Published in Nat Genet on September 14, 2003
Helminth infections: the great neglected tropical diseases. J Clin Invest (2008) 6.92
Current status of vaccines for schistosomiasis. Clin Microbiol Rev (2008) 3.47
Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity. Mol Biochem Parasitol (2009) 2.95
A research agenda for helminth diseases of humans: the problem of helminthiases. PLoS Negl Trop Dis (2012) 2.28
New perspectives on host-parasite interplay by comparative transcriptomic and proteomic analyses of Schistosoma japonicum. PLoS Pathog (2006) 2.12
The planarian Schmidtea mediterranea as a model for epigenetic germ cell specification: analysis of ESTs from the hermaphroditic strain. Proc Natl Acad Sci U S A (2005) 1.85
Schistosomiasis in the People's Republic of China: the era of the Three Gorges Dam. Clin Microbiol Rev (2010) 1.82
TGF-beta signaling controls embryo development in the parasitic flatworm Schistosoma mansoni. PLoS Pathog (2007) 1.68
Schistosoma mansoni tegument protein Sm29 is able to induce a Th1-type of immune response and protection against parasite infection. PLoS Negl Trop Dis (2008) 1.58
Developmental gene expression profiles of the human pathogen Schistosoma japonicum. BMC Genomics (2009) 1.56
Vaccines to combat the neglected tropical diseases. Immunol Rev (2011) 1.55
Trick or treat: the role of vaccines in integrated schistosomiasis control. PLoS Negl Trop Dis (2008) 1.54
Identification and characterization of novel microRNAs from Schistosoma japonicum. PLoS One (2008) 1.52
Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses. PLoS Negl Trop Dis (2009) 1.51
Unlocking the transcriptomes of two carcinogenic parasites, Clonorchis sinensis and Opisthorchis viverrini. PLoS Negl Trop Dis (2010) 1.46
Schistosoma mansoni venom allergen-like protein 4 (SmVAL4) is a novel lipid-binding SCP/TAPS protein that lacks the prototypical CAP motifs. Acta Crystallogr D Biol Crystallogr (2014) 1.41
Gene discovery for the carcinogenic human liver fluke, Opisthorchis viverrini. BMC Genomics (2007) 1.35
RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening. PLoS Negl Trop Dis (2010) 1.32
Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family. BMC Genomics (2008) 1.32
Culture for genetic manipulation of developmental stages of Schistosoma mansoni. Parasitology (2009) 1.30
Schistosoma mansoni TGF-beta receptor II: role in host ligand-induced regulation of a schistosome target gene. PLoS Pathog (2006) 1.29
RNA interference in schistosomes: machinery and methodology. Parasitology (2009) 1.27
Suppression of mRNAs encoding tegument tetraspanins from Schistosoma mansoni results in impaired tegument turnover. PLoS Pathog (2010) 1.26
Development of functional genomic tools in trematodes: RNA interference and luciferase reporter gene activity in Fasciola hepatica. PLoS Negl Trop Dis (2008) 1.22
Gene expression patterns during adaptation of a helminth parasite to different environmental niches. Genome Biol (2007) 1.20
The repertoire of G protein-coupled receptors in the human parasite Schistosoma mansoni and the model organism Schmidtea mediterranea. BMC Genomics (2011) 1.20
Protocols for gene silencing in schistosomes. Exp Parasitol (2007) 1.17
Comparative description of ten transcriptomes of newly sequenced invertebrates and efficiency estimation of genomic sampling in non-model taxa. Front Zool (2012) 1.17
Schistosoma mansoni: TGF-beta signaling pathways. Exp Parasitol (2007) 1.15
Schistosoma mansoni: the dicer gene and its expression. Exp Parasitol (2007) 1.10
Tissue specific profiling of females of Schistosoma japonicum by integrated laser microdissection microscopy and microarray analysis. PLoS Negl Trop Dis (2009) 1.10
Transcriptional changes in Schistosoma mansoni during early schistosomula development and in the presence of erythrocytes. PLoS Negl Trop Dis (2010) 1.10
Cloning and characterisation of Schistosoma japonicum insulin receptors. PLoS One (2010) 1.10
Human antibody responses of patients living in endemic areas for schistosomiasis to the tegumental protein Sm29 identified through genomic studies. Clin Exp Immunol (2006) 1.09
Controlled chaos of polymorphic mucins in a metazoan parasite (Schistosoma mansoni) interacting with its invertebrate host (Biomphalaria glabrata). PLoS Negl Trop Dis (2008) 1.09
Saci-1, -2, and -3 and Perere, four novel retrotransposons with high transcriptional activities from the human parasite Schistosoma mansoni. J Virol (2004) 1.09
