Published in Endocrinology on July 01, 2004
The metabolic consequences of sleep deprivation. Sleep Med Rev (2007) 6.07
The meter of metabolism. Cell (2008) 5.71
Associations between sleep loss and increased risk of obesity and diabetes. Ann N Y Acad Sci (2008) 4.01
Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest (2005) 3.92
Expression of ghrelin receptor mRNA in the rat and the mouse brain. J Comp Neurol (2006) 3.61
Absence of ghrelin protects against early-onset obesity. J Clin Invest (2005) 2.53
Ghrelin action in the brain controls adipocyte metabolism. J Clin Invest (2006) 2.03
Leptin-dependent control of glucose balance and locomotor activity by POMC neurons. Cell Metab (2009) 1.79
Improved rodent maternal metabolism but reduced intrauterine growth after vertical sleeve gastrectomy. Sci Transl Med (2013) 1.54
Hypothalamic and hindbrain melanocortin receptors contribute to the feeding, thermogenic, and cardiovascular action of melanocortins. Endocrinology (2009) 1.41
Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo. Proc Natl Acad Sci U S A (2006) 1.40
AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors. Nat Neurosci (2012) 1.26
Estradiol decreases the orexigenic effect of neuropeptide Y, but not agouti-related protein, in ovariectomized rats. Behav Brain Res (2008) 1.09
Ghrelin in the CNS: from hunger to a rewarding and memorable meal? Brain Res Rev (2008) 0.93
Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure. Am J Physiol Endocrinol Metab (2011) 0.90
Molecules affecting hypothalamic control of core body temperature in response to calorie intake. Front Genet (2012) 0.88
Integrating GHS into the Ghrelin System. Int J Pept (2010) 0.88
Brain innate immunity regulates hypothalamic arcuate neuronal activity and feeding behavior. Endocrinology (2015) 0.88
Ghrelin - a pleiotropic hormone secreted from endocrine x/a-like cells of the stomach. Front Neurosci (2012) 0.87
Ghrelin-induced hypothermia: a physiological basis but no clinical risk. Physiol Behav (2011) 0.86
Ghrelin, appetite regulation, and food reward: interaction with chronic stress. Int J Pept (2011) 0.86
Pro-opiomelanocortin gene transfer to the nucleus of the solitary track but not arcuate nucleus ameliorates chronic diet-induced obesity. Neuroscience (2010) 0.86
Factors associated with fasting plasma ghrelin levels in children and adolescents. World J Gastroenterol (2008) 0.85
Glucocorticoids decrease body weight and food intake and inhibit appetite regulatory peptide expression in the hypothalamus of rats. Exp Ther Med (2011) 0.85
Sensitivity of the hypothalamic paraventricular nucleus to the locomotor-activating effects of neuromedin U in obesity. Brain Res (2007) 0.85
Hypothalamic metabolic compartmentation during appetite regulation as revealed by magnetic resonance imaging and spectroscopy methods. Front Neuroenergetics (2013) 0.85
CLIC5 mutant mice are resistant to diet-induced obesity and exhibit gastric hemorrhaging and increased susceptibility to torpor. Am J Physiol Regul Integr Comp Physiol (2010) 0.84
Yin and Yang - the Gastric X/A-like Cell as Possible Dual Regulator of Food Intake. J Neurogastroenterol Motil (2012) 0.84
The hormonal signature of energy deficit: Increasing the value of food reward. Mol Metab (2013) 0.83
Pancreatic regulation of glucose homeostasis. Exp Mol Med (2016) 0.81
Simultaneous POMC gene transfer to hypothalamus and brainstem increases physical activity, lipolysis and reduces adult-onset obesity. Eur J Neurosci (2011) 0.81
Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity. Diabetes (2016) 0.81
Effect of reducing hypothalamic ghrelin receptor gene expression on energy balance. Peptides (2009) 0.80
Suppression of Ghrelin Exacerbates HFCS-Induced Adiposity and Insulin Resistance. Int J Mol Sci (2017) 0.78
Activation of somatostatin 2 receptors in the brain and the periphery induces opposite changes in circulating ghrelin levels: functional implications. Front Endocrinol (Lausanne) (2013) 0.77
Ghrelin and the central regulation of feeding and energy balance. Indian J Endocrinol Metab (2012) 0.77
Relationships between acylated ghrelin with growth hormone, insulin resistance, lipid profile, and cardio respiratory function in lean and obese men. J Res Med Sci (2011) 0.77
Ghrelin-immunopositive hypothalamic neurons tie the circadian clock and visual system to the lateral hypothalamic arousal center. Mol Metab (2012) 0.77
Gastric peptides and their regulation of hunger and satiety. Curr Gastroenterol Rep (2012) 0.77
GHS-R1a signaling in the DMH and VMH contributes to food anticipatory activity. Int J Obes (Lond) (2013) 0.77
Novel Regulator of Acylated Ghrelin, CF801, Reduces Weight Gain, Rebound Feeding after a Fast, and Adiposity in Mice. Front Endocrinol (Lausanne) (2015) 0.76
Neonatal events, such as androgenization and postnatal overfeeding, modify the response to ghrelin. Sci Rep (2014) 0.76
