Published in J Biol Chem on November 25, 1980
Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system. J Cell Biol (1988) 2.31
High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody, and appears necessary for early responses. J Cell Biol (1990) 1.78
Somatomedin receptor of human placenta: solubilization, photolabeling, partial purification, and comparison with insulin receptor. Proc Natl Acad Sci U S A (1981) 1.21
Evaluation of the antiinflammatory and phospholipase-inhibitory activity of calpactin II/lipocortin I. J Clin Invest (1988) 1.07
Epidermal growth factor (urogastrone)-mediated phosphorylation of a 35-kDa substrate in human placental membranes: relationship to the beta subunit of the guanine nucleotide regulatory complex. Proc Natl Acad Sci U S A (1986) 0.91
Growth hormone enhances hepatic epidermal growth factor receptor concentration in mice. J Clin Invest (1988) 0.88
Epidermal-growth-factor-stimulated phosphorylation of calpactin II in membrane vesicles shed from cultured A-431 cells. Biochem J (1989) 0.85
Decreased binding of epidermal growth factor in placentas from streptozotocin-diabetic rats. J Clin Invest (1987) 0.82
Minimal hydrolysis of epidermal growth factor by gastric fluid of preterm infants. Gut (1989) 0.80
Membrane receptors and hormone action. Adv Protein Chem (1976) 3.73
Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med (2000) 3.71
Insulin and epidermal growth factor. Human fibroblast receptors related to deoxyribonucleic acid synthesis and amino acid uptake. J Biol Chem (1975) 3.60
Epidermal growth factor: receptors in human fibroblasts and modulation of action by cholera toxin. Proc Natl Acad Sci U S A (1973) 3.44
Retrovirus-mediated transfer and expression of drug resistance genes in human haematopoietic progenitor cells. Nature (1986) 3.30
Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway. Nat Med (2001) 3.17
Efficient retrovirus-mediated transfer and expression of a human adenosine deaminase gene in diploid skin fibroblasts from an adenosine deaminase-deficient human. Proc Natl Acad Sci U S A (1987) 2.72
The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol (2013) 2.48
Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more. Br J Pharmacol (2007) 2.35
Epidermal growth factor. Characteristics of specific binding in membranes from liver, placenta, and other target tissues. Arch Biochem Biophys (1974) 2.34
The isolation of the native hormone-binding proteins from bovine pituitary posterior lobes. Crystallization of neurophysin-I and-II as complexes with [8-arginine]-vasopressin. Biochem J (1968) 2.24
Protease-activated receptors in inflammation, neuronal signaling and pain. Trends Pharmacol Sci (2001) 2.06
Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2. Proc Natl Acad Sci U S A (1997) 1.99
Evaluation of proteinase-activated receptor-1 (PAR1) agonists and antagonists using a cultured cell receptor desensitization assay: activation of PAR2 by PAR1-targeted ligands. J Pharmacol Exp Ther (1999) 1.93
Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue. Br J Pharmacol (1996) 1.93
Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. Proc Natl Acad Sci U S A (2001) 1.84
Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw. Br J Pharmacol (1999) 1.83
Affinity chromatography and structural analysis of Vibrio cholerae enterotoxin-ganglioside agarose and the biological effects of ganglioside-containing soluble polymers. Biochemistry (1973) 1.74
Insulin receptor: interaction with nonreceptor glycoprotein from liver cell membranes. Proc Natl Acad Sci U S A (1978) 1.68
Proteinase-activated receptor 2 (PAR2)-activating peptides: identification of a receptor distinct from PAR2 that regulates intestinal transport. Proc Natl Acad Sci U S A (1998) 1.61
Epidermal growth factor-urogastrone, a polypeptide acquiring hormonal status. Vitam Horm (1979) 1.58
Optimization of fibronectin-assisted retroviral gene transfer into human CD34+ hematopoietic cells. Hum Gene Ther (1997) 1.57
Dissociation of oxytocin and vasopressin from their carrier protein by chromatography on sephadex G-25. Br J Pharmacol Chemother (1966) 1.56
Fractionation of neurophysin by molecular-sieve and ion-exchange chromatography. Biochem J (1967) 1.55
Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle. Can J Physiol Pharmacol (1995) 1.52
Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2. Am J Physiol Lung Cell Mol Physiol (2000) 1.52
Cholera toxin and cell growth: role of membrane gangliosides. Proc Natl Acad Sci U S A (1974) 1.46
