Published in Ann Pharmacother on September 28, 2010
Age-related changes in the hepatic pharmacology and toxicology of paracetamol. Curr Gerontol Geriatr Res (2011) 1.01
Drug Burden Index in older adults: theoretical and practical issues. Clin Interv Aging (2014) 0.86
Use of Potentially Harmful Medications and Health-Related Quality of Life among People with Dementia Living in Residential Aged Care Facilities. Dement Geriatr Cogn Dis Extra (2012) 0.84
The feasibility and effect of deprescribing in older adults on mortality and health: a systematic review and meta-analysis. Br J Clin Pharmacol (2016) 0.81
Barricades and brickwalls - a qualitative study exploring perceptions of medication use and deprescribing in long-term care. BMC Geriatr (2016) 0.80
Minimizing anticholinergic drug prescribing in older hospitalized patients: a full audit cycle. Ther Adv Drug Saf (2014) 0.77
Quantification of anticholinergic and sedative drug load with the Drug Burden Index: a review of outcomes and methodological quality of studies. Eur J Clin Pharmacol (2016) 0.75
Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. J Clin Epidemiol (2012) 3.57
Aging biology and geriatric clinical pharmacology. Pharmacol Rev (2004) 3.23
The impact of frailty on the utilisation of antithrombotic therapy in older patients with atrial fibrillation. Age Ageing (2009) 3.03
A drug burden index to define the functional burden of medications in older people. Arch Intern Med (2007) 2.84
Effect of obesity on the pharmacokinetics of drugs in humans. Clin Pharmacokinet (2010) 2.32
T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells. Hepatology (2006) 2.30
Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov (2012) 2.22
Active nitric oxide produced in the red cell under hypoxic conditions by deoxyhemoglobin-mediated nitrite reduction. J Biol Chem (2003) 2.20
Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat. Hepatology (2005) 2.00
Loss of muscle strength, mass (sarcopenia), and quality (specific force) and its relationship with functional limitation and physical disability: the Concord Health and Ageing in Men Project. J Am Geriatr Soc (2010) 1.97
Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proc Natl Acad Sci U S A (2011) 1.89
Pain, frailty and comorbidity on older men: the CHAMP study. Pain (2008) 1.79
Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes. Mol Pharmacol (2008) 1.78
Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor. J Med Chem (2007) 1.77
Atypical antipsychotic medications and risk of falls in residents of aged care facilities. J Am Geriatr Soc (2005) 1.73
Number and dosage of central nervous system medications on recurrent falls in community elders: the Health, Aging and Body Composition study. J Gerontol A Biol Sci Med Sci (2009) 1.64
How fast does the Grim Reaper walk? Receiver operating characteristics curve analysis in healthy men aged 70 and over. BMJ (2011) 1.59
Drug Burden Index and physical function in older Australian men. Br J Clin Pharmacol (2009) 1.58
The Relationship between fenestrations, sieve plates and rafts in liver sinusoidal endothelial cells. PLoS One (2012) 1.54
Medication withdrawal trials in people aged 65 years and older: a systematic review. Drugs Aging (2008) 1.51
Prescribing in older people. Aust Fam Physician (2004) 1.49
Benzodiazepines and risk of hip fractures in older people: a review of the evidence. CNS Drugs (2003) 1.47
Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca2+ ions. J Biol Chem (2005) 1.40
Age-related pseudocapillarization of the human liver. J Pathol (2003) 1.39
The utility of modeling and simulation in drug development and regulatory review. J Pharm Sci (2013) 1.38
Fenestrations and lipoproteins. Cardiovasc Pathol (2010) 1.38
Dietary approaches that delay age-related diseases. Clin Interv Aging (2006) 1.37
Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats. FASEB J (2006) 1.36
Voltage-gated mobility of the Ca2+ channel cytoplasmic tails and its regulatory role. J Biol Chem (2002) 1.30
Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment. Br J Clin Pharmacol (2011) 1.26
Deprescribing trials: methods to reduce polypharmacy and the impact on prescribing and clinical outcomes. Clin Geriatr Med (2012) 1.25
Clinical pharmacology in the geriatric patient. Fundam Clin Pharmacol (2007) 1.22
Effect of central nervous system medication use on decline in cognition in community-dwelling older adults: findings from the Health, Aging And Body Composition Study. J Am Geriatr Soc (2009) 1.22
Sleep disturbances and falls in older people. J Gerontol A Biol Sci Med Sci (2007) 1.21
Associations between drug burden index and falls in older people in residential aged care. J Am Geriatr Soc (2011) 1.20
Drug burden index score and functional decline in older people. Am J Med (2009) 1.19
Serum uric acid is associated with bone health in older men: a cross-sectional population-based study. J Bone Miner Res (2011) 1.18
Frailty and use of health and community services by community-dwelling older men: the Concord Health and Ageing in Men Project. Age Ageing (2010) 1.14
Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel alpha1C subunit. Proc Natl Acad Sci U S A (2006) 1.14
Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol. Chirality (2006) 1.14
Vitamin C restores healthy aging in a mouse model for Werner syndrome. FASEB J (2009) 1.13
Three-dimensional structured illumination microscopy of liver sinusoidal endothelial cell fenestrations. J Struct Biol (2010) 1.13
Hepatic sinusoidal pseudocapillarization with aging in the non-human primate. Exp Gerontol (2003) 1.11
Drug Burden Index for international assessment of the functional burden of medications in older people. J Am Geriatr Soc (2014) 1.09
