A new rodent model to assess blood stage immunity to the Plasmodium falciparum antigen merozoite surface protein 119 reveals a protective role for invasion inhibitory antibodies.

PubWeight™: 1.61‹?› | Rank: Top 4%

🔗 View Article (PMC 2194199)

Published in J Exp Med on September 08, 2003

Authors

Tania F de Koning-Ward1, Rebecca A O'Donnell, Damien R Drew, Russell Thomson, Terence P Speed, Brendan S Crabb

Author Affiliations

1: The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville Victoria 3050, Australia.

Articles citing this

A newly discovered protein export machine in malaria parasites. Nature (2009) 2.79

Long-term clinical protection from falciparum malaria is strongly associated with IgG3 antibodies to merozoite surface protein 3. PLoS Med (2007) 2.54

PTEX is an essential nexus for protein export in malaria parasites. Nature (2014) 1.85

Development and optimization of high-throughput methods to measure Plasmodium falciparum-specific growth inhibitory antibodies. J Clin Microbiol (2006) 1.78

The importance of human FcgammaRI in mediating protection to malaria. PLoS Pathog (2007) 1.61

The fine specificity, but not the invasion inhibitory activity, of 19-kilodalton merozoite surface protein 1-specific antibodies is associated with resistance to malarial parasitemia in a cross-sectional survey in The Gambia. Infect Immun (2004) 1.44

A set of glycosylphosphatidyl inositol-anchored membrane proteins of Plasmodium falciparum is refractory to genetic deletion. Infect Immun (2006) 1.25

Tailoring subunit vaccine immunogenicity: maximizing antibody and T cell responses by using combinations of adenovirus, poxvirus and protein-adjuvant vaccines against Plasmodium falciparum MSP1. Vaccine (2010) 1.21

Chloroplast-derived vaccine antigens confer dual immunity against cholera and malaria by oral or injectable delivery. Plant Biotechnol J (2009) 1.14

Identification and characterization of a novel Plasmodium falciparum merozoite apical protein involved in erythrocyte binding and invasion. PLoS One (2008) 1.13

Plasmodium falciparum merozoite surface protein 8 is a ring-stage membrane protein that localizes to the parasitophorous vacuole of infected erythrocytes. Infect Immun (2005) 1.10

Minimal role for the circumsporozoite protein in the induction of sterile immunity by vaccination with live rodent malaria sporozoites. Infect Immun (2010) 1.06

Antibody response dynamics to the Plasmodium falciparum conserved vaccine candidate antigen, merozoite surface protein-1 C-terminal 19kD (MSP1-19kD), in Peruvians exposed to hypoendemic malaria transmission. Malar J (2008) 1.00

Plasmodium falciparum malaria in the Peruvian Amazon, a region of low transmission, is associated with immunologic memory. Infect Immun (2012) 0.99

Results from tandem Phase 1 studies evaluating the safety, reactogenicity and immunogenicity of the vaccine candidate antigen Plasmodium falciparum FVO merozoite surface protein-1 (MSP1(42)) administered intramuscularly with adjuvant system AS01. Malar J (2013) 0.97

Plasmodium falciparum PF10_0164 (ETRAMP10.3) is an essential parasitophorous vacuole and exported protein in blood stages. Eukaryot Cell (2010) 0.95

Construction of transgenic Plasmodium berghei as a model for evaluation of blood-stage vaccine candidate of Plasmodium falciparum chimeric protein 2.9. PLoS One (2009) 0.95

The Plasmodium falciparum merozoite surface protein-1 19 KD antibody response in the Peruvian Amazon predominantly targets the non-allele specific, shared sites of this antigen. Malar J (2010) 0.94

Phase I trial of an alhydrogel adjuvanted hepatitis B core virus-like particle containing epitopes of Plasmodium falciparum circumsporozoite protein. PLoS One (2008) 0.93

Baculovirus-based nasal drop vaccine confers complete protection against malaria by natural boosting of vaccine-induced antibodies in mice. Infect Immun (2009) 0.93

