Published in J Biol Chem on September 02, 2003
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. J Clin Invest (2005) 4.14
Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control. J Clin Invest (2005) 3.08
Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation. Blood (2005) 2.76
Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol (2009) 2.29
An S-nitrosothiol (SNO) synthase function of hemoglobin that utilizes nitrite as a substrate. Proc Natl Acad Sci U S A (2006) 2.21
Endothelial nitric oxide synthase in red blood cells: key to a new erythrocrine function? Redox Biol (2014) 2.18
Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2008) 2.17
Nitrite as regulator of hypoxic signaling in mammalian physiology. Med Res Rev (2009) 2.15
Nitrite anion provides potent cytoprotective and antiapoptotic effects as adjunctive therapy to reperfusion for acute myocardial infarction. Circulation (2008) 2.14
Erythrocytes are the major intravascular storage sites of nitrite in human blood. Blood (2005) 2.08
Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery. Chem Rev (2013) 2.02
Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall. Am J Physiol Heart Circ Physiol (2008) 1.88
Nitric oxide production from nitrite occurs primarily in tissues not in the blood: critical role of xanthine oxidase and aldehyde oxidase. J Biol Chem (2008) 1.82
The functional nitrite reductase activity of the heme-globins. Blood (2008) 1.58
The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal. Arch Biochem Biophys (2008) 1.36
Novel pharmacological approaches to the treatment of renal ischemia-reperfusion injury: a comprehensive review. Naunyn Schmiedebergs Arch Pharmacol (2007) 1.35
Oxygen-regulated isoforms of cytochrome c oxidase have differential effects on its nitric oxide production and on hypoxic signaling. Proc Natl Acad Sci U S A (2008) 1.33
Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation. Trends Mol Med (2009) 1.29
Nitrite reductase activity of cytochrome c. J Biol Chem (2008) 1.25
Mechanisms of nitrite bioactivation. Nitric Oxide (2013) 1.22
Low NO concentration dependence of reductive nitrosylation reaction of hemoglobin. J Biol Chem (2012) 1.20
Assessment of nitric oxide signals by triiodide chemiluminescence. Proc Natl Acad Sci U S A (2007) 1.20
Acute effect of a high nitrate diet on brain perfusion in older adults. Nitric Oxide (2010) 1.17
Enhancement of nitric oxide release from nitrosyl hemoglobin and nitrosyl myoglobin by red/near infrared radiation: potential role in cardioprotection. J Mol Cell Cardiol (2009) 1.14
Characterization of the deoxyhemoglobin binding site on human erythrocyte band 3: implications for O2 regulation of erythrocyte properties. Blood (2007) 1.13
Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation. Am J Physiol Heart Circ Physiol (2009) 1.07
Nitric oxide formation versus scavenging: the red blood cell balancing act. J Physiol (2012) 1.04
Nitrite enhances RBC hypoxic ATP synthesis and the release of ATP into the vasculature: a new mechanism for nitrite-induced vasodilation. Am J Physiol Heart Circ Physiol (2009) 1.04
Measurement of plasma nitrite by chemiluminescence without interference of S-, N-nitroso and nitrated species. Free Radic Biol Med (2007) 1.03
Quantification of intermediates formed during the reduction of nitrite by deoxyhemoglobin. J Biol Chem (2009) 1.01
Effect of blood nitrite and nitrate levels on murine platelet function. PLoS One (2013) 1.00
The potential role of the red blood cell in nitrite-dependent regulation of blood flow. Cardiovasc Res (2010) 1.00
RBC-NOS-dependent S-nitrosylation of cytoskeletal proteins improves RBC deformability. PLoS One (2013) 1.00
Effect of processing and storage on red blood cell function in vivo. Semin Perinatol (2012) 1.00
A novel role for cytochrome c: Efficient catalysis of S-nitrosothiol formation. Free Radic Biol Med (2009) 0.98
Nitric oxide in adaptation to altitude. Free Radic Biol Med (2012) 0.96
Molecular controls of the oxygenation and redox reactions of hemoglobin. Antioxid Redox Signal (2013) 0.92
Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reduction. Biochem J (2009) 0.92