Medication exposure may confound the association between dietary intake and frailty. J Gerontol A Biol Sci Med Sci (2013) 1.08
Systems pharmacology to predict drug toxicity: integration across levels of biological organization. Annu Rev Pharmacol Toxicol (2012) 1.08
Understanding drug effects in older people: the role of pharmacology. JAMA Intern Med (2013) 1.07
Modifications to the drug burden index calculation may limit interpretation of its association with clinical outcomes in older adults. Neurocrit Care (2014) 1.07
Drug Burden Index and potentially inappropriate medications in community-dwelling older people: the impact of Home Medicines Review. Drugs Aging (2010) 1.07
Mitochondrial dysfunction in some oxidative stress-related genetic diseases: Ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner Syndrome. Biogerontology (2010) 1.07
Voltage-gated rearrangements associated with differential beta-subunit modulation of the L-type Ca(2+) channel inactivation. Biophys J (2004) 1.05
The response of fenestrations, actin, and caveolin-1 to vascular endothelial growth factor in SK Hep1 cells. Am J Physiol Gastrointest Liver Physiol (2008) 1.05
Thinking through the medication list - appropriate prescribing and deprescribing in robust and frail older patients. Aust Fam Physician (2012) 1.04
Review of epidemiology and management of atrial fibrillation in developing countries. Int J Cardiol (2013) 1.04
The effects of oxidative stress on the liver sieve. J Hepatol (2004) 1.03
Comparison of anticholinergic risk scales and associations with adverse health outcomes in older people. J Am Geriatr Soc (2015) 1.01
Drug burden index, physical function, and adverse outcomes in older hospitalized patients. J Clin Pharmacol (2011) 1.01
Age-related changes in the hepatic pharmacology and toxicology of paracetamol. Curr Gerontol Geriatr Res (2011) 1.01
New short splice variants of the human cardiac Cavbeta2 subunit: redefining the major functional motifs implemented in modulation of the Cav1.2 channel. J Biol Chem (2004) 1.01
Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome. J Gerontol A Biol Sci Med Sci (2010) 1.01
Evaluation of exposure change of nonrenally eliminated drugs in patients with chronic kidney disease using physiologically based pharmacokinetic modeling and simulation. J Clin Pharmacol (2012) 1.01
Basal activity of Kupffer cells increases with old age. J Gerontol A Biol Sci Med Sci (2007) 1.00
Hyperlipidemia and surfactants: the liver sieve is a link. Atherosclerosis (2006) 1.00
The liver sieve and atherosclerosis. Pathology (2012) 1.00
Drug Burden Index associated with function in community-dwelling older people in Finland: a cross-sectional study. Ann Med (2011) 0.99
Experimental gerontological research in Australia. Exp Gerontol (2002) 0.97
Changes in reproductive hormone concentrations predict the prevalence and progression of the frailty syndrome in older men: the concord health and ageing in men project. J Clin Endocrinol Metab (2011) 0.97
Progressive familial intrahepatic cholestasis: genetic disorders of biliary transporters. J Gastroenterol Hepatol (2005) 0.96
Exendin-4 pharmacodynamics: insights from the hyperglycemic clamp technique. J Pharmacol Exp Ther (2004) 0.96
Liver dysfunction and heart failure. Am J Cardiol (2003) 0.95
Analysis of functional signaling domains from fluorescence imaging and the two-dimensional continuous wavelet transform. Biophys J (2007) 0.95
Methodological challenges in determining longitudinal associations between anticholinergic drug use and incident cognitive decline. J Am Geriatr Soc (2014) 0.95
Pathogenesis of the hyperlipidemia of Gram-negative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells. Int J Infect Dis (2010) 0.94
Drug burden index and beers criteria: impact on functional outcomes in older people living in self-care retirement villages. J Clin Pharmacol (2012) 0.94
Using Medicare administrative data to conduct postmarketing surveillance of follow-on biologics: issues and opportunities. Food Drug Law J (2008) 0.93
Central nervous system medication use and incident mobility limitation in community elders: the Health, Aging, and Body Composition study. Pharmacoepidemiol Drug Saf (2009) 0.92
Use of wavelet and fast Fourier transforms in pharmacodynamics. J Pharmacol Exp Ther (2006) 0.92
Discontinuation of risperidone in Alzheimer's disease. N Engl J Med (2013) 0.92
Discontinuation of statins in routine care settings. Ann Intern Med (2013) 0.92
Associations between frailty and serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentrations in older Australian men: the Concord Health and Ageing in Men Project. J Gerontol A Biol Sci Med Sci (2013) 0.91
Hepatic pseudocapillarization in aged mice. Exp Gerontol (2005) 0.91
Associations between serum 25-hydroxyvitamin D concentrations and multiple health conditions, physical performance measures, disability, and all-cause mortality: the Concord Health and Ageing in Men Project. J Am Geriatr Soc (2014) 0.91
The hepatic pharmacokinetics of doxorubicin and liposomal doxorubicin. Drug Metab Dispos (2004) 0.91
Associations of drug burden index with falls, general practitioner visits, and mortality in older people. Pharmacoepidemiol Drug Saf (2014) 0.91
Effects of endothelial nitric oxide synthase gene polymorphisms on platelet function, nitric oxide release, and interactions with estradiol. Pharmacogenetics (2002) 0.91
Consensus recommendations for systematic evaluation of drug-drug interaction evidence for clinical decision support. Drug Saf (2015) 0.91
Reactions of Pseudomonas aeruginosa pyocyanin with reduced glutathione. Acta Biochim Pol (2008) 0.90