Published in Br J Cancer on December 01, 1955
The impact of O2 availability on human cancer. Nat Rev Cancer (2008) 6.84
Detection and quantification of mutations in the plasma of patients with colorectal tumors. Proc Natl Acad Sci U S A (2005) 5.91
Targeting metabolic transformation for cancer therapy. Nat Rev Cancer (2010) 5.90
The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour. Br J Cancer (1968) 4.88
Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc Natl Acad Sci U S A (2007) 4.81
Tumor hypoxia imaging with [F-18] fluoromisonidazole positron emission tomography in head and neck cancer. Clin Cancer Res (2006) 3.17
Self-regulation of growth in three dimensions. J Exp Med (1973) 2.87
The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities. Antioxid Redox Signal (2014) 2.26
Nonlinear modelling of cancer: bridging the gap between cells and tumours. Nonlinearity (2010) 2.08
Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer. Br J Cancer (2007) 2.00
Evidence that hypoxia markers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver. Br J Cancer (1995) 1.96
The tumor microenvironment and metastatic disease. Clin Exp Metastasis (2008) 1.91
Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine. Br J Cancer (1977) 1.86
ATM activation and signaling under hypoxic conditions. Mol Cell Biol (2008) 1.84
Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis? J Bioenerg Biomembr (2007) 1.83
Radiation resistance of cancer stem cells: the 4 R's of radiobiology revisited. Stem Cells (2010) 1.78
Causes and effects of heterogeneous perfusion in tumors. Neoplasia (1999) 1.76
Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression. Semin Cancer Biol (2008) 1.76
Applications of magnetic resonance in model systems: cancer therapeutics. Neoplasia (2000) 1.72
An experimental method for comparing treatments of intact malignant tumours in animals and its application to the use of oxygen in radiotherapy. Br J Cancer (1960) 1.68
Angiogenesis in human coronary atherosclerotic plaques. Am J Pathol (1994) 1.65
Contributions of cell metabolism and H+ diffusion to the acidic pH of tumors. Neoplasia (2003) 1.63
Endothelial-cell proliferation in experimental tumours. Br J Cancer (1982) 1.63
[(18)F]FMISO and [(18)F]FDG PET imaging in soft tissue sarcomas: correlation of hypoxia, metabolism and VEGF expression. Eur J Nucl Med Mol Imaging (2003) 1.62
Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells. Proc Natl Acad Sci U S A (1986) 1.61
Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours. Br J Cancer (1998) 1.61
Paper-supported 3D cell culture for tissue-based bioassays. Proc Natl Acad Sci U S A (2009) 1.60
Imaging hypoxia to improve radiotherapy outcome. Nat Rev Clin Oncol (2012) 1.57
Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome. Int J Radiat Oncol Biol Phys (2007) 1.55
Cellular and molecular mechanisms underlying oxygen-dependent radiosensitivity. Radiat Res (2015) 1.53
Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model. Cancer Res (2008) 1.52
Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect. PLoS One (2009) 1.52
Apoptosis is inversely related to necrosis and determines net growth in tumors bearing constitutively expressed myc, ras, and HPV oncogenes. Am J Pathol (1994) 1.50
Hypoxia and radiation therapy: past history, ongoing research, and future promise. Curr Mol Med (2009) 1.50
Low-field magnetic resonance imaging to visualize chronic and cycling hypoxia in tumor-bearing mice. Cancer Res (2010) 1.49
The growth rate of human tumours. Br J Cancer (1966) 1.49
Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)a cet amide] : analysis of drug adducts by fluorescent antibodies vs bound radioactivity. Br J Cancer (1995) 1.47
Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways. Cancer Metab (2014) 1.45
Validation of the fluorescent dye Hoechst 33342 as a vascular space marker in tumours. Br J Cancer (1988) 1.44
Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia. Br J Cancer (1999) 1.42
Temporal heterogeneity in microregional erythrocyte flux in experimental solid tumours. Br J Cancer (1995) 1.39
The influence of carbogen breathing on tumour tissue oxygenation in man evaluated by computerised p02 histography. Br J Cancer (1992) 1.39
Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice. Proc Natl Acad Sci U S A (1994) 1.36
Radiosensitization of C3H mouse mammary tumours by a 2-nitroimidazole drug. Br J Cancer (1974) 1.35
Iodine-124-labeled iodo-azomycin-galactoside imaging of tumor hypoxia in mice with serial microPET scanning. Eur J Nucl Med Mol Imaging (2003) 1.34
Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response. Breast Cancer Res (2013) 1.33
Recent trends in targeted anticancer prodrug and conjugate design. Curr Med Chem (2008) 1.33
Imaging cycling tumor hypoxia. Cancer Res (2010) 1.32
