PubRank

R L Modlin

Author PubWeight™ 222.69‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 1991 8.85
2 Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 1999 8.63
3 Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 1991 6.12
4 An antimicrobial activity of cytolytic T cells mediated by granulysin. Science 1998 5.02
5 Induction of direct antimicrobial activity through mammalian toll-like receptors. Science 2001 4.46
6 The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids. Annu Rev Immunol 1999 4.10
7 Local production of tumor necrosis factor and IFN-gamma in tuberculous pleuritis. J Immunol 1990 3.85
8 Differential effects of cytolytic T cell subsets on intracellular infection. Science 1997 3.39
9 Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells. Science 1997 3.23
10 Cytokine patterns in the pathogenesis of human leishmaniasis. J Clin Invest 1993 3.15
11 Cytokine production at the site of disease in human tuberculosis. Infect Immun 1993 3.04
12 Cytokine production induced by Mycobacterium tuberculosis lipoarabinomannan. Relationship to chemical structure. J Immunol 1992 3.03
13 Cytokine patterns of immunologically mediated tissue damage. J Immunol 1992 2.72
14 T cell cytokine responses in persons with tuberculosis and human immunodeficiency virus infection. J Clin Invest 1994 2.51
15 Nonpeptide ligands for human gamma delta T cells. Proc Natl Acad Sci U S A 1994 2.33
16 Compartmentalization of a CD4+ T lymphocyte subpopulation in tuberculous pleuritis. J Immunol 1989 2.27
17 Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2. J Immunol 2001 2.24
18 In situ demonstration of T lymphocyte subsets in granulomatous inflammation: leprosy, rhinoscleroma and sarcoidosis. Clin Exp Immunol 1983 2.21
19 CD1c restricts responses of mycobacteria-specific T cells. Evidence for antigen presentation by a second member of the human CD1 family. J Immunol 1996 2.13
20 The mannose receptor delivers lipoglycan antigens to endosomes for presentation to T cells by CD1b molecules. Immunity 1997 2.07
21 Binding and antigen presentation of ceramide-containing glycolipids by soluble mouse and human CD1d molecules. J Exp Med 1999 2.06
22 The cytokine network in lesional and lesion-free psoriatic skin is characterized by a T-helper type 1 cell-mediated response. J Invest Dermatol 1993 2.04
23 Characterization of T cell antigens associated with the cell wall protein-peptidoglycan complex of Mycobacterium tuberculosis. J Immunol 1989 2.01
24 T lymphocyte subsets in the skin lesions of patients with leprosy. J Am Acad Dermatol 1983 2.01
25 Immunosuppressive roles for IL-10 and IL-4 in human infection. In vitro modulation of T cell responses in leprosy. J Immunol 1993 2.00
26 Interleukin 12 at the site of disease in tuberculosis. J Clin Invest 1994 1.98
27 CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ alpha beta T cell pool. J Immunol 1999 1.96
28 Analysis of fluorescence decay curves by means of the Laplace transformation. Biophys J 1975 1.96
29 A prominent role for Sp1 during lipopolysaccharide-mediated induction of the IL-10 promoter in macrophages. J Immunol 2000 1.90
30 Determination of the cytokine profile in American cutaneous leishmaniasis using the polymerase chain reaction. Clin Exp Immunol 1993 1.88
31 Interleukin-10 downregulates Mycobacterium tuberculosis-induced Th1 responses and CTLA-4 expression. Infect Immun 1996 1.85
32 Analysis of naturally occurring delayed-type hypersensitivity reactions in leprosy by in situ hybridization. J Exp Med 1989 1.82
33 Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis. J Clin Invest 1996 1.79
34 Gamma delta T lymphocytes in human tuberculosis. J Infect Dis 1992 1.78
35 Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10. J Immunol 2000 1.77
36 In situ identification of cells in human leprosy granulomas with monoclonal antibodies to interleukin 2 and its receptor. J Immunol 1984 1.74
37 Mouse CD1 is mainly expressed on hemopoietic-derived cells. J Immunol 1997 1.73
38 Patterns of cytokine production by mycobacterium-reactive human T-cell clones. Infect Immun 1993 1.72
39 IL-12 regulates T helper type 1 cytokine responses in human infectious disease. J Immunol 1994 1.65
40 Molecular recognition of lipid antigens by T cell receptors. J Exp Med 1999 1.65
41 Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis. Proc Natl Acad Sci U S A 2000 1.65
