Published in Can J Physiol Pharmacol on July 01, 1992
Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue. Br J Pharmacol (1996) 1.93
Cellular consequences of thrombin-receptor activation. Biochem J (1996) 1.45
Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br J Pharmacol (2001) 1.18
Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br J Pharmacol (2004) 1.08
Platelet thrombin receptor antagonism and atherothrombosis. Eur Heart J (2009) 1.07
Vascular actions of thrombin receptor-derived polypeptides: structure-activity profiles for contractile and relaxant effects in rat aorta. Br J Pharmacol (1995) 0.97
Enhancement of vascular permeability by specific activation of protease-activated receptor-1 in rat hindpaw: a protective role of endogenous and exogenous nitric oxide. Br J Pharmacol (1999) 0.96
Heterogeneous mechanisms of endothelium-dependent relaxation for thrombin and peptide activators of protease-activated receptor-1 in porcine isolated coronary artery. Br J Pharmacol (2000) 0.93
Contractile actions of thrombin receptor-derived polypeptides in human umbilical and placental vasculature: evidence for distinct receptor systems. Br J Pharmacol (1995) 0.90
Proteinases, proteinase-activated receptors (PARs) and the pathophysiology of cancer and diseases of the cardiovascular, musculoskeletal, nervous and gastrointestinal systems. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.89
Bronchoconstrictor effect of thrombin and thrombin receptor activating peptide in guinea-pigs in vivo. Br J Pharmacol (1999) 0.89
Contractile actions of proteinase-activated receptor-derived polypeptides in guinea-pig gastric and lung parenchymal strips: evidence for distinct receptor systems. Br J Pharmacol (2001) 0.83
Protease activated receptor 2 and the cardiovascular system. Br J Pharmacol (2002) 0.81
Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca2+ sensitivity and induces vasoconstriction in porcine pulmonary arteries. Br J Pharmacol (2010) 0.79
Proteinase-activated receptor-1 (PAR-1) activation contracts the isolated human renal artery in vitro. Br J Pharmacol (2003) 0.76
Membrane receptors and hormone action. Adv Protein Chem (1976) 3.73
Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med (2000) 3.71
Insulin and epidermal growth factor. Human fibroblast receptors related to deoxyribonucleic acid synthesis and amino acid uptake. J Biol Chem (1975) 3.60
Epidermal growth factor: receptors in human fibroblasts and modulation of action by cholera toxin. Proc Natl Acad Sci U S A (1973) 3.44
Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway. Nat Med (2001) 3.17
The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol (2013) 2.48
Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more. Br J Pharmacol (2007) 2.35
Epidermal growth factor. Characteristics of specific binding in membranes from liver, placenta, and other target tissues. Arch Biochem Biophys (1974) 2.34
Lithium-induced increase in human brain grey matter. Lancet (2000) 2.31
The isolation of the native hormone-binding proteins from bovine pituitary posterior lobes. Crystallization of neurophysin-I and-II as complexes with [8-arginine]-vasopressin. Biochem J (1968) 2.24
Pharmacological subclassification of alpha 1-adrenoceptors in vascular smooth muscle. Br J Pharmacol (1990) 2.09
Protease-activated receptors in inflammation, neuronal signaling and pain. Trends Pharmacol Sci (2001) 2.06
Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2. Proc Natl Acad Sci U S A (1997) 1.99
Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue. Br J Pharmacol (1996) 1.93
Evaluation of proteinase-activated receptor-1 (PAR1) agonists and antagonists using a cultured cell receptor desensitization assay: activation of PAR2 by PAR1-targeted ligands. J Pharmacol Exp Ther (1999) 1.93
Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. Proc Natl Acad Sci U S A (2001) 1.84
Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw. Br J Pharmacol (1999) 1.83
Affinity chromatography and structural analysis of Vibrio cholerae enterotoxin-ganglioside agarose and the biological effects of ganglioside-containing soluble polymers. Biochemistry (1973) 1.74
Insulin receptor: interaction with nonreceptor glycoprotein from liver cell membranes. Proc Natl Acad Sci U S A (1978) 1.68
Comparative study of abortive and nonabortive rabies in mice. J Infect Dis (1969) 1.62
Proteinase-activated receptor 2 (PAR2)-activating peptides: identification of a receptor distinct from PAR2 that regulates intestinal transport. Proc Natl Acad Sci U S A (1998) 1.61
Epidermal growth factor-urogastrone, a polypeptide acquiring hormonal status. Vitam Horm (1979) 1.58
Dissociation of oxytocin and vasopressin from their carrier protein by chromatography on sephadex G-25. Br J Pharmacol Chemother (1966) 1.56
Fractionation of neurophysin by molecular-sieve and ion-exchange chromatography. Biochem J (1967) 1.55
