Published in J Biol Chem on August 01, 2012
Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine. J Exp Med (2015) 1.48
α-Tubulin acetylation elevated in metastatic and basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration. Cancer Res (2014) 0.96
Elongator, a conserved complex required for wobble uridine modifications in eukaryotes. RNA Biol (2014) 0.94
Ikbkap/Elp1 deficiency causes male infertility by disrupting meiotic progression. PLoS Genet (2013) 0.90
Elongator subunit 3 positively regulates plant immunity through its histone acetyltransferase and radical S-adenosylmethionine domains. BMC Plant Biol (2013) 0.81
Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer. J Exp Med (2016) 0.77
Elongator Protein 3 (Elp3) stabilizes Snail1 and regulates neural crest migration in Xenopus. Sci Rep (2016) 0.76
Developing and mature human granulocytes express ELP 6 in the cytoplasm. Hum Antibodies (2013) 0.75
Architecture of the yeast Elongator complex. EMBO Rep (2016) 0.75
Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell (2003) 10.42
Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature (2009) 7.04
Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. Mol Cell (1999) 4.49
Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo. Mol Cell (2002) 4.35
Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin. Cell (2009) 3.80
A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme. Mol Cell (1999) 3.80
Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia. Am J Hum Genet (2001) 3.27
An early step in wobble uridine tRNA modification requires the Elongator complex. RNA (2005) 3.01
Histone modifications defining active genes persist after transcriptional and mitotic inactivation. EMBO J (2004) 2.86
Familial dysautonomia is caused by mutations of the IKAP gene. Am J Hum Genet (2001) 2.67
Isolation and mass spectrometry of transcription factor complexes. Methods (2002) 2.46
Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo. Proc Natl Acad Sci U S A (2002) 2.27
Elevated levels of two tRNA species bypass the requirement for elongator complex in transcription and exocytosis. Mol Cell (2006) 2.22
Elongator interactions with nascent mRNA revealed by RNA immunoprecipitation. Mol Cell (2004) 2.16
Transcription impairment and cell migration defects in elongator-depleted cells: implication for familial dysautonomia. Mol Cell (2006) 2.02
Purification and characterization of the human elongator complex. J Biol Chem (2001) 1.97
Transcriptional inhibition of genes with severe histone h3 hypoacetylation in the coding region. Mol Cell (2002) 1.91
Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae. Mol Cell Biol (2001) 1.87
ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot. Neuron (2011) 1.83
Human Elongator facilitates RNA polymerase II transcription through chromatin. Proc Natl Acad Sci U S A (2002) 1.75
Elongator complex: how many roles does it play? Curr Opin Cell Biol (2007) 1.71
RNA polymerase II elongator holoenzyme is composed of two discrete subcomplexes. J Biol Chem (2001) 1.65
Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation. Mol Cell (2005) 1.64
Defects in tRNA modification associated with neurological and developmental dysfunctions in Caenorhabditis elegans elongator mutants. PLoS Genet (2009) 1.62
IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration. J Cell Sci (2008) 1.56
Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration. Hum Mol Genet (2008) 1.46
The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation. PLoS Genet (2010) 1.45
GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity. Mol Cell (2004) 1.42
Translational control of cell division by Elongator. Cell Rep (2012) 1.41
Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP. Mol Cell Biol (2008) 1.35
A genome-wide shRNA screen identifies GAS1 as a novel melanoma metastasis suppressor gene. Genes Dev (2008) 1.33
The elongator complex interacts with PCNA and modulates transcriptional silencing and sensitivity to DNA damage agents. PLoS Genet (2009) 1.32
A novel specific role for I kappa B kinase complex-associated protein in cytosolic stress signaling. J Biol Chem (2002) 1.31
Elongator complex influences telomeric gene silencing and DNA damage response by its role in wobble uridine tRNA modification. PLoS Genet (2011) 1.30
Elongator function in tRNA wobble uridine modification is conserved between yeast and plants. Mol Microbiol (2010) 1.27
The elongata mutants identify a functional Elongator complex in plants with a role in cell proliferation during organ growth. Proc Natl Acad Sci U S A (2005) 1.26
The Elp2 subunit of elongator and elongating RNA polymerase II holoenzyme is a WD40 repeat protein. J Biol Chem (2000) 1.13
DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. Nature (2012) 1.11
Elongator - an emerging role in neurological disorders. Trends Mol Med (2009) 1.10