Ca2+-dependent hydrophobic-interaction chromatography. Isolation of a novel Ca2+-binding protein and protein kinase C from bovine brain. Biochem J (1984) 1.45
HLA-DQ molecules form alpha-beta heterodimers of mixed allotype. J Immunol (1988) 1.37
Detection of epidermal growth factor-urogastrone and its receptor during fetal mouse development. Proc Natl Acad Sci U S A (1980) 1.35
Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2. J Physiol (1999) 1.31
Interferon action: role of membrane gangliosides. Virology (1976) 1.29
Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity. J Leukoc Biol (2008) 1.28
Proteinase-activated receptor 2 (PAR(2)): development of a ligand-binding assay correlating with activation of PAR(2) by PAR(1)- and PAR(2)-derived peptide ligands. J Pharmacol Exp Ther (1999) 1.27
Human urogastrone and mouse epidermal growth factor share a common receptor site in cultured human fibroblasts. Life Sci (1977) 1.22
Somatomedin receptor of human placenta: solubilization, photolabeling, partial purification, and comparison with insulin receptor. Proc Natl Acad Sci U S A (1981) 1.21
Endothelium-dependent contractile actions of proteinase-activated receptor-2-activating peptides in human umbilical vein: release of a contracting factor via a novel receptor. Br J Pharmacol (1998) 1.18
Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br J Pharmacol (2001) 1.18
Isolation of a third bovine neurophysin. Biochem J (1969) 1.17
Proteinase-activated receptor-2-mediated matrix metalloproteinase-9 release from airway epithelial cells. J Allergy Clin Immunol (2000) 1.15
Isolation of the human placenta receptor for epidermal growth factor-urogastrone. Nature (1979) 1.15
Glycosylation and the activation of proteinase-activated receptor 2 (PAR(2)) by human mast cell tryptase. Br J Pharmacol (2001) 1.14
Distinct vascular actions of epidermal growth factor-urogastrone and transforming growth factor-alpha. J Pharmacol Exp Ther (1987) 1.13
Pro- and anti-inflammatory actions of thrombin: a distinct role for proteinase-activated receptor-1 (PAR1). Br J Pharmacol (1999) 1.11
Genomic instability and catalase gene amplification induced by chronic exposure to oxidative stress. Cancer Res (1998) 1.11
Insulin: interaction with membrane receprots and relationship to cyclic purine nucleotides and cell growth. Fed Proc (1975) 1.11
Proteinase-activated receptor-2 (PAR-2): regulation of salivary and pancreatic exocrine secretion in vivo in rats and mice. Br J Pharmacol (2000) 1.10
Binding of insulin and other hormones to non-receptor materials: saturability, specificity and apparent "negative cooperativity". Biochem Biophys Res Commun (1975) 1.10
Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species. Biochem J (2001) 1.08
cSrc is a major cytosolic tyrosine kinase in vascular tissue. Can J Physiol Pharmacol (1999) 1.07
Evaluation of the antiinflammatory and phospholipase-inhibitory activity of calpactin II/lipocortin I. J Clin Invest (1988) 1.07
Long-term expression of human adenosine deaminase in mice after transplantation of bone marrow infected with amphotropic retroviral vectors. Hum Gene Ther (1990) 1.07
Lectin-agarose immobilization, a new method for detecting soluble membrane receptors. Application to studies with epidermal growth factor-urogastrone and transcobalamin-II. J Biol Chem (1979) 1.07
Hormone receptor complexes and their modulation of membrane function. Recent Prog Horm Res (1975) 1.07
Vascular actions of thrombin receptor peptide. Can J Physiol Pharmacol (1992) 1.06
Adult hemoglobin synthesis by reticulocytes from the human fetus at midtrimester. Science (1971) 1.06
Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist. Br J Pharmacol (2001) 1.05
The relationship between neurophysin and the soluble proteins of pituitary neurosecretory granules. Biochem J (1967) 1.05
Epidermal growth factor-urogastrone: biological activity and receptor binding of derivatives. Mol Pharmacol (1980) 1.05
Protease-activated receptor-1 stimulates Ca(2+)-dependent Cl(-) secretion in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol (2001) 1.02
Towards gene therapy for hemophilia B. Mol Biol Med (1987) 1.02
Alpha-hydrazino-ornithine blocks net synthesis of putrescine but not of RNA and DNA. Nature (1974) 1.02
Insulin and epidermal growth factor-urogastrone: affinity crosslinking to specific binding sites in rat liver membranes. Proc Natl Acad Sci U S A (1978) 1.01