Proton spectroscopic imaging of the thalamus in treatment-naive pediatric obsessive-compulsive disorder. Biol Psychiatry (2000) 1.54
Clinical and preclinical evidence for the neurotrophic effects of mood stabilizers: implications for the pathophysiology and treatment of manic-depressive illness. Biol Psychiatry (2000) 1.53
Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle. Can J Physiol Pharmacol (1995) 1.52
Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2. Am J Physiol Lung Cell Mol Physiol (2000) 1.52
Prefrontal cortex as the site of estrogen's effect on cognition. Psychoneuroendocrinology (2001) 1.48
Lithium at 50: have the neuroprotective effects of this unique cation been overlooked? Biol Psychiatry (1999) 1.46
Cholera toxin and cell growth: role of membrane gangliosides. Proc Natl Acad Sci U S A (1974) 1.46
Ca2+-dependent hydrophobic-interaction chromatography. Isolation of a novel Ca2+-binding protein and protein kinase C from bovine brain. Biochem J (1984) 1.45
Decrease in caudate glutamatergic concentrations in pediatric obsessive-compulsive disorder patients taking paroxetine. J Am Acad Child Adolesc Psychiatry (2000) 1.44
Neuroplasticity and cellular resilience in mood disorders. Mol Psychiatry (2000) 1.38
Detection of epidermal growth factor-urogastrone and its receptor during fetal mouse development. Proc Natl Acad Sci U S A (1980) 1.35
Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2. J Physiol (1999) 1.31
Interferon action: role of membrane gangliosides. Virology (1976) 1.29
Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity. J Leukoc Biol (2008) 1.28
Proteinase-activated receptor 2 (PAR(2)): development of a ligand-binding assay correlating with activation of PAR(2) by PAR(1)- and PAR(2)-derived peptide ligands. J Pharmacol Exp Ther (1999) 1.27
Human urogastrone and mouse epidermal growth factor share a common receptor site in cultured human fibroblasts. Life Sci (1977) 1.22
Evidence of altered energy metabolism in autistic children. Prog Neuropsychopharmacol Biol Psychiatry (1999) 1.22
Effects of high ambient temperature on various stages of rabies virus infection in mice. Infect Immun (1974) 1.21
Somatomedin receptor of human placenta: solubilization, photolabeling, partial purification, and comparison with insulin receptor. Proc Natl Acad Sci U S A (1981) 1.21
Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness. J Clin Psychiatry (2000) 1.18
Endothelium-dependent contractile actions of proteinase-activated receptor-2-activating peptides in human umbilical vein: release of a contracting factor via a novel receptor. Br J Pharmacol (1998) 1.18
Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br J Pharmacol (2001) 1.18
Isolation of a third bovine neurophysin. Biochem J (1969) 1.17
Decrease in thalamic volumes of pediatric patients with obsessive-compulsive disorder who are taking paroxetine. Arch Gen Psychiatry (2000) 1.16
Proteinase-activated receptor-2-mediated matrix metalloproteinase-9 release from airway epithelial cells. J Allergy Clin Immunol (2000) 1.15
Isolation of the human placenta receptor for epidermal growth factor-urogastrone. Nature (1979) 1.15
Role of the amino- and carboxyl-terminal domains of thrombin receptor-derived polypeptides in biological activity in vascular endothelium and gastric smooth muscle: evidence for receptor subtypes. Mol Pharmacol (1993) 1.15
Glycosylation and the activation of proteinase-activated receptor 2 (PAR(2)) by human mast cell tryptase. Br J Pharmacol (2001) 1.14
Subtypes of alpha 1-adrenoceptors involved in noradrenaline-induced contractions of rat thoracic aorta and dog carotid artery. Jpn J Pharmacol (1991) 1.14
Distinct vascular actions of epidermal growth factor-urogastrone and transforming growth factor-alpha. J Pharmacol Exp Ther (1987) 1.13
Insulin: interaction with membrane receprots and relationship to cyclic purine nucleotides and cell growth. Fed Proc (1975) 1.11
Pro- and anti-inflammatory actions of thrombin: a distinct role for proteinase-activated receptor-1 (PAR1). Br J Pharmacol (1999) 1.11
Binding of insulin and other hormones to non-receptor materials: saturability, specificity and apparent "negative cooperativity". Biochem Biophys Res Commun (1975) 1.10
Proteinase-activated receptor-2 (PAR-2): regulation of salivary and pancreatic exocrine secretion in vivo in rats and mice. Br J Pharmacol (2000) 1.10
Single ionic channels induced by palytoxin in guinea-pig ventricular myocytes. Br J Pharmacol (1988) 1.09
Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species. Biochem J (2001) 1.08
Evaluation of the antiinflammatory and phospholipase-inhibitory activity of calpactin II/lipocortin I. J Clin Invest (1988) 1.07
cSrc is a major cytosolic tyrosine kinase in vascular tissue. Can J Physiol Pharmacol (1999) 1.07
Hormone receptor complexes and their modulation of membrane function. Recent Prog Horm Res (1975) 1.07