Development of a chimeric Plasmodium berghei strain expressing the repeat region of the P. vivax circumsporozoite protein for in vivo evaluation of vaccine efficacy. Infect Immun (2013) 0.93

Growth-inhibitory antibodies are not necessary for protective immunity to malaria infection. Infect Immun (2009) 0.91

Malaria vaccines: where next? PLoS Pathog (2009) 0.90

Plasmodium berghei circumvents immune responses induced by merozoite surface protein 1- and apical membrane antigen 1-based vaccines. PLoS One (2010) 0.90

Plasmodium falciparum line-dependent association of in vitro growth-inhibitory activity and risk of malaria. Infect Immun (2012) 0.85

A key role for Plasmodium subtilisin-like SUB1 protease in egress of malaria parasites from host hepatocytes. J Biol Chem (2013) 0.85

The generation and evaluation of two panels of epitope-matched mouse IgG1, IgG2a, IgG2b and IgG3 antibodies specific for Plasmodium falciparum and Plasmodium yoelii merozoite surface protein 1-19 (MSP1(19)). Exp Parasitol (2012) 0.84

The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment. Sci Rep (2013) 0.84

Genetic linkage of autologous T cell epitopes in a chimeric recombinant construct improves anti-parasite and anti-disease protective effect of a malaria vaccine candidate. Vaccine (2010) 0.83

The machinery underlying malaria parasite virulence is conserved between rodent and human malaria parasites. Nat Commun (2016) 0.82

Fine specificity of anti-MSP119 antibodies and multiplicity of Plasmodium falciparum merozoite surface protein 1 types in individuals in Nigeria with sub-microscopic infection. Malar J (2010) 0.81

A polyvalent hybrid protein elicits antibodies against the diverse allelic types of block 2 in Plasmodium falciparum merozoite surface protein 1. Vaccine (2011) 0.81

Transgenic rodent Plasmodium berghei parasites as tools for assessment of functional immunogenicity and optimization of human malaria vaccines. Eukaryot Cell (2008) 0.81

ZIPCO, a putative metal ion transporter, is crucial for Plasmodium liver-stage development. EMBO Mol Med (2014) 0.80

In Vivo Function of PTEX88 in Malaria Parasite Sequestration and Virulence. Eukaryot Cell (2015) 0.79

The P. falciparum Cell-Traversal Protein for Ookinetes and Sporozoites as a Candidate for Pre-Erythrocytic and Transmission-Blocking Vaccines. Infect Immun (2016) 0.78

Immunogenicity and in vitro protective efficacy of recombinant Mycobacterium bovis bacille Calmette Guerin (rBCG) expressing the 19 kDa merozoite surface protein-1 (MSP-1(19)) antigen of Plasmodium falciparum. Parasitol Res (2010) 0.78

Kinetics of humoral and memory B cell response induced by the Plasmodium falciparum 19-kilodalton merozoite surface protein 1 in mice. Infect Immun (2011) 0.78

Plasmodium falciparum: immunization with MSP1-42 induced non-inhibitory antibodies that have no blocking activities but enhanced the potency of inhibitory anti-MSP1-42 antibodies. Exp Parasitol (2006) 0.76

Development of a Plasmodium berghei transgenic parasite expressing the full-length Plasmodium vivax circumsporozoite VK247 protein for testing vaccine efficacy in a murine model. Malar J (2016) 0.76

The structure of Plasmodium yoelii merozoite surface protein 119, antibody specificity and implications for malaria vaccine design. Open Biol (2014) 0.75

Articles cited by this

Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes. J Exp Med (1990) 5.04

A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies. J Exp Med (1990) 4.90

Antibodies that inhibit malaria merozoite surface protein-1 processing and erythrocyte invasion are blocked by naturally acquired human antibodies. J Exp Med (1997) 2.92

Antibodies against merozoite surface protein (MSP)-1(19) are a major component of the invasion-inhibitory response in individuals immune to malaria. J Exp Med (2001) 2.80

