Published in J Biol Chem on September 05, 2003
The mTOR signalling pathway in human cancer. Int J Mol Sci (2012) 2.38
Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism. Biochem J (2004) 1.89
Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span. J Leukoc Biol (2008) 1.40
Nitric oxide enhances salt tolerance in maize seedlings through increasing activities of proton-pump and Na+/H+ antiport in the tonoplast. Planta (2006) 1.25
Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway. Am J Physiol Cell Physiol (2010) 1.12
Gene expression analysis of tuberous sclerosis complex cortical tubers reveals increased expression of adhesion and inflammatory factors. Brain Pathol (2009) 1.12
Epigallocatechin-3-gallate (EGCG) attenuates inflammation in MRL/lpr mouse mesangial cells. Cell Mol Immunol (2010) 1.08
Phosphatidic acid is a leukocyte chemoattractant that acts through S6 kinase signaling. J Biol Chem (2010) 1.00
Therapeutic targeting of the mTOR-signalling pathway in cancer: benefits and limitations. Br J Pharmacol (2014) 0.96
Enzymatic measurement of phosphatidic acid in cultured cells. J Lipid Res (2009) 0.96
Frontier of epilepsy research - mTOR signaling pathway. Exp Mol Med (2011) 0.95
Epilepsy related to developmental tumors and malformations of cortical development. Neurotherapeutics (2014) 0.93
Role of the mTOR pathway in LPS-activated monocytes: influence of hypertonic saline. J Surg Res (2010) 0.92
Fetal brain lesions in tuberous sclerosis complex: TORC1 activation and inflammation. Brain Pathol (2012) 0.91
LPS induces the degradation of programmed cell death protein 4 (PDCD4) to release Twist2, activating c-Maf transcription to promote interleukin-10 production. J Biol Chem (2014) 0.88
Regulation of Lipid Signaling by Diacylglycerol Kinases during T Cell Development and Function. Front Immunol (2013) 0.87
Efficacy of phosphatidic acid ingestion on lean body mass, muscle thickness and strength gains in resistance-trained men. J Int Soc Sports Nutr (2012) 0.86
Mutation of Y179 on phospholipase D2 (PLD2) upregulates DNA synthesis in a PI3K-and Akt-dependent manner. Cell Signal (2007) 0.86
Retrograde changes in presynaptic function driven by dendritic mTORC1. J Neurosci (2012) 0.84
Rebamipide-induced downregulation of phospholipase D inhibits inflammation and proliferation in gastric cancer cells. Exp Mol Med (2010) 0.82
Tumor progression and the different faces of the PERK kinase. Oncogene (2015) 0.80
Activation of AMPK/TSC2/PLD by alcohol regulates mTORC1 and mTORC2 assembly in C2C12 myocytes. Alcohol Clin Exp Res (2013) 0.78
The effects of phosphatidic acid supplementation on strength, body composition, muscular endurance, power, agility, and vertical jump in resistance trained men. J Int Soc Sports Nutr (2016) 0.78
Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis. Mol Nutr Food Res (2016) 0.78
Effect of phosphatidylcholine on pld gene expression level of Aspergillus fumigatus by the real time PCR method and investigations of these genes using bioinformatics analysis. Iran J Microbiol (2012) 0.75
Dysregulation of the (immuno)proteasome pathway in malformations of cortical development. J Neuroinflammation (2016) 0.75
Everolimus treatment downregulates renocortical cyclooxygenase-2 expression in the rat kidney. Br J Pharmacol (2005) 0.75
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell (2012) 3.38
Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Rep (2008) 2.90
Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol Pharmacol (2006) 2.00
Sequential activation of phosphatidylinositol 3-kinase, beta Pix, Rac1, and Nox1 in growth factor-induced production of H2O2. Mol Cell Biol (2004) 1.82
Identification of a compound that directly stimulates phospholipase C activity. Mol Pharmacol (2003) 1.67
Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exercise. Proc Natl Acad Sci U S A (2012) 1.53
A nucleolin-targeted multimodal nanoparticle imaging probe for tracking cancer cells using an aptamer. J Nucl Med (2009) 1.51
O-GlcNAcase is essential for embryonic development and maintenance of genomic stability. Aging Cell (2012) 1.49
A cellular RNA-binding protein enhances internal ribosomal entry site-dependent translation through an interaction downstream of the hepatitis C virus polyprotein initiation codon. Mol Cell Biol (2004) 1.46
Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor. J Biol Chem (2003) 1.41
Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis. J Biol Chem (2002) 1.38
Induction of cellular senescence by insulin-like growth factor binding protein-5 through a p53-dependent mechanism. Mol Biol Cell (2007) 1.38
NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation. Mol Cell Biol (2004) 1.37
