Published in Cell Stem Cell on January 03, 2013
Epigenetic reprogramming in cancer. Science (2013) 3.47
Sox2 cooperates with inflammation-mediated Stat3 activation in the malignant transformation of foregut basal progenitor cells. Cell Stem Cell (2013) 2.23
SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma. Nature (2014) 2.15
The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma. Cancer Cell (2014) 1.65
Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT. Cell (2016) 1.36
SOX9: a stem cell transcriptional regulator of secreted niche signaling factors. Genes Dev (2014) 1.34
Adult neural stem cells stake their ground. Trends Neurosci (2014) 1.30
Dedifferentiation and reprogramming: origins of cancer stem cells. EMBO Rep (2014) 1.16
Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis. Cell Stem Cell (2014) 1.11
Sox2 promotes malignancy in glioblastoma by regulating plasticity and astrocytic differentiation. Neoplasia (2014) 1.10
SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas. J Clin Invest (2014) 1.10
The structure, function and evolution of proteins that bind DNA and RNA. Nat Rev Mol Cell Biol (2014) 1.10
SOX2 and cancer: current research and its implications in the clinic. Clin Transl Med (2014) 1.06
SOX2 reprograms resident astrocytes into neural progenitors in the adult brain. Stem Cell Reports (2015) 1.06
Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses. EMBO Mol Med (2013) 1.04
CRISPR reveals a distal super-enhancer required for Sox2 expression in mouse embryonic stem cells. PLoS One (2014) 1.04
Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression. Nat Commun (2014) 1.04
Mobilized adult pituitary stem cells contribute to endocrine regeneration in response to physiological demand. Cell Stem Cell (2013) 1.03
Role of SOX family of transcription factors in central nervous system tumors. Am J Cancer Res (2014) 1.01
A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12. EMBO Mol Med (2014) 0.99
Molecular features of cellular reprogramming and development. Nat Rev Mol Cell Biol (2016) 0.93
Serine Protease Activation Essential for Endothelial-Mesenchymal Transition in Vascular Calcification. Circ Res (2015) 0.92
Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal. Genome Res (2014) 0.91
Identification of FDA-approved drugs targeting breast cancer stem cells along with biomarkers of sensitivity. Sci Rep (2013) 0.90
Extensive ex vivo expansion of functional human erythroid precursors established from umbilical cord blood cells by defined factors. Mol Ther (2013) 0.90
miR-126 functions as a tumor suppressor in osteosarcoma by targeting Sox2. Int J Mol Sci (2013) 0.90
SOX2 regulates self-renewal and tumorigenicity of stem-like cells of head and neck squamous cell carcinoma. Br J Cancer (2014) 0.89
SOX2 is a cancer-specific regulator of tumour initiating potential in cutaneous squamous cell carcinoma. Nat Commun (2014) 0.89
DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis. BMC Genomics (2015) 0.88
Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells. Cell Rep (2015) 0.88
Molecular and functional interactions between AKT and SOX2 in breast carcinoma. Oncotarget (2015) 0.88
Esophageal Cancer: Insights From Mouse Models. Cancer Growth Metastasis (2015) 0.88
Positive feedback loop between Sox2 and Sox6 inhibits neuronal differentiation in the developing central nervous system. Proc Natl Acad Sci U S A (2014) 0.87
C. elegans SoxB genes are dispensable for embryonic neurogenesis but required for terminal differentiation of specific neuron types. Development (2015) 0.87
Thyroid tumor-initiating cells: increasing evidence and opportunities for anticancer therapy (review). Oncol Rep (2014) 0.86
SOX1 down-regulates β-catenin and reverses malignant phenotype in nasopharyngeal carcinoma. Mol Cancer (2014) 0.85
An epigenetic gateway to brain tumor cell identity. Nat Neurosci (2015) 0.85
Sox9: a master regulator of the pancreatic program. Rev Diabet Stud (2014) 0.84
SOX10, a novel HMG-box-containing tumor suppressor, inhibits growth and metastasis of digestive cancers by suppressing the Wnt/β-catenin pathway. Oncotarget (2014) 0.84
Regeneration of Xenopus laevis spinal cord requires Sox2/3 expressing cells. Dev Biol (2015) 0.84
Systematic variation in the pattern of gene paralog retention between the teleost superorders Ostariophysi and Acanthopterygii. Genome Biol Evol (2014) 0.84