Progress and challenges for malaria vaccines. Nature (2002) 2.50

Stable transgene expression in Plasmodium falciparum. Mol Biochem Parasitol (1997) 2.44

Human antibodies to the 19kDa C-terminal fragment of Plasmodium falciparum merozoite surface protein 1 inhibit parasite growth in vitro. Parasite Immunol (1999) 2.39

Functional conservation of the malaria vaccine antigen MSP-119across distantly related Plasmodium species. Nat Med (2000) 2.15

Target antigens of purified human immunoglobulins which inhibit growth of Plasmodium falciparum in vitro. Nature (1982) 2.11

Gene targeting in malaria parasites. Methods (1997) 2.03

Merozoite surface protein 1, immune evasion, and vaccines against asexual blood stage malaria. Parassitologia (1999) 2.01

Mapping of the region predominantly recognized by antibodies to the Plasmodium falciparum merozoite surface antigen MSA 1. Mol Biochem Parasitol (1992) 1.64

Differential effect of immunoglobulin on the in vitro growth of several isolates of Plasmodium falciparum. Infect Immun (1983) 1.54

The development of genetic tools for dissecting the biology of malaria parasites. Annu Rev Microbiol (2000) 1.39

The major merozoite surface protein as a malaria vaccine target. Parasitol Today (1993) 1.36

Functional equivalence of structurally distinct ribosomes in the malaria parasite, Plasmodium berghei. J Biol Chem (2001) 1.34

Malaria vaccines. Proc Natl Acad Sci U S A (1999) 1.26

Specificities of antibodies that inhibit merozoite dispersal from malaria-infected erythrocytes. Mol Biochem Parasitol (1989) 1.01

Antigenic and sequence diversity at the C-terminus of the merozoite surface protein-1 from rodent malaria isolates, and the binding of protective monoclonal antibodies. Mol Biochem Parasitol (1999) 0.95

Long-term in vitro cultures of Plasmodium berghei and preliminary observations on gametocytogenesis. Int J Parasitol (1984) 0.94

A robust neutralization test for Plasmodium falciparum malaria. J Exp Med (2001) 0.88

Developmental regulation of a Plasmodium gene involves the generation of stage-specific 5' untranslated sequences. Mol Biochem Parasitol (1998) 0.84

Articles by these authors

Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics (2003) 100.88

Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res (2003) 52.74

Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res (2002) 40.03

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell (2010) 39.09

GOstat: find statistically overrepresented Gene Ontologies within a group of genes. Bioinformatics (2004) 30.14

International network of cancer genome projects. Nature (2010) 20.35

A genotype calling algorithm for affymetrix SNP arrays. Bioinformatics (2005) 10.43

Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature (2007) 7.91

Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm. PLoS Biol (2008) 6.30

A benchmark for Affymetrix GeneChip expression measures. Bioinformatics (2004) 5.99

Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Nature (2008) 5.96

Invasion of red blood cells by malaria parasites. Cell (2006) 5.94

Exploration, normalization, and genotype calls of high-density oligonucleotide SNP array data. Biostatistics (2006) 5.20

Summarizing and correcting the GC content bias in high-throughput sequencing. Nucleic Acids Res (2012) 4.94

Subtype and pathway specific responses to anticancer compounds in breast cancer. Proc Natl Acad Sci U S A (2011) 4.55

Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum. Cell (2005) 4.33

Expression profiling in primates reveals a rapid evolution of human transcription factors. Nature (2006) 4.26

Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes. Cell (2008) 3.80

Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity. Nat Immunol (2006) 3.57

Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites. Genome Biol (2006) 3.45

Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes. Cell (2007) 3.37

A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria. Nature (2005) 2.99

Spotted long oligonucleotide arrays for human gene expression analysis. Genome Res (2003) 2.95

A single-array preprocessing method for estimating full-resolution raw copy numbers from all Affymetrix genotyping arrays including GenomeWideSNP 5 & 6. Bioinformatics (2009) 2.90