The effects of ghrelin on energy balance and psychomotor activity in a goldfish model: an overview. Int J Pept (2011) 0.75
Intracerebroventricular administration of leptin increase physical activity but has no effect on thermogenesis in cold-acclimated rats. Sci Rep (2015) 0.75
Macronutrient Regulation of Ghrelin and Peptide YY in Pediatric Obesity and Prader-Willi Syndrome. J Clin Endocrinol Metab (2015) 0.75
Food Seeking in a Risky Environment: A Method for Evaluating Risk and Reward Value in Food Seeking and Consumption in Mice. Front Neurosci (2017) 0.75
Novel hypophysiotropic AgRP2 neurons and pineal cells revealed by BAC transgenesis in zebrafish. Sci Rep (2017) 0.75
Obesity vaccines. Hum Vaccin Immunother (2013) 0.75
Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo. PLoS One (2017) 0.75
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron (2003) 6.05
Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science (2004) 5.98
Agouti-related peptide-expressing neurons are mandatory for feeding. Nat Neurosci (2005) 4.44
Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci (2006) 4.25
Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest (2011) 4.17
UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature (2008) 3.91
A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest (2006) 3.81
Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev (2004) 3.79
The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest (2003) 3.62
Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab (2004) 3.54
A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell (2009) 3.28
Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nat Med (2011) 3.09
Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab (2009) 3.07
Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nat Med (2006) 2.72
An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity (2010) 2.71
STAT3 inhibition of gluconeogenesis is downregulated by SirT1. Nat Cell Biol (2009) 2.67
Neurobiology of feeding and energy expenditure. Annu Rev Neurosci (2007) 2.64
Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci U S A (2004) 2.57
A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. Cell Metab (2007) 2.48
Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell (2013) 2.43
Nicotine decreases food intake through activation of POMC neurons. Science (2011) 2.41
Modeling human cortical development in vitro using induced pluripotent stem cells. Proc Natl Acad Sci U S A (2012) 2.41
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest (2006) 2.38
High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nat Neurosci (2011) 2.36
Natural hypometabolism during hibernation and daily torpor in mammals. Respir Physiol Neurobiol (2004) 2.28
ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury. J Neurosci (2002) 2.25
Automated chemiluminescence-immunoassay for aldosterone during dynamic testing: comparison to radioimmunoassays with and without extraction steps. Clin Chem (2006) 2.20
Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. J Neurosci (2004) 2.13
Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity. Cell (2013) 2.11
Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure. J Pharmacol Exp Ther (2002) 2.10
Mitochondrial uncoupling proteins in the CNS: in support of function and survival. Nat Rev Neurosci (2005) 2.06
FoxO1 target Gpr17 activates AgRP neurons to regulate food intake. Cell (2012) 2.03
Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans. Diabetes (2010) 2.01
Maternal and offspring pools of osteocalcin influence brain development and functions. Cell (2013) 2.00
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev (2012) 1.99
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proc Natl Acad Sci U S A (2009) 1.89
Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity. Gastroenterology (2010) 1.80
Uncoupling protein-2 regulates lifespan in mice. Am J Physiol Endocrinol Metab (2009) 1.78
Cannabinoids, opioids and eating behavior: the molecular face of hedonism? Brain Res Rev (2005) 1.75
Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity. J Neurosci (2010) 1.73
Identification of proliferative and mature β-cells in the islets of Langerhans. Nature (2016) 1.71
Oligodendrocyte regeneration after neonatal hypoxia requires FoxO1-mediated p27Kip1 expression. J Neurosci (2012) 1.68
Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease. J Neurosci (2005) 1.67
Cross-talk between estrogen and leptin signaling in the hypothalamus. Am J Physiol Endocrinol Metab (2008) 1.67
Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metab (2009) 1.66
The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss. J Clin Invest (2014) 1.61
High circulating ghrelin: a potential cause for hyperphagia and obesity in prader-willi syndrome. J Clin Endocrinol Metab (2002) 1.59
N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake. Cell (2008) 1.57
