Published in J Biol Chem on October 14, 2002
Bacterial fatty acid synthesis and its relationships with polyketide synthetic pathways. Methods Enzymol (2009) 1.50
The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life. Nat Prod Rep (2014) 1.32
Diversity of nonribosomal peptide synthetases involved in the biosynthesis of lipopeptide biosurfactants. Int J Mol Sci (2010) 1.20
Cloning and characterization of the pyrrolomycin biosynthetic gene clusters from Actinosporangium vitaminophilum ATCC 31673 and Streptomyces sp. strain UC 11065. Antimicrob Agents Chemother (2006) 1.09
Mechanism and substrate recognition of human holo ACP synthase. Chem Biol (2007) 1.05
The phosphopantetheinyl transferase superfamily: phylogenetic analysis and functional implications in cyanobacteria. Appl Environ Microbiol (2006) 1.05
4'-phosphopantetheinyl transferase-encoding npgA is essential for siderophore biosynthesis in Aspergillus nidulans. Curr Genet (2003) 1.04
The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum. J Ind Microbiol Biotechnol (2004) 1.00
In vivo production of artificial nonribosomal peptide products in the heterologous host Escherichia coli. Appl Environ Microbiol (2004) 0.97
Functional characterization of an evolutionarily distinct phosphopantetheinyl transferase in the apicomplexan Cryptosporidium parvum. Eukaryot Cell (2005) 0.93
A homogeneous resonance energy transfer assay for phosphopantetheinyl transferase. Anal Biochem (2009) 0.90
Acyl carrier protein synthases from gram-negative, gram-positive, and atypical bacterial species: Biochemical and structural properties and physiological implications. J Bacteriol (2006) 0.84
Characterization of PPTNs, a cyanobacterial phosphopantetheinyl transferase from Nodularia spumigena NSOR10. J Bacteriol (2007) 0.84
Fluorescent techniques for discovery and characterization of phosphopantetheinyl transferase inhibitors. J Antibiot (Tokyo) (2013) 0.81
Lincosamide synthetase--a unique condensation system combining elements of nonribosomal peptide synthetase and mycothiol metabolism. PLoS One (2015) 0.81
Improvement of natamycin production by engineering of phosphopantetheinyl transferases in Streptomyces chattanoogensis L10. Appl Environ Microbiol (2013) 0.81
Characterization and evolutionary implications of the triad Asp-Xxx-Glu in group II phosphopantetheinyl transferases. PLoS One (2014) 0.77
Characterization of Cfa1, a monofunctional acyl carrier protein involved in the biosynthesis of the phytotoxin coronatine. J Bacteriol (2004) 0.76
Identification and characterization of the spiruchostatin biosynthetic gene cluster enable yield improvement by overexpressing a transcriptional activator. J Ind Microbiol Biotechnol (2014) 0.76
Identification of the Sfp-Type PPTase EppA from the Lichenized Fungus Evernia prunastri. PLoS One (2016) 0.75
Two functionally distinctive phosphopantetheinyl transferases from amoeba Dictyostelium discoideum. PLoS One (2011) 0.75
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Siderophore-based iron acquisition and pathogen control. Microbiol Mol Biol Rev (2007) 4.87
Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics. Chem Rev (2005) 4.64
PrediSi: prediction of signal peptides and their cleavage positions. Nucleic Acids Res (2004) 3.93
Biosynthesis of nonribosomal peptides1. Annu Rev Microbiol (2004) 3.64
Virtual Footprint and PRODORIC: an integrative framework for regulon prediction in prokaryotes. Bioinformatics (2005) 2.82
PRODORIC: prokaryotic database of gene regulation. Nucleic Acids Res (2003) 2.81
Nonribosomal peptides: from genes to products. Nat Prod Rep (2003) 2.73
JCat: a novel tool to adapt codon usage of a target gene to its potential expression host. Nucleic Acids Res (2005) 2.60
Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases. Proc Natl Acad Sci U S A (2002) 2.51
RNA-dependent cysteine biosynthesis in archaea. Science (2005) 2.50
Crystal structure of the termination module of a nonribosomal peptide synthetase. Science (2008) 2.02
The complete genome sequence of the algal symbiont Dinoroseobacter shibae: a hitchhiker's guide to life in the sea. ISME J (2009) 2.00
Dissection of the mechanism for the stringent factor RelA. Mol Cell (2002) 1.98
Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes. EMBO J (2003) 1.98
Nanoarchaeum equitans creates functional tRNAs from separate genes for their 5'- and 3'-halves. Nature (2005) 1.97
