Published in BMB Rep on June 30, 2008
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Phosphoinositide signalling in cancer: beyond PI3K and PTEN. Nat Rev Cancer (2010) 2.35
Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation. Structure (2012) 1.73
EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling. Growth Factors (2012) 1.13
Phospholipase signalling networks in cancer. Nat Rev Cancer (2012) 1.10
Role of phospholipase Cε in physiological phosphoinositide signaling networks. Cell Signal (2012) 1.10
Characterization of phospholipase C gamma enzymes with gain-of-function mutations. J Biol Chem (2009) 1.09
A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility. Genes Immun (2011) 1.08
Identification of a novel binding partner of phospholipase cβ1: translin-associated factor X. PLoS One (2010) 1.06
Surfactant phospholipid metabolism. Biochim Biophys Acta (2012) 1.03
Male infertility-linked point mutation disrupts the Ca2+ oscillation-inducing and PIP(2) hydrolysis activity of sperm PLCζ. Biochem J (2011) 1.01
Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker region. J Cell Sci (2011) 0.98
An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation. Nat Struct Mol Biol (2011) 0.98
The phospholipase C isozymes and their regulation. Subcell Biochem (2012) 0.97
Odorant-stimulated phosphoinositide signaling in mammalian olfactory receptor neurons. Cell Signal (2009) 0.97
Suppression of PLCbeta2 by endotoxin plays a role in the adenosine A(2A) receptor-mediated switch of macrophages from an inflammatory to an angiogenic phenotype. Am J Pathol (2009) 0.96
Modulation of Ca²+ activity in cardiomyocytes through caveolae-Gαq interactions. Biophys J (2011) 0.96
Phospholipase Cβ1 is linked to RNA interference of specific genes through translin-associated factor X. FASEB J (2012) 0.95
The small G protein Rac1 activates phospholipase Cdelta1 through phospholipase Cbeta2. J Biol Chem (2010) 0.94
PLCζ causes Ca(2+) oscillations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P(2). Mol Biol Cell (2011) 0.94
Distinct phospholipase C-β isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostasis and wound closure. Mol Cell Biol (2013) 0.94
The glycerophosphoinositols: cellular metabolism and biological functions. Cell Mol Life Sci (2009) 0.93
Semaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex. Mol Cell Biol (2009) 0.93
Critical role for mast cell Stat5 activity in skin inflammation. Cell Rep (2014) 0.93
Structural insights into phospholipase C-β function. Mol Pharmacol (2013) 0.92
Differential expression of phospholipase C epsilon 1 is associated with chronic atrophic gastritis and gastric cancer. PLoS One (2012) 0.92
Phosphoinositide phosphatases and disease. J Lipid Res (2008) 0.92
Identification of Ser/Thr phosphorylation sites in the C2-domain of phospholipase C γ2 (PLCγ2) using TRPM7-kinase. Cell Signal (2012) 0.92
The adapter protein APPL1 links FSH receptor to inositol 1,4,5-trisphosphate production and is implicated in intracellular Ca(2+) mobilization. Endocrinology (2011) 0.92
Deletion of PLCB1 gene in schizophrenia-affected patients. J Cell Mol Med (2012) 0.91
Update on vascular endothelial Ca(2+) signalling: A tale of ion channels, pumps and transporters. World J Biol Chem (2012) 0.91
Signal-activated phospholipase regulation of leukocyte chemotaxis. J Lipid Res (2008) 0.90
Reduction of phosphoinositide-phospholipase C beta1 methylation predicts the responsiveness to azacitidine in high-risk MDS. Proc Natl Acad Sci U S A (2009) 0.90
Molecular mechanisms of N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation and degranulation in mouse neutrophils: phospholipase D is dispensable. Mol Cell Biol (2012) 0.89
Twenty-first century mast cell stabilizers. Br J Pharmacol (2013) 0.89
Mechanism of activation and inactivation of Gq/phospholipase C-β signaling nodes. Chem Rev (2011) 0.87
Calcium signaling in mammalian egg activation and embryo development: the influence of subcellular localization. Mol Reprod Dev (2012) 0.87
Membrane environment exerts an important influence on rac-mediated activation of phospholipase Cγ2. Mol Cell Biol (2011) 0.87
Role of phospholipase C-β in RNA interference. Adv Biol Regul (2013) 0.87
Differential regulation of phospholipase C-beta2 activity and membrane interaction by Galphaq, Gbeta1gamma2, and Rac2. J Biol Chem (2009) 0.87