42 Molecular interaction of CD1b with lipoglycan antigens. Immunity 1998 1.60
43 In situ characterization of T lymphocyte subsets in the reactional states of leprosy. Clin Exp Immunol 1983 1.60
44 The tyrosine-containing cytoplasmic tail of CD1b is essential for its efficient presentation of bacterial lipid antigens. Immunity 1998 1.59
45 Genetically restricted suppressor T-cell clones derived from lepromatous leprosy lesions. Nature 1986 1.56
46 Tumor necrosis factor production in patients with leprosy. Infect Immun 1992 1.55
47 Suppressor T lymphocytes from lepromatous leprosy skin lesions. J Immunol 1986 1.55
48 Isolation and characterization of the highly immunogenic cell wall-associated protein of Mycobacterium leprae. J Immunol 1989 1.54
49 Immunoreactivity of a 10-kDa antigen of Mycobacterium tuberculosis. J Immunol 1992 1.52
50 A predominance of the T cell receptor V gamma 2/V delta 2 subset in human mycobacteria-responsive T cells suggests germline gene encoded recognition. J Immunol 1991 1.52
51 Stigma variations: observations on suppressor T cells and leprosy. Annu Rev Immunol 1992 1.51
52 T cell mediated immunity to Mycobacterium tuberculosis. Curr Opin Microbiol 1999 1.46
53 IL-10 production in cutaneous basal and squamous cell carcinomas. A mechanism for evading the local T cell immune response. J Immunol 1995 1.42
54 T-cell release of granulysin contributes to host defense in leprosy. Nat Med 2001 1.40
55 Dermatology-Important Advances in Clinical Medicine: Kaposi's Sarcoma: Current Trends. West J Med 1983 1.40
56 Granulysin, a T cell product, kills bacteria by altering membrane permeability. J Immunol 2000 1.39
57 Evidence for clonal selection of gamma/delta T cells in response to a human pathogen. J Exp Med 1991 1.38
58 Down-regulation of CD1 on antigen-presenting cells by infection with Mycobacterium tuberculosis. J Immunol 1998 1.35
59 IL-15, an immunomodulator of T cell responses in intracellular infection. J Immunol 1997 1.34
60 Immunologic responsiveness in American cutaneous leishmaniasis lesions. J Immunol 1990 1.33
61 CD1 expression by dendritic cells in human leprosy lesions: correlation with effective host immunity. J Immunol 1999 1.32
62 Single-cell cytokine analysis of gamma delta T cell responses to nonpeptide mycobacterial antigens. J Immunol 1997 1.30
63 Toll-like receptors: molecular mechanisms of the mammalian immune response. Immunology 2000 1.27
64 Cytokine patterns at the site of mycobacterial infection. Immunobiology 1994 1.26
65 IL-18 promotes type 1 cytokine production from NK cells and T cells in human intracellular infection. J Immunol 1999 1.24
66 Local expression of antiinflammatory cytokines in cancer. J Clin Invest 1993 1.21
67 Antigen specificity of gamma delta T lymphocytes. FASEB J 1991 1.16
68 The role of Toll-like receptors in host defense against microbial infection. Curr Opin Immunol 2001 1.15
69 Immunological significance of Mycobacterium leprae cell walls. Proc Natl Acad Sci U S A 1988 1.15
70 Predictors of short-term prognosis in patients with pulmonary tuberculosis. J Infect Dis 1988 1.15
71 Determinants of T cell reactivity to the Mycobacterium leprae GroES homologue. J Immunol 1997 1.14
72 In situ characterization of the cellular immune response in American cutaneous leishmaniasis. Clin Exp Immunol 1985 1.13
73 Evidence for human CD4+ T cells in the CD1-restricted repertoire: derivation of mycobacteria-reactive T cells from leprosy lesions. J Immunol 2000 1.12
74 The T cell receptors of human gamma delta T cells reactive to Mycobacterium tuberculosis are encoded by specific V genes but diverse V-J junctions. J Immunol 1991 1.11
75 IL-15 enhances the response of human gamma delta T cells to nonpeptide [correction of nonpetide] microbial antigens. J Immunol 1998 1.10
76 Evidence for a superantigen in human tuberculosis. Immunity 1994 1.10
77 In situ and in vitro characterization of the cellular immune response in erythema nodosum leprosum. J Immunol 1986 1.09
78 Microanatomic clonality of gamma delta T cells in human leishmaniasis lesions. J Immunol 1992 1.08
79 Expression of interleukin-12 in synovial tissue from patients with rheumatoid arthritis. Arthritis Rheum 1998 1.05
80 Immune mechanisms in bacterial and parasitic diseases: protective immunity versus pathology. Curr Opin Immunol 1991 1.05
