Published in J Biol Chem on September 08, 2003
MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology. PLoS One (2008) 1.39
Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases. Biochim Biophys Acta (2009) 1.33
Oxidative stress and transcriptional regulation in Alzheimer disease. Alzheimer Dis Assoc Disord (2007) 1.29
Structural insights into the mechanism of amine oxidation by monoamine oxidases A and B. Arch Biochem Biophys (2007) 1.23
Inhibition of 2-oxoglutarate dehydrogenase in potato tuber suggests the enzyme is limiting for respiration and confirms its importance in nitrogen assimilation,. Plant Physiol (2008) 1.13
Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease. Free Radic Biol Med (2012) 1.04
Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease. Free Radic Biol Med (2012) 1.04
Preferentially increased nitration of alpha-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson's disease. Anal Chem (2009) 1.03
Calcium and mitochondrial reactive oxygen species generation: how to read the facts. J Alzheimers Dis (2010) 0.96
Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomes. J Neurosci (2011) 0.94
Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesis. Free Radic Biol Med (2013) 0.94
A mitocentric view of Alzheimer's disease suggests multi-faceted treatments. J Alzheimers Dis (2010) 0.93
Mitochondrial enzymes and endoplasmic reticulum calcium stores as targets of oxidative stress in neurodegenerative diseases. J Bioenerg Biomembr (2004) 0.91
Mao-B elevation decreases parkin's ability to efficiently clear damaged mitochondria: protective effects of rapamycin. Free Radic Res (2012) 0.89
Oxidant-induced changes in mitochondria and calcium dynamics in the pathophysiology of Alzheimer's disease. Ann N Y Acad Sci (2008) 0.89
Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins. Neurobiol Dis (2009) 0.88
Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitors. Angew Chem Int Ed Engl (2012) 0.88
Characterization of detergent purified recombinant rat liver monoamine oxidase B expressed in Pichia pastoris. Protein Expr Purif (2008) 0.87
Up-regulation of the mitochondrial malate dehydrogenase by oxidative stress is mediated by miR-743a. J Neurochem (2011) 0.87
S-glutathionylation reactions in mitochondrial function and disease. Front Cell Dev Biol (2014) 0.86
Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction. Free Radic Biol Med (2008) 0.86
Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: implications for early intervention on disease progression. Neurobiol Dis (2010) 0.85
The Role of Mitochondrial Reactive Oxygen Species in Cardiovascular Injury and Protective Strategies. Oxid Med Cell Longev (2016) 0.83
Expression of zebrafish (Danio rerio) monoamine oxidase (MAO) in Pichia pastoris: purification and comparison with human MAO A and MAO B. Protein Expr Purif (2010) 0.81
An update on the role of mitochondrial α-ketoglutarate dehydrogenase in oxidative stress. Mol Cell Neurosci (2012) 0.80
Topological probes of monoamine oxidases A and B in rat liver mitochondria: inhibition by TEMPO-substituted pargyline analogues and inactivation by proteolysis. Biochemistry (2011) 0.79
Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Oncotarget (2016) 0.79
Formation of reactive oxygen species by human and bacterial pyruvate and 2-oxoglutarate dehydrogenase multienzyme complexes reconstituted from recombinant components. Free Radic Biol Med (2015) 0.78
Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol (2011) 0.78
Metabolic control analysis in a cellular model of elevated MAO-B: relevance to Parkinson's disease. Neurotox Res (2009) 0.77
Synthesis, molecular modeling, and in vitro screening of monoamine oxidase inhibitory activities of some novel hydrazone derivatives. J Neural Transm (Vienna) (2013) 0.76
Nebivolol Ameliorates Cardiac NLRP3 Inflammasome Activation in a Juvenile-Adolescent Animal Model of Diet-Induced Obesity. Sci Rep (2016) 0.76
The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity. Cancer Metab (2017) 0.75
Assessing mitochondrial dysfunction in cells. Biochem J (2011) 6.36
Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure. J Neurochem (2009) 2.92
Quantitative microplate-based respirometry with correction for oxygen diffusion. Anal Chem (2009) 2.86
Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease. Neuron (2003) 2.80
Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone. J Neurosci (2007) 2.23
Calpain I induces cleavage and release of apoptosis-inducing factor from isolated mitochondria. J Biol Chem (2004) 2.17
Cellular senescence: a link between cancer and age-related degenerative disease? Semin Cancer Biol (2011) 1.98
The relationship between free and total calcium concentrations in the matrix of liver and brain mitochondria. J Biol Chem (2003) 1.97