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat Neurosci (2013) 1.57
Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets. Am J Physiol Endocrinol Metab (2013) 1.54
CPG2: a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors. Neuron (2004) 1.52
Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning. Endocrinology (2003) 1.50
Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism. J Neurosci (2009) 1.50
Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism. Trends Mol Med (2011) 1.49
The diagnosis and treatment of primary hyperaldosteronism in Germany: results on 555 patients from the German Conn Registry. Dtsch Arztebl Int (2009) 1.46
Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes (2009) 1.46
Genetic determinants of serum testosterone concentrations in men. PLoS Genet (2011) 1.45
Antibodies to cannabinoid type 1 receptor co-react with stomatin-like protein 2 in mouse brain mitochondria. Eur J Neurosci (2013) 1.45
Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons. J Clin Invest (2007) 1.45
Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation. Cell Metab (2007) 1.39
Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis. EMBO Rep (2012) 1.32
Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons. Nat Rev Drug Discov (2012) 1.29
Differential influences of peroxisome proliferator-activated receptors gamma and -alpha on food intake and energy homeostasis. Diabetes (2003) 1.29
Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells. Diabetes (2006) 1.27
AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors. Nat Neurosci (2012) 1.26
Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome. J Endocrinol (2010) 1.26
Brain circuits regulating energy homeostasis. Regul Pept (2008) 1.24
Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. Eur J Pharmacol (2002) 1.24
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation. PLoS Genet (2012) 1.23
Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochem Pharmacol (2002) 1.21
Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology (2006) 1.21
Regulatory T cells in obesity: the leptin connection. Trends Mol Med (2010) 1.21
Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes. J Clin Invest (2012) 1.21
Early-life experience reduces excitation to stress-responsive hypothalamic neurons and reprograms the expression of corticotropin-releasing hormone. J Neurosci (2010) 1.21
A case of non-scaling in mammalian physiology? Body size, digestive capacity, food intake, and ingesta passage in mammalian herbivores. Comp Biochem Physiol A Mol Integr Physiol (2007) 1.19
Thoughts for food: brain mechanisms and peripheral energy balance. Neuron (2006) 1.19
Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation. Cell Metab (2012) 1.18
Hypothalamic control of energy balance: insights into the role of synaptic plasticity. Trends Neurosci (2013) 1.18
High prevalence of reduced fecundity in men with congenital adrenal hyperplasia. J Clin Endocrinol Metab (2009) 1.17
Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice. Physiol Genomics (2006) 1.16
Adrenal venous sampling: evaluation of the German Conn's registry. Hypertension (2011) 1.15
Obesity and the neuroendocrine control of energy homeostasis: the role of spontaneous locomotor activity. J Nutr (2005) 1.13
Neuronal control of energy homeostasis. FEBS Lett (2007) 1.13
Feeding signals and brain circuitry. Eur J Neurosci (2009) 1.12
A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. Hum Mol Genet (2011) 1.10
Risk factors associated with a low glomerular filtration rate in primary aldosteronism. J Clin Endocrinol Metab (2008) 1.08
Physiologic concentrations of exogenously infused ghrelin reduces insulin secretion without affecting insulin sensitivity in healthy humans. J Clin Endocrinol Metab (2013) 1.08
Cortical glial fibrillary acidic protein-positive cells generate neurons after perinatal hypoxic injury. J Neurosci (2011) 1.07
Orexin neuronal changes in the locus coeruleus of the aging rhesus macaque. Neurobiol Aging (2006) 1.07
Developmental programming of the hypothalamus: a matter of fat. Nat Med (2006) 1.06
Exercise-induced synaptogenesis in the hippocampus is dependent on UCP2-regulated mitochondrial adaptation. J Neurosci (2008) 1.06
Efficacy of 12-month treatment with the GH receptor antagonist pegvisomant in patients with acromegaly resistant to long-term, high-dose somatostatin analog treatment: effect on IGF-I levels, tumor mass, hypertension and glucose tolerance. Eur J Endocrinol (2006) 1.05
Role of ghrelin polymorphisms in obesity based on three different studies. Obes Res (2002) 1.05
Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits. J Neurosci (2010) 1.05
Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats. Endocrinology (2013) 1.05
Correlation between body weight changes and postoperative pain in rats treated with meloxicam or buprenorphine. Lab Anim (NY) (2009) 1.05