Published in Neuron on August 28, 2003
Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci U S A (2003) 10.56
In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. Cell Stem Cell (2007) 5.32
TGFbeta signalling: a complex web in cancer progression. Nat Rev Cancer (2010) 5.27
Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci U S A (2004) 4.70
Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell (2011) 4.29
SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci U S A (2007) 4.19
SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Genes Dev (2006) 4.11
Isolation of neural stem cells from the postnatal cerebellum. Nat Neurosci (2005) 3.97
A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas. Stem Cells (2007) 3.62
Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. Nat Neurosci (2009) 3.47
Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell (2007) 3.41
Dynamic contribution of nestin-expressing stem cells to adult neurogenesis. J Neurosci (2007) 3.37
Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell (2012) 3.30
Cross talk between microRNA and epigenetic regulation in adult neurogenesis. J Cell Biol (2010) 3.16
The sox family of transcription factors: versatile regulators of stem and progenitor cell fate. Cell Stem Cell (2013) 2.97
Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis. Development (2009) 2.82
Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors. Int J Biochem Cell Biol (2007) 2.78
In vivo reprogramming of astrocytes to neuroblasts in the adult brain. Nat Cell Biol (2013) 2.56
Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea. Proc Natl Acad Sci U S A (2008) 2.52
Notch signaling controls the balance of ciliated and secretory cell fates in developing airways. Development (2009) 2.33
Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination. Proc Natl Acad Sci U S A (2005) 2.29
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma. Cell (2016) 2.27
Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche. Neuron (2014) 2.25
Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease. J Clin Invest (2011) 2.23
The establishment of neuronal properties is controlled by Sox4 and Sox11. Genes Dev (2006) 2.21
Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium. Am J Physiol Gastrointest Liver Physiol (2009) 2.21
REST regulates distinct transcriptional networks in embryonic and neural stem cells. PLoS Biol (2008) 2.12
SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland. Proc Natl Acad Sci U S A (2008) 2.01
Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells. Mol Cell Biol (2004) 2.00
Geminin regulates neuronal differentiation by antagonizing Brg1 activity. Genes Dev (2005) 1.99
Sequentially acting Sox transcription factors in neural lineage development. Genes Dev (2011) 1.97
Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus. Neurobiol Aging (2006) 1.89
Predicting the human epigenome from DNA motifs. Nat Methods (2014) 1.88
Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS. Neuron (2012) 1.86
EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells. Genes Dev (2010) 1.81
Neural stem cell self-renewal. Crit Rev Oncol Hematol (2007) 1.76
Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma. BMC Cancer (2011) 1.74
Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer. Br J Cancer (2011) 1.69
A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube. Genes Dev (2005) 1.68
Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke. J Cereb Blood Flow Metab (2007) 1.64
Requirement for Foxd3 in the maintenance of neural crest progenitors. Development (2008) 1.64
Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells. Genes Dev (2004) 1.63
Insights into neural stem cell biology from flies. Philos Trans R Soc Lond B Biol Sci (2008) 1.61
ATP-dependent chromatin remodeling in neural development. Curr Opin Neurobiol (2009) 1.58
Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas. PLoS One (2011) 1.57
The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone. Proc Natl Acad Sci U S A (2006) 1.56
Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling. J Neurosci (2011) 1.55
Tumor necrosis factor alpha triggers proliferation of adult neural stem cells via IKK/NF-kappaB signaling. BMC Neurosci (2006) 1.52
CD133 (Prominin) negative human neural stem cells are clonogenic and tripotent. PLoS One (2009) 1.50
The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation. Dev Biol (2012) 1.50
Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube. Philos Trans R Soc Lond B Biol Sci (2008) 1.48
The timing of differentiation of adult hippocampal neurons is crucial for spatial memory. PLoS Biol (2008) 1.44
Regulation of interkinetic nuclear migration by cell cycle-coupled active and passive mechanisms in the developing brain. EMBO J (2011) 1.44
Canonical Wnt signaling dynamically controls multiple stem cell fate decisions during vertebrate body formation. Dev Cell (2012) 1.43
Over-expression of hNGF in adult human olfactory bulb neural stem cells promotes cell growth and oligodendrocytic differentiation. PLoS One (2013) 1.41
Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes. Exp Neurol (2005) 1.41
Integrating physiological regulation with stem cell and tissue homeostasis. Neuron (2011) 1.41
SOX2-LIN28/let-7 pathway regulates proliferation and neurogenesis in neural precursors. Proc Natl Acad Sci U S A (2013) 1.39
Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral cortex. Stem Cell Reports (2014) 1.38
Human cytomegalovirus infection causes premature and abnormal differentiation of human neural progenitor cells. J Virol (2010) 1.38
In vivo conversion of astrocytes to neurons in the injured adult spinal cord. Nat Commun (2014) 1.38
An embryonic stem cell-like signature identifies poorly differentiated lung adenocarcinoma but not squamous cell carcinoma. Clin Cancer Res (2009) 1.38
Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron (2012) 1.37
Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expression. Cell Stem Cell (2012) 1.33
SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state. PLoS Genet (2013) 1.32
