Published in Trends Neurosci on September 01, 2003
Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more. Br J Pharmacol (2007) 2.35
Frontiers in pruritus research: scratching the brain for more effective itch therapy. J Clin Invest (2006) 1.90
The multiple pathways for itch and their interactions with pain. Trends Neurosci (2010) 1.61
A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis. Proc Natl Acad Sci U S A (2005) 1.45
Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice. Br J Pharmacol (2008) 1.29
Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis. J Exp Med (2006) 1.25
PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin. Nat Commun (2011) 1.09
Mechanisms of protease-activated receptor 2-evoked hyperexcitability of nociceptive neurons innervating the mouse colon. J Physiol (2007) 1.00
New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms? Pflugers Arch (2013) 0.97
Protease-activated receptor 2-mediated protection of myocardial ischemia-reperfusion injury: role of transient receptor potential vanilloid receptors. Am J Physiol Regul Integr Comp Physiol (2009) 0.96
Learning and memory deficits in mice lacking protease activated receptor-1. Neurobiol Learn Mem (2007) 0.93
Modulation of visceral pain and inflammation by protease-activated receptors. Br J Pharmacol (2004) 0.93
Activity of recombinant trypsin isoforms on human proteinase-activated receptors (PAR): mesotrypsin cannot activate epithelial PAR-1, -2, but weakly activates brain PAR-1. Br J Pharmacol (2005) 0.90
Expression of protease-activated receptors and tissue factor in human liver. Virchows Arch (2005) 0.85
Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase-activated receptor-2. Br J Pharmacol (2015) 0.83
The role of kinin B1 and B2 receptors in the scratching behaviour induced by proteinase-activated receptor-2 agonists in mice. Br J Pharmacol (2010) 0.83
Protease-activated receptors as therapeutic targets in visceral pain. Curr Neuropharmacol (2013) 0.82
The C-terminus of murine S100A9 protein inhibits hyperalgesia induced by the agonist peptide of protease-activated receptor 2 (PAR2). Br J Pharmacol (2006) 0.81
Activation of protease-activated receptor 2-mediated signaling by mast cell tryptase modulates cytokine production in primary cultured astrocytes. Mediators Inflamm (2013) 0.78
Evolution of the protease-activated receptor family in vertebrates. Int J Mol Med (2016) 0.77
The effects of trypsin on rat brain astrocyte activation. Iran J Neurol (2013) 0.76
Attenuated cold sensitivity in TRPM8 null mice. Neuron (2007) 4.73
The neurobiology of itch. Nat Rev Neurosci (2006) 3.25
Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Endocr Rev (2005) 2.42
IL-31: a new link between T cells and pruritus in atopic skin inflammation. J Allergy Clin Immunol (2006) 2.39
Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiol Rev (2006) 2.30
Role for protease activity in visceral pain in irritable bowel syndrome. J Clin Invest (2007) 2.09
Cytokines and chemokines orchestrate atopic skin inflammation. J Allergy Clin Immunol (2006) 2.08
Frontiers in pruritus research: scratching the brain for more effective itch therapy. J Clin Invest (2006) 1.90
The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia. Sci Signal (2011) 1.75
Evaluation of protease-activated receptor 2 in murine models of arthritis. Arthritis Rheum (2007) 1.70
"Outside-to-inside" (and now back to "outside") pathogenic mechanisms in atopic dermatitis. J Invest Dermatol (2008) 1.64
Tumor immune escape by the loss of homeostatic chemokine expression. Proc Natl Acad Sci U S A (2007) 1.58
Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp Dermatol (2004) 1.52
Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor. Am J Physiol Cell Physiol (2011) 1.51
Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains. Brain Res (2003) 1.43
Tumor-derived matrix metalloproteinase-1 targets endothelial proteinase-activated receptor 1 promoting endothelial cell activation. Cancer Res (2006) 1.42
Human cardiomyocytes express high level of Na+/glucose cotransporter 1 (SGLT1). J Cell Biochem (2003) 1.36
Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling. J Biol Chem (2009) 1.27
The TGR5 receptor mediates bile acid-induced itch and analgesia. J Clin Invest (2013) 1.27