Lectin-agarose immobilization, a new method for detecting soluble membrane receptors. Application to studies with epidermal growth factor-urogastrone and transcobalamin-II. J Biol Chem (1979) 1.07
Brain neutralization of rabies virus to distinguish recovered animals from previously vaccinated animals. J Immunol (1966) 1.06
Adult hemoglobin synthesis by reticulocytes from the human fetus at midtrimester. Science (1971) 1.06
Pharmacological characterization of alpha 1-adrenoceptor subtypes in the human prostate: functional and binding studies. Br J Urol (1994) 1.06
Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist. Br J Pharmacol (2001) 1.05
The relationship between neurophysin and the soluble proteins of pituitary neurosecretory granules. Biochem J (1967) 1.05
Epidermal growth factor-urogastrone: biological activity and receptor binding of derivatives. Mol Pharmacol (1980) 1.05
Action of thrombin receptor polypeptide in gastric smooth muscle: identification of a core pentapeptide retaining full thrombin-mimetic intrinsic activity. Mol Pharmacol (1992) 1.04
Comparison between sympathetic adrenergic and purinergic transmission in the dog mesenteric artery. J Physiol (1989) 1.03
Protease-activated receptor-1 stimulates Ca(2+)-dependent Cl(-) secretion in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol (2001) 1.02
Alpha-hydrazino-ornithine blocks net synthesis of putrescine but not of RNA and DNA. Nature (1974) 1.02
Insulin and epidermal growth factor-urogastrone: affinity crosslinking to specific binding sites in rat liver membranes. Proc Natl Acad Sci U S A (1978) 1.01
Airway epithelial cells release eosinophil survival-promoting factors (GM-CSF) after stimulation of proteinase-activated receptor 2. J Allergy Clin Immunol (2001) 1.01
Parallel contractile signal transduction pathways activated by receptors for thrombin and epidermal growth factor-urogastrone in guinea pig gastric smooth muscle: blockade by inhibitors of mitogen-activated protein kinase-kinase and phosphatidyl inositol 3'-kinase. J Pharmacol Exp Ther (1998) 1.01
Normal amino acid uptake by cultured human fibroblasts does not require gamma-glutamyl transpeptidase. Biochem Biophys Res Commun (1976) 1.01
Solubilization and isolation of the human placenta receptor for epidermal growth factor-urogastrone. J Biol Chem (1980) 1.00
Characterization of the receptor for epidermal growth factor-urogastrone in human placenta membranes. J Biol Chem (1980) 1.00
Topographic separation of adenylate cyclase and hormone receptors in the plasma membrane of toad erythrocyte ghosts. Proc Natl Acad Sci U S A (1977) 0.99
Proteinase activated receptor 2: Role of extracellular loop 2 for ligand-mediated activation. Br J Pharmacol (1999) 0.99
Actions of thrombin and thrombin receptor peptide analogues in gastric and aortic smooth muscle: development of bioassays for structure-activity studies. Life Sci (1992) 0.98
Modulation of CNS signal transduction pathways and gene expression by mood-stabilizing agents: therapeutic implications. J Clin Psychiatry (1999) 0.97
Vascular actions of thrombin receptor-derived polypeptides: structure-activity profiles for contractile and relaxant effects in rat aorta. Br J Pharmacol (1995) 0.97
Vascular actions of epidermal growth factor-urogastrone: possible relationship to prostaglandin production. Can J Physiol Pharmacol (1985) 0.96
A dose-response study in animals to evaluate the anticoagulant effect of the stage 2 unfractionated heparin USP monograph change. Regul Toxicol Pharmacol (2011) 0.96
Dual endothelium-dependent vascular activities of proteinase-activated receptor-2-activating peptides: evidence for receptor heterogeneity. Br J Pharmacol (1998) 0.95
A polymorphic protease-activated receptor 2 (PAR2) displaying reduced sensitivity to trypsin and differential responses to PAR agonists. J Biol Chem (2000) 0.94
Functional magnetic resonance imaging of motor activation in the human cervical spinal cord. Neuroimage (1996) 0.93
Independent variation of beta-adrenergic receptor binding and catecholamine-stimulated adenylate cyclase activity in rat erythrocytes. Life Sci (1976) 0.92
Modulation by epidermal growth factor--urogastrone of contraction in isolated canine helical mesenteric arterial strips. Can J Physiol Pharmacol (1986) 0.92
Epidermal growth factor-urogastrone causes vasodilatation in the anesthetized dog. J Clin Invest (1987) 0.92
Susceptibility of carnivora to rabies virus administered orally. Am J Epidemiol (1971) 0.91
Epidermal growth factor (urogastrone)-mediated phosphorylation of a 35-kDa substrate in human placental membranes: relationship to the beta subunit of the guanine nucleotide regulatory complex. Proc Natl Acad Sci U S A (1986) 0.91
Prolonged incubation period of rabies in a naturally infected insectivorous bat, Eptesicus fuscus (Beauvois). J Wildl Dis (1970) 0.91
Characteristics of the solubilized insulin receptor of human placenta. Life Sci (1978) 0.91