81 Immunology. A Toll for DNA vaccines. Nature 2000 1.05
82 Expression of adhesion molecules in leprosy lesions. Infect Immun 1991 1.05
83 Granulysin: a lethal weapon of cytolytic T cells. Immunol Today 1999 1.03
84 Signaling lymphocytic activation molecule is expressed on CD40 ligand-activated dendritic cells and directly augments production of inflammatory cytokines. J Immunol 2001 1.03
85 Potentiation of the macrophage 25-hydroxyvitamin D-1-hydroxylation reaction by human tuberculous pleural effusion fluid. J Clin Endocrinol Metab 1989 1.02
86 Transpleural gradient of 1,25-dihydroxyvitamin D in tuberculous pleuritis. J Clin Invest 1989 1.01
87 Selection of T lymphocytes bearing limited T-cell receptor beta chains in the response to a human pathogen. Proc Natl Acad Sci U S A 1993 1.01
88 The role of gamma delta T lymphocytes in infection. Curr Opin Immunol 1991 1.01
89 T-lymphocyte subsets in lymph nodes from homosexual men. JAMA 1983 1.01
90 Interferon-gamma differentially regulates interleukin-12 and interleukin-10 production in leprosy. J Clin Invest 1997 1.01
91 CTL-mediated killing of intracellular Mycobacterium tuberculosis is independent of target cell nuclear apoptosis. J Immunol 2000 1.00
92 A role for IL-12 receptor expression and signal transduction in host defense in leprosy. J Immunol 2001 0.98
93 CD1 and the expanding universe of T cell antigens. J Immunol 1995 0.98
94 Altered distribution of B and T lymphocytes in lymph-nodes from homosexual men with Kaposi's sarcoma. Lancet 1983 0.98
95 Tissue and blood T-lymphocyte subpopulations in erythema nodosum leprosum. Arch Dermatol 1985 0.95
96 CD1-restricted T cells and resistance to polysaccharide-encapsulated bacteria. Immunol Today 1998 0.95
97 T-cell recognition of non-peptide antigens. Curr Opin Immunol 1996 0.94
98 Immunopathology of leprosy skin lesions. Semin Dermatol 1991 0.94
99 CD1 presentation of microbial nonpeptide antigens to T cells. J Clin Invest 1997 0.93
100 Epidermal keratinocyte Ia expression, Langerhans cell hyperplasia and lymphocytic infiltration in skin lesions of leprosy. Clin Exp Immunol 1986 0.93
101 An immunopathologic evaluation of lymph nodes from monkey and man with acquired immune deficiency syndrome and related conditions. Hematol Oncol 1985 0.93
102 A role for CD40-CD40 ligand interactions in the generation of type 1 cytokine responses in human leprosy. J Immunol 2000 0.93
103 The immunology of tuberculous pleurisy. Semin Respir Infect 1988 0.92
104 Molecular recognition of human CD1b antigen complexes: evidence for a common pattern of interaction with alpha beta TCRs. J Immunol 2000 0.92
105 Demonstration in situ of subsets of T-lymphocytes in sarcoidosis. Am J Dermatopathol 1984 0.91
106 Cytotoxic T lymphocytes in resistance to tuberculosis. Adv Exp Med Biol 1998 0.90
107 Isolation of mycobacterium-reactive CD1-restricted T cells from patients with human immunodeficiency virus infection. J Clin Invest 1998 0.90
108 An in situ immunohistological study of Mitsuda reactions. Int J Lepr Other Mycobact Dis 1985 0.89
109 CD4+ type 1 and CD8+ type 2 T cell subsets in human leishmaniasis have distinct T cell receptor repertoires. J Immunol 1993 0.89
110 Kaposi's sarcoma in homosexual men: an immunohistochemical study. J Am Acad Dermatol 1983 0.87
111 CD1-restricted T-cells influence IgG subclass and IgE production. J Allergy Clin Immunol 1998 0.87
112 Human cellular immune responses to Mycobacterium tuberculosis. Curr Top Microbiol Immunol 1996 0.87
113 Gamma/delta T cell receptor positive T cells in the inflammatory joint: lack of association with response to soluble antigens. Cell Immunol 1991 0.87
114 Peripheral blood mononuclear cells express mutated NCCT mRNA in Gitelman's syndrome: evidence for abnormal thiazide-sensitive NaCl cotransport. J Am Soc Nephrol 1998 0.87
115 Immunoperoxidase techniques applied to dermatopathology. J Cutan Pathol 1983 0.87
116 Multiple sclerosis: limited diversity of the V delta 2-J delta 3 T-cell receptor in chronic active lesions. Ann Neurol 1995 0.86
117 CD1 presents antigens from a gram-negative bacterium, Haemophilus influenzae type B. Infect Immun 1998 0.86
118 Cytotoxic T cell responses to intracellular pathogens. Curr Opin Immunol 1998 0.86
119 T cells bearing V beta 6 T cell receptors in the cell-mediated immune response to Mycobacterium leprae. J Immunol 1993 0.86
