Published in Mol Ther on September 01, 2003
High-resolution genome-wide mapping of transposon integration in mammals. Mol Cell Biol (2005) 3.10
Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse. Proc Natl Acad Sci U S A (2005) 1.72
Comparative analysis of transposable element vector systems in human cells. Mol Ther (2010) 1.66
miR-29 inhibits bleomycin-induced pulmonary fibrosis in mice. Mol Ther (2012) 1.56
Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies. Mol Ther (2008) 1.47
Translating Sleeping Beauty transposition into cellular therapies: victories and challenges. Bioessays (2010) 1.42
Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system. Blood (2005) 1.40
piggyBac transposon-mediated long-term gene expression in mice. Mol Ther (2010) 1.33
Excision of Sleeping Beauty transposons: parameters and applications to gene therapy. J Gene Med (2004) 1.30
Hybrid lentivirus-transposon vectors with a random integration profile in human cells. Mol Ther (2009) 1.26
The expanding universe of transposon technologies for gene and cell engineering. Mob DNA (2010) 1.08
Comparative genomic integration profiling of Sleeping Beauty transposons mobilized with high efficacy from integrase-defective lentiviral vectors in primary human cells. Mol Ther (2011) 1.04
Synergetic Targeted Delivery of Sleeping-Beauty Transposon System to Mesenchymal Stem Cells Using LPD Nanoparticles Modified with a Phage-Displayed Targeting Peptide. Adv Funct Mater (2013) 0.95
Pigs taking wing with transposons and recombinases. Genome Biol (2007) 0.94
Gene expression in lung and liver after intravenous infusion of polyethylenimine complexes of Sleeping Beauty transposons. Hum Gene Ther (2010) 0.92
Inhibition of angiogenesis and suppression of colorectal cancer metastatic to the liver using the Sleeping Beauty Transposon System. Mol Cancer (2011) 0.89
DNA transposon-based gene vehicles - scenes from an evolutionary drive. J Biomed Sci (2013) 0.89
Cellular immune response against firefly luciferase after sleeping beauty-mediated gene transfer in vivo. Hum Gene Ther (2014) 0.86
Genomic analysis of Sleeping Beauty transposon integration in human somatic cells. PLoS One (2014) 0.85
Polyethylenimine-mediated gene delivery to the lung and therapeutic applications. Drug Des Devel Ther (2009) 0.84
Vectors for inhaled gene therapy in lung cancer. Application for nano oncology and safety of bio nanotechnology. Int J Mol Sci (2012) 0.80
Efficient sleeping beauty DNA transposition from DNA minicircles. Mol Ther Nucleic Acids (2013) 0.79
Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies. Semin Cell Dev Biol (2014) 0.79
Transposon-mediated mutagenesis of somatic cells in the mouse for cancer gene identification. Methods (2009) 0.78
Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells. Stem Cells Int (2011) 0.78
Sleeping Beauty transposon system for genetic etiological research and gene therapy of cancers. Cancer Biol Ther (2015) 0.76
Sleeping Beauty-Mediated Drug Resistance Gene Transfer in Human Hematopoietic Progenitor Cells. Hum Gene Ther (2015) 0.75
An Efficient Electroporation Protocol for the Genetic Modification of Mammalian Cells. Front Bioeng Biotechnol (2017) 0.75
Novel therapeutic approaches for various cancer types using a modified sleeping beauty-based gene delivery system. PLoS One (2014) 0.75
A novel method for somatic transgenesis of the mouse prostate using the Sleeping Beauty transposon system. Prostate (2014) 0.75
Restoration of dystrophin expression using the Sleeping Beauty transposon. PLoS Curr (2011) 0.75
Pluripotency of mesenchymal stem cells derived from adult marrow. Nature (2002) 19.57
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature (2011) 13.30
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31
Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse. Nature (2005) 6.40
Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature (2005) 6.20
Recurrent R-spondin fusions in colon cancer. Nature (2012) 5.10
A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science (2009) 4.16
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nat Biotechnol (2009) 3.44
Gene transfer into genomes of human cells by the sleeping beauty transposon system. Mol Ther (2003) 3.34
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature (2012) 3.23
Harnessing a high cargo-capacity transposon for genetic applications in vertebrates. PLoS Genet (2006) 2.99
Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature (2012) 2.96
Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system. Cancer Res (2008) 2.57
Structure-function analysis of the inverted terminal repeats of the sleeping beauty transposon. J Mol Biol (2002) 2.30
Extensive somatic L1 retrotransposition in colorectal tumors. Genome Res (2012) 2.29
A transposon and transposase system for human application. Mol Ther (2010) 2.28
Efficient nonmeiotic allele introgression in livestock using custom endonucleases. Proc Natl Acad Sci U S A (2013) 2.22
Mammalian germ-line transgenesis by transposition. Proc Natl Acad Sci U S A (2002) 2.13
Forging a critical alliance: Addressing the research needs of the United States critical illness and injury community. Crit Care Med (2009) 2.03
Efficient gene delivery and gene expression in zebrafish using the Sleeping Beauty transposon. Dev Biol (2003) 2.01
Transposon mutagenesis of the mouse germline. Genetics (2003) 2.00
RNA as a source of transposase for Sleeping Beauty-mediated gene insertion and expression in somatic cells and tissues. Mol Ther (2005) 1.98
Academic and career development of pulmonary and critical care physician-scientists. Am J Respir Crit Care Med (2005) 1.96
A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice. Cancer Res (2009) 1.86
Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers. PLoS Genet (2006) 1.84