Role of oxidative stress in paraquat-induced dopaminergic cell degeneration. J Neurochem (2005) 1.59
In situ respiration and bioenergetic status of mitochondria in primary cerebellar granule neuronal cultures exposed continuously to glutamate. J Biol Chem (2004) 1.57
Time to talk SENS: critiquing the immutability of human aging. Ann N Y Acad Sci (2002) 1.42
Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration. J Neurosci (2007) 1.41
Mitochondrial α-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo. Neurosci Lett (2010) 1.40
Redox imbalance in Parkinson's disease. Biochim Biophys Acta (2008) 1.39
MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology. PLoS One (2008) 1.39
The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway. J Biol Chem (2004) 1.37
Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice. J Neurochem (2007) 1.32
Reversible inhibition of mitochondrial complex I activity following chronic dopaminergic glutathione depletion in vitro: implications for Parkinson's disease. Free Radic Biol Med (2006) 1.32
Glutathione, iron and Parkinson's disease. Biochem Pharmacol (2002) 1.32
Acute glutathione depletion restricts mitochondrial ATP export in cerebellar granule neurons. J Biol Chem (2005) 1.30
Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion. J Biol Chem (2009) 1.30
Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: implications for Parkinson disease. J Biol Chem (2005) 1.28
Measurement of instantaneous velocity vectors of organelle transport: mitochondrial transport and bioenergetics in hippocampal neurons. Biophys J (2008) 1.26
Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T. Gene (2008) 1.26
Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. J Neurosci Res (2009) 1.25
Oxidative and nitrative protein modifications in Parkinson's disease. Free Radic Biol Med (2008) 1.25
Iron and paraquat as synergistic environmental risk factors in sporadic Parkinson's disease accelerate age-related neurodegeneration. J Neurosci (2007) 1.21
Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors. J Neurosci (2006) 1.19
Dopaminergic neurons. Int J Biochem Cell Biol (2004) 1.19
Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age. Neurobiol Aging (2006) 1.18
Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance. J Neurosci (2007) 1.18
Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Free Radic Biol Med (2009) 1.17
UCPs--unlikely calcium porters. Nat Cell Biol (2008) 1.17
Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium-induced de- and hyperpolarization of neuronal mitochondria. J Physiol (2012) 1.07
Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration. Brain Res (2006) 1.05
Iron elevations in the aging Parkinsonian brain: a consequence of impaired iron homeostasis? J Neurochem (2010) 1.05
Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease. Free Radic Biol Med (2012) 1.04
Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease. Free Radic Biol Med (2012) 1.04
Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease. J Biol Chem (2009) 1.03
Preferentially increased nitration of alpha-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson's disease. Anal Chem (2009) 1.03
A disruption in iron-sulfur center biogenesis via inhibition of mitochondrial dithiol glutaredoxin 2 may contribute to mitochondrial and cellular iron dysregulation in mammalian glutathione-depleted dopaminergic cells: implications for Parkinson's disease. Antioxid Redox Signal (2009) 1.03
Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (Complex I) from rodent brain and a dopaminergic neuronal cell line. Mol Cell Proteomics (2004) 1.00
Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity. J Neurochem (2009) 1.00
Iron-enhanced paraquat-mediated dopaminergic cell death due to increased oxidative stress as a consequence of microglial activation. Free Radic Biol Med (2008) 0.99
Relationships between superoxide levels and delayed calcium deregulation in cultured cerebellar granule cells exposed continuously to glutamate. J Neurochem (2004) 0.99
Iron dysregulation and neurodegeneration: the molecular connection. Mol Interv (2006) 0.96
Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomes. J Neurosci (2011) 0.94
Role of HIF-1 in iron regulation: potential therapeutic strategy for neurodegenerative disorders. Curr Mol Med (2006) 0.93
Plasma membrane potential oscillations in insulin secreting Ins-1 832/13 cells do not require glycolysis and are not initiated by fluctuations in mitochondrial bioenergetics. J Biol Chem (2012) 0.91
Quantitative mapping of reversible mitochondrial Complex I cysteine oxidation in a Parkinson disease mouse model. J Biol Chem (2011) 0.90
Mao-B elevation decreases parkin's ability to efficiently clear damaged mitochondria: protective effects of rapamycin. Free Radic Res (2012) 0.89
