Published in Protein Sci on June 01, 1992
Exosites in the substrate specificity of blood coagulation reactions. J Thromb Haemost (2007) 1.61
Structural Stability, Transitions, and Interactions within SoxYZCD-Thiosulphate from Sulfurimonas denitrificans: An In Silico Molecular Outlook for Maintaining Environmental Sulphur Cycle. J Biophys (2016) 1.38
Thrombin hydrolysis of human osteopontin is dependent on thrombin anion-binding exosites. J Biol Chem (2008) 1.01
Electrostatic potentials and electrostatic interaction energies of rat cytochrome b5 and a simulated anion-exchange adsorbent surface. Biophys J (1994) 0.99
Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms. Protein Sci (1993) 0.93
3-Nitrotyrosine as a spectroscopic probe for investigating protein protein interactions. Protein Sci (2006) 0.88
Biophysical investigation of GpIbalpha binding to thrombin anion binding exosite II. Biochemistry (2009) 0.85
Structural investigation of the alpha-1-antichymotrypsin: prostate-specific antigen complex by comparative model building. Protein Sci (1996) 0.83
Characterization of bothrojaracin interaction with human prothrombin. Protein Sci (2001) 0.82
Binding of phosphorus-containing inhibitors to thermolysin studied by the Poisson-Boltzmann method. Protein Sci (1995) 0.80
Focusing of electric fields in the active site of Cu-Zn superoxide dismutase: effects of ionic strength and amino-acid modification. Proteins (1986) 5.53
Electrostatic energy and macromolecular function. Annu Rev Biophys Biophys Chem (1991) 2.86
The structure of a complex of recombinant hirudin and human alpha-thrombin. Science (1990) 2.71
Energetics of charge-charge interactions in proteins. Proteins (1988) 2.56
Electrostatic effects in proteins. Annu Rev Biophys Biophys Chem (1985) 2.51
Kinetics of the inhibition of thrombin by hirudin. Biochemistry (1986) 2.33
Refined structure of the hirudin-thrombin complex. J Mol Biol (1991) 2.06
Electrostatic effects in myoglobin. Hydrogen ion equilibria in sperm whale ferrimyoglobin. Biochemistry (1974) 1.66
Quantitative evaluation of the contribution of ionic interactions to the formation of the thrombin-hirudin complex. Biochemistry (1989) 1.61
Regulation of thrombin generation and functions. Semin Thromb Hemost (1988) 1.39
Calculation of electrostatic interactions in proteins. Methods Enzymol (1986) 1.32
A protein engineering study of the role of aspartate 158 in the catalytic mechanism of papain. Biochemistry (1990) 1.32
Use of site-directed mutagenesis to investigate the basis for the specificity of hirudin. Biochemistry (1988) 1.18
Solution structure of recombinant hirudin and the Lys-47----Glu mutant: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study. Biochemistry (1989) 1.13
Covalent structures of beta and gamma autolytic derivatives of human alpha-thrombin. J Biol Chem (1984) 1.11
Preparation and characterization of proteolyzed forms of human alpha-thrombin. Thromb Res (1988) 0.95
Structure-function relationships in human alpha- and gamma-thrombins. Mol Cell Biochem (1984) 0.94
Lysine/fibrin binding sites of kringles modeled after the structure of kringle 1 of prothrombin. Proteins (1988) 0.93
Ionic interactions in the formation of the thrombin-hirudin complex. Biochem J (1991) 0.92
Human alpha- to zeta-thrombin cleavage occurs with neutrophil cathepsin G or chymotrypsin while fibrinogen clotting activity is retained. Biochemistry (1990) 0.91
Basis for the reduced affinity of beta T- and gamma T-thrombin for hirudin. Biochemistry (1991) 0.83
The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment. EMBO J (1989) 4.49
Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor. II. Crystallographic refinement at 1.9 A resolution. J Mol Biol (1974) 3.17
The structure of a complex of recombinant hirudin and human alpha-thrombin. Science (1990) 2.71
The metzincins--topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases. Protein Sci (1995) 2.63
Primary structure of human neutrophil elastase. Proc Natl Acad Sci U S A (1987) 2.45
The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction. EMBO J (1990) 2.44
X-ray crystallographic structure of the light-harvesting biliprotein C-phycocyanin from the thermophilic cyanobacterium Mastigocladus laminosus and its resemblance to globin structures. J Mol Biol (1985) 2.42
The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer. J Biol Chem (1993) 2.39
The cystatins: protein inhibitors of cysteine proteinases. FEBS Lett (1991) 2.33
Kinetics of the inhibition of thrombin by hirudin. Biochemistry (1986) 2.33
The refined crystal structure of bovine beta-trypsin at 1.8 A resolution. II. Crystallographic refinement, calcium binding site, benzamidine binding site and active site at pH 7.0. J Mol Biol (1975) 2.24
Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1. Nature (1997) 2.17
Structural basis for the activation of human procaspase-7. Proc Natl Acad Sci U S A (2001) 2.14
Structure of human des(1-45) factor Xa at 2.2 A resolution. J Mol Biol (1993) 2.07
Refined structure of the hirudin-thrombin complex. J Mol Biol (1991) 2.06
Refined three-dimensional structures of two cyanobacterial C-phycocyanins at 2.1 and 2.5 A resolution. A common principle of phycobilin-protein interaction. J Mol Biol (1987) 2.06
Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex. Nature (2000) 2.04
alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure. Biochemistry (1990) 2.03
Structure of the hirugen and hirulog 1 complexes of alpha-thrombin. J Mol Biol (1991) 1.89
Thrombin functions as an inflammatory mediator through activation of its receptor. J Exp Med (1996) 1.87
The ternary microplasmin-staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action. Nat Struct Biol (1998) 1.85
The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain. J Mol Biol (1996) 1.82
