Published in EMBO J on March 01, 2002
Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integrase. Nat Methods (2006) 3.32
High-efficiency transformation of Plasmodium falciparum by the lepidopteran transposable element piggyBac. Proc Natl Acad Sci U S A (2005) 2.48
Retracted Branched tricarboxylic acid metabolism in Plasmodium falciparum. Nature (2010) 1.92
Protein export marks the early phase of gametocytogenesis of the human malaria parasite Plasmodium falciparum. Mol Cell Proteomics (2010) 1.92
Strict pairing of var promoters and introns is required for var gene silencing in the malaria parasite Plasmodium falciparum. J Biol Chem (2006) 1.78
Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol (2009) 1.72
HDP-a novel heme detoxification protein from the malaria parasite. PLoS Pathog (2008) 1.55
Tetracycline analogue-regulated transgene expression in Plasmodium falciparum blood stages using Toxoplasma gondii transactivators. Proc Natl Acad Sci U S A (2005) 1.49
piggyBac is an effective tool for functional analysis of the Plasmodium falciparum genome. BMC Microbiol (2009) 1.34
Development of fluorescent Plasmodium falciparum for in vitro growth inhibition assays. Malar J (2010) 1.31
Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes. Proc Natl Acad Sci U S A (2012) 1.24
A cluster of ring stage-specific genes linked to a locus implicated in cytoadherence in Plasmodium falciparum codes for PEXEL-negative and PEXEL-positive proteins exported into the host cell. Mol Biol Cell (2006) 1.20
Frequent recombination events generate diversity within the multi-copy variant antigen gene families of Plasmodium falciparum. Int J Parasitol (2008) 1.13
Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in Plasmodium falciparum. Mol Microbiol (2007) 1.12
Repetitive elements in genomes of parasitic protozoa. Microbiol Mol Biol Rev (2003) 1.09
Active transcription is required for maintenance of epigenetic memory in the malaria parasite Plasmodium falciparum. J Mol Biol (2008) 1.06
A regulatable transgene expression system for cultured Plasmodium falciparum parasites. Malar J (2008) 1.06
Genome-wide nucleosome mapping of Plasmodium falciparum reveals histone-rich coding and histone-poor intergenic regions and chromatin remodeling of core and subtelomeric genes. BMC Genomics (2009) 1.06
Ectopic recombination of a malaria var gene during mitosis associated with an altered var switch rate. J Mol Biol (2009) 0.98
Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies. PLoS Pathog (2011) 0.97
Development of the piggyBac transposable system for Plasmodium berghei and its application for random mutagenesis in malaria parasites. BMC Genomics (2011) 0.97
DNA repair mechanisms and their biological roles in the malaria parasite Plasmodium falciparum. Microbiol Mol Biol Rev (2014) 0.96
Validation of a modified method for Bxb1 mycobacteriophage integrase-mediated recombination in Plasmodium falciparum by localization of the H-protein of the glycine cleavage complex to the mitochondrion. Mol Biochem Parasitol (2010) 0.95
PfAlbas constitute a new eukaryotic DNA/RNA-binding protein family in malaria parasites. Nucleic Acids Res (2011) 0.94
Analysis of the molecular mechanisms governing the stage-specific expression of a prototypical housekeeping gene during intraerythrocytic development of P. falciparum. J Mol Biol (2011) 0.93
Systematic analysis of FKBP inducible degradation domain tagging strategies for the human malaria parasite Plasmodium falciparum. PLoS One (2012) 0.93
Clustering of dispersed ribosomal DNA and its role in gene regulation and chromosome-end associations in malaria parasites. Proc Natl Acad Sci U S A (2010) 0.92
Plasmodium falciparum virulence determinants unveiled. Genome Biol (2002) 0.91
Human red blood cell-adapted Plasmodium knowlesi parasites: a new model system for malaria research. Cell Microbiol (2014) 0.91
Plate-based transfection and culturing technique for genetic manipulation of Plasmodium falciparum. Malar J (2012) 0.91
Identification of a cis-acting DNA-protein interaction implicated in singular var gene choice in Plasmodium falciparum. Cell Microbiol (2012) 0.87
Variable numbers of tandem repeats in Plasmodium falciparum genes. J Mol Evol (2010) 0.87
A highly conserved segmental duplication in the subtelomeres of Plasmodium falciparum chromosomes varies in copy number. Malar J (2008) 0.87
Plasmodium telomeres and telomerase: the usual actors in an unusual scenario. Chromosome Res (2005) 0.86
A transposon toolkit for gene transfer and mutagenesis in protozoan parasites. Genetica (2009) 0.85
Deciphering the principles that govern mutually exclusive expression of Plasmodium falciparum clag3 genes. Nucleic Acids Res (2015) 0.84
An integrated strategy for efficient vector construction and multi-gene expression in Plasmodium falciparum. Malar J (2013) 0.83