In vitro and in vivo neuroprotection by gamma-glutamylcysteine ethyl ester against MPTP: relevance to the role of glutathione in Parkinson's disease. Neurosci Lett (2006) 0.89
Chronic expression of H-ferritin in dopaminergic midbrain neurons results in an age-related expansion of the labile iron pool and subsequent neurodegeneration: implications for Parkinson's disease. Brain Res (2009) 0.89
Up-regulation of gamma-glutamyl transpeptidase activity following glutathione depletion has a compensatory rather than an inhibitory effect on mitochondrial complex I activity: implications for Parkinson's disease. Free Radic Biol Med (2006) 0.89
Ironing out Parkinson's disease: is therapeutic treatment with iron chelators a real possibility? Aging Cell (2002) 0.89
Lithium protects against oxidative stress-mediated cell death in α-synuclein-overexpressing in vitro and in vivo models of Parkinson's disease. J Neurosci Res (2011) 0.89
Glutathione decreases in dopaminergic PC12 cells interfere with the ubiquitin protein degradation pathway: relevance for Parkinson's disease? J Neurochem (2002) 0.88
Inhibition of caspases protects cerebellar granule cells of the weaver mouse from apoptosis and improves behavioral phenotype. J Biol Chem (2002) 0.88
Synergistic effects of environmental risk factors and gene mutations in Parkinson's disease accelerate age-related neurodegeneration. J Neurochem (2010) 0.87
Coupling endoplasmic reticulum stress to the cell death program in dopaminergic cells: effect of paraquat. Neuromolecular Med (2008) 0.87
Late-life hemoglobin and the incidence of Parkinson's disease. Neurobiol Aging (2010) 0.87
The role of c-Jun N-terminal kinase (JNK) in Parkinson's disease. IUBMB Life (2003) 0.87
Endoplasmic reticulum stress-induced cell death in dopaminergic cells: effect of resveratrol. J Mol Neurosci (2009) 0.87
Glutathione depletion in immortalized midbrain-derived dopaminergic neurons results in increases in the labile iron pool: implications for Parkinson's disease. Free Radic Biol Med (2008) 0.87
Nitrosylation and nitration of mitochondrial complex I in Parkinson's disease. Free Radic Res (2010) 0.87
Barbiturates induce mitochondrial depolarization and potentiate excitotoxic neuronal death. J Neurosci (2002) 0.85
Perspectives on MAO-B in aging and neurological disease: where do we go from here? Mol Neurobiol (2004) 0.85
Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: implications for early intervention on disease progression. Neurobiol Dis (2010) 0.85
No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease. J Neurosci (2012) 0.84
Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration. J Neurosci (2006) 0.83
Age-related behavioral phenotype of an astrocytic monoamine oxidase-B transgenic mouse model of Parkinson's disease. PLoS One (2013) 0.83
Anti-inflammatory role of the isoflavone diadzein in lipopolysaccharide-stimulated microglia: implications for Parkinson's disease. Neurotox Res (2012) 0.83
Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells. J Biol Chem (2013) 0.82
A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans. Aging (Albany NY) (2013) 0.82
Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans. Metallomics (2014) 0.82
Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data. Free Radic Biol Med (2008) 0.82
A possible novel anti-inflammatory mechanism for the pharmacological prolyl hydroxylase inhibitor 3,4-dihydroxybenzoate: implications for use as a therapeutic for Parkinson's disease. Parkinsons Dis (2012) 0.81
The high-affinity D2/D3 agonist D512 protects PC12 cells from 6-OHDA-induced apoptotic cell death and rescues dopaminergic neurons in the MPTP mouse model of Parkinson's disease. J Neurochem (2014) 0.80
Mutant α-synuclein and aging reduce neurogenesis in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Aging Cell (2010) 0.80
Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: implications for early intervention on disease progression. Neurobiol Dis (2011) 0.80
Acute and long-term response of dopamine nigrostriatal synapses to a single, low-dose episode of 3-nitropropionic acid-mediated chemical hypoxia. Synapse (2010) 0.78
Genetic iron chelation protects against proteasome inhibition-induced dopamine neuron degeneration. Neurobiol Dis (2009) 0.77
Catecholamine metabolism drives generation of mitochondrial DNA deletions in dopaminergic neurons. Brain (2013) 0.77
Metabolic control analysis in a cellular model of elevated MAO-B: relevance to Parkinson's disease. Neurotox Res (2009) 0.77
Prospects and challenges for the use of stem cell technologies to develop novel therapies for Parkinson disease. Cell Cycle (2011) 0.76
Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin. Antioxid Redox Signal (2015) 0.76
Reactive oxygen and nitrogen species in neurodegeneration. Free Radic Biol Med (2013) 0.75