An iron-sulfur cluster domain in Elp3 important for the structural integrity of elongator. J Biol Chem (2008) 1.08
Three-dimensional culture system as a model for studying cancer cell invasion capacity and anticancer drug sensitivity. Anticancer Res (2004) 1.04
A multiprotein complex that interacts with RNA polymerase II elongator. J Biol Chem (2001) 1.03
The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase. Nat Struct Mol Biol (2012) 1.02
Role of elongator subunit Elp3 in Drosophila melanogaster larval development and immunity. Genetics (2011) 1.01
Familial dysautonomia. Curr Opin Genet Dev (2002) 1.01
Olfactory stem cells, a new cellular model for studying molecular mechanisms underlying familial dysautonomia. PLoS One (2010) 0.98
Molecular architecture, structure-function relationship, and importance of the Elp3 subunit for the RNA binding of holo-elongator. J Biol Chem (2004) 0.95
Familial dysautonomia: update and recent advances. Curr Probl Pediatr Adolesc Health Care (2006) 0.94
Elongator, a conserved multitasking complex? Mol Microbiol (2010) 0.93
Crystal structure of elongator subcomplex Elp4-6. J Biol Chem (2012) 0.91
Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells. Biochem Pharmacol (2008) 0.86
Cloning and characterization of the human gene DERP6, which activates transcriptional activities of p53. Mol Biol Rep (2006) 0.79
Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling. Open Biol (2012) 0.77
Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. Trends Biochem Sci (2005) 5.01
Procalcitonin usefulness for the initiation of antibiotic treatment in intensive care unit patients. Crit Care Med (2012) 4.76
Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin. Cell (2009) 3.80
Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology of pyramidal neurons in the neocortex. Neuron (2005) 2.70
Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis. Neuron (2010) 2.54
Model of chemotherapy-induced myelosuppression with parameter consistency across drugs. J Clin Oncol (2002) 2.43
Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization. Invest Ophthalmol Vis Sci (2003) 2.20
Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Mol Cell (2011) 2.13
Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated? Trends Biochem Sci (2008) 2.08
Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif. Dev Cell (2006) 2.06
Transcription impairment and cell migration defects in elongator-depleted cells: implication for familial dysautonomia. Mol Cell (2006) 2.02
Neurogenin 2 controls cortical neuron migration through regulation of Rnd2. Nature (2008) 1.94
Coupling of cell migration with neurogenesis by proneural bHLH factors. Proc Natl Acad Sci U S A (2006) 1.87
A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin. Proc Natl Acad Sci U S A (2008) 1.86
The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation. J Immunol (2009) 1.76
NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells. Oncogene (2003) 1.71
A role for proneural genes in the maturation of cortical progenitor cells. Cereb Cortex (2006) 1.68
Characterization of the proneural gene regulatory network during mouse telencephalon development. BMC Biol (2008) 1.59
Proteomic mass spectra classification using decision tree based ensemble methods. Bioinformatics (2005) 1.52
NF-κB, stem cells and breast cancer: the links get stronger. Breast Cancer Res (2011) 1.51
Cystatin C blood level as a risk factor for death after heart surgery. Eur Heart J (2007) 1.48
Cytoplasmic IkappaBalpha increases NF-kappaB-independent transcription through binding to histone deacetylase (HDAC) 1 and HDAC3. J Biol Chem (2003) 1.47
Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning. Proc Natl Acad Sci U S A (2008) 1.47
GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity. Mol Cell (2004) 1.42
Is cystatin C useful for the detection and the estimation of low glomerular filtration rate in heart transplant patients? Transplantation (2007) 1.41
Measurement uncertainty of creatinine in low values: Another good reason not to use the MDRD formula with low creatinine values. Clin Biochem (2006) 1.38
Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF. J Biol Chem (2007) 1.30
Proliferative generation of mammalian auditory hair cells in culture. Mech Dev (2002) 1.29
Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate. Nat Neurosci (2011) 1.29
A new tool in the field of in-vitro diagnosis of allergy: preliminary results in the comparison of ImmunoCAP© 250 with the ImmunoCAP© ISAC. Clin Chem Lab Med (2010) 1.19
Cell "circadian" cycle: new role for mammalian core clock genes. Cell Cycle (2009) 1.14
Expression patterns of miR-96, miR-182 and miR-183 in the development inner ear. Gene Expr Patterns (2009) 1.14
Molecular layers underlying cytoskeletal remodelling during cortical development. Trends Neurosci (2009) 1.14