Target-site preferences of Sleeping Beauty transposons. J Mol Biol (2004) 1.83
Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc Natl Acad Sci U S A (2012) 1.82
Cell of origin strongly influences genetic selection in a mouse model of T-ALL. Blood (2011) 1.78
Preferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injection. Nat Protoc (2007) 1.73
Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse. Proc Natl Acad Sci U S A (2005) 1.72
Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis. Development (2010) 1.64
Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis. Nat Genet (2013) 1.60
Sleeping beauty transposon-mediated gene therapy for prolonged expression. Adv Genet (2005) 1.60
Duration of expression and activity of Sleeping Beauty transposase in mouse liver following hydrodynamic DNA delivery. Mol Ther (2010) 1.57
De novo induction of genetically engineered brain tumors in mice using plasmid DNA. Cancer Res (2009) 1.49
Structure-based prediction of insertion-site preferences of transposons into chromosomes. Nucleic Acids Res (2006) 1.48
Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies. Mol Ther (2008) 1.47
Correction of metabolic, craniofacial, and neurologic abnormalities in MPS I mice treated at birth with adeno-associated virus vector transducing the human alpha-L-iduronidase gene. Mol Ther (2004) 1.44
Translating Sleeping Beauty transposition into cellular therapies: victories and challenges. Bioessays (2010) 1.42
Developmental acquisition of T3-sensitive Na-K-ATPase stimulation by rat alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol (2006) 1.40
Novel molecular and computational methods improve the accuracy of insertion site analysis in Sleeping Beauty-induced tumors. PLoS One (2011) 1.38
Precision editing of large animal genomes. Adv Genet (2012) 1.34
Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality. Cancer Res (2009) 1.34
Expression of VE-cadherin in zebrafish embryos: a new tool to evaluate vascular development. Dev Dyn (2004) 1.34
Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia. Gastroenterology (2010) 1.33
Prolonged expression of a lysosomal enzyme in mouse liver after Sleeping Beauty transposon-mediated gene delivery: implications for non-viral gene therapy of mucopolysaccharidoses. J Gene Med (2007) 1.33
Excision of Sleeping Beauty transposons: parameters and applications to gene therapy. J Gene Med (2004) 1.30
Infusing CD19-directed T cells to augment disease control in patients undergoing autologous hematopoietic stem-cell transplantation for advanced B-lymphoid malignancies. Hum Gene Ther (2012) 1.29
Hopping around the tumor genome: transposons for cancer gene discovery. Cancer Res (2005) 1.28
Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system. Mol Ther (2009) 1.24
Identification of PDE4D as a proliferation promoting factor in prostate cancer using a Sleeping Beauty transposon-based somatic mutagenesis screen. Cancer Res (2009) 1.22
Messenger RNA as a source of transposase for sleeping beauty transposon-mediated correction of hereditary tyrosinemia type I. Mol Ther (2007) 1.21
The Sleeping Beauty transposon system: a non-viral vector for gene therapy. Hum Mol Genet (2011) 1.18
Dynamic gene expression after systemic delivery of plasmid DNA as determined by in vivo bioluminescence imaging. Hum Gene Ther (2005) 1.18
Insertional mutagenesis in mice: new perspectives and tools. Nat Rev Genet (2005) 1.18
DDE transposases: Structural similarity and diversity. Adv Drug Deliv Rev (2010) 1.16
Nucleotide bias observed with a short SELEX RNA aptamer library. Nucleic Acid Ther (2011) 1.15
Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis. PLoS Genet (2013) 1.15
A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene. Blood (2008) 1.12
A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer. Proc Natl Acad Sci U S A (2012) 1.12
Targeting DNA With Fingers and TALENs. Mol Ther Nucleic Acids (2012) 1.12
Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance. Cancer Discov (2013) 1.10
A facile method for somatic, lifelong manipulation of multiple genes in the mouse liver. Hepatology (2008) 1.09
A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis. Proc Natl Acad Sci U S A (2011) 1.09
Transposon vectors for gene-trap insertional mutagenesis in vertebrates. Genesis (2004) 1.09
Predicting preferential DNA vector insertion sites: implications for functional genomics and gene therapy. Genome Biol (2007) 1.08
Cancer gene discovery using the Sleeping Beauty transposon. Cell Cycle (2005) 1.08
Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice. Blood (2006) 1.06
Neural differentiation and incorporation of bone marrow-derived multipotent adult progenitor cells after single cell transplantation into blastocyst stage mouse embryos. Cell Transplant (2003) 1.05
Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon. BMC Biotechnol (2006) 1.05
Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity. Oncotarget (2014) 1.04
Efficient mammalian germline transgenesis by cis-enhanced Sleeping Beauty transposition. Transgenic Res (2010) 1.04
3,3',5-Triiodo-L-thyronine up-regulation of Na,K-ATPase activity and cell surface expression in alveolar epithelial cells is Src kinase- and phosphoinositide 3-kinase-dependent. J Biol Chem (2004) 1.04
Strategies for selection marker-free swine transgenesis using the Sleeping Beauty transposon system. Transgenic Res (2011) 1.04
Trp53 loss during in vitro selection contributes to acquired Ara-C resistance in acute myeloid leukemia. Exp Hematol (2006) 1.03
Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach. Cancer Res (2010) 1.03
Integration and long-term expression in xenografted human glioblastoma cells using a plasmid-based transposon system. Mol Ther (2004) 1.03
Repressible transgenic model of NRAS oncogene-driven mast cell disease in the mouse. Blood (2005) 1.02