Heterologous expression of the filarial nematode alt gene products reveals their potential to inhibit immune function. BMC Biol (2005) 1.08
Evolution of a novel subfamily of nuclear receptors with members that each contain two DNA binding domains. BMC Evol Biol (2007) 1.08
Biomphalaria glabrata transcriptome: identification of cell-signalling, transcriptional control and immune-related genes from open reading frame expressed sequence tags (ORESTES). Dev Comp Immunol (2006) 1.08
Developmental transcriptomic features of the carcinogenic liver fluke, Clonorchis sinensis. PLoS Negl Trop Dis (2011) 1.07
Profiling Schistosoma mansoni development using serial analysis of gene expression (SAGE). Exp Parasitol (2007) 1.07
Homology-based annotation of non-coding RNAs in the genomes of Schistosoma mansoni and Schistosoma japonicum. BMC Genomics (2009) 1.06
An EST screen from the annelid Pomatoceros lamarckii reveals patterns of gene loss and gain in animals. BMC Evol Biol (2009) 1.05
Phenotypic screen of early-developing larvae of the blood fluke, schistosoma mansoni, using RNA interference. PLoS Negl Trop Dis (2009) 1.04
Experimental vaccines in animal models for schistosomiasis. Parasitol Res (2008) 1.04
Schistosomiasis--a century searching for chemotherapeutic drugs. Parasitol Res (2006) 1.03
A portrait of the transcriptome of the neglected trematode, Fasciola gigantica--biological and biotechnological implications. PLoS Negl Trop Dis (2011) 1.02
Steroids in aquatic invertebrates. Ecotoxicology (2007) 1.01
SmTRC1, a novel Schistosoma mansoni DNA transposon, discloses new families of animal and fungi transposons belonging to the CACTA superfamily. BMC Evol Biol (2006) 1.00
Insights into the functional biology of schistosomes. Parasit Vectors (2011) 0.99
Gene Atlasing of digestive and reproductive tissues in Schistosoma mansoni. PLoS Negl Trop Dis (2011) 0.98
A transcriptomic analysis of Echinococcus granulosus larval stages: implications for parasite biology and host adaptation. PLoS Negl Trop Dis (2012) 0.98
Schistosoma mansoni infection of juvenile Biomphalaria glabrata induces a differential stress response between resistant and susceptible snails. Exp Parasitol (2009) 0.98
A quantitative view of the transcriptome of Schistosoma mansoni adult-worms using SAGE. BMC Genomics (2007) 0.97
Single nucleotide polymorphisms identification in expressed genes of Schistosoma mansoni. Mol Biochem Parasitol (2007) 0.96
Eukaryotic protein kinases (ePKs) of the helminth parasite Schistosoma mansoni. BMC Genomics (2011) 0.96
Schistosoma mansoni Stomatin like protein-2 is located in the tegument and induces partial protection against challenge infection. PLoS Negl Trop Dis (2010) 0.94
Survey of transcripts expressed by the invasive juvenile stage of the liver fluke Fasciola hepatica. BMC Genomics (2010) 0.93
Thyroid hormone receptor orthologues from invertebrate species with emphasis on Schistosoma mansoni. BMC Evol Biol (2007) 0.93
Pumping iron: a potential target for novel therapeutics against schistosomes. Trends Parasitol (2007) 0.93
Schistosoma comparative genomics: integrating genome structure, parasite biology and anthelmintic discovery. Trends Parasitol (2011) 0.92
Platyhelminth Venom Allergen-Like (VAL) proteins: revealing structural diversity, class-specific features and biological associations across the phylum. Parasitology (2012) 0.92
SjTPdb: integrated transcriptome and proteome database and analysis platform for Schistosoma japonicum. BMC Genomics (2008) 0.90
Use of genomic DNA as an indirect reference for identifying gender-associated transcripts in morphologically identical, but chromosomally distinct, Schistosoma mansoni cercariae. PLoS Negl Trop Dis (2008) 0.90
Previous or ongoing schistosome infections do not compromise the efficacy of the attenuated cercaria vaccine. Infect Immun (2006) 0.89
Gene expression profile of Clonorchis sinensis metacercariae. Parasitol Res (2007) 0.89
Ov-APR-1, an aspartic protease from the carcinogenic liver fluke, Opisthorchis viverrini: functional expression, immunolocalization and subsite specificity. Int J Biochem Cell Biol (2008) 0.89
A family of diverse Kunitz inhibitors from Echinococcus granulosus potentially involved in host-parasite cross-talk. PLoS One (2009) 0.89
Screening the Schistosoma mansoni transcriptome for genes differentially expressed in the schistosomulum stage in search for vaccine candidates. Parasitol Res (2010) 0.89