Structural adaptation of microvessel diameters in response to metabolic stimuli: where are the oxygen sensors? Am J Physiol Heart Circ Physiol (2009) 0.92
Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis. Am J Physiol Heart Circ Physiol (2008) 0.91
Hemoglobin redox reactions and red blood cell aging. Antioxid Redox Signal (2012) 0.91
Effects of T- and R-state stabilization on deoxyhemoglobin-nitrite reactions and stimulation of nitric oxide signaling. Nitric Oxide (2011) 0.90
HBOC vasoactivity: interplay between nitric oxide scavenging and capacity to generate bioactive nitric oxide species. Antioxid Redox Signal (2013) 0.89
Crystal structures of manganese- and cobalt-substituted myoglobin in complex with NO and nitrite reveal unusual ligand conformations. J Inorg Biochem (2007) 0.89
Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH. Acta Neurochir Suppl (2008) 0.89
Therapeutic Potential of the Nitrite-Generated NO Pathway in Vascular Dysfunction. Front Immunol (2013) 0.88
Hemoglobin-mediated nitric oxide signaling. Free Radic Biol Med (2013) 0.88
Fe(II) oxidation is an innate capability of nitrate-reducing bacteria that involves abiotic and biotic reactions. J Bacteriol (2013) 0.86
A flow cytometric analysis of the inhibition of platelet reactivity due to nitrite reduction by deoxygenated erythrocytes. PLoS One (2014) 0.85
Effect of chronic sodium nitrite therapy on monocrotaline-induced pulmonary hypertension. Nitric Oxide (2012) 0.85
How to protect liver graft with nitric oxide. World J Gastroenterol (2011) 0.85
Nitrite consumption in ischemic rat heart catalyzed by distinct blood-borne and tissue factors. Am J Physiol Heart Circ Physiol (2008) 0.83
Structural and functional studies indicating altered redox properties of hemoglobin E: implications for production of bioactive nitric oxide. J Biol Chem (2011) 0.83
The reaction of cell-free oxyhemoglobin with nitrite under physiologically relevant conditions: Implications for nitrite-based therapies. Nitric Oxide (2008) 0.83
Polymorphisms in the HBB gene relate to individual cardiorespiratory adaptation in response to endurance training. Br J Sports Med (2006) 0.83
Parallel evolution of nitric oxide signaling: diversity of synthesis and memory pathways. Front Biosci (Landmark Ed) (2011) 0.83
Bioanalytical profile of the L-arginine/nitric oxide pathway and its evaluation by capillary electrophoresis. J Chromatogr B Analyt Technol Biomed Life Sci (2007) 0.83
Generating S-nitrosothiols from hemoglobin: mechanisms, conformational dependence, and physiological relevance. J Biol Chem (2013) 0.82
A new paramagnetic intermediate formed during the reaction of nitrite with deoxyhemoglobin. J Am Chem Soc (2011) 0.82
The quaternary hemoglobin conformation regulates the formation of the nitrite-induced bioactive intermediate and the dissociation of nitric oxide from this intermediate. Nitric Oxide (2011) 0.81
Intracellular conversion of environmental nitrate and nitrite to nitric oxide with resulting developmental toxicity to the crustacean Daphnia magna. PLoS One (2010) 0.81
Protein disulfide isomerase may facilitate the efflux of nitrite derived S-nitrosothiols from red blood cells. Redox Biol (2013) 0.81
Erythrocytes induce proinflammatory endothelial activation in hypoxia. Am J Respir Cell Mol Biol (2012) 0.81
Cross-linking with O-raffinose lowers oxygen affinity and stabilizes haemoglobin in a non-cooperative T-state conformation. Biochem J (2004) 0.80
Role of hemoglobin oxygenation in the modulation of red blood cell mechanical properties by nitric oxide. Nitric Oxide (2009) 0.80
A computational model for nitric oxide, nitrite and nitrate biotransport in the microcirculation: effect of reduced nitric oxide consumption by red blood cells and blood velocity. Microvasc Res (2010) 0.79
Nitrite-induced improved blood circulation associated with an increase in a pool of RBC-NO with no bioactivity. Adv Exp Med Biol (2009) 0.79
Mechanisms for cellular NO oxidation and nitrite formation in lung epithelial cells. Free Radic Biol Med (2013) 0.79