Identification and molecular characterization of an Alba-family protein from human malaria parasite Plasmodium falciparum. Nucleic Acids Res (2011) 0.80
A Plasmodium falciparum FcB1-schizont-EST collection providing clues to schizont specific gene structure and polymorphism. BMC Genomics (2009) 0.79
Novel nanosomes for gene delivery to Plasmodium falciparum-infected red blood cells. Sci Rep (2013) 0.79
A nuclear targeting system in Plasmodium falciparum. Malar J (2010) 0.78
Moving "Forward" in Plasmodium Genetics through a Transposon-Based Approach. J Trop Med (2012) 0.77
Human malaria parasites in continuous culture. Science (1976) 59.70
Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol (1979) 23.90
The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes. Cell (1995) 10.35
Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes. Cell (1995) 9.31
Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes. Cell (1995) 9.31
Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature (2000) 8.46
Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. Proc Natl Acad Sci U S A (1997) 5.75
Frequent ectopic recombination of virulence factor genes in telomeric chromosome clusters of P. falciparum. Nature (2000) 3.90
Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine. Proc Natl Acad Sci U S A (1996) 3.86
Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Science (1998) 3.83
Protein trafficking to the plastid of Plasmodium falciparum is via the secretory pathway. EMBO J (2000) 3.49
The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Nature (1999) 3.44
Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear stress. Cell (1997) 3.35
Characterization of promoters and stable transfection by homologous and nonhomologous recombination in Plasmodium falciparum. Proc Natl Acad Sci U S A (1996) 2.75
Malaria. Cooperative silencing elements in var genes. Nature (2001) 2.62
Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation. Proc Natl Acad Sci U S A (1998) 2.50
Homologous recombination within subtelomeric repeat sequences generates chromosome size polymorphisms in P. falciparum. Cell (1988) 2.46
Stable transgene expression in Plasmodium falciparum. Mol Biochem Parasitol (1997) 2.44
Chromosome size polymorphisms in Plasmodium falciparum can involve deletions and are frequent in natural parasite populations. Cell (1986) 2.27
Large deletions result from breakage and healing of P. falciparum chromosomes. Cell (1988) 2.10
Chromosome-sized DNA molecules of Plasmodium falciparum. Science (1985) 2.06
Molecules on the surface of the Plasmodium falciparum infected erythrocyte and their role in malaria pathogenesis and immune evasion. Mol Biochem Parasitol (2001) 1.99
Random association of Epstein-Barr virus genomes with host cell metaphase chromosomes in Burkitt's lymphoma-derived cell lines. J Virol (1985) 1.91
Molecular aspects of severe malaria. Clin Microbiol Rev (2000) 1.64
Characterisation of a repetitive DNA sequence from the malaria parasite, Plasmodium falciparum. Mol Biochem Parasitol (1986) 1.61
Plasmid maintenance of derivatives of oriP of Epstein-Barr virus. J Virol (1995) 1.57
A central role for Plasmodium falciparum subtelomeric regions in spatial positioning and telomere length regulation. EMBO J (2002) 1.56
Plasmodium telomeres: a pathogen's perspective. Curr Opin Microbiol (2001) 1.53
The var genes of Plasmodium falciparum are located in the subtelomeric region of most chromosomes. EMBO J (1996) 1.41
A cDNA clone expressing a rhoptry protein of Plasmodium falciparum. Mol Biochem Parasitol (1987) 1.31
Chromosome size polymorphism in Plasmodium falciparum can involve deletions of the subtelomeric pPFrep20 sequence. Nucleic Acids Res (1988) 1.29
Yeast telomere repeat sequence (TRS) improves circular plasmid segregation, and TRS plasmid segregation involves the RAP1 gene product. Mol Cell Biol (1992) 1.29
Plasmodium falciparum: isolation of large numbers of parasite clones from infected blood samples. Exp Parasitol (1996) 1.25
Genomic organisation and chromatin structure of Plasmodium falciparum chromosome ends. Mol Biochem Parasitol (2000) 1.24
The yeast silent information regulator Sir4p anchors and partitions plasmids. Mol Cell Biol (1997) 1.21
Highly reiterated non-coding sequence in the genome of Plasmodium falciparum is composed of 21 base-pair tandem repeats. J Mol Biol (1985) 1.21
An alteration in concatameric structure is associated with efficient segregation of plasmids in transfected Plasmodium falciparum parasites. Nucleic Acids Res (2001) 1.19
Replication, expression and segregation of plasmid-borne DNA in genetically transformed malaria parasites. Mol Biochem Parasitol (1997) 1.12
Expressed var genes are found in Plasmodium falciparum subtelomeric regions. Mol Cell Biol (1997) 1.11
Enhancement of telomere-plasmid segregation by the X-telomere associated sequence in Saccharomyces cerevisiae involves SIR2, SIR3, SIR4 and ABF1. Genetics (1994) 1.08