Genome sequences of the biotechnologically important Bacillus megaterium strains QM B1551 and DSM319. J Bacteriol (2011) 1.86
Ways of assembling complex natural products on modular nonribosomal peptide synthetases. Chembiochem (2002) 1.85
Bacillus megaterium--from simple soil bacterium to industrial protein production host. Appl Microbiol Biotechnol (2007) 1.85
Nonribosomal peptide synthetases: structures and dynamics. Curr Opin Struct Biol (2010) 1.83
Mechanistic and structural basis of stereospecific Cbeta-hydroxylation in calcium-dependent antibiotic, a daptomycin-type lipopeptide. ACS Chem Biol (2007) 1.77
Insights into the biosynthesis and stability of the lasso peptide capistruin. Chem Biol (2009) 1.75
Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans. EMBO J (2005) 1.74
Functional dissection of surfactin synthetase initiation module reveals insights into the mechanism of lipoinitiation. Chem Biol (2010) 1.72
JProGO: a novel tool for the functional interpretation of prokaryotic microarray data using Gene Ontology information. Nucleic Acids Res (2006) 1.69
Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. Nature (2008) 1.66
Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases. Proc Natl Acad Sci U S A (2002) 1.64
Long-term anaerobic survival of the opportunistic pathogen Pseudomonas aeruginosa via pyruvate fermentation. J Bacteriol (2004) 1.63
Inhibition of aryl acid adenylation domains involved in bacterial siderophore synthesis. FEBS J (2006) 1.61
Conformational switches modulate protein interactions in peptide antibiotic synthetases. Science (2006) 1.61
SYSTOMONAS--an integrated database for systems biology analysis of Pseudomonas. Nucleic Acids Res (2007) 1.55
The biochemistry of heme biosynthesis. Arch Biochem Biophys (2008) 1.53
Crystal structure of DltA. Implications for the reaction mechanism of non-ribosomal peptide synthetase adenylation domains. J Biol Chem (2008) 1.50
Evidence for a monomeric structure of nonribosomal Peptide synthetases. Chem Biol (2002) 1.49
Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE. Structure (2002) 1.49
Structure and function of enzymes in heme biosynthesis. Protein Sci (2010) 1.48
Isolation and structural characterization of capistruin, a lasso peptide predicted from the genome sequence of Burkholderia thailandensis E264. J Am Chem Soc (2008) 1.47
Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides. Microbiol Mol Biol Rev (2006) 1.41
Copper stress affects iron homeostasis by destabilizing iron-sulfur cluster formation in Bacillus subtilis. J Bacteriol (2010) 1.40
Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase. Structure (2007) 1.40
The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A. Nat Chem Biol (2012) 1.39
PRODORIC (release 2009): a database and tool platform for the analysis of gene regulation in prokaryotes. Nucleic Acids Res (2008) 1.39
Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis. Nat Prod Rep (2007) 1.38
Bacterial cold shock responses. Sci Prog (2003) 1.37
Ebony, a novel nonribosomal peptide synthetase for beta-alanine conjugation with biogenic amines in Drosophila. J Biol Chem (2003) 1.36
Anaerobic survival of Pseudomonas aeruginosa by pyruvate fermentation requires an Usp-type stress protein. J Bacteriol (2006) 1.34
Identification of a gene cluster for biosynthesis of mannosylerythritol lipids in the basidiomycetous fungus Ustilago maydis. Appl Environ Microbiol (2006) 1.33
JVirGel: Calculation of virtual two-dimensional protein gels. Nucleic Acids Res (2003) 1.33
Exploitation of the selectivity-conferring code of nonribosomal peptide synthetases for the rational design of novel peptide antibiotics. Biochemistry (2002) 1.33
Genomewide transcriptional analysis of the cold shock response in Bacillus subtilis. J Bacteriol (2002) 1.32
Cloning and characterization of the biosynthetic gene cluster for kutznerides. Proc Natl Acad Sci U S A (2007) 1.31
Cold-induced putative DEAD box RNA helicases CshA and CshB are essential for cold adaptation and interact with cold shock protein B in Bacillus subtilis. J Bacteriol (2006) 1.30
The Fnr regulon of Bacillus subtilis. J Bacteriol (2006) 1.29
The anaerobic regulatory network required for Pseudomonas aeruginosa nitrate respiration. J Bacteriol (2007) 1.29