A newly discovered protein export machine in malaria parasites. Nature (2009) 2.79

PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer. Proc Natl Acad Sci U S A (2010) 2.79

Using control genes to correct for unwanted variation in microarray data. Biostatistics (2011) 2.70

Sex ratio adjustment and kin discrimination in malaria parasites. Nature (2008) 2.68

Functional genomic analysis of oligodendrocyte differentiation. J Neurosci (2006) 2.64

Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity. Nat Cell Biol (2010) 2.38

Evidence that invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein-1 (MSP-1 19) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of Africa. J Immunol (2004) 2.32

Mining a tandem mass spectrometry database to determine the trends and global factors influencing peptide fragmentation. Anal Chem (2003) 2.28

Statistical modeling of sequencing errors in SAGE libraries. Bioinformatics (2004) 2.25

Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development. Genome Biol (2011) 2.18

Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex. PLoS Biol (2006) 2.17

Integrative analysis of RUNX1 downstream pathways and target genes. BMC Genomics (2008) 2.14

Utility of currently recommended pediatric dyslipidemia classifications in predicting dyslipidemia in adulthood: evidence from the Childhood Determinants of Adult Health (CDAH) study, Cardiovascular Risk in Young Finns Study, and Bogalusa Heart Study. Circulation (2007) 2.07

Molecular identification of a malaria merozoite surface sheddase. PLoS Pathog (2005) 2.06

The association of pediatric low- and high-density lipoprotein cholesterol dyslipidemia classifications and change in dyslipidemia status with carotid intima-media thickness in adulthood evidence from the cardiovascular risk in Young Finns study, the Bogalusa Heart study, and the CDAH (Childhood Determinants of Adult Health) study. J Am Coll Cardiol (2009) 2.00

The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast. Mol Microbiol (2005) 1.98

Network inference using informative priors. Proc Natl Acad Sci U S A (2008) 1.96

Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum. J Biol Chem (2005) 1.95

An aspartyl protease directs malaria effector proteins to the host cell. Nature (2010) 1.92

Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparum. Mol Cell Proteomics (2006) 1.86

The role of osmiophilic bodies and Pfg377 expression in female gametocyte emergence and mosquito infectivity in the human malaria parasite Plasmodium falciparum. Mol Microbiol (2007) 1.84

Gene set enrichment analysis made simple. Stat Methods Med Res (2009) 1.79

Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nat Genet (2012) 1.79

Regulation of apicomplexan actin-based motility. Nat Rev Microbiol (2006) 1.78

Evaluation of affinity-based genome-wide DNA methylation data: effects of CpG density, amplification bias, and copy number variation. Genome Res (2010) 1.77

VAR2CSA is the principal ligand for chondroitin sulfate A in two allogeneic isolates of Plasmodium falciparum. Mol Biochem Parasitol (2006) 1.77

Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8alpha+ dendritic cells. Proc Natl Acad Sci U S A (2008) 1.73

A quartet of PIF bHLH factors provides a transcriptionally centered signaling hub that regulates seedling morphogenesis through differential expression-patterning of shared target genes in Arabidopsis. PLoS Genet (2013) 1.73

Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol (2009) 1.72

Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites. Nucleic Acids Res (2009) 1.71

A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycle. J Biol Chem (2002) 1.71

Morphology and kinetics of the three distinct phases of red blood cell invasion by Plasmodium falciparum merozoites. Int J Parasitol (2008) 1.70

TumorBoost: normalization of allele-specific tumor copy numbers from a single pair of tumor-normal genotyping microarrays. BMC Bioinformatics (2010) 1.70

A genetic screen for improved plasmid segregation reveals a role for Rep20 in the interaction of Plasmodium falciparum chromosomes. EMBO J (2002) 1.69

Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development. J Immunol (2013) 1.68

A Tetrahymena Piwi bound to mature tRNA 3' fragments activates the exonuclease Xrn2 for RNA processing in the nucleus. Mol Cell (2012) 1.65

Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria. J Immunol (2010) 1.65

Pediatric metabolic syndrome predicts adulthood metabolic syndrome, subclinical atherosclerosis, and type 2 diabetes mellitus but is no better than body mass index alone: the Bogalusa Heart Study and the Cardiovascular Risk in Young Finns Study. Circulation (2010) 1.62

IP-10-mediated T cell homing promotes cerebral inflammation over splenic immunity to malaria infection. PLoS Pathog (2009) 1.61

The importance of human FcgammaRI in mediating protection to malaria. PLoS Pathog (2007) 1.61

Identification of candidate growth promoting genes in ovarian cancer through integrated copy number and expression analysis. PLoS One (2010) 1.60

A single-sample method for normalizing and combining full-resolution copy numbers from multiple platforms, labs and analysis methods. Bioinformatics (2009) 1.53

A comparison of Affymetrix gene expression arrays. BMC Bioinformatics (2007) 1.53

Reticulocyte and erythrocyte binding-like proteins function cooperatively in invasion of human erythrocytes by malaria parasites. Infect Immun (2010) 1.52

Trafficking of STEVOR to the Maurer's clefts in Plasmodium falciparum-infected erythrocytes. EMBO J (2005) 1.50

Tetracycline analogue-regulated transgene expression in Plasmodium falciparum blood stages using Toxoplasma gondii transactivators. Proc Natl Acad Sci U S A (2005) 1.49

The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling. J Biol Chem (2006) 1.45

The fine specificity, but not the invasion inhibitory activity, of 19-kilodalton merozoite surface protein 1-specific antibodies is associated with resistance to malarial parasitemia in a cross-sectional survey in The Gambia. Infect Immun (2004) 1.44

Competition and the evolution of reproductive restraint in malaria parasites. Am Nat (2011) 1.42

High-quality DNA sequence capture of 524 disease candidate genes. Proc Natl Acad Sci U S A (2011) 1.41

A novel family of Apicomplexan glideosome-associated proteins with an inner membrane-anchoring role. J Biol Chem (2009) 1.40

Molecular analysis of gene expression in the developing pontocerebellar projection system. Neuron (2002) 1.37

Protocol matters: which methylome are you actually studying? Epigenomics (2010) 1.37

Genome-wide analysis of glucocorticoid receptor binding regions in adipocytes reveal gene network involved in triglyceride homeostasis. PLoS One (2010) 1.36

SNPs on chips: the hidden genetic code in expression arrays. Biol Psychiatry (2006) 1.36

Comparing somatic mutation-callers: beyond Venn diagrams. BMC Bioinformatics (2013) 1.35

Force of infection is key to understanding the epidemiology of Plasmodium falciparum malaria in Papua New Guinean children. Proc Natl Acad Sci U S A (2012) 1.33

Development of fluorescent Plasmodium falciparum for in vitro growth inhibition assays. Malar J (2010) 1.31

Global analyses of mRNA translational control during early Drosophila embryogenesis. Genome Biol (2007) 1.30

Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasite. PLoS Pathog (2010) 1.29

A dynamic programming approach for the alignment of signal peaks in multiple gas chromatography-mass spectrometry experiments. BMC Bioinformatics (2007) 1.29

Truncation of merozoite surface protein 3 disrupts its trafficking and that of acidic-basic repeat protein to the surface of Plasmodium falciparum merozoites. Mol Microbiol (2002) 1.28

Chemotherapy, within-host ecology and the fitness of drug-resistant malaria parasites. Evolution (2010) 1.27

A set of glycosylphosphatidyl inositol-anchored membrane proteins of Plasmodium falciparum is refractory to genetic deletion. Infect Immun (2006) 1.25

Transmission stage investment of malaria parasites in response to in-host competition. Proc Biol Sci (2007) 1.25

Evidence for a common role for the serine-type Plasmodium falciparum serine repeat antigen proteases: implications for vaccine and drug design. Infect Immun (2007) 1.23