Sry-type HMG box 18 contributes to the differentiation of bone marrow-derived mesenchymal stem cells to endothelial cells. Differentiation (2015) 0.84
Profiling gene promoter occupancy of Sox2 in two phenotypically distinct breast cancer cell subsets using chromatin immunoprecipitation and genome-wide promoter microarrays. Breast Cancer Res (2014) 0.83
Sox6 up-regulation by macrophage migration inhibitory factor promotes survival and maintenance of mouse neural stem/progenitor cells. PLoS One (2013) 0.83
Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticity. EMBO J (2015) 0.83
Immunohistochemical molecular phenotypes of gastric cancer based on SOX2 and CDX2 predict patient outcome. BMC Cancer (2014) 0.83
Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. Elife (2017) 0.83
Concise review: breast cancer stem cells: regulatory networks, stem cell niches, and disease relevance. Stem Cells Transl Med (2014) 0.83
Upregulation of SOX9 in osteosarcoma and its association with tumor progression and patients' prognosis. Diagn Pathol (2013) 0.83
Progress and renewal in gustation: new insights into taste bud development. Development (2015) 0.83
QKI impairs self-renewal and tumorigenicity of oral cancer cells via repression of SOX2. Cancer Biol Ther (2014) 0.82
Expression of multiple Sox genes through embryonic development in the ctenophore Mnemiopsis leidyi is spatially restricted to zones of cell proliferation. Evodevo (2014) 0.82
Endogenous molecular network reveals two mechanisms of heterogeneity within gastric cancer. Oncotarget (2015) 0.82
mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance. Expert Opin Ther Targets (2016) 0.82
miR-21 promotes the differentiation of hair follicle-derived neural crest stem cells into Schwann cells. Neural Regen Res (2014) 0.82
SOX2 expression is regulated by BRAF and contributes to poor patient prognosis in colorectal cancer. PLoS One (2014) 0.82
Personalized and targeted therapy of esophageal squamous cell carcinoma: an update. Ann N Y Acad Sci (2016) 0.82
Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis. Nat Commun (2015) 0.81
YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells. Stem Cells (2015) 0.81
SRY interference of normal regulation of the RET gene suggests a potential role of the Y-chromosome gene in sexual dimorphism in Hirschsprung disease. Hum Mol Genet (2014) 0.81
Antagonistic cross-regulation between Sox9 and Sox10 controls an anti-tumorigenic program in melanoma. PLoS Genet (2015) 0.81
SOXE transcription factors form selective dimers on non-compact DNA motifs through multifaceted interactions between dimerization and high-mobility group domains. Sci Rep (2015) 0.81
SOX4 inhibits GBM cell growth and induces G0/G1 cell cycle arrest through Akt-p53 axis. BMC Neurol (2014) 0.81
Cobblestone-area forming cells derived from patients with mantle cell lymphoma are enriched for CD133+ tumor-initiating cells. PLoS One (2014) 0.81
Specification and epigenetic programming of the human germ line. Nat Rev Genet (2016) 0.80
Epithelial-to-Mesenchymal Transition in the Pathogenesis and Therapy of Head and Neck Cancer. Cancers (Basel) (2017) 0.80
The network of pluripotency, epithelial-mesenchymal transition, and prognosis of breast cancer. Breast Cancer (Dove Med Press) (2015) 0.80
High-content analysis of tumour cell invasion in three-dimensional spheroid assays. Oncoscience (2015) 0.80
Global changes in gene expression of Barrett's esophagus compared to normal squamous esophagus and gastric cardia tissues. PLoS One (2014) 0.80
miRNA-124 down-regulates SOX8 expression and suppresses cell proliferation in non-small cell lung cancer. Int J Clin Exp Pathol (2014) 0.80
Down-regulation of Sox11 is required for efficient osteogenic differentiation of adipose-derived stem cells. Mol Cells (2014) 0.80
SOX15 and other SOX family members are important mediators of tumorigenesis in multiple cancer types. Oncoscience (2014) 0.80
Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide. Neuro Oncol (2016) 0.80
Placental mesenchymal stromal cells rescue ambulation in ovine myelomeningocele. Stem Cells Transl Med (2015) 0.79
Associations between SOX2 and miR-200b expression with the clinicopathological characteristics and prognosis of patients with glioma. Exp Ther Med (2015) 0.79
Molecular and genetic aspects of odontogenic lesions. Head Neck Pathol (2014) 0.79