Genetic defect in phospholipase Cδ1 protects mice from obesity by regulating thermogenesis and adipogenesis. Diabetes (2011) 0.86
Evidence for a second, high affinity Gbetagamma binding site on Galphai1(GDP) subunits. J Biol Chem (2009) 0.86
Phosphatidylinositol transfer proteins and instructive regulation of lipid kinase biology. Biochim Biophys Acta (2015) 0.85
Hydrolysis rates of different small interfering RNAs (siRNAs) by the RNA silencing promoter complex, C3PO, determines their regulation by phospholipase Cβ. J Biol Chem (2013) 0.84
K562 cell proliferation is modulated by PLCβ1 through a PKCα-mediated pathway. Cell Cycle (2013) 0.84
Phospholipases of mineralization competent cells and matrix vesicles: roles in physiological and pathological mineralizations. Int J Mol Sci (2013) 0.84
A loss in cellular protein partners promotes α-synuclein aggregation in cells resulting from oxidative stress. Biochemistry (2013) 0.83
Phospholipase C-β3 regulates FcɛRI-mediated mast cell activation by recruiting the protein phosphatase SHP-1. Immunity (2011) 0.82
Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons. Front Cell Neurosci (2014) 0.82
Nuclear phosphoinositide-specific phospholipase C β1 controls cytoplasmic CCL2 mRNA levels in HIV-1 gp120-stimulated primary human macrophages. PLoS One (2013) 0.82
Membrane-induced allosteric control of phospholipase C-β isozymes. J Biol Chem (2014) 0.82
Epidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin-17 levels in mice. Nat Commun (2012) 0.82
Linking alpha-synuclein properties with oxidation: a hypothesis on a mechanism underling cellular aggregation. J Bioenerg Biomembr (2014) 0.82
Phospholipase C-β3 is a key modulator of IL-8 expression in cystic fibrosis bronchial epithelial cells. J Immunol (2011) 0.82
Oocyte activation and phospholipase C zeta (PLCζ): diagnostic and therapeutic implications for assisted reproductive technology. Cell Commun Signal (2012) 0.82
ESCRT machinery potentiates HIV-1 utilization of the PI(4,5)P(2)-PLC-IP3R-Ca(2+) signaling cascade. J Mol Biol (2011) 0.81
Critical roles of Gi/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels. Proc Natl Acad Sci U S A (2016) 0.81
Phospholipase cε, an effector of ras and rap small GTPases, is required for airway inflammatory response in a mouse model of bronchial asthma. PLoS One (2014) 0.81
Ezrin silencing remodulates the expression of Phosphoinositide-specific Phospholipase C enzymes in human osteosarcoma cell lines. J Cell Commun Signal (2014) 0.81
PLC-γ1 signaling plays a subtype-specific role in postbinding cell entry of influenza A virus. J Virol (2013) 0.81
Phospholipase C-β1 and β4 contribute to non-genetic cell-to-cell variability in histamine-induced calcium signals in HeLa cells. PLoS One (2014) 0.81
GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis. Mol Biol Cell (2015) 0.81
Severe infantile epileptic encephalopathy due to mutations in PLCB1: expansion of the genotypic and phenotypic disease spectrum. Dev Med Child Neurol (2014) 0.81
Interplay between cell migration and neurite outgrowth determines SH2B1β-enhanced neurite regeneration of differentiated PC12 cells. PLoS One (2012) 0.81
Ca2+-independent binding of anionic phospholipids by phospholipase C δ1 EF-hand domain. J Biol Chem (2013) 0.81
PDZ domain-containing 1 (PDZK1) protein regulates phospholipase C-β3 (PLC-β3)-specific activation of somatostatin by forming a ternary complex with PLC-β3 and somatostatin receptors. J Biol Chem (2012) 0.81
Divergent effect of mammalian PLCζ in generating Ca²⁺ oscillations in somatic cells compared with eggs. Biochem J (2011) 0.81
The proteome of mouse cerebral arteries. J Cereb Blood Flow Metab (2014) 0.81
The correlation between multidomain enzymes and multiple activation mechanisms--the case of phospholipase Cβ and its membrane interactions. Biochim Biophys Acta (2011) 0.80
A self-scaffolding model for G protein signaling. J Mol Biol (2009) 0.80
DAG tales: the multiple faces of diacylglycerol--stereochemistry, metabolism, and signaling. Cell Mol Life Sci (2015) 0.80
Phosphatidylinositol (4,5) bisphosphate controls T cell activation by regulating T cell rigidity and organization. PLoS One (2011) 0.80
Identification of Leptospira interrogans phospholipase C as a novel virulence factor responsible for intracellular free calcium ion elevation during macrophage death. PLoS One (2013) 0.80