Fluorine geochemistry in bedrock groundwater of South Korea. Sci Total Environ (2007) 1.35
Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane. Mol Biol Cell (2008) 1.30
Serum amyloid A binding to formyl peptide receptor-like 1 induces synovial hyperplasia and angiogenesis. J Immunol (2006) 1.30
Understanding of the roles of phospholipase D and phosphatidic acid through their binding partners. Prog Lipid Res (2011) 1.29
Exploration of replicative senescence-associated genes in human dermal fibroblasts by cDNA microarray technology. Exp Gerontol (2004) 1.29
Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb. Mol Cell Biol (2009) 1.25
Interferon-gamma induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells. Mech Ageing Dev (2008) 1.24
o-GlcNAc transferase is activated by CaMKIV-dependent phosphorylation under potassium chloride-induced depolarization in NG-108-15 cells. Cell Signal (2007) 1.23
Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling. J Immunol (2004) 1.20
Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas. Anticancer Res (2003) 1.19
Nonuniform Ca2+ transients in arrhythmogenic Purkinje cells that survive in the infarcted canine heart. Cardiovasc Res (2003) 1.17
GABAA receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein. J Neurosci (2004) 1.17
Toll-like receptor 9-mediated cytosolic phospholipase A2 activation regulates expression of inducible nitric oxide synthase. Biochem Biophys Res Commun (2007) 1.15
Thioredoxin as a reducing agent for mammalian methionine sulfoxide reductases B lacking resolving cysteine. Biochem Biophys Res Commun (2008) 1.14
S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells. Biochem Biophys Res Commun (2007) 1.13
Down-regulation of a forkhead transcription factor, FOXO3a, accelerates cellular senescence in human dermal fibroblasts. J Gerontol A Biol Sci Med Sci (2005) 1.13
Proteomic analysis of tumor necrosis factor-alpha-induced secretome of human adipose tissue-derived mesenchymal stem cells. J Proteome Res (2010) 1.12
Regulation of replicative senescence by insulin-like growth factor-binding protein 3 in human umbilical vein endothelial cells. Aging Cell (2007) 1.11
Sensitization of epidermal growth factor-induced signaling by bradykinin is mediated by c-Src. Implications for a role of lipid microdomains. J Biol Chem (2003) 1.11
PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals. Cell Signal (2006) 1.11
Phospholipase signalling networks in cancer. Nat Rev Cancer (2012) 1.10
Activation of CXCR2 by extracellular matrix degradation product acetylated Pro-Gly-Pro has therapeutic effects against sepsis. Am J Respir Crit Care Med (2011) 1.08
AMPK activator, AICAR, inhibits palmitate-induced apoptosis in osteoblast. Bone (2008) 1.07
Janus kinase-signal transducer and activator of transcription mediates phosphatidic acid-induced interleukin (IL)-1beta and IL-6 production. Mol Pharmacol (2005) 1.06
Periostin-binding DNA aptamer inhibits breast cancer growth and metastasis. Mol Ther (2013) 1.06
Human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by AMP-activated protein kinase. J Cell Physiol (2012) 1.05
The interaction of phospholipase C-beta3 with Shank2 regulates mGluR-mediated calcium signal. J Biol Chem (2005) 1.05
The electrically evoked auditory change complex: preliminary results from nucleus cochlear implant users. Ear Hear (2008) 1.04
Lysophosphatidylcholine activates adipocyte glucose uptake and lowers blood glucose levels in murine models of diabetes. J Biol Chem (2009) 1.04
Differential activation of formyl peptide receptor-like 1 by peptide ligands. J Immunol (2003) 1.03
Molecular cloning and characterization of a novel phospholipase C, PLC-eta. Biochem J (2005) 1.02
Evolutionary conservation in multiple faces of protein interaction. Proteins (2009) 1.02
Localization of phospholipase D1 to caveolin-enriched membrane via palmitoylation: implications for epidermal growth factor signaling. Mol Biol Cell (2002) 1.02
CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice. Diabetologia (2014) 1.01
Calcineurin is expressed and plays a critical role in inflammatory arthritis. J Immunol (2006) 1.01
Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem (2002) 1.01
Hepatocyte growth factor induced up-regulations of VEGF through Egr-1 in hepatocellular carcinoma cells. Clin Exp Metastasis (2009) 1.00
BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway. Mol Cells (2006) 1.00
Group IB secretory phospholipase A2 stimulates CXC chemokine ligand 8 production via ERK and NF-kappa B in human neutrophils. J Immunol (2004) 0.99
Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells. Mol Pharmacol (2002) 0.99