Transient repetitive exposure to low level light therapy enhances collateral blood vessel growth in the ischemic hindlimb of the tight skin mouse. Photochem Photobiol (2013) 0.79
Extreme differences between hemoglobins I and II of the clam Lucina pectinalis in their reactions with nitrite. Biochim Biophys Acta (2010) 0.79
Impact of nitric-oxide-mediated vasodilation and oxidative stress on renal medullary oxygenation: a modeling study. Am J Physiol Renal Physiol (2015) 0.78
Carbon dioxide influence on nitric oxide production in endothelial cells and astrocytes: cellular mechanisms. Brain Res (2011) 0.78
Nitrite induces the extravasation of iron oxide nanoparticles in hypoxic tumor tissue. NMR Biomed (2014) 0.77
Effect of storage on levels of nitric oxide metabolites in platelet preparations. Transfusion (2012) 0.77
The role of red blood cell S-nitrosation in nitrite bioactivation and its modulation by leucine and glucose. Redox Biol (2016) 0.77
Evaluating the capacity to generate and preserve nitric oxide bioactivity in highly purified earthworm erythrocruorin: a giant polymeric hemoglobin with potential blood substitute properties. J Biol Chem (2014) 0.76
Inhibitory effect of nitrite on coagulation processes demonstrated by thrombelastography. Nitric Oxide (2014) 0.76
Reversible binding of hemoglobin to band 3 constitutes the molecular switch that mediates O2 regulation of erythrocyte properties. Blood (2016) 0.75
Interactions of nitrosylhemoglobin and carboxyhemoglobin with erythrocyte. Nitric Oxide (2007) 0.75
Measurement of plasma nitrite by chemiluminescence. Methods Mol Biol (2010) 0.75
The effect of high altitude on nasal nitric oxide levels. Eur Arch Otorhinolaryngol (2014) 0.75
A drug burden index to define the functional burden of medications in older people. Arch Intern Med (2007) 2.84
Effect of obesity on the pharmacokinetics of drugs in humans. Clin Pharmacokinet (2010) 2.32
Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy. Clin Cancer Res (2006) 1.97
Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes. Mol Pharmacol (2008) 1.78
Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor. J Med Chem (2007) 1.77
Drug Burden Index and physical function in older Australian men. Br J Clin Pharmacol (2009) 1.58
Red blood cells induce hypoxic lung inflammation. Blood (2008) 1.49
S-nitrosohemoglobin: a mechanism for its formation in conjunction with nitrite reduction by deoxyhemoglobin. Nitric Oxide (2006) 1.47
Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca2+ ions. J Biol Chem (2005) 1.40
The utility of modeling and simulation in drug development and regulatory review. J Pharm Sci (2013) 1.38
Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats. FASEB J (2006) 1.36
Voltage-gated mobility of the Ca2+ channel cytoplasmic tails and its regulatory role. J Biol Chem (2002) 1.30
Heme degradation by reactive oxygen species. Antioxid Redox Signal (2004) 1.24
Drug burden index score and functional decline in older people. Am J Med (2009) 1.19
Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel alpha1C subunit. Proc Natl Acad Sci U S A (2006) 1.14
Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol. Chirality (2006) 1.14
Hydrogen-peroxide-induced heme degradation in red blood cells: the protective roles of catalase and glutathione peroxidase. Biochim Biophys Acta (2003) 1.11
Iron-deficiency anaemia enhances red blood cell oxidative stress. Free Radic Res (2008) 1.10
Drug Burden Index for international assessment of the functional burden of medications in older people. J Am Geriatr Soc (2014) 1.09
Systems pharmacology to predict drug toxicity: integration across levels of biological organization. Annu Rev Pharmacol Toxicol (2012) 1.08
Association of the red cell distribution width with red blood cell deformability. Adv Exp Med Biol (2013) 1.06
Racial discrimination is associated with a measure of red blood cell oxidative stress: a potential pathway for racial health disparities. Int J Behav Med (2012) 1.05
Voltage-gated rearrangements associated with differential beta-subunit modulation of the L-type Ca(2+) channel inactivation. Biophys J (2004) 1.05
