Published in Nature on August 17, 1957
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The tryptophan synthetase system. Bacteriol Rev (1960) 7.09
Genomic views of distant-acting enhancers. Nature (2009) 6.27
THE EFFECTS OF DELETIONS, POINT MUTATIONS, REVERSIONS AND SUPPRESSOR MUTATIONS ON THE TWO COMPONENTS OF THE TRYPTOPHAN SYNTHETASE OF ESCHERICHIA COLI. Proc Natl Acad Sci U S A (1959) 5.39
Allogeneic hematopoietic stem-cell transplantation for sickle cell disease. N Engl J Med (2009) 4.59
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The properties of altered proteins from mutants bearing one or two lesions in the same gene. Proc Natl Acad Sci U S A (1961) 2.24
THE ENZYMATIC ACTIVITY ASSOCIATED WITH THE PROTEIN IMMUNOLOGICALLY RELATED TO TRYPTOPHAN SYNTHETASE. Proc Natl Acad Sci U S A (1958) 2.15
Hypocatalasemia: a new genetic carrier state. J Clin Invest (1960) 2.14
The vaso-occlusive crisis of sickle cell disease. BMJ (1991) 2.09
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Design of therapeutic proteins with enhanced stability. Proc Natl Acad Sci U S A (2009) 2.01
Correction of sickle cell disease by homologous recombination in embryonic stem cells. Blood (2006) 1.92
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An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer. EMBO J (2002) 1.57
The state of hemoglobin in sickled erythrocytes. J Exp Med (1966) 1.56
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Understanding the shape of sickled red cells. Biophys J (2004) 1.32
Role of arginine 180 and glutamic acid 177 of ricin toxin A chain in enzymatic inactivation of ribosomes. Mol Cell Biol (1990) 1.31
Personal genomes in progress: from the human genome project to the personal genome project. Dialogues Clin Neurosci (2010) 1.29
A comparison of the electrophoretic characteristics of the human normal and sickle erythrocyte. Biochem J (1964) 1.26
The rate of hemolysis in sickle cell disease correlates with the quantity of active von Willebrand factor in the plasma. Blood (2011) 1.24
Electron microscopy of fibers and discs of hemoglobin S having sixfold symmetry. Proc Natl Acad Sci U S A (1977) 1.16
Heme on innate immunity and inflammation. Front Pharmacol (2014) 1.15
Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait. Blood (2012) 1.13
Atlantic cod (Gadus morhua) hemoglobin genes: multiplicity and polymorphism. BMC Genet (2009) 1.08
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A genetic electrophoretic variant of human hair alpha polypeptides. Am J Hum Genet (1975) 1.07
Relations between mutations and base sequences in the amino acid code. Proc Natl Acad Sci U S A (1962) 1.07
Infrared imaging of nitric oxide-mediated blood flow in human sickle cell disease. Microvasc Res (2012) 1.06
The Nature and Significance of the Bohr Effect in Mammalian Hemoglobins. J Gen Physiol (1960) 1.04
Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes. Proc Natl Acad Sci U S A (2011) 1.04
Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway. Blood (2011) 1.03
Recombinant human hemoglobins designed for gene therapy of sickle cell disease. Proc Natl Acad Sci U S A (1994) 1.02
The hypothalamic-neurohypophyseal system: from genome to physiology. J Neuroendocrinol (2012) 1.01
AGGRESCAN3D (A3D): server for prediction of aggregation properties of protein structures. Nucleic Acids Res (2015) 1.00
Percutaneous implantation of autologous bone marrow osteoprogenitor cells as treatment of bone avascular necrosis related to sickle cell disease. Open Orthop J (2008) 0.99
The roots of bioinformatics in protein evolution. PLoS Comput Biol (2010) 0.98
The metabolic error in primary hyperoxaluria. Arch Dis Child (1965) 0.98
Chemical modifications that inhibit gelation of sickle hemoglobin. Proc Natl Acad Sci U S A (1974) 0.94
Dichloromethane as an antisickling agent in sickle cell hemoglobin. Proc Natl Acad Sci U S A (1976) 0.94
Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies. Mol Cell Biol (2014) 0.94
Biting off more than you can chew: sexual selection on the free amino acid composition of the spermatophylax in decorated crickets. Proc Biol Sci (2012) 0.94
The effect of deoxygenation on whole-cell conductance of red blood cells from healthy individuals and patients with sickle cell disease. Blood (2006) 0.94
Redox-dependent impairment of vascular function in sickle cell disease. Free Radic Biol Med (2007) 0.93
A novel technique based on a PNA hybridization probe and FRET principle for quantification of mutant genotype in fibrous dysplasia/McCune-Albright syndrome. Nucleic Acids Res (2004) 0.93
