Published in Adv Genet on January 01, 2005
Efficient TALEN-mediated gene knockout in livestock. Proc Natl Acad Sci U S A (2012) 4.99
Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor. Blood (2010) 3.57
A transposon and transposase system for human application. Mol Ther (2010) 2.28
Preferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injection. Nat Protoc (2007) 1.73
Structure-based prediction of insertion-site preferences of transposons into chromosomes. Nucleic Acids Res (2006) 1.48
Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system. Blood (2005) 1.40
Gene transfer efficiency and genome-wide integration profiling of Sleeping Beauty, Tol2, and piggyBac transposons in human primary T cells. Mol Ther (2010) 1.38
Precision editing of large animal genomes. Adv Genet (2012) 1.34
Prolonged expression of a lysosomal enzyme in mouse liver after Sleeping Beauty transposon-mediated gene delivery: implications for non-viral gene therapy of mucopolysaccharidoses. J Gene Med (2007) 1.33
Gene therapy for cancer treatment: past, present and future. Clin Med Res (2006) 1.30
Infusing CD19-directed T cells to augment disease control in patients undergoing autologous hematopoietic stem-cell transplantation for advanced B-lymphoid malignancies. Hum Gene Ther (2012) 1.29
Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system. Mol Ther (2009) 1.24
Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity. Gene Ther (2009) 1.17
DDE transposases: Structural similarity and diversity. Adv Drug Deliv Rev (2010) 1.16
Postintegrative gene silencing within the Sleeping Beauty transposition system. Mol Cell Biol (2007) 1.15
A new approach to gene therapy using Sleeping Beauty to genetically modify clinical-grade T cells to target CD19. Immunol Rev (2014) 1.14
The piggyBac transposon holds promise for human gene therapy. Proc Natl Acad Sci U S A (2006) 1.12
A look to future directions in gene therapy research for monogenic diseases. PLoS Genet (2006) 1.11
Stable transgene expression in primitive human CD34+ hematopoietic stem/progenitor cells, using the Sleeping Beauty transposon system. Hum Gene Ther (2009) 1.08
The expanding universe of transposon technologies for gene and cell engineering. Mob DNA (2010) 1.08
Predicting preferential DNA vector insertion sites: implications for functional genomics and gene therapy. Genome Biol (2007) 1.08
Unexpectedly high copy number of random integration but low frequency of persistent expression of the Sleeping Beauty transposase after trans delivery in primary human T cells. Hum Gene Ther (2010) 0.97
Synergetic Targeted Delivery of Sleeping-Beauty Transposon System to Mesenchymal Stem Cells Using LPD Nanoparticles Modified with a Phage-Displayed Targeting Peptide. Adv Funct Mater (2013) 0.95
Role of protein tyrosine phosphatases in cancer. Prog Nucleic Acid Res Mol Biol (2006) 0.92
Gene expression in lung and liver after intravenous infusion of polyethylenimine complexes of Sleeping Beauty transposons. Hum Gene Ther (2010) 0.92
Tumor-directed gene therapy in mice using a composite nonviral gene delivery system consisting of the piggyBac transposon and polyethylenimine. BMC Cancer (2009) 0.91
Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma. J Hepatol (2013) 0.91
Meganuclease and transposon mediated transgenesis in medaka. Genome Biol (2007) 0.90
DNA transposon-based gene vehicles - scenes from an evolutionary drive. J Biomed Sci (2013) 0.89
Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance. AIDS Res Ther (2008) 0.88
Investigation of oncogenic cooperation in simple liver-specific transgenic mouse models using noninvasive in vivo imaging. PLoS One (2013) 0.87
Vascular biology and pathobiology of the liver: Report of a single-topic symposium. Hepatology (2008) 0.85
Induction of protective cytotoxic T-cell responses by a B-cell-based cellular vaccine requires stable expression of antigen. Gene Ther (2009) 0.83
Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System. Mol Ther (2016) 0.80
Chimeric antibody receptors (CARs): driving T-cell specificity to enhance anti-tumor immunity. Front Biosci (Schol Ed) (2012) 0.79
Virion-associated cofactor high-mobility group DNA-binding protein-1 facilitates transposition from the herpes simplex virus/Sleeping Beauty amplicon vector platform. Hum Gene Ther (2010) 0.79
Transposon mediated integration of plasmid DNA into the subventricular zone of neonatal mice to generate novel models of glioblastoma. J Vis Exp (2015) 0.79
Effective gene trapping mediated by Sleeping Beauty transposon. PLoS One (2012) 0.79
Prolongation of heart allograft survival after long-term expression of soluble MHC class I antigens and vIL-10 in the liver by AAV-plasmid-mediated gene transfer. Langenbecks Arch Surg (2008) 0.78
Transposon transgenesis in Xenopus. Methods (2010) 0.78