Endogenous Wnt signaling maintains neural progenitor cell potency. Stem Cells (2009) 1.32
Neurod1 suppresses hair cell differentiation in ear ganglia and regulates hair cell subtype development in the cochlea. PLoS One (2010) 1.30
Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell-derived neural transplants. J Cell Biol (2004) 1.29
Sox2 activates cell proliferation and differentiation in the respiratory epithelium. Am J Respir Cell Mol Biol (2010) 1.29
Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis. PLoS One (2008) 1.28
A directional Wnt/beta-catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the Xenopus retina. Development (2009) 1.28
Notch signaling alters sensory or neuronal cell fate specification of inner ear stem cells. J Neurosci (2011) 1.27
Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells. Proc Natl Acad Sci U S A (2007) 1.26
Clinical, genetic and imaging findings identify new causes for corpus callosum development syndromes. Brain (2014) 1.26
Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear. Hum Mol Genet (2008) 1.25
Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning. Genes Dev (2012) 1.24
SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells. Oncogene (2014) 1.23
A mechanism regulating the onset of Sox2 expression in the embryonic neural plate. PLoS Biol (2008) 1.23
Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior. Neuron (2010) 1.23
Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors. J Cell Biol (2009) 1.22
MicroRNAs in adult and embryonic neurogenesis. Neuromolecular Med (2009) 1.22
Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc. Proc Natl Acad Sci U S A (2012) 1.22
Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampus. Neuropsychopharmacology (2009) 1.21
Distinct transcriptional regulatory modules underlie STAT3's cell type-independent and cell type-specific functions. Nucleic Acids Res (2013) 1.21
Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1. Stem Cells (2012) 1.20
The Yin and Yang of Sox proteins: Activation and repression in development and disease. J Neurosci Res (2009) 1.20
The evolution of nervous system patterning: insights from sea urchin development. Development (2011) 1.20
Activation of neural and pluripotent stem cell signatures correlates with increased malignancy in human glioma. PLoS One (2011) 1.16
Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesis. Cell Stem Cell (2011) 1.16
Expression of pax6 and sox2 in adult olfactory epithelium. J Comp Neurol (2010) 1.16
The transcription factor Sox2 is required for osteoblast self-renewal. Cell Death Differ (2010) 1.16
Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6. Development (2011) 1.15
B1 SOX coordinate cell specification with patterning and morphogenesis in the early zebrafish embryo. PLoS Genet (2010) 1.15
FoxM1 in tumorigenicity of the neuroblastoma cells and renewal of the neural progenitors. Cancer Res (2011) 1.15
Proliferative and transcriptional identity of distinct classes of neural precursors in the mammalian olfactory epithelium. Development (2010) 1.15
A transgenic mouse model of metastatic carcinoma involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotype. Proc Natl Acad Sci U S A (2004) 1.15
Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1. PLoS Biol (2005) 1.14
Multilineage potential of stable human mesenchymal stem cell line derived from fetal marrow. PLoS One (2007) 1.14
High SOX2 levels predict better outcome in non-small cell lung carcinomas. PLoS One (2013) 1.13
The Sox-2 regulatory regions display their activities in two distinct types of multipotent stem cells. Mol Cell Biol (2004) 1.13
SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult. Dev Neurosci (2005) 4.48
Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1. J Cell Biol (2003) 3.80
Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev (2002) 3.49
SKPs derive from hair follicle precursors and exhibit properties of adult dermal stem cells. Cell Stem Cell (2009) 3.20
Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Gene Expr Patterns (2002) 1.61
The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone. Proc Natl Acad Sci U S A (2006) 1.56
Sox2 expression defines a heterogeneous population of neurosphere-forming cells in the adult murine brain. Aging Cell (2005) 1.42
Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors. Dev Cell (2012) 1.34
Complete genome sequence of "Enterobacter lignolyticus" SCF1. Stand Genomic Sci (2011) 1.24
Proliferative and transcriptional identity of distinct classes of neural precursors in the mammalian olfactory epithelium. Development (2010) 1.15
Directed differentiation of neural cells to hypothalamic dopaminergic neurons. Development (2005) 1.13
Nap1-regulated neuronal cytoskeletal dynamics is essential for the final differentiation of neurons in cerebral cortex. Neuron (2007) 1.10
Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro. Proc Natl Acad Sci U S A (2005) 1.00
Identification of the immunodominant HY H2-D(k) epitope and evaluation of the role of direct and indirect antigen presentation in HY responses. J Immunol (2005) 0.94
"Runx"ing towards sensory differentiation. Neuron (2006) 0.93
Discovery of microorganisms and enzymes involved in high-solids decomposition of rice straw using metagenomic analyses. PLoS One (2013) 0.91
SOX2 maintains the quiescent progenitor cell state of postnatal retinal Muller glia. Development (2013) 0.90
Oct4 is required ~E7.5 for proliferation in the primitive streak. PLoS Genet (2013) 0.89
Induction of hepatic differentiation in embryonic stem cells by co-culture with embryonic cardiac mesoderm. Surgery (2003) 0.88
Eye development and retinogenesis. Cold Spring Harb Perspect Biol (2012) 0.87
Application of phenotypic microarrays to environmental microbiology. Curr Opin Biotechnol (2012) 0.85
SOX2 hypomorphism disrupts development of the prechordal floor and optic cup. Mech Dev (2012) 0.81
Cleft Palate in a Mouse Model of SOX2 Haploinsufficiency. Cleft Palate Craniofac J (2013) 0.77
Furthering orthodontic research? J Orthod (2014) 0.75