YB-1 regulates Sox2 to coordinately sustain stemness and tumorigenic properties in a phenotypically distinct subset of breast cancer cells. BMC Cancer (2014) 0.79
Transcriptome analysis reveals differentially expressed genes associated with germ cell and gonad development in the Southern bluefin tuna (Thunnus maccoyii). BMC Genomics (2016) 0.79
Prognostic significance of SOX-1 expression in human hepatocelluar cancer. Int J Clin Exp Pathol (2015) 0.78
En1 directs superior olivary complex neuron positioning, survival, and expression of FoxP1. Dev Biol (2015) 0.78
miR-30 Family Controls Proliferation and Differentiation of Intestinal Epithelial Cell Models by Directing a Broad Gene Expression Program That Includes SOX9 and the Ubiquitin Ligase Pathway. J Biol Chem (2016) 0.78
Sox2 in the adult rat sensory nervous system. Histochem Cell Biol (2013) 0.78
Ube2s regulates Sox2 stability and mouse ES cell maintenance. Cell Death Differ (2015) 0.78
Comprehensive profiling reveals mechanisms of SOX2-mediated cell fate specification in human ESCs and NPCs. Cell Res (2016) 0.78
The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers. Oncotarget (2015) 0.78
Structure-function relationships in human testis-determining factor SRY: an aromatic buttress underlies the specific DNA-bending surface of a high mobility group (HMG) box. J Biol Chem (2014) 0.78
Characterization of Bbx, a member of a novel subfamily of the HMG-box superfamily together with Cic. Dev Genes Evol (2014) 0.78
Conversion of Adipose Tissue-Derived Mesenchymal Stem Cells to Neural Stem Cell-Like Cells by a Single Transcription Factor, Sox2. Cell Reprogram (2015) 0.78
SOX2 boosts major tumor progression genes in prostate cancer and is a functional biomarker of lymph node metastasis. Oncotarget (2016) 0.78
Sox2 transcription network acts as a molecular switch to regulate properties of neural stem cells. World J Stem Cells (2014) 0.78
Enhancer Analysis Unveils Genetic Interactions between TLX and SOX2 in Neural Stem Cells and In Vivo Reprogramming. Stem Cell Reports (2015) 0.78
Roles of N-Myc and STAT interactor in cancer: From initiation to dissemination. Int J Cancer (2016) 0.78
Triple negative breast cancers comprise a highly tumorigenic cell subpopulation detectable by its high responsiveness to a Sox2 regulatory region 2 (SRR2) reporter. Oncotarget (2015) 0.78
Epigenetic regulation of sox30 is associated with testis development in mice. PLoS One (2014) 0.78
SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer. BMC Cancer (2016) 0.77
miRNA-124 down-regulates SOX8 expression and suppresses cell proliferation in non-small cell lung cancer. Int J Clin Exp Pathol (2014) 0.77
Oxidative stress induces the acquisition of cancer stem-like phenotype in breast cancer detectable by using a Sox2 regulatory region-2 (SRR2) reporter. Oncotarget (2016) 0.77
Cleft Palate in a Mouse Model of SOX2 Haploinsufficiency. Cleft Palate Craniofac J (2013) 0.77
The Sox transcriptional factors: Functions during intestinal development in vertebrates. Semin Cell Dev Biol (2016) 0.77
SOX2 is required to maintain cancer stem cells in ovarian cancer. Cancer Sci (2017) 0.76
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29
Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol (2007) 21.93
An extended transcriptional network for pluripotency of embryonic stem cells. Cell (2008) 14.64
Mediator and cohesin connect gene expression and chromatin architecture. Nature (2010) 14.34
Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev (2003) 12.38
A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature (1990) 10.97
Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell (2005) 9.84
MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell (2009) 8.14
A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. Nature (1990) 7.93
SOX2 functions to maintain neural progenitor identity. Neuron (2003) 7.48
SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet (2009) 7.48
Role of the murine reprogramming factors in the induction of pluripotency. Cell (2009) 7.46
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell (2012) 7.17
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet (2010) 6.81
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature (2008) 6.69
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nat Cell Biol (2007) 6.69
Pioneer transcription factors: establishing competence for gene expression. Genes Dev (2011) 6.01
Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nat Neurosci (2003) 5.65
In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. Cell Stem Cell (2007) 5.32
Hair follicle stem cells are specified and function in early skin morphogenesis. Cell Stem Cell (2008) 5.02
Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nat Genet (2012) 4.70
Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science (2000) 4.65
SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult. Dev Neurosci (2005) 4.48
Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell (2011) 4.29
Direct reprogramming of fibroblasts into neural stem cells by defined factors. Cell Stem Cell (2012) 4.28
Molecular dissection of mesenchymal-epithelial interactions in the hair follicle. PLoS Biol (2005) 4.27
Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell (2007) 4.18
Depletion of definitive gut endoderm in Sox17-null mutant mice. Development (2002) 4.13
SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Genes Dev (2006) 4.11
A dermal niche for multipotent adult skin-derived precursor cells. Nat Cell Biol (2004) 4.06
Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Cell (2011) 4.04
Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell (2011) 3.94
Facilitators and impediments of the pluripotency reprogramming factors' initial engagement with the genome. Cell (2012) 3.80
Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain. Development (2004) 3.75
Enhancer decommissioning by LSD1 during embryonic stem cell differentiation. Nature (2012) 3.67
Sox2 is required for sensory organ development in the mammalian inner ear. Nature (2005) 3.58
Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development (2007) 3.56
Pluripotency factors in embryonic stem cells regulate differentiation into germ layers. Cell (2011) 3.53
Direct conversion of fibroblasts into stably expandable neural stem cells. Cell Stem Cell (2012) 3.52
Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. Dev Cell (2002) 3.39
Strategies for homeostatic stem cell self-renewal in adult tissues. Cell (2011) 3.33
Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell (2012) 3.30
A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours. Nature (2011) 3.25
Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development (2009) 3.25
SKPs derive from hair follicle precursors and exhibit properties of adult dermal stem cells. Cell Stem Cell (2009) 3.20
Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages. Mech Dev (1999) 3.12
Chromatin connections to pluripotency and cellular reprogramming. Cell (2011) 3.07
From stem cells to neurons and glia: a Soxist's view of neural development. Trends Neurosci (2005) 3.07
SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells. Neuron (2003) 2.98
Small increases in the level of Sox2 trigger the differentiation of mouse embryonic stem cells. Stem Cells (2008) 2.93
Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts. Development (2005) 2.91
Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. Nat Neurosci (2009) 2.85
Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis. Development (2009) 2.82
Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors. Cell Stem Cell (2009) 2.79
Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. Genes Dev (2002) 2.69
Vertebrate endoderm development and organ formation. Annu Rev Cell Dev Biol (2009) 2.67
Multiple roles for Sox2 in the developing and adult mouse trachea. Development (2009) 2.62
Neural crest development is regulated by the transcription factor Sox9. Development (2003) 2.62
Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. Nat Genet (2011) 2.56
EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting. Cell (2010) 2.54
Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea. Proc Natl Acad Sci U S A (2008) 2.52
Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors. EMBO J (2011) 2.51
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev (2010) 2.50
Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells. Cell Stem Cell (2012) 2.49
Identification of Sox-2 regulatory region which is under the control of Oct-3/4-Sox-2 complex. Nucleic Acids Res (2002) 2.49
Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells. Cell Stem Cell (2008) 2.31
Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination. Proc Natl Acad Sci U S A (2005) 2.29
