Published in Chembiochem on September 05, 2003
Siderophore-based iron acquisition and pathogen control. Microbiol Mol Biol Rev (2007) 4.87
Engineering the substrate specificity of the DhbE adenylation domain by yeast cell surface display. Chem Biol (2013) 1.51
Antitubercular nucleosides that inhibit siderophore biosynthesis: SAR of the glycosyl domain. J Med Chem (2006) 1.41
Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis. Bioorg Med Chem Lett (2008) 1.19
Synthetic microcin C analogs targeting different aminoacyl-tRNA synthetases. J Bacteriol (2009) 1.03
Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules. J Am Chem Soc (2007) 1.02
Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategy. Chem Soc Rev (2008) 0.98
MccE provides resistance to protein synthesis inhibitor microcin C by acetylating the processed form of the antibiotic. J Biol Chem (2010) 0.98
Targeting iron assimilation to develop new antibacterials. Expert Opin Drug Discov (2012) 0.97
Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes. J Am Chem Soc (2010) 0.95
Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesis. Chembiochem (2011) 0.94
Iron trafficking as an antimicrobial target. Biometals (2009) 0.91
Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategy. Biochim Biophys Acta (2015) 0.88
Proteomic analysis of polyketide and nonribosomal peptide biosynthesis. Curr Opin Chem Biol (2010) 0.81
Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa. ACS Chem Biol (2016) 0.76
Design, synthesis, and biological evaluation of α-hydroxyacyl-AMS inhibitors of amino acid adenylation enzymes. Bioorg Med Chem Lett (2016) 0.75
Active site-directed proteomic probes for adenylation domains in nonribosomal peptide synthetases. Chem Commun (Camb) (2015) 0.75
FRET monitoring of a nonribosomal peptide synthetase. Nat Chem Biol (2017) 0.75
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Siderophore-based iron acquisition and pathogen control. Microbiol Mol Biol Rev (2007) 4.87
Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics. Chem Rev (2005) 4.64
Biosynthesis of nonribosomal peptides1. Annu Rev Microbiol (2004) 3.64
Nonribosomal peptides: from genes to products. Nat Prod Rep (2003) 2.73
Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases. Proc Natl Acad Sci U S A (2002) 2.51
Crystal structure of the termination module of a nonribosomal peptide synthetase. Science (2008) 2.02
Dissection of the mechanism for the stringent factor RelA. Mol Cell (2002) 1.98
Ways of assembling complex natural products on modular nonribosomal peptide synthetases. Chembiochem (2002) 1.85
Nonribosomal peptide synthetases: structures and dynamics. Curr Opin Struct Biol (2010) 1.83
Mechanistic and structural basis of stereospecific Cbeta-hydroxylation in calcium-dependent antibiotic, a daptomycin-type lipopeptide. ACS Chem Biol (2007) 1.77
Insights into the biosynthesis and stability of the lasso peptide capistruin. Chem Biol (2009) 1.75
Functional dissection of surfactin synthetase initiation module reveals insights into the mechanism of lipoinitiation. Chem Biol (2010) 1.72
Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. Nature (2008) 1.66
Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases. Proc Natl Acad Sci U S A (2002) 1.64
Inhibition of aryl acid adenylation domains involved in bacterial siderophore synthesis. FEBS J (2006) 1.61
Conformational switches modulate protein interactions in peptide antibiotic synthetases. Science (2006) 1.61
Crystal structure of DltA. Implications for the reaction mechanism of non-ribosomal peptide synthetase adenylation domains. J Biol Chem (2008) 1.50
Evidence for a monomeric structure of nonribosomal Peptide synthetases. Chem Biol (2002) 1.49
Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE. Structure (2002) 1.49
Isolation and structural characterization of capistruin, a lasso peptide predicted from the genome sequence of Burkholderia thailandensis E264. J Am Chem Soc (2008) 1.47
Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides. Microbiol Mol Biol Rev (2006) 1.41
Copper stress affects iron homeostasis by destabilizing iron-sulfur cluster formation in Bacillus subtilis. J Bacteriol (2010) 1.40
Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase. Structure (2007) 1.40
The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A. Nat Chem Biol (2012) 1.39
Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis. Nat Prod Rep (2007) 1.38
Bacterial cold shock responses. Sci Prog (2003) 1.37
Ebony, a novel nonribosomal peptide synthetase for beta-alanine conjugation with biogenic amines in Drosophila. J Biol Chem (2003) 1.36
DNA nanotechnology: Chemical copying of connectivity. Nature (2002) 1.35