120 In situ identification of activated Ta1+ T lymphocytes in human leprosy skin lesions. Int J Lepr Other Mycobact Dis 1987 0.86
121 IL-7 in the cell-mediated immune response to a human pathogen. J Immunol 1995 0.85
122 Regulation of cytokine patterns in leprosy. Ann N Y Acad Sci 1994 0.85
123 Limited T-cell receptor beta-chain diversity of a T-helper cell type 1-like response to Mycobacterium leprae. Infect Immun 1992 0.84
124 Evidence for functional subsets of CD4+ and CD8+ T cells in human disease: lymphokine patterns in leprosy. Chem Immunol 1992 0.84
125 In situ localization of T lymphocytes in disseminated coccidioidomycosis. J Infect Dis 1985 0.84
126 Lepromin-induced suppressor cells in lepromatous leprosy. Cell Immunol 1987 0.83
127 In situ characterization of T lymphocyte subsets in leprosy granulomas. Int J Lepr Other Mycobact Dis 1982 0.83
128 Immunohistological evidence of lymphokine production and lymphocyte activation antigens in tuberculin reactions. Clin Exp Immunol 1987 0.82
129 Distribution of cells bearing the Tac antigen during ontogeny of human lymphoid tissue. J Immunol 1985 0.81
130 Kaposi's sarcoma. Int J Dermatol 1983 0.81
131 CD2 expression and function in lepromatous leprosy. Infect Immun 1989 0.81
132 Selective accumulation of T cells according to T-cell receptor V beta gene usage in skin cancer. J Invest Dermatol 1994 0.80
133 T cell and cytokine patterns in leprosy skin lesions. Springer Semin Immunopathol 1992 0.80
134 Activation of toll-like receptors by microbial lipoproteins. Scand J Infect Dis 2001 0.80
135 Signaling lymphocytic activation molecule expression and regulation in human intracellular infection correlate with Th1 cytokine patterns. J Immunol 2001 0.80
136 Selective expansion of V delta 1 + T cells from leprosy skin lesions. J Invest Dermatol 1992 0.79
137 Effect of cyclosporine A in erythema nodosum leprosum. J Immunol 1986 0.78
138 Role of granulysin in immunity to leprosy. Lepr Rev 2000 0.78
139 Peripheral blood T lymphocyte subsets in leprosy. Int J Lepr Other Mycobact Dis 1984 0.78
140 T-lymphocytes in leprosy lesions. Curr Top Microbiol Immunol 1990 0.77
141 Antigens and antigen-presenting molecules for gamma delta T cells. Curr Top Microbiol Immunol 1991 0.77
142 Immunopathologic demonstration of T lymphocyte subpopulations and interleukin 2 in granuloma annulare. Pediatr Dermatol 1984 0.77
143 Demonstration of a subpopulation of Ia+ T-helper cells in mycosis fungoides and the Sézary syndrome. Am J Dermatopathol 1983 0.77
144 Gamma delta T cells in leprosy lesions. Curr Top Microbiol Immunol 1991 0.76
145 In situ detection of amastigotes in American cutaneous leishmaniasis, using monoclonal antibodies. Trans R Soc Trop Med Hyg 1986 0.76
146 Identification of cells lining pseudovascular spaces of benign pigmented nevi. Am J Dermatopathol 1984 0.75
147 Chips, infections, and national security. Science 2001 0.75
148 In situ characterization of T lymphocyte subpopulations in leprosy in the mangabey monkey. Clin Exp Immunol 1986 0.75
149 T-lymphocyte clones from leprosy skin lesions. Lepr Rev 1986 0.75
150 Mechanisms of immunological unresponsiveness in the spectra of leprosy and leishmaniasis. Adv Exp Med Biol 1988 0.75
151 Human monoclonal antibodies that distinguish cutaneous malignant melanomas from benign nevi in fixed tissue sections. J Invest Dermatol 1986 0.75
152 Leprosy: new insight into an ancient disease. J Am Acad Dermatol 1987 0.75
153 Comparison of S-100 and OKT6 antisera in human skin. J Invest Dermatol 1984 0.75
154 Granuloma annulare. Identification of cells in the cutaneous infiltrate by immunoperoxidase techniques. Arch Pathol Lab Med 1984 0.75
155 Kaposi's sarcoma and autoimmune thrombocytopenia. Cancer Invest 1984 0.75
156 Leprosy. Immunol Ser 1989 0.75
157 Evidence for a superantigen in the pathogenesis of tuberculosis. Springer Semin Immunopathol 1996 0.75
158 Drosophila, the savvy exterminator. Nat Immunol 2000 0.75
159 Altered distribution of T-lymphocyte subpopulations in lymph nodes from patients with acquired immunodeficiency-like syndrome and hemophilia. J Pediatr 1983 0.75
160 B7-1, but not CD28, is crucial for the maintenance of the CD4+ T cell responses in human leprosy. J Immunol 1998 0.75
161 CD1: clues on a new antigen-presenting pathway. Res Immunol 1996 0.75