Anaerobic adaptation in Pseudomonas aeruginosa: definition of the Anr and Dnr regulons. Environ Microbiol (2010) 1.24
Anaerobic physiology of Pseudomonas aeruginosa in the cystic fibrosis lung. Int J Med Microbiol (2010) 1.23
Oxygen-independent coproporphyrinogen-III oxidase HemN from Escherichia coli. J Biol Chem (2002) 1.22
Inhibition of the D-alanine:D-alanyl carrier protein ligase from Bacillus subtilis increases the bacterium's susceptibility to antibiotics that target the cell wall. FEBS J (2005) 1.21
Ferri-bacillibactin uptake and hydrolysis in Bacillus subtilis. Mol Microbiol (2006) 1.21
Reactions catalyzed by mature and recombinant nonribosomal peptide synthetases. Methods Enzymol (2004) 1.20
The Bacillus subtilis transition state regulator AbrB binds to the -35 promoter region of comK. FEMS Microbiol Lett (2003) 1.20
Pathways for phosphatidylcholine biosynthesis in bacteria. Microbiology (2003) 1.20
ProdoNet: identification and visualization of prokaryotic gene regulatory and metabolic networks. Nucleic Acids Res (2008) 1.18
Mutational analysis of the C-domain in nonribosomal peptide synthesis. Eur J Biochem (2002) 1.18
The thioesterase domain of the fengycin biosynthesis cluster: a structural base for the macrocyclization of a non-ribosomal lipopeptide. J Mol Biol (2006) 1.16
A short story about a big magic bug. Bioeng Bugs (2010) 1.16
Structure and function of radical SAM enzymes. Curr Opin Chem Biol (2004) 1.16
Characterization of JG024, a pseudomonas aeruginosa PB1-like broad host range phage under simulated infection conditions. BMC Microbiol (2010) 1.15
Production and secretion of recombinant Leuconostoc mesenteroides dextransucrase DsrS in Bacillus megaterium. Biotechnol Bioeng (2005) 1.14
Identification and functional analysis of enzymes required for precorrin-2 dehydrogenation and metal ion insertion in the biosynthesis of sirohaem and cobalamin in Bacillus megaterium. Biochem J (2003) 1.13
A biosynthetic gene cluster for a secreted cellobiose lipid with antifungal activity from Ustilago maydis. Mol Microbiol (2007) 1.12
Daptomycin, a bacterial lipopeptide synthesized by a nonribosomal machinery. J Biol Chem (2010) 1.11
A multifaceted study of Pseudomonas aeruginosa shutdown by virulent podovirus LUZ19. MBio (2013) 1.11
Crystal structure of the nitrogenase-like dark operative protochlorophyllide oxidoreductase catalytic complex (ChlN/ChlB)2. J Biol Chem (2010) 1.11
An improved Escherichia coli donor strain for diparental mating. FEMS Microbiol Lett (2009) 1.10
MetaQuant: a tool for the automatic quantification of GC/MS-based metabolome data. Bioinformatics (2006) 1.10
Chirality of peptide bond-forming condensation domains in nonribosomal peptide synthetases: the C5 domain of tyrocidine synthetase is a (D)C(L) catalyst. Biochemistry (2003) 1.09
Genetic tools for the investigation of Roseobacter clade bacteria. BMC Microbiol (2009) 1.07
Rational design of a bimodular model system for the investigation of heterocyclization in nonribosomal peptide biosynthesis. Chem Biol (2004) 1.07
Functional characterization of 4'-phosphopantetheinyl transferase genes of bacterial and fungal origin by complementation of Saccharomyces cerevisiae lys5. FEMS Microbiol Lett (2002) 1.07
Bacillus subtilis Fnr senses oxygen via a [4Fe-4S] cluster coordinated by three cysteine residues without change in the oligomeric state. Mol Microbiol (2006) 1.06
Aminoacyl adenylate substrate analogues for the inhibition of adenylation domains of nonribosomal peptide synthetases. Chembiochem (2003) 1.06
Sequencing and characterization of Pseudomonas aeruginosa phage JG004. BMC Microbiol (2011) 1.04
Structural and functional comparison of HemN to other radical SAM enzymes. Biol Chem (2005) 1.04
Identification and characterization of the lysobactin biosynthetic gene cluster reveals mechanistic insights into an unusual termination module architecture. Chem Biol (2011) 1.04
Two [4Fe-4S] clusters containing radical SAM enzyme SkfB catalyze thioether bond formation during the maturation of the sporulation killing factor. J Am Chem Soc (2013) 1.03
Loading peptidyl-coenzyme A onto peptidyl carrier proteins: a novel approach in characterizing macrocyclization by thioesterase domains. J Am Chem Soc (2003) 1.03
Characterization of the cobaltochelatase CbiXL: evidence for a 4Fe-4S center housed within an MXCXXC motif. J Biol Chem (2003) 1.03