Identification of a gene cluster for biosynthesis of mannosylerythritol lipids in the basidiomycetous fungus Ustilago maydis. Appl Environ Microbiol (2006) 1.33
Exploitation of the selectivity-conferring code of nonribosomal peptide synthetases for the rational design of novel peptide antibiotics. Biochemistry (2002) 1.33
Genomewide transcriptional analysis of the cold shock response in Bacillus subtilis. J Bacteriol (2002) 1.32
Cloning and characterization of the biosynthetic gene cluster for kutznerides. Proc Natl Acad Sci U S A (2007) 1.31
Cold-induced putative DEAD box RNA helicases CshA and CshB are essential for cold adaptation and interact with cold shock protein B in Bacillus subtilis. J Bacteriol (2006) 1.30
Hydrazide oligonucleotides: new chemical modification for chip array attachment and conjugation. Nucleic Acids Res (2002) 1.29
Inhibition of the D-alanine:D-alanyl carrier protein ligase from Bacillus subtilis increases the bacterium's susceptibility to antibiotics that target the cell wall. FEBS J (2005) 1.21
Ferri-bacillibactin uptake and hydrolysis in Bacillus subtilis. Mol Microbiol (2006) 1.21
Reactions catalyzed by mature and recombinant nonribosomal peptide synthetases. Methods Enzymol (2004) 1.20
The Bacillus subtilis transition state regulator AbrB binds to the -35 promoter region of comK. FEMS Microbiol Lett (2003) 1.20
Mutational analysis of the C-domain in nonribosomal peptide synthesis. Eur J Biochem (2002) 1.18
The thioesterase domain of the fengycin biosynthesis cluster: a structural base for the macrocyclization of a non-ribosomal lipopeptide. J Mol Biol (2006) 1.16
A biosynthetic gene cluster for a secreted cellobiose lipid with antifungal activity from Ustilago maydis. Mol Microbiol (2007) 1.12
Daptomycin, a bacterial lipopeptide synthesized by a nonribosomal machinery. J Biol Chem (2010) 1.11
Characterization of a new type of phosphopantetheinyl transferase for fatty acid and siderophore synthesis in Pseudomonas aeruginosa. J Biol Chem (2002) 1.10
Chirality of peptide bond-forming condensation domains in nonribosomal peptide synthetases: the C5 domain of tyrocidine synthetase is a (D)C(L) catalyst. Biochemistry (2003) 1.09
Rational design of a bimodular model system for the investigation of heterocyclization in nonribosomal peptide biosynthesis. Chem Biol (2004) 1.07
Functional characterization of 4'-phosphopantetheinyl transferase genes of bacterial and fungal origin by complementation of Saccharomyces cerevisiae lys5. FEMS Microbiol Lett (2002) 1.07
Identification and characterization of the lysobactin biosynthetic gene cluster reveals mechanistic insights into an unusual termination module architecture. Chem Biol (2011) 1.04
Two [4Fe-4S] clusters containing radical SAM enzyme SkfB catalyze thioether bond formation during the maturation of the sporulation killing factor. J Am Chem Soc (2013) 1.03
Loading peptidyl-coenzyme A onto peptidyl carrier proteins: a novel approach in characterizing macrocyclization by thioesterase domains. J Am Chem Soc (2003) 1.03
Coping with the cold: the cold shock response in the Gram-positive soil bacterium Bacillus subtilis. Philos Trans R Soc Lond B Biol Sci (2002) 1.02
Structure-based mutational analysis of the 4'-phosphopantetheinyl transferases Sfp from Bacillus subtilis: carrier protein recognition and reaction mechanism. Biochemistry (2004) 1.01
The structural diversity of acidic lipopeptide antibiotics. Chembiochem (2009) 1.01
Learning from nature's drug factories: nonribosomal synthesis of macrocyclic peptides. J Bacteriol (2003) 1.00
Synthesis and derivatization of daptomycin: a chemoenzymatic route to acidic lipopeptide antibiotics. J Am Chem Soc (2004) 1.00
The linear pentadecapeptide gramicidin is assembled by four multimodular nonribosomal peptide synthetases that comprise 16 modules with 56 catalytic domains. J Biol Chem (2003) 1.00
Recognition of hybrid peptidyl carrier proteins/acyl carrier proteins in nonribosomal peptide synthetase modules by the 4'-phosphopantetheinyl transferases AcpS and Sfp. J Biol Chem (2002) 1.00
Crosslinking studies of protein-protein interactions in nonribosomal peptide biosynthesis. Chem Biol (2009) 1.00
The iterative gramicidin s thioesterase catalyzes peptide ligation and cyclization. Chem Biol (2007) 0.98
Peptide macrocyclization: the reductase of the nostocyclopeptide synthetase triggers the self-assembly of a macrocyclic imine. J Am Chem Soc (2006) 0.97
Mutational analysis of a type II thioesterase associated with nonribosomal peptide synthesis. Eur J Biochem (2004) 0.97
Stereospecific enzymatic transformation of alpha-ketoglutarate to (2S,3R)-3-methyl glutamate during acidic lipopeptide biosynthesis. J Am Chem Soc (2007) 0.97
Lasso peptides from proteobacteria: Genome mining employing heterologous expression and mass spectrometry. Biopolymers (2013) 0.97
Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase. Biochemistry (2002) 0.96
Dissecting the maturation steps of the lasso peptide microcin J25 in vitro. Chembiochem (2012) 0.96
Copper acquisition is mediated by YcnJ and regulated by YcnK and CsoR in Bacillus subtilis. J Bacteriol (2009) 0.95
Sigma L is important for cold shock adaptation of Bacillus subtilis. J Bacteriol (2006) 0.94
The glucagon receptor antagonist BI-32169 constitutes a new class of lasso peptides. FEBS Lett (2009) 0.94
Structural basis for the erythro-stereospecificity of the L-arginine oxygenase VioC in viomycin biosynthesis. FEBS J (2009) 0.93
SufU is an essential iron-sulfur cluster scaffold protein in Bacillus subtilis. J Bacteriol (2010) 0.92
Iron starvation triggers the stringent response and induces amino acid biosynthesis for bacillibactin production in Bacillus subtilis. J Bacteriol (2006) 0.92
Caulosegnins I-III: a highly diverse group of lasso peptides derived from a single biosynthetic gene cluster. J Am Chem Soc (2012) 0.92
Chemo- and regioselective peptide cyclization triggered by the N-terminal fatty acid chain length: the recombinant cyclase of the calcium-dependent antibiotic from Streptomyces coelicolor. Biochemistry (2004) 0.92
Elucidation of the complete ferrichrome A biosynthetic pathway in Ustilago maydis. Mol Microbiol (2009) 0.92
How to tailor non-ribosomal peptide products--new clues about the structures and mechanisms of modifying enzymes. Mol Biosyst (2008) 0.92
Characterization of a mutation in the acetolactate synthase of Bacillus subtilis that causes a cold-sensitive phenotype. FEMS Microbiol Lett (2007) 0.91
Where chemistry meets biology: the chemoenzymatic synthesis of nonribosomal peptides and polyketides. Curr Opin Biotechnol (2007) 0.91
Mutational analysis of peptidyl carrier protein and acyl carrier protein synthase unveils residues involved in protein-protein recognition. Biochemistry (2004) 0.90
Stereospecific synthesis of threo- and erythro-beta-hydroxyglutamic acid during kutzneride biosynthesis. J Am Chem Soc (2009) 0.90
Xanthomonins I-III: a new class of lasso peptides with a seven-residue macrolactam ring. Angew Chem Int Ed Engl (2014) 0.90
The siderophore-interacting protein YqjH acts as a ferric reductase in different iron assimilation pathways of Escherichia coli. Biochemistry (2011) 0.90
Timing of epimerization and condensation reactions in nonribosomal peptide assembly lines: kinetic analysis of phenylalanine activating elongation modules of tyrocidine synthetase B. Biochemistry (2002) 0.90
Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist. Angew Chem Int Ed Engl (2011) 0.90
Radical S-adenosylmethionine enzyme catalyzed thioether bond formation in sactipeptide biosynthesis. Curr Opin Chem Biol (2013) 0.89
Decreasing the ring size of a cyclic nonribosomal peptide antibiotic by in-frame module deletion in the biosynthetic genes. J Am Chem Soc (2002) 0.89
The antibacterial threaded-lasso peptide capistruin inhibits bacterial RNA polymerase. J Mol Biol (2011) 0.89
Harnessing the chemical activation inherent to carrier protein-bound thioesters for the characterization of lipopeptide fatty acid tailoring enzymes. J Am Chem Soc (2008) 0.89
The Synechocystis sp. PCC6803 Sfp-type phosphopantetheinyl transferase does not possess characteristic broad-range activity. Chembiochem (2009) 0.89
A tRNA-dependent two-enzyme pathway for the generation of singly and doubly methylated ditryptophan 2,5-diketopiperazines. Biochemistry (2013) 0.89
Biosynthesis of the siderophore rhodochelin requires the coordinated expression of three independent gene clusters in Rhodococcus jostii RHA1. J Am Chem Soc (2011) 0.89
The astexin-1 lasso peptides: biosynthesis, stability, and structural studies. Chem Biol (2013) 0.89
Role of DptE and DptF in the lipidation reaction of daptomycin. FEBS J (2008) 0.88
The major facilitator superfamily-type transporter YmfE and the multidrug-efflux activator Mta mediate bacillibactin secretion in Bacillus subtilis. J Bacteriol (2008) 0.88
Systematic and quantitative analysis of protein-protein recognition between nonribosomal peptide synthetases investigated in the tyrocidine biosynthetic template. Biochemistry (2003) 0.88
Insights into the generation of structural diversity in a tRNA-dependent pathway for highly modified bioactive cyclic dipeptides. Chem Biol (2013) 0.88
Structural basis and stereochemistry of triscatecholate siderophore binding by FeuA. Angew Chem Int Ed Engl (2009) 0.88
Environmental salinity determines the specificity and need for Tat-dependent secretion of the YwbN protein in Bacillus subtilis. PLoS One (2011) 0.88
Topoisomer differentiation of molecular knots by FTICR MS: lessons from class II lasso peptides. J Am Soc Mass Spectrom (2011) 0.86