A dynamic model of membrane-bound phospholipase Cβ2 activation by Gβγ subunits. Mol Pharmacol (2011) 0.80
Activating cysteinyl leukotriene receptor 2 (CYSLTR2) mutations in blue nevi. Mod Pathol (2016) 0.79
Phosphoinositide-specific phospholipase C β 1b (PI-PLCβ1b) interactome: affinity purification-mass spectrometry analysis of PI-PLCβ1b with nuclear protein. Mol Cell Proteomics (2013) 0.79
Phospholipase C-independent effects of 3M3FBS in murine colon. Eur J Pharmacol (2009) 0.79
Structural divergence and loss of phosphoinositide-specific phospholipase C signaling components during the evolution of the green plant lineage: implications from structural characteristics of algal components. Front Plant Sci (2014) 0.79
HIV Assembly and Budding: Ca(2+) Signaling and Non-ESCRT Proteins Set the Stage. Mol Biol Int (2012) 0.79
Ezrin-related Phosphoinositide pathway modifies RhoA and Rac1 in human osteosarcoma cell lines. J Cell Commun Signal (2015) 0.79
A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated CaV1.2 Calcium Channel Function. J Biol Chem (2015) 0.79
The effect of membrane domains on the G protein-phospholipase Cbeta signaling pathway. Crit Rev Biochem Mol Biol (2010) 0.79
Evolutionary conservation of the signaling proteins upstream of cyclic AMP-dependent kinase and protein kinase C in gastropod mollusks. Brain Behav Evol (2009) 0.79
Phosphoinositide-specific Phospholipase C β1 gene deletion in bipolar disorder affected patient. J Cell Commun Signal (2012) 0.78
Integrated analysis miRNA and mRNA profiling in patients with severe oligozoospermia reveals miR-34c-3p downregulates PLCXD3 expression. Oncotarget (2016) 0.78
Phospholipase C-β in immune cells. Adv Biol Regul (2013) 0.78
Insulin receptor-mediated signaling via phospholipase C-γ regulates growth and differentiation in Drosophila. PLoS One (2011) 0.78
Splice site SNPs of phospholipase PLCXD3 are significantly associated with variant and sporadic Creutzfeldt-Jakob disease. BMC Med Genet (2013) 0.78
The phospholipase C inhibitor U73122 attenuates trans-10, cis-12 conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes. J Nutr (2013) 0.78
Expression of Phosphoinositide-specific phospholipase C enzymes in human osteosarcoma cell lines. J Cell Commun Signal (2013) 0.78
Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly. Front Microbiol (2014) 0.78
Lypopolysaccharide downregulates the expression of selected phospholipase C genes in cultured endothelial cells. Inflammation (2013) 0.78
Phospholipase C-η2 interacts with nuclear and cytoplasmic LIMK-1 during retinoic acid-stimulated neurite growth. Histochem Cell Biol (2015) 0.78
Signalling in the genomic era. J Cell Commun Signal (2010) 0.77
The breast cancer susceptibility gene product (γ-synuclein) alters cell behavior through it interaction with phospholipase Cβ. Cell Signal (2015) 0.77
Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1. PLoS One (2015) 0.77
RNA-induced silencing attenuates G protein-mediated calcium signals. FASEB J (2016) 0.77
Osmotic Stress Reduces Ca2+ Signals through Deformation of Caveolae. J Biol Chem (2015) 0.77
HeLa cell response proteome alterations induced by mammalian reovirus T3D infection. Virol J (2013) 0.76
Measuring fast calcium fluxes in cardiomyocytes. J Vis Exp (2011) 0.76
Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell (2008) 10.49
Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain. Nat Neurosci (2011) 7.37
Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nat Genet (2006) 5.29
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health. Oncotarget (2011) 3.43
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell (2012) 3.38
In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc Natl Acad Sci U S A (2013) 3.10
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. Aging (Albany NY) (2011) 2.72
Phosphoinositide signalling in cancer: beyond PI3K and PTEN. Nat Rev Cancer (2010) 2.35
Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. N Engl J Med (2012) 2.08
Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol Pharmacol (2006) 2.00
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance. Oncotarget (2012) 1.96
Illuminating cell-cycle progression in the developing zebrafish embryo. Proc Natl Acad Sci U S A (2009) 1.88
Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response. Oncotarget (2012) 1.85
Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development. Cancer Res (2004) 1.84
Sequential activation of phosphatidylinositol 3-kinase, beta Pix, Rac1, and Nox1 in growth factor-induced production of H2O2. Mol Cell Biol (2004) 1.82
A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency. Am J Hum Genet (2012) 1.81
Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin. Nat Cell Biol (2004) 1.73
Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation. Structure (2012) 1.73
Identification of a compound that directly stimulates phospholipase C activity. Mol Pharmacol (2003) 1.67
Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma. Int J Cancer (2003) 1.66
Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis. Carcinogenesis (2009) 1.62
GSK-3 as potential target for therapeutic intervention in cancer. Oncotarget (2014) 1.56
NK cells and cancer. J Immunol (2007) 1.56
Phosphoinositide-phospholipase C beta1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia. J Clin Oncol (2008) 1.56
Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation. J Cell Biol (2011) 1.56
Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis. J Cell Biol (2002) 1.55
Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exercise. Proc Natl Acad Sci U S A (2012) 1.53
A nucleolin-targeted multimodal nanoparticle imaging probe for tracking cancer cells using an aptamer. J Nucl Med (2009) 1.51
Phospholipase C epsilon: linking second messengers and small GTPases. Trends Cell Biol (2006) 1.49
O-GlcNAcase is essential for embryonic development and maintenance of genomic stability. Aging Cell (2012) 1.49
Structural and mechanistic insights into ras association domains of phospholipase C epsilon. Mol Cell (2006) 1.48
PLC regulation: emerging pictures for molecular mechanisms. Trends Biochem Sci (2010) 1.48
Recombinant phospholipase Czeta has high Ca2+ sensitivity and induces Ca2+ oscillations in mouse eggs. J Biol Chem (2003) 1.46
A cellular RNA-binding protein enhances internal ribosomal entry site-dependent translation through an interaction downstream of the hepatitis C virus polyprotein initiation codon. Mol Cell Biol (2004) 1.46
Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells. Cancer Res (2009) 1.42
Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor. J Biol Chem (2003) 1.41
Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase. J Biol Chem (2004) 1.41
Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways. J Cell Physiol (2011) 1.40
Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis. J Biol Chem (2002) 1.38
X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO. J Biochem (2005) 1.37
NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation. Mol Cell Biol (2004) 1.37
Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia. Expert Opin Investig Drugs (2009) 1.36
Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma. FASEB J (2010) 1.35
Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry. Immunity (2005) 1.33
PLCgamma1 is essential for early events in integrin signalling required for cell motility. J Cell Sci (2005) 1.32
Pharmacological evidence for the involvement of diacylglycerol lipase in depolarization-induced endocanabinoid release. Neuropharmacology (2007) 1.31
Regulatory links between PLC enzymes and Ras superfamily GTPases: signalling via PLCepsilon. Adv Enzyme Regul (2009) 1.31
Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane. Mol Biol Cell (2008) 1.30
Serum amyloid A binding to formyl peptide receptor-like 1 induces synovial hyperplasia and angiogenesis. J Immunol (2006) 1.30
The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes. Mol Biol Cell (2007) 1.30
Understanding of the roles of phospholipase D and phosphatidic acid through their binding partners. Prog Lipid Res (2011) 1.29
A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme. J Biol Chem (2005) 1.28
PAF and EZH2 induce Wnt/β-catenin signaling hyperactivation. Mol Cell (2013) 1.27
Single- and multiple-molecule dynamics of the signaling from H-Ras to cRaf-1 visualized on the plasma membrane of living cells. Chemphyschem (2003) 1.26
Structural basis for conformational dynamics of GTP-bound Ras protein. J Biol Chem (2010) 1.26