Bovine chymotrypsinogen A X-ray crystal structure analysis and refinement of a new crystal form at 1.8 A resolution. J Mol Biol (1985) 1.81
Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold. EMBO J (1999) 1.79
Crystal structure of bovine trypsinogen at 1-8 A resolution. II. Crystallographic refinement, refined crystal structure and comparison with bovine trypsin. J Mol Biol (1977) 1.79
The Na+ binding site of thrombin. J Biol Chem (1995) 1.77
Crystal and molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI. Eur J Biochem (1974) 1.76
X-ray crystal structure of the complex of human leukocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitor. EMBO J (1986) 1.76
The high-resolution X-ray crystal structure of the complex formed between subtilisin Carlsberg and eglin c, an elastase inhibitor from the leech Hirudo medicinalis. Structural analysis, subtilisin structure and interface geometry. Eur J Biochem (1987) 1.75
Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme. Proc Natl Acad Sci U S A (1998) 1.70
Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform. Biochemistry (1991) 1.69
cDNA cloning of porcine brain prolyl endopeptidase and identification of the active-site seryl residue. Biochemistry (1991) 1.66
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium. Proc Natl Acad Sci U S A (2000) 1.65
Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition. EMBO J (1990) 1.65
A player of many parts: the spotlight falls on thrombin's structure. Thromb Res (1993) 1.64
The 2.5 A X-ray crystal structure of the acid-stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine alpha-chymotrypsin. EMBO J (1988) 1.61
Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors. Neuron (1992) 1.60
Crystal structures of the membrane-binding C2 domain of human coagulation factor V. Nature (1999) 1.58
X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B. Proc Natl Acad Sci U S A (1995) 1.58
The crystal and molecular structure of triclinic tetraphenylporphyrin. J Am Chem Soc (1967) 1.57
The 2.8 A crystal structure of Gla-domainless activated protein C. EMBO J (1996) 1.56
Amino acid sequence of the ribonuclease inhibitor from porcine liver reveals the presence of leucine-rich repeats. Biochemistry (1988) 1.55
The interaction of thrombin with fibrinogen. A structural basis for its specificity. Eur J Biochem (1992) 1.53
The ornithodorin-thrombin crystal structure, a key to the TAP enigma? EMBO J (1996) 1.53
Crystal structure analysis and refinement at 2.5 A of hexameric C-phycocyanin from the cyanobacterium Agmenellum quadruplicatum. The molecular model and its implications for light-harvesting. J Mol Biol (1986) 1.50
Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin. Biochemistry (1993) 1.49
Inflammation, sepsis, and coagulation. Haematologica (1999) 1.49
Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors. Biochemistry (1995) 1.48
Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. Biochemistry (1994) 1.46
Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin. EMBO J (1995) 1.45
Comparison of the crystal structures of a flavodoxin in its three oxidation states at cryogenic temperatures. J Mol Biol (1991) 1.44
The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin. Protein Sci (1994) 1.44
Human beta-tryptase is a ring-like tetramer with active sites facing a central pore. Nature (1998) 1.43
Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug. Proc Natl Acad Sci U S A (1997) 1.38
Mechanism of inhibition of papain by chicken egg white cystatin. Inhibition constants of N-terminally truncated forms and cyanogen bromide fragments of the inhibitor. FEBS Lett (1989) 1.38
An ambiguous structure of a DNA 15-mer thrombin complex. Acta Crystallogr D Biol Crystallogr (1996) 1.38
The Ca2+ ion and membrane binding structure of the Gla domain of Ca-prothrombin fragment 1. Biochemistry (1992) 1.37
First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases. EMBO J (1993) 1.36
Refined 1.8 A X-ray crystal structure of astacin, a zinc-endopeptidase from the crayfish Astacus astacus L. Structure determination, refinement, molecular structure and comparison with thermolysin. J Mol Biol (1993) 1.34
Induction of the bovine trypsinogen-trypsin transition by peptides sequentially similar to the N-terminus of trypsin. FEBS Lett (1976) 1.34
Refined three-dimensional structure of phycoerythrocyanin from the cyanobacterium Mastigocladus laminosus at 2.7 A. J Mol Biol (1990) 1.33
Proteinase-activated receptor-2: expression by human neutrophils. J Cell Sci (1997) 1.33
X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition. J Biol Chem (1996) 1.33
Protein chemical and kinetic characterization of recombinant porcine ribonuclease inhibitor expressed in Saccharomyces cerevisiae. Biochemistry (1990) 1.32
Structural implications for the role of the N terminus in the 'superactivation' of collagenases. A crystallographic study. FEBS Lett (1994) 1.32
The clot thickens: clues provided by thrombin structure. Trends Biochem Sci (1995) 1.30
Lysis inhibition in Escherichia coli infected with bacteriophage T4. J Virol (1967) 1.30
The molecular environment of the Na+ binding site of thrombin. Biophys Chem (1997) 1.29
Effects of mutations in the hinge region of serpins. Biochemistry (1993) 1.29
The refinement and the structure of the dimer of alpha-chymotrypsin at 1.67-A resolution. J Biol Chem (1985) 1.27
Changing residue 338 in human factor IX from arginine to alanine causes an increase in catalytic activity. J Biol Chem (1998) 1.24
Structural features of a superfamily of zinc-endopeptidases: the metzincins. Curr Opin Struct Biol (1995) 1.22
Kinetic studies of fructokinase I of pea seeds. Arch Biochem Biophys (1984) 1.21
The 2.0-A crystal structure of tachylectin 5A provides evidence for the common origin of the innate immunity and the blood coagulation systems. Proc Natl Acad Sci U S A (2001) 1.21
Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases. