaB activation via CIKS/Act1: physiologic significance and signaling mechanisms. J Biol Chem (2011) 1.16
Inhibitory kappa B Kinases as targets for pharmacological regulation. Br J Pharmacol (2012) 1.14
A protein secreted by the respiratory pathogen Chlamydia pneumoniae impairs IL-17 signalling via interaction with human Act1. Cell Microbiol (2009) 1.07
CIKS (Act1 or TRAF3IP2) mediates Angiotensin-II-induced Interleukin-18 expression, and Nox2-dependent cardiomyocyte hypertrophy. J Mol Cell Cardiol (2012) 1.06
A CC' loop decoy peptide blocks the interaction between Act1 and IL-17RA to attenuate IL-17- and IL-25-induced inflammation. Sci Signal (2011) 0.98
A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis. J Exp Med (2015) 0.93
The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis. Biochem J (2004) 0.88
Crystal structure of IL-17 receptor B SEFIR domain. J Immunol (2013) 0.85
A custom 148 gene-based resequencing chip and the SNP explorer software: new tools to study antibody deficiency. Hum Mutat (2010) 0.81
CIKS/DDX3X interaction controls the stability of the Zc3h12a mRNA induced by IL-17. J Immunol (2015) 0.79
A Novel Nuclear Function for the Interleukin-17 Signaling Adaptor Protein Act1. PLoS One (2016) 0.75
Dual role of Act1 in keratinocyte differentiation and host defense: TRAF3IP2 silencing alters keratinocyte differentiation while inhibiting IL-17 responses. J Invest Dermatol (2017) 0.75
Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. Trends Biochem Sci (2005) 5.01
Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin. Cell (2009) 3.80
Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated? Trends Biochem Sci (2008) 2.08
Transcription impairment and cell migration defects in elongator-depleted cells: implication for familial dysautonomia. Mol Cell (2006) 2.02
ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB. J Biol Chem (2006) 1.91
The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation. J Immunol (2009) 1.76
NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells. Oncogene (2003) 1.71
APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. Mol Cell Biol (2009) 1.58
NF-kappaB in solid tumors. Biochem Pharmacol (2006) 1.57
Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. J Biol Chem (2002) 1.55
NF-κB, stem cells and breast cancer: the links get stronger. Breast Cancer Res (2011) 1.51
Cytoplasmic IkappaBalpha increases NF-kappaB-independent transcription through binding to histone deacetylase (HDAC) 1 and HDAC3. J Biol Chem (2003) 1.47
The adipokine visfatin induces tissue factor expression in human coronary artery endothelial cells: another piece in the adipokines puzzle. Thromb Res (2012) 1.45
GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity. Mol Cell (2004) 1.42
Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). J Biol Chem (2001) 1.40
The neutrophil gelatinase-associated lipocalin (NGAL), a NF-kappaB-regulated gene, is a survival factor for thyroid neoplastic cells. Proc Natl Acad Sci U S A (2008) 1.35
Oncogenic and anti-apoptotic activity of NF-kappa B in human thyroid carcinomas. J Biol Chem (2004) 1.32
Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF. J Biol Chem (2007) 1.30
Role of NF-kappaB in thyroid cancer. Mol Cell Endocrinol (2009) 1.21
Nuclear factor-{kappa}B contributes to anaplastic thyroid carcinomas through up-regulation of miR-146a. J Clin Endocrinol Metab (2010) 1.20
A20 is a negative regulator of BCL10- and CARMA3-mediated activation of NF-kappaB. J Cell Sci (2008) 1.18
Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-κB activation and endoplasmic reticulum stress-induced cell death. J Cell Physiol (2011) 1.14
Molecular layers underlying cytoskeletal remodelling during cortical development. Trends Neurosci (2009) 1.14
Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator. J Biol Chem (2004) 1.12
DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. Nature (2012) 1.11
Decrease of Bcl-xL and augmentation of thymocyte apoptosis in GILZ overexpressing transgenic mice. Blood (2004) 1.10
Elongator - an emerging role in neurological disorders. Trends Mol Med (2009) 1.10
The emerging role of lysine acetylation of non-nuclear proteins. Cell Mol Life Sci (2010) 1.07
TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation. J Biol Chem (2011) 1.05
Novel toll-like receptor 9 agonist induces epidermal growth factor receptor (EGFR) inhibition and synergistic antitumor activity with EGFR inhibitors. Clin Cancer Res (2006) 1.05
Central role of the scaffold protein tumor necrosis factor receptor-associated factor 2 in regulating endoplasmic reticulum stress-induced apoptosis. J Biol Chem (2005) 1.05
p27(Kip1) is a microtubule-associated protein that promotes microtubule polymerization during neuron migration. Dev Cell (2012) 1.05
Potentiation of tumor necrosis factor-induced NF-kappa B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha. Mol Cell Biol (2003) 1.04
Deregulated NF-kappaB activity in haematological malignancies. Biochem Pharmacol (2006) 1.04
Thyroglobulin as an autoantigen: what can we learn about immunopathogenicity from the correlation of antigenic properties with protein structure? Immunology (2004) 1.03
Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways. Biochem Pharmacol (2007) 1.02
Promoter-dependent effect of IKKalpha on NF-kappaB/p65 DNA binding. J Biol Chem (2007) 1.01
The repressing function of the oncoprotein BCL-3 requires CtBP, while its polyubiquitination and degradation involve the E3 ligase TBLR1. Mol Cell Biol (2010) 1.00
Thermal stability and aggregation of sulfolobus solfataricus beta-glycosidase are dependent upon the N-epsilon-methylation of specific lysyl residues: critical role of in vivo post-translational modifications. J Biol Chem (2003) 0.99
TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation. FEBS Lett (2002) 0.99
TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activation. Biochem J (2006) 0.99
Folding of thyroglobulin in the calnexin/calreticulin pathway and its alteration by loss of Ca2+ from the endoplasmic reticulum. Biochem J (2003) 0.98
Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15. J Biol Chem (2004) 0.98
Regulation of HER-2 oncogene expression by cyclooxygenase-2 and prostaglandin E2. Oncogene (2004) 0.97
Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling. J Biol Chem (2004) 0.96
The intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing. J Alzheimers Dis (2004) 0.93
A phase 1-2, prospective, double blind, randomized study of the safety and efficacy of Sulfasalazine for the treatment of progressing malignant gliomas: study protocol of [ISRCTN45828668]. BMC Cancer (2006) 0.91
The two isoforms of the Na+/Ca2+ exchanger, NCX1 and NCX3, constitute novel additional targets for the prosurvival action of Akt/protein kinase B pathway. Mol Pharmacol (2007) 0.91
Induction of the alternative NF-κB pathway by lymphotoxin αβ (LTαβ) relies on internalization of LTβ receptor. Mol Cell Biol (2011) 0.90
The seventh ring: exploring TRAF7 functions. J Cell Physiol (2012) 0.90
TNF receptor-associated factor 1 is a positive regulator of the NF-kappaB alternative pathway. Mol Immunol (2009) 0.89
RbAp48 is a target of nuclear factor-kappaB activity in thyroid cancer. J Clin Endocrinol Metab (2007) 0.89
Endoplasmic reticulum stress causes thyroglobulin retention in this organelle and triggers activation of nuclear factor-kappa B via tumor necrosis factor receptor-associated factor 2. Endocrinology (2002) 0.89
TRAF2 and p38 are involved in B cells CD40-mediated APE/Ref-1 nuclear translocation: a novel pathway in B cell activation. Mol Immunol (2007) 0.88
DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator. J Biol Chem (2012) 0.88
Raloxifene-induced myeloma cell apoptosis: a study of nuclear factor-kappaB inhibition and gene expression signature. Mol Pharmacol (2006) 0.87
BCL-3 degradation involves its polyubiquitination through a FBW7-independent pathway and its binding to the proteasome subunit PSMB1. J Biol Chem (2010) 0.87
Protection against Pseudomonas aeruginosa lung infection in mice by recombinant OprF-pulsed dendritic cell immunization. BMC Microbiol (2010) 0.86
NGAL controls the metastatic potential of anaplastic thyroid carcinoma cells. J Clin Endocrinol Metab (2012) 0.86
The three CARMA sisters: so different, so similar: a portrait of the three CARMA proteins and their involvement in human disorders. J Cell Physiol (2014) 0.86
Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells. Biochem Pharmacol (2008) 0.86
Exposure of HL-60 human leukaemic cells to 4-hydroxynonenal promotes the formation of adduct(s) with alpha-enolase devoid of plasminogen binding activity. Biochem J (2009) 0.85
Further insights in the mechanisms of interleukin-1beta stimulation of osteoprotegerin in osteoblast-like cells. J Bone Miner Res (2007) 0.85
Interleukin-6 receptor shedding is enhanced by interleukin-1beta and tumor necrosis factor alpha and is partially mediated by tumor necrosis factor alpha-converting enzyme in osteoblast-like cells. Arthritis Rheum (2005) 0.84
Generation and functional characterization of a BCL10-inhibitory peptide that represses NF-kappaB activation. Biochem J (2009) 0.84
Down-regulation of wild-type p53-induced phosphatase 1 (Wip1) plays a critical role in regulating several p53-dependent functions in premature senescent tumor cells. J Biol Chem (2013) 0.84