Pretreatment prediction of brain tumors' response to radiation therapy using high b-value diffusion-weighted MRI. Neoplasia (2004) 1.32
Heterogeneous vascular dependence of tumor cell populations. Am J Pathol (2001) 1.31
Hypoxic cell radiosensitizers and local control by X-ray of a transplanted tumour in mice. Br J Cancer (1977) 1.31
Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels. Nat Commun (2012) 1.30
Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis. J Cell Mol Med (2009) 1.28
Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activation. Cancer Cell (2008) 1.27
A method for estimating the oxygen consumption rate in multicellular tumour spheroids. J R Soc Interface (2014) 1.25
Applications of magnetic resonance in model systems: tumor biology and physiology. Neoplasia (2000) 1.25
Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity. Proc Natl Acad Sci U S A (1993) 1.24
Immunotherapy for cancer. J R Soc Med (2002) 1.24
The influence of changes in tumor hypoxia on dose-painting treatment plans based on 18F-FMISO positron emission tomography. Int J Radiat Oncol Biol Phys (2008) 1.22
Evaluation of a compartmental model for estimating tumor hypoxia via FMISO dynamic PET imaging. Phys Med Biol (2009) 1.22
DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX. Mol Cell Biol (2004) 1.22
A novel technique for measuring human tissue pO2 at the cellular level. Br J Cancer (1986) 1.21
Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy. Br J Cancer (2009) 1.20
Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer. Mol Cancer Ther (2010) 1.20
Vascular structure of five human malignant melanomas grown in athymic nude mice. Br J Cancer (1982) 1.19
Hypoxia in models of lung cancer: implications for targeted therapeutics. Clin Cancer Res (2010) 1.19
The response to carbogen breathing in experimental tumour models monitored by gradient-recalled echo magnetic resonance imaging. Br J Cancer (1997) 1.16
Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide]. Br J Cancer (1995) 1.16
Monoclonal antibody to an intracellular antigen images human melanoma transplants in nu/nu mice. Proc Natl Acad Sci U S A (1987) 1.15
Tumour vasculature--a potential therapeutic target. Br J Cancer (1995) 1.14
Influence of glucose and oxygen supply conditions on the oxygenation of multicellular spheroids. Br J Cancer (1986) 1.14
DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. Mol Cell Biol (2006) 1.13
The mechanisms by which hyperbaric oxygen and carbogen improve tumour oxygenation. Br J Cancer (1995) 1.13
A hypoxia-regulated adeno-associated virus vector for cancer-specific gene therapy. Neoplasia (2001) 1.13
Effects of agents which inhibit the regulation of intracellular pH on murine solid tumours. Br J Cancer (1992) 1.13
A nanoporous, transparent microcontainer for encapsulated islet therapy. J Diabetes Sci Technol (2009) 1.12
PET-CT for radiotherapy treatment planning and response monitoring in solid tumors. Nat Rev Clin Oncol (2011) 1.11
Flow cytometric evaluation of hypoxic cells in solid experimental tumours using fluorescence immunodetection. Br J Cancer (1991) 1.11
Bioreductive drugs and the selective induction of tumour hypoxia. Br J Cancer (1990) 1.10
The prognostic value of PET and PET/CT in cervical cancer. Cancer Imaging (2008) 1.10
Nicotinamide, Fluosol DA and Carbogen: a strategy to reoxygenate acutely and chronically hypoxic cells in vivo. Br J Cancer (1991) 1.07
Noninvasive molecular imaging of hypoxia in human xenografts: comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers. Cancer Res (2008) 1.07
The role of HIF prolyl hydroxylases in tumour growth. J Cell Mol Med (2010) 1.06
The tumor microenvironment in non-small-cell lung cancer. Semin Radiat Oncol (2010) 1.06
Microenvironment and radiation therapy. Biomed Res Int (2012) 1.06
Effect of induced host anaemia on the viability and radiosensitivity of murine malignant cells in vivo. Br J Cancer (1971) 1.06
Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells. J Cancer Res Clin Oncol (2010) 1.05
Carbogen breathing increases prostate cancer oxygenation: a translational MRI study in murine xenografts and humans. Br J Cancer (2009) 1.04
Hypoxia imaging-directed radiation treatment planning. Eur J Nucl Med Mol Imaging (2006) 1.04
Intermittent blood flow in the KHT sarcoma--flow cytometry studies using Hoechst 33342. Br J Cancer (1990) 1.04
The effects of melphalan and misonidazole on the vasculature of a murine sarcoma. Br J Cancer (1987) 1.01
Immunohistochemical detection of a hypoxia marker in spontaneous canine tumours. Br J Cancer (1990) 1.00
Photoswitchable nanoparticles for in vivo cancer chemotherapy. Proc Natl Acad Sci U S A (2013) 0.99
Defining normoxia, physoxia and hypoxia in tumours-implications for treatment response. Br J Radiol (2014) 0.99
A low carbohydrate, high protein diet combined with celecoxib markedly reduces metastasis. Carcinogenesis (2014) 0.99