Genetic fatalism and social policy: the implications of behavior genetics research. Yale J Biol Med (1995) 0.92
A human embryonic hemoglobin inhibits Hb S polymerization in vitro and restores a normal phenotype to mouse models of sickle cell disease. Proc Natl Acad Sci U S A (2002) 0.92
Splenic complications of sickle cell anemia and the role of splenectomy. ISRN Hematol (2010) 0.89
Sickle cell trait is not associated with endemic Burkitt lymphoma: an ethnicity and malaria endemicity-matched case-control study suggests factors controlling EBV may serve as a predictive biomarker for this pediatric cancer. Int J Cancer (2013) 0.88
ETS1 suppresses tumorigenicity of human colon cancer cells. Proc Natl Acad Sci U S A (1995) 0.88
Hematopoietic stem cells: transcriptional regulation, ex vivo expansion and clinical application. Curr Mol Med (2012) 0.87
Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin. Curr Opin Genet Dev (2015) 0.87
The Properties of Red Blood Cells from Patients Heterozygous for HbS and HbC (HbSC Genotype). Anemia (2010) 0.87
Traditional herbal management of sickle cell anemia: lessons from Nigeria. Anemia (2012) 0.86
Malaria continues to select for sickle cell trait in Central Africa. Proc Natl Acad Sci U S A (2015) 0.85
Resolving the variable genome and epigenome in human disease. J Intern Med (2012) 0.85
Role of extracellular hemoglobin in thrombosis and vascular occlusion in patients with sickle cell anemia. Anemia (2010) 0.85
Direct laser trapping for measuring the behavior of transfused erythrocytes in a sickle cell anemia patient. Biomed Opt Express (2012) 0.85
Pathological basis of symptoms and crises in sickle cell disorder: implications for counseling and psychotherapy. Hematol Rep (2010) 0.84
Hepatobiliary Manifestations of Sickle Cell Anemia. Gastroenterology Res (2010) 0.83
Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation. Proc Natl Acad Sci U S A (2015) 0.83
Genetic Study of a Family Possessing Hemoglobins S and C, and Classical Thalassemia. Am J Hum Genet (1961) 0.82
Orthopaedic manifestations of sickle-cell disease. Yale J Biol Med (1990) 0.82
Stems and standards: social interaction in the search for blood stem cells. J Hist Biol (2010) 0.82
Hematopoietic Stem Cell Transplantation in Adult Sickle Cell Disease: Problems and Solutions. Turk J Haematol (2015) 0.82
Sex Determination: Diagnostic Methods. Br Med J (1960) 0.82
Predictive tools for stabilization of therapeutic proteins. MAbs (2009) 0.81
Pluripotent stem cells in research and treatment of hemoglobinopathies. Cold Spring Harb Perspect Med (2012) 0.81
High-level genomic integration, epigenetic changes, and expression of sleeping beauty transgene. Biochemistry (2010) 0.81
Detection of sickle cell hemoglobin in Haiti by genotyping and hemoglobin solubility tests. Am J Trop Med Hyg (2014) 0.81
Proteotoxicity and cardiac dysfunction. Circ Res (2015) 0.81
The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis). Haematologica (2016) 0.80
Regulation of disease-associated gene expression in the 3D genome. Nat Rev Mol Cell Biol (2016) 0.80
Delivery of nucleic acid therapeutics by genetically engineered hematopoietic stem cells. Adv Drug Deliv Rev (2010) 0.79
Fatal 1918 pneumonia case complicated by erythrocyte sickling. Emerg Infect Dis (2010) 0.78
Targeted intracellular delivery of proteins with spatial and temporal control. Mol Pharm (2014) 0.78
Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children. Am J Hum Genet (2016) 0.78
The pulmonary physician in critical care * Illustrative case 6: Acute chest syndrome of sickle cell anaemia. Thorax (2003) 0.77
Examining protein surface structure in highly conserved sequence variants with mass spectrometry. Biochemistry (2012) 0.77
Cellular normoxic biophysical markers of hydroxyurea treatment in sickle cell disease. Proc Natl Acad Sci U S A (2016) 0.77
Liver stiffness increases acutely during sickle cell vaso-occlusive crisis. Am J Hematol (2013) 0.77
Novel HDAd/EBV Reprogramming Vector and Highly Efficient Ad/CRISPR-Cas Sickle Cell Disease Gene Correction. Sci Rep (2016) 0.76
Augmented water binding and low cellular water content in erythrocytes of camel and camelids. Biophys J (1998) 0.76
Carbon-fiber microelectrode amperometry reveals sickle-cell-induced inflammation and chronic morphine effects on single mast cells. ACS Chem Biol (2012) 0.76
Incredible RNA: Dual Functions of Coding and Noncoding. Mol Cells (2016) 0.76
Incidence of sickle cell disease and other hemoglobin variants in 10,095 Lebanese neonates. PLoS One (2014) 0.76
Fin whale MDH-1 and MPI allozyme variation is not reflected in the corresponding DNA sequences. Ecol Evol (2014) 0.76