A DNA repair complex functions as an Oct4/Sox2 coactivator in embryonic stem cells. Cell (2011) 2.29
Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans. J Clin Invest (2006) 2.27
Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development. Genes Dev (2001) 2.18
Mutations in SOX2 cause anophthalmia-esophageal-genital (AEG) syndrome. Hum Mol Genet (2006) 2.17
Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling. Proc Natl Acad Sci U S A (2011) 2.13
Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation. Dev Biol (2008) 2.06
SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland. Proc Natl Acad Sci U S A (2008) 2.01
Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells. Mol Cell Biol (2004) 2.00
Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. J Cell Biol (2005) 2.00
Sequentially acting Sox transcription factors in neural lineage development. Genes Dev (2011) 1.97
Sox2 is required for development of taste bud sensory cells. Genes Dev (2006) 1.97
Sox2 roles in neural stem cells. Int J Biochem Cell Biol (2009) 1.95
Distinct regulatory mechanisms and functions for p53-activated and p53-repressed DNA damage response genes in embryonic stem cells. Mol Cell (2012) 1.94
Evidence that SOX2 overexpression is oncogenic in the lung. PLoS One (2010) 1.93
Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectoderm. Development (2000) 1.83
Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues. Cancer Res (2006) 1.80
Cell lineage mapping of taste bud cells and keratinocytes in the mouse tongue and soft palate. Stem Cells (2009) 1.80
Gene expression dynamics during germline specification in mice identified by quantitative single-cell gene expression profiling. Biol Reprod (2006) 1.78
SOX9 induces and maintains neural stem cells. Nat Neurosci (2010) 1.74
Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cells. PLoS One (2009) 1.69
Sox9 is expressed in mouse multipotent retinal progenitor cells and functions in Müller glial cell development. J Comp Neurol (2008) 1.65
Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells. Genes Dev (2004) 1.63
Impaired generation of mature neurons by neural stem cells from hypomorphic Sox2 mutants. Development (2008) 1.58
Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors. Dev Cell (2012) 1.57
BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone. Cell Res (2010) 1.51
Region-specific expression of chicken Sox2 in the developing gut and lung epithelium: regulation by epithelial-mesenchymal interactions. Dev Dyn (1998) 1.50
Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells. Nature (2011) 1.50
Phosphorylation of Sox2 cooperates in reprogramming to pluripotent stem cells. Stem Cells (2010) 1.48
Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. J Biol Chem (2005) 1.46
SOX-partner code for cell specification: Regulatory target selection and underlying molecular mechanisms. Int J Biochem Cell Biol (2009) 1.46
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell (2007) 21.58
Disease-specific induced pluripotent stem cells. Cell (2008) 16.95
Induced pluripotent stem cells generated without viral integration. Science (2008) 13.38
Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell (2008) 12.45
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol (2010) 9.24
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol (2009) 7.59
Guidelines and techniques for the generation of induced pluripotent stem cells. Cell Stem Cell (2008) 7.57
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature (2010) 7.05
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature (2009) 6.85
Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells. Genesis (2006) 6.64
A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell (2008) 5.99
Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem Cells (2009) 5.69
Oct4 expression is not required for mouse somatic stem cell self-renewal. Cell Stem Cell (2007) 5.29
Induced pluripotency: history, mechanisms, and applications. Genes Dev (2010) 4.89
Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells. Nat Cell Biol (2011) 4.77
Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression. Stem Cells (2008) 4.67
Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell (2002) 4.56
Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat Biotechnol (2008) 4.41
A molecular roadmap of reprogramming somatic cells into iPS cells. Cell (2012) 4.41