Clinical, cellular, and molecular aspects in the pathophysiology of rosacea. J Investig Dermatol Symp Proc (2011) 1.27
UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling. Proc Natl Acad Sci U S A (2013) 1.26
Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases. J Invest Dermatol (2007) 1.25
Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo. FASEB J (2003) 1.22
Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit. Mol Pharmacol (2002) 1.22
Pathophysiology of pruritus in atopic dermatitis: an overview. Exp Dermatol (2002) 1.21
Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling. Proc Natl Acad Sci U S A (2007) 1.21
Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1. J Biol Chem (2007) 1.21
Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. J Cell Biol (2007) 1.20
Blockade of the thrombin receptor protease-activated receptor-1 with a small-molecule antagonist prevents thrombus formation and vascular occlusion in nonhuman primates. J Pharmacol Exp Ther (2003) 1.20
Abeta peptides can enter the brain through a defective blood-brain barrier and bind selectively to neurons. Brain Res (2007) 1.18
Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism. Can J Physiol Pharmacol (2003) 1.17
Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B. J Invest Dermatol (2005) 1.16
Retracted A role for proteinase-activated receptor-1 in inflammatory bowel diseases. J Clin Invest (2004) 1.15
Efficacy and safety of once-daily topical brimonidine tartrate gel 0.5% for the treatment of moderate to severe facial erythema of rosacea: results of two randomized, double-blind, and vehicle-controlled pivotal studies. J Drugs Dermatol (2013) 1.14
Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor kappaB in human dermal microvascular endothelial cells. J Invest Dermatol (2002) 1.12
Neurophysiology of pruritus: cutaneous elicitation of itch. Arch Dermatol (2003) 1.12
Ubiquitin-dependent down-regulation of the neurokinin-1 receptor. J Biol Chem (2006) 1.12
Molecular cloning and functional expression of the human sodium channel beta1B subunit, a novel splicing variant of the beta1 subunit. Eur J Biochem (2003) 1.12
Neurovascular and neuroimmune aspects in the pathophysiology of rosacea. J Investig Dermatol Symp Proc (2011) 1.10
Characterization of thrombin-induced leukocyte rolling and adherence: a potential proinflammatory role for proteinase-activated receptor-4. J Immunol (2002) 1.10
Neuronal sensitization for histamine-induced itch in lesional skin of patients with atopic dermatitis. Arch Dermatol (2003) 1.09
PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin. Nat Commun (2011) 1.09
Proteinase-activated receptor-2 in the skin: receptor expression, activation and function during health and disease. Drug News Perspect (2008) 1.08
Whole-exome sequencing of DNA from peripheral blood mononuclear cells (PBMC) and EBV-transformed lymphocytes from the same donor. BMC Genomics (2011) 1.08
Recycling and resensitization of the neurokinin 1 receptor. Influence of agonist concentration and Rab GTPases. J Biol Chem (2004) 1.07
Protease-activated receptor-2 activation: a major role in the pathogenesis of Porphyromonas gingivalis infection. Am J Pathol (2006) 1.07
IL-33: a novel danger signal system in atopic dermatitis. J Invest Dermatol (2012) 1.05
Successful treatment of generalized eruptive histiocytoma with PUVA. J Dtsch Dermatol Ges (2007) 1.05
Acute colitis induction by oil of mustard results in later development of an IBS-like accelerated upper GI transit in mice. Am J Physiol Gastrointest Liver Physiol (2005) 1.04
Mouse model of touch-evoked itch (alloknesis). J Invest Dermatol (2012) 1.04
Neurophysiology of pruritus: interaction of itch and pain. Arch Dermatol (2003) 1.03
Neutrophils and the kallikrein-kinin system in proteinase-activated receptor 4-mediated inflammation in rodents. Br J Pharmacol (2005) 1.03
Distribution and expression of non-neuronal transient receptor potential (TRPV) ion channels in rosacea. J Invest Dermatol (2011) 1.02
Endothelin-converting enzyme-1 degrades internalized somatostatin-14. Endocrinology (2008) 1.01
Pruritus in elderly patients--eruptions of senescence. Semin Cutan Med Surg (2011) 0.98