Microarray based analysis of temperature and oxidative stress induced messenger RNA in Schistosoma mansoni. Mol Biochem Parasitol (2008) 0.89
SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni. PLoS Negl Trop Dis (2009) 0.89
Comparative transcriptome analysis between planarian Dugesia japonica and other platyhelminth species. BMC Genomics (2012) 0.88
Whole-organ isolation approach as a basis for tissue-specific analyses in Schistosoma mansoni. PLoS Negl Trop Dis (2013) 0.88
Altered patterns of gene expression underlying the enhanced immunogenicity of radiation-attenuated schistosomes. PLoS Negl Trop Dis (2008) 0.88
Molecular cloning and identification of a novel Clonorchis sinensis gene encoding a tegumental protein. Parasitol Res (2007) 0.87
The Schistosoma mansoni transcriptome: an update. Exp Parasitol (2007) 0.87
Analysis of Schistosoma mansoni genes shared with Deuterostomia and with possible roles in host interactions. BMC Genomics (2007) 0.87
Schistosoma mansoni venom allergen like proteins present differential allergic responses in a murine model of airway inflammation. PLoS Negl Trop Dis (2012) 0.87
Sm14 of Schistosoma mansoni in fusion with tetanus toxin fragment C induces immunoprotection against tetanus and schistosomiasis in mice. Infect Immun (2004) 0.87
Comparative study of transcriptome profiles of mechanical- and skin-transformed Schistosoma mansoni schistosomula. PLoS Negl Trop Dis (2013) 0.87
Transcriptome analysis of Taenia solium cysticerci using Open Reading Frame ESTs (ORESTES). Parasit Vectors (2009) 0.87
Schistosoma mansoni Egg, Adult Male and Female Comparative Gene Expression Analysis and Identification of Novel Genes by RNA-Seq. PLoS Negl Trop Dis (2015) 0.86
Molecular cloning and characterization of novel glutamate-gated chloride channel subunits from Schistosoma mansoni. PLoS Pathog (2013) 0.86
An improved and secreted luciferase reporter for schistosomes. Mol Biochem Parasitol (2007) 0.86
The Sinbad retrotransposon from the genome of the human blood fluke, Schistosoma mansoni, and the distribution of related Pao-like elements. BMC Evol Biol (2005) 0.86
In vitro manipulation of gene expression in larval Schistosoma: a model for postgenomic approaches in Trematoda. Parasitology (2009) 0.86
Computational vaccinology: an important strategy to discover new potential S. mansoni vaccine candidates. J Biomed Biotechnol (2011) 0.85
Identification of the Schistosoma mansoni TNF-alpha receptor gene and the effect of human TNF-alpha on the parasite gene expression profile. PLoS Negl Trop Dis (2009) 0.84
Analysis of regulatory protease sequences identified through bioinformatic data mining of the Schistosoma mansoni genome. BMC Genomics (2009) 0.84
The use of Open Reading frame ESTs (ORESTES) for analysis of the honey bee transcriptome. BMC Genomics (2004) 0.84
Characterization of a UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus. Biochem J (2004) 0.84
Characterization of the Schistosoma transcriptome opens up the world of helminth genomics. Genome Biol (2003) 0.84
Combinatory microarray and SuperSAGE analyses identify pairing-dependently transcribed genes in Schistosoma mansoni males, including follistatin. PLoS Negl Trop Dis (2013) 0.84
Structural insights into parasite eIF4E binding specificity for m7G and m2,2,7G mRNA caps. J Biol Chem (2009) 0.83
Application of RNAi to Genomic Drug Target Validation in Schistosomes. PLoS Negl Trop Dis (2015) 0.83
Gonad RNA-specific qRT-PCR analyses identify genes with potential functions in schistosome reproduction such as SmFz1 and SmFGFRs. Front Genet (2014) 0.83
Two allelic isoforms of the serotonin transporter from Schistosoma mansoni display electrogenic transport and high selectivity for serotonin. Eur J Pharmacol (2009) 0.83
Schistosoma tegument proteins in vaccine and diagnosis development: an update. J Parasitol Res (2012) 0.83
Expression of TGF-beta-like molecules in the life cycle of Schistosoma japonicum. Parasitol Res (2005) 0.82
Comparative real-time PCR and enzyme analysis of selected gender-associated molecules in Schistosoma japonicum. Parasitology (2008) 0.82
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A (2002) 20.48
Genome sequence of Aedes aegypti, a major arbovirus vector. Science (2007) 9.19
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res (2004) 9.18
The genome of the blood fluke Schistosoma mansoni. Nature (2009) 5.94
Novel insights into the genomic basis of citrus canker based on the genome sequences of two strains of Xanthomonas fuscans subsp. aurantifolii. BMC Genomics (2010) 4.03
RATT: Rapid Annotation Transfer Tool. Nucleic Acids Res (2011) 3.29
Annotated expressed sequence tags and cDNA microarrays for studies of brain and behavior in the honey bee. Genome Res (2002) 2.78
Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells. Infect Immun (2005) 2.51
Protein secretion systems in bacterial-host associations, and their description in the Gene Ontology. BMC Microbiol (2009) 2.35
A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni. PLoS Negl Trop Dis (2012) 2.32
Cyanobacterial contribution to algal nuclear genomes is primarily limited to plastid functions. Curr Biol (2006) 2.03
Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription. Genome Biol (2007) 2.03
Genome sequences of three agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria. J Bacteriol (2009) 1.96
Detection by polymerase chain reaction of Schistosoma mansoni DNA in human serum and feces. Am J Trop Med Hyg (2002) 1.92
The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products. Mol Biochem Parasitol (2008) 1.89
A newly identified leptospiral adhesin mediates attachment to laminin. Infect Immun (2006) 1.85
Transcriptional patterns in both host and bacterium underlie a daily rhythm of anatomical and metabolic change in a beneficial symbiosis. Proc Natl Acad Sci U S A (2010) 1.82
Proteins exposed at the adult schistosome surface revealed by biotinylation. Mol Cell Proteomics (2005) 1.81
The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags. Proc Natl Acad Sci U S A (2003) 1.79
Analysis of ten Brucella genomes reveals evidence for horizontal gene transfer despite a preferred intracellular lifestyle. J Bacteriol (2009) 1.76
The eukaryotic nucleotide excision repair pathway. Biochimie (2003) 1.73
GRASSIUS: a platform for comparative regulatory genomics across the grasses. Plant Physiol (2008) 1.72
Analysis and functional annotation of an expressed sequence tag collection for tropical crop sugarcane. Genome Res (2003) 1.70
Next-generation phage display: integrating and comparing available molecular tools to enable cost-effective high-throughput analysis. PLoS One (2009) 1.66
The genome sequence of the gram-positive sugarcane pathogen Leifsonia xyli subsp. xyli. Mol Plant Microbe Interact (2004) 1.65
Insights into a dinoflagellate genome through expressed sequence tag analysis. BMC Genomics (2005) 1.65
The tegument surface membranes of the human blood parasite Schistosoma mansoni: a proteomic analysis after differential extraction. Proteomics (2006) 1.63
Distinct seasonal assemblages of arbuscular mycorrhizal fungi revealed by massively parallel pyrosequencing. New Phytol (2011) 1.61
Identification of novel proteases and immunomodulators in the secretions of schistosome cercariae that facilitate host entry. Mol Cell Proteomics (2006) 1.54
The secreted salivary proteome of the pea aphid Acyrthosiphon pisum characterised by mass spectrometry. Proteomics (2009) 1.53
The Schistosoma mansoni soluble proteome: a comparison across four life-cycle stages. Mol Biochem Parasitol (2004) 1.52
Comparison of a polymerase chain reaction and the Kato-Katz technique for diagnosing infection with Schistosoma mansoni. Am J Trop Med Hyg (2003) 1.49
Large-scale transcriptome analyses reveal new genetic marker candidates of head, neck, and thyroid cancer. Cancer Res (2005) 1.47
Migration of the plastid genome to the nucleus in a peridinin dinoflagellate. Curr Biol (2004) 1.45
Distribution of nitrogen fixation and nitrogenase-like sequences amongst microbial genomes. BMC Genomics (2012) 1.44
How DNA lesions are turned into powerful killing structures: insights from UV-induced apoptosis. Mutat Res (2008) 1.43
Long noncoding intronic RNAs are differentially expressed in primary and metastatic pancreatic cancer. Mol Cancer (2011) 1.42
ESTWeb: bioinformatics services for EST sequencing projects. Bioinformatics (2003) 1.37
PAMDB, a multilocus sequence typing and analysis database and website for plant-associated microbes. Phytopathology (2010) 1.35
Whole-genome analysis of Leptospira interrogans to identify potential vaccine candidates against leptospirosis. FEMS Microbiol Lett (2005) 1.34
Effects of colonization, luminescence, and autoinducer on host transcription during development of the squid-vibrio association. Proc Natl Acad Sci U S A (2008) 1.32