Reprogramming of pancreatic beta cells into induced pluripotent stem cells. Curr Biol (2008) 4.34
Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell (2011) 4.29
Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells. Nat Genet (2009) 4.28
Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell (2004) 3.94
Chromatin connections to pluripotency and cellular reprogramming. Cell (2011) 3.07
Tgfbeta signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc. Curr Biol (2009) 2.89
Harnessing the potential of induced pluripotent stem cells for regenerative medicine. Nat Cell Biol (2011) 2.74
A reprogrammable mouse strain from gene-targeted embryonic stem cells. Nat Methods (2009) 2.65
A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells. Cell Stem Cell (2010) 2.65
Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination. Cell Stem Cell (2013) 2.51
Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet (2012) 2.35
Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system. Cell Stem Cell (2012) 2.35
Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells. J Cell Sci (2009) 2.33
ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable. Proc Natl Acad Sci U S A (2006) 2.16
Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei. Proc Natl Acad Sci U S A (2002) 2.05
Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming. Cell Stem Cell (2013) 1.91
Highly coordinated proteome dynamics during reprogramming of somatic cells to pluripotency. Cell Rep (2012) 1.84
Chromatin dynamics during cellular reprogramming. Nature (2013) 1.79
New advances in iPS cell research do not obviate the need for human embryonic stem cells. Cell Stem Cell (2007) 1.68
Nuclear cloning of embryonal carcinoma cells. Proc Natl Acad Sci U S A (2004) 1.61
Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors. Dev Cell (2012) 1.57
When fibroblasts MET iPSCs. Cell Stem Cell (2010) 1.48
Fibroblast-derived induced pluripotent stem cells show no common retroviral vector insertions. Stem Cells (2009) 1.41
Early TCR expression and aberrant T cell development in mice with endogenous prerearranged T cell receptor genes. J Immunol (2007) 1.41
Induced pluripotent stem cells and reprogramming: seeing the science through the hype. Nat Rev Genet (2009) 1.36
Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization. Genes Dev (2003) 1.25
Cross-regulation of the Nanog and Cdx2 promoters. Cell Res (2009) 1.23
Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Development (2013) 1.19
The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming. Cell Stem Cell (2013) 1.19
Sox2 marks epithelial competence to generate teeth in mammals and reptiles. Development (2013) 1.16
X chromosome choice occurs independently of asynchronous replication timing. J Cell Biol (2005) 1.14
T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell. Proc Natl Acad Sci U S A (2010) 1.13
The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell (2012) 1.08
Efficient generation of iPS cells from skeletal muscle stem cells. PLoS One (2011) 1.06
Direct in vivo VH to JH rearrangement violating the 12/23 rule. J Exp Med (2005) 1.05
Stem cells assessed. Nat Rev Mol Cell Biol (2012) 1.05
On the cloning of animals from terminally differentiated cells. Nat Genet (2007) 1.03
Position-dependent silencing of germline Vß segments on TCRß alleles containing preassembled VßDJßCß1 genes. J Immunol (2010) 0.91
Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation. J Exp Med (2014) 0.91
Stem cells: iPS cells under attack. Nature (2011) 0.89
TCR beta feedback signals inhibit the coupling of recombinationally accessible V beta 14 segments with DJ beta complexes. J Immunol (2009) 0.87
Nuclear cloning, stem cells, and genomic reprogramming. Cloning Stem Cells (2002) 0.82
A variant CRISPR-Cas9 system adds versatility to genome engineering. Proc Natl Acad Sci U S A (2013) 0.81
Modeling Rett syndrome with stem cells. Cell (2010) 0.80
Removing reprogramming roadblocks: Mbd3 depletion allows deterministic iPSC generation. Cell Stem Cell (2013) 0.79
gPS navigates germ cells to pluripotency. Cell Stem Cell (2009) 0.77
Without a trace? PiggyBac-ing toward pluripotency. Nat Methods (2009) 0.77
A gutsy way to grow: intestinal stem cells as nutrient sensors. Cell (2011) 0.76
Reproductive biology: Stem cells bear eggs. Nature (2012) 0.76
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