Nitrite enhances RBC hypoxic ATP synthesis and the release of ATP into the vasculature: a new mechanism for nitrite-induced vasodilation. Am J Physiol Heart Circ Physiol (2009) 1.04
Measurement of plasma nitrite by chemiluminescence without interference of S-, N-nitroso and nitrated species. Free Radic Biol Med (2007) 1.03
New short splice variants of the human cardiac Cavbeta2 subunit: redefining the major functional motifs implemented in modulation of the Cav1.2 channel. J Biol Chem (2004) 1.01
Quantification of intermediates formed during the reduction of nitrite by deoxyhemoglobin. J Biol Chem (2009) 1.01
Intermediates detected by visible spectroscopy during the reaction of nitrite with deoxyhemoglobin: the effect of nitrite concentration and diphosphoglycerate. Biochemistry (2007) 1.01
Evaluation of exposure change of nonrenally eliminated drugs in patients with chronic kidney disease using physiologically based pharmacokinetic modeling and simulation. J Clin Pharmacol (2012) 1.01
Heme degradation and oxidative stress in murine models for hemoglobinopathies: thalassemia, sickle cell disease and hemoglobin C disease. Blood Cells Mol Dis (2008) 1.00
Redox reactions of hemoglobin. Antioxid Redox Signal (2004) 0.99
Nitrite infusion increases cerebral blood flow and decreases mean arterial blood pressure in rats: a role for red cell NO. Nitric Oxide (2007) 0.98
Site-specific cross-linking of human and bovine hemoglobins differentially alters oxygen binding and redox side reactions producing rhombic heme and heme degradation. Biochemistry (2002) 0.96
Exendin-4 pharmacodynamics: insights from the hyperglycemic clamp technique. J Pharmacol Exp Ther (2004) 0.96
Analysis of functional signaling domains from fluorescence imaging and the two-dimensional continuous wavelet transform. Biophys J (2007) 0.95
Drug burden index and beers criteria: impact on functional outcomes in older people living in self-care retirement villages. J Clin Pharmacol (2012) 0.94
Using Medicare administrative data to conduct postmarketing surveillance of follow-on biologics: issues and opportunities. Food Drug Law J (2008) 0.93
Use of wavelet and fast Fourier transforms in pharmacodynamics. J Pharmacol Exp Ther (2006) 0.92
Effects of endothelial nitric oxide synthase gene polymorphisms on platelet function, nitric oxide release, and interactions with estradiol. Pharmacogenetics (2002) 0.91
Consensus recommendations for systematic evaluation of drug-drug interaction evidence for clinical decision support. Drug Saf (2015) 0.91
Binding of hemoglobin to red cell membranes with eosin-5-maleimide-labeled band 3: analysis of centrifugation and fluorescence data. Biochemistry (2002) 0.90
Nitric oxide redox reactions and red cell biology. Antioxid Redox Signal (2006) 0.89
Red cell perturbations by amyloid beta-protein. Biochim Biophys Acta (2003) 0.88
Revision of instructions to authors for pharmacology research and perspectives: enhancing the quality and transparency of published work. Pharmacol Res Perspect (2015) 0.87
Effect of angiotensin-converting enzyme insertion/deletion polymorphism DD genotype on high-frequency heart rate variability in African Americans. Am J Cardiol (2003) 0.87
Pharmacoepidemiology in the postmarketing assessment of the safety and efficacy of drugs in older adults. J Gerontol A Biol Sci Med Sci (2011) 0.87
A pilot randomized clinical trial utilizing the drug burden index to reduce exposure to anticholinergic and sedative medications in older people. Ann Pharmacother (2010) 0.87
A 2012 Workshop: Vaccine and Drug Ontology in the Study of Mechanism and Effect (VDOSME 2012). J Biomed Semantics (2012) 0.87
Role of the membrane in the formation of heme degradation products in red blood cells. Life Sci (2009) 0.86
Simultaneous modeling of abciximab plasma concentrations and ex vivo pharmacodynamics in patients undergoing coronary angioplasty. J Pharmacol Exp Ther (2003) 0.86
Effects of the physical work environment on physiological measures of stress. Eur J Cardiovasc Prev Rehabil (2010) 0.86
Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Exp Gerontol (2007) 0.85