Diathesis and disease. The Osler oration, 1963. Can Med Assoc J (1963) 0.75
ON THE SIMILARITY OF CHAIN LENGTH OF NUCLEIC ACIDS. Proc Natl Acad Sci U S A (1959) 0.75
New insights from monogenic diabetes for "common" type 2 diabetes. Front Genet (2015) 0.75
The mongolism-leukemia syndrome. Report of a case. Calif Med (1963) 0.75
A specific chemical difference between the globins of normal human and sickle-cell anaemia haemoglobin. Nature (1956) 6.51
Abnormal human haemoglobins. I. The comparison of normal human and sickle-cell haemoglobins by fingerprinting. Biochim Biophys Acta (1958) 4.90
Gene evolution and the haemoglobins. Nature (1961) 3.27
Sulphydryl groups in haemoglobins. Biochem J (1955) 2.60
Genetic basis of the thalassaemia diseases. Nature (1959) 2.57
Recommendations for the nomenclature of hemoglobins. J Biol Chem (1961) 2.56
Allelomorphism and the chemical differences of the human haemoglobins A, S and C. Nature (1958) 2.12
Four adult haemoglobin types in one person. Nature (1961) 1.59
Separation of the peptide chains of human globin. Nature (1959) 1.57
Abnormal human haemoglobins. III. The chemical difference between normal and sickle cell haemoglobins. Biochim Biophys Acta (1959) 1.43
Abnormal human haemoglobins. II. The chymotryptic digestion of the trypsin-resistant core of haemoglobins A and S. Biochim Biophys Acta (1958) 1.43
The action of fluorodinitrobenzene on bacterial cell walls. Biochim Biophys Acta (1957) 1.34
Human haemoglobin A2: chemistry, genetics and evolution. Nature (1961) 1.30
Chemistry of the abnormal human haemoglobins. Br Med Bull (1959) 1.28
CHEMICAL STUDIES ON AMINO ACID ACCEPTOR RIBONUCLEIC ACIDS. II. ATTEMPTS AT PARTIAL DIGESTION OF YEAST AMINO ACID ACCEPTOR RIBONUCLEIC ACID WITH PANCREATIC RIBONUCLEASE. Biochemistry (1964) 1.15
Human haemoglobin A2. II. The chemistry of some peptides peculiar to haemoglobin A2. Biochim Biophys Acta (1962) 1.09
Isoelectric point of chymotrypsinogen by a Donnan equilibrium method. Nature (1952) 1.08
Abnormal human haemoglobins. V. Chemical investigation of haemoglobins A, G, C, X from one individual. Biochim Biophys Acta (1961) 1.02
Human haemoglobin E: the chemical effect of gene mutation. Nature (1959) 1.02
The identification of peptide end-groups as dimethylamino acids. J Biol Chem (1953) 0.99
Genetic control of foetal and adult human haemoglobin. Nature (1961) 0.97
A terminal peptide sequence of human haemoglobin? Nature (1959) 0.92
The sulphydryl groups of sickle-cell haemoglobin. Biochem J (1957) 0.88
Synthesis of polymeric peptides in proteinase-catalyzed transamidation reactions. J Biol Chem (1953) 0.87
Recommendations for the nomenclature of haemoglobins. Lancet (1961) 0.86
Abnormal human haemoglobins. VI. The chemical difference between haemoglobins A and E. Biochim Biophys Acta (1961) 0.85
Abnormal human haemoglobins. IV. The chemical difference between normal human haemoglobin and haemoglobin C. Biochim Biophys Acta (1960) 0.85
Haemoglobin F and the genetic control of protein structure. Nature (1961) 0.84
Abnormal human haemoglobins. VII. The comparison of normal human haemoglobin and haemoglobin D-Chicago. Biochim Biophys Acta (1961) 0.84
Comparison of normal adult human haemoglobin with haemoglobin I by 'fingerprinting'. Nature (1959) 0.84
A MOLECULAR MODEL FOR THALASSEMIA. Ann N Y Acad Sci (1964) 0.82
Abnormal human haemoglobins. Proc R Soc Med (1958) 0.80
A micro end-group method for peptides. Nature (1950) 0.79
Biochemical genetics at the molecular level. Am J Med (1963) 0.78
The application of Edman's peptide degradation method to horse myoglobin and haemoglobin. Biochim Biophys Acta (1955) 0.78
Autolysis products of pepsin. Nature (1951) 0.76
AMINOACYL POSITION IN AMINOACYL SRNA. Science (1964) 0.76
Recommendations for the nomenclature of hemoglobins. Blut (1961) 0.75
CHEMICAL STUDIES ON AMINO ACID ACCEPTOR RIBONUCLEIC ACIDS. 3. THE DEGRADATION OF PURIFIED ALANINE- AND VALINE-SPECIFIC YEAST S-RNA'S BY PANCREATIC RIBONUCLEASE. Biochemistry (1964) 0.75
A public school program for the severely mentally handicapped child. Am J Ment Defic (1955) 0.75
CONTROL MECHANISMS IN HEMOGLOBIN SYNTHESIS. Medicine (Baltimore) (1964) 0.75
Recommendations for the nomenclature of hemoglobins. Science (1961) 0.75
SH groups in haemoglobins. Biochem J (1954) 0.75
Recommendations for the nomenclature of hemoglobins. J Mol Biol (1961) 0.75
The stepwise reductive cleavage of DNP-peptides. Biochim Biophys Acta (1956) 0.75
The evolution of a protein. Fed Proc (1963) 0.75
[The structure of abnormal hemoglobins]. Expos Annu Biochim Med (1958) 0.75