CARs in chronic lymphocytic leukemia -- ready to drive. Curr Hematol Malig Rep (2013) 0.77
Polymeric Materials for Gene Delivery and DNA Vaccination. Adv Mater (2008) 0.76
Comparison of liver oncogenic potential among human RAS isoforms. Oncotarget (2016) 0.76
Endogenous transposases affect differently Sleeping Beauty and Frog Prince transposons in fish cells. Mar Biotechnol (NY) (2010) 0.76
Vector modifications to eliminate transposase expression following piggyBac-mediated transgenesis. Sci Rep (2014) 0.76
Chimeric Antigen Receptors: A Cell and Gene Therapy Perspective. Mol Ther (2017) 0.75
Targeted delivery of in situ PCR-amplified Sleeping Beauty transposon genes to cancer cells with lipid-based nanoparticle-like protocells. Biomaterials (2017) 0.75
Transposon-mediated Generation of Cellular and Mouse Models of Splicing Mutations to Assess the Efficacy of snRNA-based Therapeutics. Mol Ther Nucleic Acids (2016) 0.75
An Immunosuppressive Dendritic Cell Subset Accumulates at Secondary Sites and Promotes Metastasis in Pancreatic Cancer. Cancer Res (2017) 0.75
Pluripotency of mesenchymal stem cells derived from adult marrow. Nature (2002) 19.57
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature (2011) 13.30
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31
In vivo genome editing using a high-efficiency TALEN system. Nature (2012) 7.11
p53 activation by knockdown technologies. PLoS Genet (2007) 6.85
Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse. Nature (2005) 6.40
Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature (2005) 6.20
Recurrent R-spondin fusions in colon cancer. Nature (2012) 5.10
A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science (2009) 4.16
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nat Biotechnol (2009) 3.44
Sarcoma derived from cultured mesenchymal stem cells. Stem Cells (2006) 3.40
Gene transfer into genomes of human cells by the sleeping beauty transposon system. Mol Ther (2003) 3.34
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature (2012) 3.23
Harnessing a high cargo-capacity transposon for genetic applications in vertebrates. PLoS Genet (2006) 2.99
Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature (2012) 2.96
In vivo protein trapping produces a functional expression codex of the vertebrate proteome. Nat Methods (2011) 2.85
A primer for morpholino use in zebrafish. Zebrafish (2009) 2.60
Extensive somatic L1 retrotransposition in colorectal tumors. Genome Res (2012) 2.29
A transposon and transposase system for human application. Mol Ther (2010) 2.28
Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system. Blood (2009) 2.15
Mammalian germ-line transgenesis by transposition. Proc Natl Acad Sci U S A (2002) 2.13
Efficient gene delivery and gene expression in zebrafish using the Sleeping Beauty transposon. Dev Biol (2003) 2.01
Transposon mutagenesis of the mouse germline. Genetics (2003) 2.00
RNA as a source of transposase for Sleeping Beauty-mediated gene insertion and expression in somatic cells and tissues. Mol Ther (2005) 1.98
WNT5A mutations in patients with autosomal dominant Robinow syndrome. Dev Dyn (2010) 1.91
A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice. Cancer Res (2009) 1.86
Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers. PLoS Genet (2006) 1.84
Target-site preferences of Sleeping Beauty transposons. J Mol Biol (2004) 1.83
Enhancer trapping in zebrafish using the Sleeping Beauty transposon. BMC Genomics (2004) 1.73
Preferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injection. Nat Protoc (2007) 1.73
Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse. Proc Natl Acad Sci U S A (2005) 1.72
Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis. Development (2010) 1.64
Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis. Nat Genet (2013) 1.60
Genome-wide reverse genetics framework to identify novel functions of the vertebrate secretome. PLoS One (2006) 1.60
Gene-breaking transposon mutagenesis reveals an essential role for histone H2afza in zebrafish larval development. Mech Dev (2006) 1.53
Functional analysis of human hematopoietic stem cell gene expression using zebrafish. PLoS Biol (2005) 1.52
Revealing the role of phospholipase Cβ3 in the regulation of VEGF-induced vascular permeability. Blood (2012) 1.51
De novo induction of genetically engineered brain tumors in mice using plasmid DNA. Cancer Res (2009) 1.49
Structure-based prediction of insertion-site preferences of transposons into chromosomes. Nucleic Acids Res (2006) 1.48
Nicotine response genetics in the zebrafish. Proc Natl Acad Sci U S A (2009) 1.45
Wnt5 signaling in vertebrate pancreas development. BMC Biol (2005) 1.45
Correction of metabolic, craniofacial, and neurologic abnormalities in MPS I mice treated at birth with adeno-associated virus vector transducing the human alpha-L-iduronidase gene. Mol Ther (2004) 1.44