Sorting nexin 16 regulates EGF receptor trafficking by phosphatidylinositol-3-phosphate interaction with the Phox domain. J Cell Sci (2004) 0.99
Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in VEGF-induced phosphorylation of MEK and ERK. Am J Physiol Heart Circ Physiol (2004) 0.98
Toll-like receptor 9 dependent activation of MAPK and NF-kB is required for the CpG ODN-induced matrix metalloproteinase-9 expression. Exp Mol Med (2007) 0.98
Comparative analysis of the secretory proteome of human adipose stromal vascular fraction cells during adipogenesis. Proteomics (2010) 0.98
Differential activation of formyl peptide receptor signaling by peptide ligands. Mol Pharmacol (2003) 0.98
Inhibition of muscarinic receptor-linked phospholipase D activation by association with tubulin. J Biol Chem (2004) 0.98
A combination of Lox-1 and Nox1 regulates TLR9-mediated foam cell formation. Cell Signal (2008) 0.97
Molecular basis of R-type calcium channels in central amygdala neurons of the mouse. Proc Natl Acad Sci U S A (2002) 0.97
The roles of phospholipase D in EGFR signaling. Biochim Biophys Acta (2009) 0.97
Adiponectin inhibits palmitate-induced apoptosis through suppression of reactive oxygen species in endothelial cells: involvement of cAMP/protein kinase A and AMP-activated protein kinase. J Endocrinol (2010) 0.97
Phospholipase D2 directly interacts with aldolase via Its PH domain. Biochemistry (2002) 0.97
G2 arrest and apoptosis by 2-amino-N-quinoline-8-yl-benzenesulfonamide (QBS), a novel cytotoxic compound. Biochem Pharmacol (2005) 0.97
MMP-2 functions as a negative regulator of chondrogenic cell condensation via down-regulation of the FAK-integrin beta1 interaction. Dev Biol (2007) 0.96
Sphingosine 1-phosphate in amniotic fluid modulates cyclooxygenase-2 expression in human amnion-derived WISH cells. J Biol Chem (2003) 0.96
α-Lipoic acid attenuates vascular calcification via reversal of mitochondrial function and restoration of Gas6/Axl/Akt survival pathway. J Cell Mol Med (2012) 0.96
Supramolecular fishing for plasma membrane proteins using an ultrastable synthetic host-guest binding pair. Nat Chem (2010) 0.96
Interleukin-1beta induces MUC2 gene expression and mucin secretion via activation of PKC-MEK/ERK, and PI3K in human airway epithelial cells. J Korean Med Sci (2002) 0.95
Identification of cellular proteins enhancing activities of internal ribosomal entry sites by competition with oligodeoxynucleotides. Nucleic Acids Res (2004) 0.95
Subtype-specific role of phospholipase C-beta in bradykinin and LPA signaling through differential binding of different PDZ scaffold proteins. Cell Signal (2010) 0.95
Phospholipase D2 induces stress fiber formation through mediating nucleotide exchange for RhoA. Cell Signal (2011) 0.95
Phospholipase C-gamma1 is a guanine nucleotide exchange factor for dynamin-1 and enhances dynamin-1-dependent epidermal growth factor receptor endocytosis. J Cell Sci (2004) 0.94
N-terminal site-specific mono-PEGylation of epidermal growth factor. Pharm Res (2003) 0.94
Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity. Cell Signal (2009) 0.94
Glycogen synthase kinase 3beta and beta-catenin pathway is involved in toll-like receptor 4-mediated NADPH oxidase 1 expression in macrophages. FEBS J (2010) 0.94
The functional and compositional properties of lipoproteins are altered in patients with metabolic syndrome with increased cholesteryl ester transfer protein activity. Int J Mol Med (2010) 0.94
Comparative proteomic analysis of the insulin-induced L6 myotube secretome. Proteomics (2009) 0.93
Prevalence of human papillomavirus and Chlamydia trachomatis infection among women attending cervical cancer screening in the Republic of Korea. Eur J Cancer Prev (2009) 0.93
Emodin regulates glucose utilization by activating AMP-activated protein kinase. J Biol Chem (2013) 0.93
Ribozyme-mediated selective induction of new gene activity in hepatitis C virus internal ribosome entry site-expressing cells by targeted trans-splicing. Mol Ther (2003) 0.93
Cyclic AMP controls mTOR through regulation of the dynamic interaction between Rheb and phosphodiesterase 4D. Mol Cell Biol (2010) 0.93
The agonists of formyl peptide receptors prevent development of severe sepsis after microbial infection. J Immunol (2010) 0.93
Serum amyloid A induces contrary immune responses via formyl peptide receptor-like 1 in human monocytes. Mol Pharmacol (2006) 0.93
Fibrinogen gamma-A chain precursor in CSF: a candidate biomarker for Alzheimer's disease. BMC Neurol (2007) 0.93
Role of NADPH oxidase-2 in lipopolysaccharide-induced matrix metalloproteinase expression and cell migration. Immunol Cell Biol (2009) 0.92