Parallel contractile signal transduction pathways activated by receptors for thrombin and epidermal growth factor-urogastrone in guinea pig gastric smooth muscle: blockade by inhibitors of mitogen-activated protein kinase-kinase and phosphatidyl inositol 3'-kinase. J Pharmacol Exp Ther (1998) 1.01
Airway epithelial cells release eosinophil survival-promoting factors (GM-CSF) after stimulation of proteinase-activated receptor 2. J Allergy Clin Immunol (2001) 1.01
Normal amino acid uptake by cultured human fibroblasts does not require gamma-glutamyl transpeptidase. Biochem Biophys Res Commun (1976) 1.01
Solubilization and isolation of the human placenta receptor for epidermal growth factor-urogastrone. J Biol Chem (1980) 1.00
Topographic separation of adenylate cyclase and hormone receptors in the plasma membrane of toad erythrocyte ghosts. Proc Natl Acad Sci U S A (1977) 0.99
Proteinase activated receptor 2: Role of extracellular loop 2 for ligand-mediated activation. Br J Pharmacol (1999) 0.99
Actions of thrombin and thrombin receptor peptide analogues in gastric and aortic smooth muscle: development of bioassays for structure-activity studies. Life Sci (1992) 0.98
Vascular actions of thrombin receptor-derived polypeptides: structure-activity profiles for contractile and relaxant effects in rat aorta. Br J Pharmacol (1995) 0.97
Vascular actions of epidermal growth factor-urogastrone: possible relationship to prostaglandin production. Can J Physiol Pharmacol (1985) 0.96
Dual endothelium-dependent vascular activities of proteinase-activated receptor-2-activating peptides: evidence for receptor heterogeneity. Br J Pharmacol (1998) 0.95
A polymorphic protease-activated receptor 2 (PAR2) displaying reduced sensitivity to trypsin and differential responses to PAR agonists. J Biol Chem (2000) 0.94
Independent variation of beta-adrenergic receptor binding and catecholamine-stimulated adenylate cyclase activity in rat erythrocytes. Life Sci (1976) 0.92
Modulation by epidermal growth factor--urogastrone of contraction in isolated canine helical mesenteric arterial strips. Can J Physiol Pharmacol (1986) 0.92
Epidermal growth factor-urogastrone causes vasodilatation in the anesthetized dog. J Clin Invest (1987) 0.92
Characteristics of the solubilized insulin receptor of human placenta. Life Sci (1978) 0.91
Epidermal growth factor (urogastrone)-mediated phosphorylation of a 35-kDa substrate in human placental membranes: relationship to the beta subunit of the guanine nucleotide regulatory complex. Proc Natl Acad Sci U S A (1986) 0.91
Beta-adrenergic receptors and adenylate cyclase activity in rat reticulocytes and mature erythrocytes. Biochem Pharmacol (1979) 0.91
Erythropoietin: isolation by affinity chromatography with lectin-agarose derivatives. Proc Natl Acad Sci U S A (1977) 0.90
Contractile actions of thrombin receptor-derived polypeptides in human umbilical and placental vasculature: evidence for distinct receptor systems. Br J Pharmacol (1995) 0.90
Changes in the binding of concanavalin A and wheat germ agglutinin to human lymphocytes during in vitro transformation. Biochem Biophys Res Commun (1973) 0.90
Characterization of the particulate and soluble acceptor for transcobalamin II from human placenta and rabbit liver. Biochim Biophys Acta (1980) 0.89
Expression of protease activated receptor-2 (PAR-2) in central airways of smokers and non-smokers. Thorax (2002) 0.89
Effects of epidermal growth factor (urogastrone) on gluconeogenesis, glucose oxidation, and glycogen synthesis in isolated rat hepatocytes. Biochem Cell Biol (1989) 0.89
Epidermal growth factor induction of apolipoprotein A-I is mediated by the Ras-MAP kinase cascade and Sp1. J Biol Chem (2001) 0.88
Hormone receptor interactions at the cell membrane. Pharmacol Rev (1978) 0.88
Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1. J Biol Chem (2000) 0.87
A comparison between relaxation and assertive training with asthmatic male children. Biol Psychiatry (1977) 0.87
Comparative studies on human placental insulin and basic somatomedin receptors. J Cell Biochem (1982) 0.87
The effects of interferon on epidermal growth factor action. Biochem Biophys Res Commun (1980) 0.87
Distinct signal transduction pathways for angiotensin-II in guinea pig gastric smooth muscle: differential blockade by indomethacin and tyrosine kinase inhibitors. J Pharmacol Exp Ther (1993) 0.87
Tyrosine kinase inhibitors and the contractile action of G-protein-linked vascular agonists. Can J Physiol Pharmacol (1994) 0.86
Epidermal growth factor (urogastrone)-stimulated gluconeogenesis in isolated mouse hepatocytes. Arch Biochem Biophys (1987) 0.86