Oxidative stress and hemorheological changes induced by acute treadmill exercise. Clin Hemorheol Microcirc (2003) 0.84
Do red blood cell-beta-amyloid interactions alter oxygen delivery in Alzheimer's disease? Adv Exp Med Biol (2008) 0.84
Determination of s-nitrosothiols in biological fluids by chemiluminescence. Methods Mol Biol (2011) 0.84
Geriatric drug evaluation: where are we now and where should we be in the future? Arch Intern Med (2011) 0.84
Vascular endothelial barrier dysfunction mediated by amyloid-beta proteins. J Alzheimers Dis (2009) 0.84
Assessment of antioxidant activity of eugenol in vitro and in vivo. Methods Mol Biol (2010) 0.83
Nitroprusside inhibits calcium-induced impairment of red blood cell deformability. Transfusion (2013) 0.82
Identification of plasma membrane macro- and microdomains from wavelet analysis of FRET microscopy. Biophys J (2005) 0.82
A new paramagnetic intermediate formed during the reaction of nitrite with deoxyhemoglobin. J Am Chem Soc (2011) 0.82
Red cell interactions with amyloid-beta(1-40) fibrils in a murine model. Neurobiol Dis (2005) 0.81
Erythrocytes induce proinflammatory endothelial activation in hypoxia. Am J Respir Cell Mol Biol (2012) 0.81
Alterations in the red blood cell membrane proteome in alzheimer's subjects reflect disease-related changes and provide insight into altered cell morphology. Proteome Sci (2010) 0.81
Enhanced Aβ(1-40) production in endothelial cells stimulated with fibrillar Aβ(1-42). PLoS One (2013) 0.81
The quaternary hemoglobin conformation regulates the formation of the nitrite-induced bioactive intermediate and the dissociation of nitric oxide from this intermediate. Nitric Oxide (2011) 0.81
Cross-linking with O-raffinose lowers oxygen affinity and stabilizes haemoglobin in a non-cooperative T-state conformation. Biochem J (2004) 0.80
Oxidative damage to DNA and single strand break repair capacity: relationship to other measures of oxidative stress in a population cohort. Mutat Res (2012) 0.80
Hemoglobin redox reactions and oxidative stress. Redox Rep (2003) 0.80
A fluorimetric semi-microplate format assay of protein carbonyls in blood plasma. Anal Biochem (2010) 0.79
Age-related changes in mean corpuscular volume in adult whites and African Americans. J Am Geriatr Soc (2011) 0.78
Mapping the dose-effect relationship of orbofiban from sparse data with an artificial neural network. J Pharm Sci (2005) 0.78
Influence of beta-amyloid fibrils on the interactions between red blood cells and endothelial cells. Neurol Res (2004) 0.78
SOD2 deficiency in hematopoietic cells in mice results in reduced red blood cell deformability and increased heme degradation. Exp Hematol (2012) 0.78
Routes for formation of S-nitrosothiols in blood. Cell Biochem Biophys (2013) 0.77
Pharmacodynamic profile of short-term readministration of abciximab in healthy subjects. Am Heart J (2002) 0.77
Internal Spin Trapping of Thiyl Radical during the Complexation and Reduction of Cobalamin with Glutathione and Dithiothrietol. J Porphyr Phthalocyanines (2012) 0.76
Studies on heme release from normal and metal ion reconstituted hemoglobin mediated through ionic surfactant. Biopolymers (2005) 0.76
Reducing drugs in older adults is more. Arch Intern Med (2011) 0.75
Measures of drug toxicity in older adults. Arch Intern Med (2008) 0.75
Change in criteria for USP dissolution performance verification tests. AAPS PharmSciTech (2009) 0.75
Considering the vascular hypothesis of Alzheimer's disease: effect of copper associated amyloid on red blood cells. Adv Exp Med Biol (2013) 0.75
Advice on statistical analysis, and new journal guidance for experimental design and analysis. Pharmacol Res Perspect (2015) 0.75
Measurement of plasma nitrite by chemiluminescence. Methods Mol Biol (2010) 0.75
Metrologic approaches to setting acceptance criteria: unacceptable and unusual characteristics. J Pharm Biomed Anal (2008) 0.75
Abciximab pharmacodynamic model with neural networks used to integrate sources of patient variability. Clin Pharmacol Ther (2004) 0.75
Kullback-Leibler clustering of continuous wavelet transform measures of heart rate variability. Biomed Sci Instrum (2004) 0.75