Par2 inactivation inhibits early production of TSLP, but not cutaneous inflammation, in Netherton syndrome adult mouse model. J Invest Dermatol (2010) 0.98
Neuroimmune interactions in allergic skin diseases. Curr Opin Allergy Clin Immunol (2007) 0.97
Efficacy and safety of ivermectin 1% cream in treatment of papulopustular rosacea: results of two randomized, double-blind, vehicle-controlled pivotal studies. J Drugs Dermatol (2014) 0.96
Agonists of proteinase-activated receptor-2 affect transendothelial migration and apoptosis of human neutrophils. Exp Dermatol (2007) 0.95
Activity-dependent neurotrophic factor-9 and NAP promote neurite outgrowth in rat hippocampal and cortical cultures. J Mol Neurosci (2005) 0.95
Functional characterization and expression analysis of the proteinase-activated receptor-2 in human cutaneous mast cells. J Invest Dermatol (2006) 0.94
Regulatory network of inflammation downstream of proteinase-activated receptors. BMC Physiol (2007) 0.93
Microfluidic reveals generation of platelet-strings on tumor-activated endothelium. Thromb Haemost (2007) 0.92
A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity. Anal Biochem (2009) 0.92
Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation. BMC Physiol (2007) 0.91
Characterization of serine palmitoyltransferase in normal human tissues. J Histochem Cytochem (2003) 0.91
Cerebellar diffuse amyloid plaques are derived from dendritic Abeta42 accumulations in Purkinje cells. Neurobiol Aging (2002) 0.91
Role of matriptase and proteinase-activated receptor-2 in nonmelanoma skin cancer. J Invest Dermatol (2009) 0.90
Role of protease-activated receptors in human skin fibrosis and scleroderma. Exp Dermatol (2011) 0.90
Small intestinal cannabinoid receptor changes following a single colonic insult with oil of mustard in mice. Front Pharmacol (2010) 0.90
Anatomy and neurophysiology of pruritus. Semin Cutan Med Surg (2011) 0.89
Proteinase-activated receptor-1 is an anti-inflammatory signal for colitis mediated by a type 2 immune response. Inflamm Bowel Dis (2005) 0.89
Management of itch in atopic dermatitis. Semin Cutan Med Surg (2011) 0.89
Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection. J Immunol (2008) 0.89
Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones. J Physiol (2011) 0.88
Intermedin: a skin peptide that is downregulated in atopic dermatitis. J Invest Dermatol (2006) 0.88
Proteinase-activated receptor-2 (PAR2): a tumor suppressor in skin carcinogenesis. J Invest Dermatol (2007) 0.88
A consolidated approach to analyzing data from high-throughput protein microarrays with an application to immune response profiling in humans. J Comput Biol (2007) 0.87
Rosacea: The cytokine and chemokine network. J Investig Dermatol Symp Proc (2011) 0.87
Transient receptor potential ankyrin 1 mediates chronic pancreatitis pain in mice. Am J Physiol Gastrointest Liver Physiol (2013) 0.87
Improvement in facial erythema within 30 minutes of initial application of brimonidine tartrate in patients with rosacea. J Drugs Dermatol (2014) 0.87
Role of spinal neurotransmitter receptors in itch: new insights into therapies and drug development. CNS Neurosci Ther (2010) 0.86
Neuronal expression of vimentin in the Alzheimer's disease brain may be part of a generalized dendritic damage-response mechanism. Brain Res (2009) 0.86
Pruritus and renal failure. Semin Cutan Med Surg (2011) 0.86
Psychoneuroimmunology of psychological stress and atopic dermatitis: pathophysiologic and therapeutic updates. Acta Derm Venereol (2012) 0.86
Long-term safety of ivermectin 1% cream vs azelaic acid 15% gel in treating inflammatory lesions of rosacea: results of two 40-week controlled, investigator-blinded trials. J Drugs Dermatol (2014) 0.86
PAR-2 inhibition reverses experimental pulmonary hypertension. Circ Res (2012) 0.85
Innovative management of pruritus. Dermatol Clin (2010) 0.85
Alpha7 nicotinic acetylcholine receptor expression by vascular smooth muscle cells facilitates the deposition of Abeta peptides and promotes cerebrovascular amyloid angiopathy. Brain Res (2008) 0.84
Thrombin receptor: An endogenous inhibitor of inflammatory pain, activating opioid pathways. Pain (2009) 0.84
Localization of mu-opioid receptor 1A on sensory nerve fibers in human skin. Regul Pept (2002) 0.84