Telomeric tethers. Nature (2000) 0.78
Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature (2002) 8.92
Targeting malaria virulence and remodeling proteins to the host erythrocyte. Science (2004) 7.01
Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Nature (2008) 5.96
Invasion of red blood cells by malaria parasites. Cell (2006) 5.94
Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum. Cell (2005) 4.33
Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites. Cell (2005) 4.26
Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes. Cell (2008) 3.80
Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity. Nat Immunol (2006) 3.57
Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites. Genome Biol (2006) 3.45
Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations. Nat Med (2002) 3.29
Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa. PLoS Pathog (2007) 3.27
Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method. Mol Biochem Parasitol (2004) 3.13
Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum. Science (2003) 3.08
A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria. Nature (2005) 2.99
Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasites. Cell Host Microbe (2009) 2.95
Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science (2005) 2.81
A newly discovered protein export machine in malaria parasites. Nature (2009) 2.79
Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles. Cell (2013) 2.76
5' flanking region of var genes nucleate histone modification patterns linked to phenotypic inheritance of virulence traits in malaria parasites. Mol Microbiol (2007) 2.72
Contribution of the pfmdr1 gene to antimalarial drug-resistance. Acta Trop (2005) 2.72
Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination. Int J Parasitol (2002) 2.70
Malaria parasite proteins that remodel the host erythrocyte. Nat Rev Microbiol (2009) 2.62
Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes. EMBO J (2003) 2.56
A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A. EMBO Rep (2005) 2.53
Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription. BMC Genomics (2011) 2.53
A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites. J Biol Chem (2005) 2.50
Type II fatty acid synthesis is essential only for malaria parasite late liver stage development. Cell Microbiol (2008) 2.49
Super-resolution dissection of coordinated events during malaria parasite invasion of the human erythrocyte. Cell Host Microbe (2011) 2.37
The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites. Proc Natl Acad Sci U S A (2008) 2.33
Erythrocyte-binding antigen 175 mediates invasion in Plasmodium falciparum utilizing sialic acid-dependent and -independent pathways. Proc Natl Acad Sci U S A (2003) 2.31
Independent translocation of two micronemal proteins in developing Plasmodium falciparum merozoites. Infect Immun (2002) 2.26
Gambian children successfully treated with chloroquine can harbor and transmit Plasmodium falciparum gametocytes carrying resistance genes. Am J Trop Med Hyg (2002) 2.25
Allelic polymorphisms in apical membrane antigen-1 are responsible for evasion of antibody-mediated inhibition in Plasmodium falciparum. Mol Microbiol (2004) 2.24
Identification of multiple chondroitin sulfate A (CSA)-binding domains in the var2CSA gene transcribed in CSA-binding parasites. J Infect Dis (2005) 2.24
That was then but this is now: malaria research in the time of an eradication agenda. Science (2010) 2.23
Reticulocyte-binding protein homologue 5 - an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum. Int J Parasitol (2008) 2.19
Transcriptional variation in the malaria parasite Plasmodium falciparum. Genome Res (2012) 2.15
Transfection of the human malaria parasite Plasmodium falciparum. Methods Mol Biol (2004) 2.10
A novel erythrocyte binding antigen-175 paralogue from Plasmodium falciparum defines a new trypsin-resistant receptor on human erythrocytes. J Biol Chem (2003) 2.08
Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum. Mol Microbiol (2005) 2.02
Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes by Plasmodium falciparum. Mol Microbiol (2005) 1.98
The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast. Mol Microbiol (2005) 1.98
Variation in use of erythrocyte invasion pathways by Plasmodium falciparum mediates evasion of human inhibitory antibodies. J Clin Invest (2008) 1.96
Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum. J Biol Chem (2005) 1.95
Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites. J Biol Chem (2010) 1.95
Contribution of parasite proteins to altered mechanical properties of malaria-infected red blood cells. Blood (2002) 1.93
An aspartyl protease directs malaria effector proteins to the host cell. Nature (2010) 1.92
Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand. Proc Natl Acad Sci U S A (2010) 1.91
Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparum. Mol Cell Proteomics (2006) 1.86
Antigenic variation in Plasmodium falciparum is associated with movement of var loci between subnuclear locations. Proc Natl Acad Sci U S A (2005) 1.85
The role of osmiophilic bodies and Pfg377 expression in female gametocyte emergence and mosquito infectivity in the human malaria parasite Plasmodium falciparum. Mol Microbiol (2007) 1.84
Invasion by P. falciparum merozoites suggests a hierarchy of molecular interactions. PLoS Pathog (2005) 1.82
Negative selection using yeast cytosine deaminase/uracil phosphoribosyl transferase in Plasmodium falciparum for targeted gene deletion by double crossover recombination. Mol Biochem Parasitol (2006) 1.81
Invasion of host cells by malaria parasites: a tale of two protein families. Mol Microbiol (2007) 1.79
Association between naturally acquired antibodies to erythrocyte-binding antigens of Plasmodium falciparum and protection from malaria and high-density parasitemia. Clin Infect Dis (2010) 1.79
Regulation of apicomplexan actin-based motility. Nat Rev Microbiol (2006) 1.78
VAR2CSA is the principal ligand for chondroitin sulfate A in two allogeneic isolates of Plasmodium falciparum. Mol Biochem Parasitol (2006) 1.77
A novel semi-automatic image processing approach to determine Plasmodium falciparum parasitemia in Giemsa-stained thin blood smears. BMC Cell Biol (2008) 1.73
Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8alpha+ dendritic cells. Proc Natl Acad Sci U S A (2008) 1.73
Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA. Proc Natl Acad Sci U S A (2010) 1.73
Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol (2009) 1.72
Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design. Proc Natl Acad Sci U S A (2009) 1.72
Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites. Nucleic Acids Res (2009) 1.71
A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycle. J Biol Chem (2002) 1.71
Morphology and kinetics of the three distinct phases of red blood cell invasion by Plasmodium falciparum merozoites. Int J Parasitol (2008) 1.70
Moving in and renovating: exporting proteins from Plasmodium into host erythrocytes. Nat Rev Microbiol (2010) 1.69
Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development. J Immunol (2013) 1.68
Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors. PLoS Pathog (2009) 1.67
Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria. J Immunol (2010) 1.65
Role of the Plasmodium export element in trafficking parasite proteins to the infected erythrocyte. Traffic (2008) 1.64
Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum. Nat Biotechnol (2009) 1.64
IP-10-mediated T cell homing promotes cerebral inflammation over splenic immunity to malaria infection. PLoS Pathog (2009) 1.61
The importance of human FcgammaRI in mediating protection to malaria. PLoS Pathog (2007) 1.61
A new rodent model to assess blood stage immunity to the Plasmodium falciparum antigen merozoite surface protein 119 reveals a protective role for invasion inhibitory antibodies. J Exp Med (2003) 1.61
Plasmodium falciparum erythrocyte membrane protein-1 specifically suppresses early production of host interferon-gamma. Cell Host Microbe (2007) 1.61
Signal-mediated export of proteins from the malaria parasite to the host erythrocyte. J Cell Biol (2005) 1.57
Trafficking of the major virulence factor to the surface of transfected P. falciparum-infected erythrocytes. Blood (2005) 1.56
A central role for Plasmodium falciparum subtelomeric regions in spatial positioning and telomere length regulation. EMBO J (2002) 1.56
Selective inhibition of a two-step egress of malaria parasites from the host erythrocyte. J Biol Chem (2003) 1.54
Reticulocyte and erythrocyte binding-like proteins function cooperatively in invasion of human erythrocytes by malaria parasites. Infect Immun (2010) 1.52
Trafficking of STEVOR to the Maurer's clefts in Plasmodium falciparum-infected erythrocytes. EMBO J (2005) 1.50
Tetracycline analogue-regulated transgene expression in Plasmodium falciparum blood stages using Toxoplasma gondii transactivators. Proc Natl Acad Sci U S A (2005) 1.49
Quantitative protein expression profiling reveals extensive post-transcriptional regulation and post-translational modifications in schizont-stage malaria parasites. Genome Biol (2008) 1.48
A novel protein kinase family in Plasmodium falciparum is differentially transcribed and secreted to various cellular compartments of the host cell. Mol Microbiol (2007) 1.48
Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum. Trends Parasitol (2011) 1.47
Plasmodium falciparum heterochromatin protein 1 binds to tri-methylated histone 3 lysine 9 and is linked to mutually exclusive expression of var genes. Nucleic Acids Res (2009) 1.46