Efficient and stable transgene expression in human embryonic stem cells using transposon-mediated gene transfer. Stem Cells (2007) 1.44
Genetic determinants of hyaloid and retinal vasculature in zebrafish. BMC Dev Biol (2007) 1.40
Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system. Blood (2005) 1.40
Gene transfer efficiency and genome-wide integration profiling of Sleeping Beauty, Tol2, and piggyBac transposons in human primary T cells. Mol Ther (2010) 1.38
Syndecan-2 is essential for angiogenic sprouting during zebrafish development. Blood (2003) 1.38
Identifying secretomes in people, pufferfish and pigs. Nucleic Acids Res (2004) 1.35
Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality. Cancer Res (2009) 1.34
Expression of VE-cadherin in zebrafish embryos: a new tool to evaluate vascular development. Dev Dyn (2004) 1.34
The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish. Blood (2006) 1.34
Prolonged expression of a lysosomal enzyme in mouse liver after Sleeping Beauty transposon-mediated gene delivery: implications for non-viral gene therapy of mucopolysaccharidoses. J Gene Med (2007) 1.33
Neuropilin-1 modulates p53/caspases axis to promote endothelial cell survival. PLoS One (2007) 1.32
Gene insertion and long-term expression in lung mediated by the Sleeping Beauty transposon system. Mol Ther (2003) 1.31
Mojo Hand, a TALEN design tool for genome editing applications. BMC Bioinformatics (2013) 1.29
Hopping around the tumor genome: transposons for cancer gene discovery. Cancer Res (2005) 1.28
Wnt5a is required for cardiac outflow tract septation in mice. Pediatr Res (2007) 1.27
SCORE imaging: specimen in a corrected optical rotational enclosure. Zebrafish (2010) 1.26
Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system. Mol Ther (2009) 1.24
A picornaviral 2A-like sequence-based tricistronic vector allowing for high-level therapeutic gene expression coupled to a dual-reporter system. Mol Ther (2005) 1.23
Identification of PDE4D as a proliferation promoting factor in prostate cancer using a Sleeping Beauty transposon-based somatic mutagenesis screen. Cancer Res (2009) 1.22
Messenger RNA as a source of transposase for sleeping beauty transposon-mediated correction of hereditary tyrosinemia type I. Mol Ther (2007) 1.21
The Sleeping Beauty transposon system: a non-viral vector for gene therapy. Hum Mol Genet (2011) 1.18
Dynamic gene expression after systemic delivery of plasmid DNA as determined by in vivo bioluminescence imaging. Hum Gene Ther (2005) 1.18
Insertional mutagenesis in mice: new perspectives and tools. Nat Rev Genet (2005) 1.18
Sleeping beauty transposition from nonintegrating lentivirus. Mol Ther (2009) 1.18
An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells. Nat Commun (2013) 1.17
Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis. PLoS Genet (2013) 1.15
Lessons from morpholino-based screening in zebrafish. Brief Funct Genomics (2011) 1.14
Direct gene transfer to the CNS prevents emergence of neurologic disease in a murine model of mucopolysaccharidosis type I. Neurobiol Dis (2011) 1.14
A TALE of two nucleases: gene targeting for the masses? Zebrafish (2011) 1.14
The CRISPR system--keeping zebrafish gene targeting fresh. Zebrafish (2013) 1.13
A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer. Proc Natl Acad Sci U S A (2012) 1.12
Zebrafish as a genomics research model. Curr Pharm Biotechnol (2004) 1.12
A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene. Blood (2008) 1.12
A unique role for 6-O sulfation modification in zebrafish vascular development. Dev Biol (2005) 1.12
Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance. Cancer Discov (2013) 1.10
A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis. Proc Natl Acad Sci U S A (2011) 1.09
Differential adeno-associated virus mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar puncture. Mol Pain (2010) 1.09
A facile method for somatic, lifelong manipulation of multiple genes in the mouse liver. Hepatology (2008) 1.09
Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells. Blood (2006) 1.08
Cancer gene discovery using the Sleeping Beauty transposon. Cell Cycle (2005) 1.08
Characterization of expanded intermediate cell mass in zebrafish chordin morphant embryos. Dev Biol (2005) 1.07
A PATO-compliant zebrafish screening database (MODB): management of morpholino knockdown screen information. BMC Bioinformatics (2008) 1.07
Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice. Blood (2006) 1.06
Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon. BMC Biotechnol (2006) 1.05
Neural differentiation and incorporation of bone marrow-derived multipotent adult progenitor cells after single cell transplantation into blastocyst stage mouse embryos. Cell Transplant (2003) 1.05