The emerging multiple roles of nuclear Akt. Biochim Biophys Acta (2012) 1.25
Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester. Cancer Res (2008) 1.25
Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb. Mol Cell Biol (2009) 1.25
Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon. Oncogene (2002) 1.24
PTPN14 is required for the density-dependent control of YAP1. Genes Dev (2012) 1.23
Multiplexed FRET to image multiple signaling events in live cells. Biophys J (2008) 1.23
o-GlcNAc transferase is activated by CaMKIV-dependent phosphorylation under potassium chloride-induced depolarization in NG-108-15 cells. Cell Signal (2007) 1.23
Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac. J Cell Biol (2004) 1.22
Intranuclear 3'-phosphoinositide metabolism and Akt signaling: new mechanisms for tumorigenesis and protection against apoptosis? Cell Signal (2006) 1.22
Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals that PP1 is a positive regulator of Raf-1 in vivo. J Biol Chem (2002) 1.21
Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family small GTPases. J Biol Chem (2005) 1.21
Integrins in mechanotransduction. Curr Opin Cell Biol (2013) 1.21
Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling. J Immunol (2004) 1.20
Activation of the small GTPase Rac1 by a specific guanine-nucleotide-exchange factor suffices to induce glucose uptake into skeletal-muscle cells. Biol Cell (2008) 1.19
GABAA receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein. J Neurosci (2004) 1.17
Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells. Cell Cycle (2011) 1.17
Rapid global fitting of large fluorescence lifetime imaging microscopy datasets. PLoS One (2013) 1.16
S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells. Biochem Biophys Res Commun (2007) 1.13
Phosphatidic acid regulates systemic inflammatory responses by modulating the Akt-mammalian target of rapamycin-p70 S6 kinase 1 pathway. J Biol Chem (2003) 1.13
Proteomic analysis of tumor necrosis factor-alpha-induced secretome of human adipose tissue-derived mesenchymal stem cells. J Proteome Res (2010) 1.12
Developmental functions of the P120-catenin sub-family. Biochim Biophys Acta (2006) 1.12
Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation. J Biol Chem (2013) 1.11
PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals. Cell Signal (2006) 1.11
Sensitization of epidermal growth factor-induced signaling by bradykinin is mediated by c-Src. Implications for a role of lipid microdomains. J Biol Chem (2003) 1.11
Phospholipase signalling networks in cancer. Nat Rev Cancer (2012) 1.10
Requirement of Wnt/beta-catenin signaling in pronephric kidney development. Mech Dev (2008) 1.09
Maintenance of tumor initiating cells of defined genetic composition by nucleostemin. Proc Natl Acad Sci U S A (2011) 1.09
The role of EF-hand domains and C2 domain in regulation of enzymatic activity of phospholipase Czeta. J Biol Chem (2005) 1.09
Characterization of phospholipase C gamma enzymes with gain-of-function mutations. J Biol Chem (2009) 1.09
FLIM FRET technology for drug discovery: automated multiwell-plate high-content analysis, multiplexed readouts and application in situ. Chemphyschem (2011) 1.08
Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C epsilon. Mol Cell Biol (2005) 1.08
Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1. Mol Cell Biol (2007) 1.07
Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers. J Biol Chem (2011) 1.07
A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein. J Cell Biol (2006) 1.07
The protein kinase Akt/PKB regulates both prelamin A degradation and Lmna gene expression. FASEB J (2013) 1.06
Advances in targeting signal transduction pathways. Oncotarget (2012) 1.06
Periostin-binding DNA aptamer inhibits breast cancer growth and metastasis. Mol Ther (2013) 1.06
Human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by AMP-activated protein kinase. J Cell Physiol (2012) 1.05
The interaction of phospholipase C-beta3 with Shank2 regulates mGluR-mediated calcium signal. J Biol Chem (2005) 1.05
Phospholipase Cepsilon regulates ovulation in Caenorhabditis elegans. Dev Biol (2004) 1.05
Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2. Mol Cell (2009) 1.05
Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells. Cancer Res (2008) 1.04