Identifying components of the NF-kappaB pathway in the beneficial Euprymna scolopes-Vibrio fischeri light organ symbiosis. Appl Environ Microbiol (2005) 1.30
An SOS-regulated operon involved in damage-inducible mutagenesis in Caulobacter crescentus. Nucleic Acids Res (2005) 1.30
Comparative genomics reveals diversity among xanthomonads infecting tomato and pepper. BMC Genomics (2011) 1.30
The detection limits for estimates of infection intensity in schistosomiasis mansoni established by a study in non-human primates. Int J Parasitol (2006) 1.26
Discovery of a functional protein complex of netrin-4, laminin gamma1 chain, and integrin alpha6beta1 in mouse neural stem cells. Proc Natl Acad Sci U S A (2009) 1.24
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. Eur Arch Psychiatry Clin Neurosci (2009) 1.23
Protein variation in blood-dwelling schistosome worms generated by differential splicing of micro-exon gene transcripts. Genome Res (2010) 1.22
Gene discovery in an invasive tephritid model pest species, the Mediterranean fruit fly, Ceratitis capitata. BMC Genomics (2008) 1.22
Invasion of skin by schistosome cercariae: some neglected facts. Trends Parasitol (2003) 1.22
High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Genome Res (2004) 1.21
Differential sensitivity of malignant glioma cells to methylating and chloroethylating anticancer drugs: p53 determines the switch by regulating xpc, ddb2, and DNA double-strand breaks. Cancer Res (2007) 1.21
A comparative proteomic study of the undeveloped and developed Schistosoma mansoni egg and its contents: the miracidium, hatch fluid and secretions. Int J Parasitol (2009) 1.20
Microarray analysis identifies genes preferentially expressed in the lung schistosomulum of Schistosoma mansoni. Int J Parasitol (2005) 1.19
An annotated cDNA library of juvenile Euprymna scolopes with and without colonization by the symbiont Vibrio fischeri. BMC Genomics (2006) 1.19
Glycomics analysis of Schistosoma mansoni egg and cercarial secretions. Mol Cell Proteomics (2007) 1.19
Expression analysis and in silico characterization of intronic long noncoding RNAs in renal cell carcinoma: emerging functional associations. Mol Cancer (2013) 1.18
In vitro schistosomicidal activity of curcumin against Schistosoma mansoni adult worms. Parasitol Res (2008) 1.18
Proteomic analysis of the schistosome tegument and its surface membranes. Mem Inst Oswaldo Cruz (2006) 1.18
Multiserotype protection of mice against pneumococcal colonization of the nasopharynx and middle ear by killed nonencapsulated cells given intranasally with a nontoxic adjuvant. Infect Immun (2004) 1.18
Gene expression profiling reveals molecular marker candidates of laryngeal squamous cell carcinoma. Oncol Rep (2009) 1.17
Role of recombination in the evolution of the model plant pathogen Pseudomonas syringae pv. tomato DC3000, a very atypical tomato strain. Appl Environ Microbiol (2008) 1.17
Enzymatic shaving of the tegument surface of live schistosomes for proteomic analysis: a rational approach to select vaccine candidates. PLoS Negl Trop Dis (2011) 1.17
Leptospiral TlyC is an extracellular matrix-binding protein and does not present hemolysin activity. FEBS Lett (2009) 1.16
Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteins. J Proteomics (2011) 1.16
Recognition of pneumococcal isolates by antisera raised against PspA fragments from different clades. J Med Microbiol (2008) 1.14
The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation. PLoS Genet (2013) 1.14
Comparative analysis of the complete plastid genome sequence of the red alga Gracilaria tenuistipitata var. liui provides insights into the evolution of rhodoplasts and their relationship to other plastids. J Mol Evol (2004) 1.13
Conserved tissue expression signatures of intronic noncoding RNAs transcribed from human and mouse loci. Genomics (2008) 1.12
Taenia solium DNA is present in the cerebrospinal fluid of neurocysticercosis patients and can be used for diagnosis. Eur Arch Psychiatry Clin Neurosci (2006) 1.11
'Oming in on schistosomes: prospects and limitations for post-genomics. Trends Parasitol (2006) 1.11
Heat stress promotes mitochondrial instability and oxidative responses in yeast deficient in thiazole biosynthesis. Res Microbiol (2005) 1.10
Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis. J Neural Transm (Vienna) (2008) 1.10
Sequencing and analysis of chromosome 1 of Eimeria tenella reveals a unique segmental organization. Genome Res (2007) 1.10