Plasmatic cystatin C for the estimation of glomerular filtration rate in intensive care units. Intensive Care Med (2004) 1.11
DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. Nature (2012) 1.11
Biomarker discovery for inflammatory bowel disease, using proteomic serum profiling. Biochem Pharmacol (2006) 1.10
Elongator - an emerging role in neurological disorders. Trends Mol Med (2009) 1.10
EFHC1 interacts with microtubules to regulate cell division and cortical development. Nat Neurosci (2009) 1.09
Vinflunine: a new microtubule inhibitor agent. Clin Cancer Res (2008) 1.09
Actin bundling in plants. Cell Motil Cytoskeleton (2009) 1.09
Critical role of tryptophan 154 for the activity and stability of class D beta-lactamases. Biochemistry (2009) 1.08
Discovery of new rheumatoid arthritis biomarkers using the surface-enhanced laser desorption/ionization time-of-flight mass spectrometry ProteinChip approach. Arthritis Rheum (2005) 1.08
De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis. J Leukoc Biol (2007) 1.07
The emerging role of lysine acetylation of non-nuclear proteins. Cell Mol Life Sci (2010) 1.07
Challenges for biomarker discovery in body fluids using SELDI-TOF-MS. J Biomed Biotechnol (2009) 1.05
p27(Kip1) is a microtubule-associated protein that promotes microtubule polymerization during neuron migration. Dev Cell (2012) 1.05
Potentiation of tumor necrosis factor-induced NF-kappa B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha. Mol Cell Biol (2003) 1.04
Deregulated NF-kappaB activity in haematological malignancies. Biochem Pharmacol (2006) 1.04
Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways. Biochem Pharmacol (2007) 1.02
Monomeric calgranulins measured by SELDI-TOF mass spectrometry and calprotectin measured by ELISA as biomarkers in arthritis. Clin Chem (2008) 1.02
Promoter-dependent effect of IKKalpha on NF-kappaB/p65 DNA binding. J Biol Chem (2007) 1.01
Comparison of second- and third-generation anti-cyclic citrullinated peptide antibodies assays for detecting rheumatoid arthritis. Clin Chim Acta (2007) 1.00
Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils. Biochemistry (2008) 1.00
Crystal structure of the Actinomadura R39 DD-peptidase reveals new domains in penicillin-binding proteins. J Biol Chem (2005) 1.00
The repressing function of the oncoprotein BCL-3 requires CtBP, while its polyubiquitination and degradation involve the E3 ligase TBLR1. Mol Cell Biol (2010) 1.00
Neurotransmitters regulate cell migration in the telencephalon. Eur J Neurosci (2007) 1.00
TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activation. Biochem J (2006) 0.99
Period 2 regulates neural stem/progenitor cell proliferation in the adult hippocampus. BMC Neurosci (2009) 0.98
Characterization of the promoters of Epsilon glutathione transferases in the mosquito Anopheles gambiae and their response to oxidative stress. Biochem J (2005) 0.97
Regulation of HER-2 oncogene expression by cyclooxygenase-2 and prostaglandin E2. Oncogene (2004) 0.97
Role of the adaptor protein CIKS in the activation of the IKK complex. Biochem Biophys Res Commun (2003) 0.96
Proteomics for prediction and characterization of response to infliximab in Crohn's disease: a pilot study. Clin Biochem (2008) 0.95
Analytical study of three cystatin C assays and their impact on cystatin C-based GFR-prediction equations. Clin Chim Acta (2008) 0.95
Sox10 promotes the survival of cochlear progenitors during the establishment of the organ of Corti. Dev Biol (2009) 0.94
Glial but not neuronal development in the cochleo-vestibular ganglion requires Sox10. J Neurochem (2010) 0.93
The proapoptotic C16-ceramide-dependent pathway requires the death-promoting factor Btf in colon adenocarcinoma cells. J Proteome Res (2009) 0.93
Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells. Nat Commun (2013) 0.93
False positive PTH results: an easy strategy to test and detect analytical interferences in routine practice. Clin Chim Acta (2007) 0.92
A phase 1-2, prospective, double blind, randomized study of the safety and efficacy of Sulfasalazine for the treatment of progressing malignant gliomas: study protocol of [ISRCTN45828668]. BMC Cancer (2006) 0.91
Vitamin D: current status and perspectives. Clin Chem Lab Med (2009) 0.90
Induction of the alternative NF-κB pathway by lymphotoxin αβ (LTαβ) relies on internalization of LTβ receptor. Mol Cell Biol (2011) 0.90
Analytical evaluation of the new Abbott Architect 25-OH vitamin D assay. Clin Biochem (2012) 0.89
Glycine receptor α2 subunit activation promotes cortical interneuron migration. Cell Rep (2013) 0.89
Cdk6-dependent regulation of G(1) length controls adult neurogenesis. Stem Cells (2011) 0.88
Discovery and biochemical characterisation of four novel biomarkers for osteoarthritis. Ann Rheum Dis (2011) 0.88