Cell encapsulation and oxygenation in nanoporous microcontainers. Biomed Microdevices (2009) 0.99
Dual role of CO2/HCO3(-) buffer in the regulation of intracellular pH of three-dimensional tumor growths. J Biol Chem (2011) 0.99
In vivo metabolic effects of hyperglycemia in murine radiation-induced fibrosarcoma: a 31P NMR investigation. Proc Natl Acad Sci U S A (1984) 0.98
Where it's at really matters: in situ in vivo vascular endothelial growth factor spatially correlates with electron paramagnetic resonance pO2 images in tumors of living mice. Mol Imaging Biol (2011) 0.98
A comparison of the imaging characteristics and microregional distribution of 4 hypoxia PET tracers. J Nucl Med (2014) 0.97
The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol (1953) 12.04
Oxygenation in radiotherapy. II. Clinical application. Br J Radiol (1957) 3.32
High-pressure oxygen and radiotherapy. Lancet (1955) 2.90
Oxygenation in radiotherapy. I. Radiobiological considerations. Br J Radiol (1957) 1.84
Influence of oxygen tension on x-ray-induced chromosomal damage in Ehrlich ascites tumor cells irradiated in vitro and in vivo. Radiat Res (1959) 1.68
An experimental method for comparing treatments of intact malignant tumours in animals and its application to the use of oxygen in radiotherapy. Br J Cancer (1960) 1.68
The effect of ionizing radiations on the broad bean root. VIII. Growth rate studies and histological analyses. Br J Radiol (1951) 1.44
DETERMINATION OF THE OXYHAEMOGLOBIN DISSOCIATION CURVES FOR MOUSE AND RAT BLOOD. J Physiol (1964) 1.34
The effect of ionizing radiations on the broad bean root. VIII. Br J Radiol (1951) 1.25
The transition from röntgen to rad. Br J Radiol (1956) 1.17
The nuecleic acid content of cells in the meristematic elongating and fully elongated segments of roots of Vicia faba. Exp Cell Res (1955) 1.10
Some characteristics of biological damage induced by ionizing radiations. Radiat Res (1954) 1.06
The effect of ionizing radiations on the broad bean root. VIII. Br J Radiol (1951) 0.94
The oxygen effect in mammals. Brookhaven Symp Biol (1961) 0.94
Anaesthesia for radiotherapy under high-pressure oxygen. Br J Anaesth (1955) 0.89
Effect of nitric oxide on the radiosensitivity of tumour cells. Nature (1958) 0.89
CHROMOSOME ABNORMALITY AND RADIATION SENSITIVITY IN STORED ASCITES-TUMOUR CELLS. Mutat Res (1964) 0.86
Radiobiologic basis of oxygen as a modifying factor in radiation therapy. Am J Roentgenol Radium Ther Nucl Med (1961) 0.86
The initiation and development of cellular damage by ionizing radiations; the thirty-second Silvanus Thompson Memorial Lecture. Br J Radiol (1953) 0.86
Conditions which affect the biologic damage resulting from exposure to radiation. Acta radiol (1954) 0.85
Structural changes produced in microspores of Tradescantia by alpha-radiation. J Genet (1947) 0.83
The effect of ionizing radiations on the broad bean root. VIII. Br J Radiol (1951) 0.82
The experimental determination by ionization methods of the rate of emission of beta- and gamma-ray energy by radioactive substances; the isotopes Na24, P32, Co60 and I131. Br J Radiol (1949) 0.80
Definition of the terms `protection' and `restoration'. Acta radiol (1954) 0.78
Radiobiology and cancer. Nature (1957) 0.75
The formation of hydrogen peroxide by alpha-radiation in the presence of the enzyme carboxypeptidase. Biochem J (1952) 0.75
The effect of ionizing radiations on the broad bean root. VIII. Br J Radiol (1951) 0.75
General principles of assay and standardization of radioactive isotopes. Br Med Bull (1952) 0.75
High-pressure oxygen and radiotherapy. Med World (1958) 0.75
[Anesthesia for radiotherapy under high oxygen pressure]. Anaesthesist (1960) 0.75
[Not Available]. Krebsarzt (1949) 0.75
The energy transfer from ionizing particles to an aqueous medium and its bearing on the interpretation of radiochemical and radiobiological change. J Cell Physiol Suppl (1952) 0.75
Comparison of the lethal effect of neutrons and gamma rays on mouse tumours; by irradiation of grafted tumours in vivo; by irradiation of tumour fragments in vitro. Br J Radiol (1948) 0.75
A preliminary note on some biological effects of alpha radiation on the frog tadpole. Br J Radiol (1948) 0.75
Cellular radiobiology. Annu Rev Nucl Sci (1956) 0.75
Actions of radiations on living cell, 1946 and after the second Douglas Lae memorial lecture. Br J Radiol (1952) 0.75
The effect of ionizing radiations on the broad bean root. Br J Radiol (1950) 0.75
Comparative studies of the biological effects of x-rays, neutrons and other ionizing radiations. Br Med Bull (1946) 0.75
The influence of oxygen and peroxides on the response of mammalian cells and tissues to ionizing radiations. Prog Nucl Energy 6 Biol Sci (1959) 0.75
Non-medical aspects of medical radiology. Br J Radiol (1950) 0.75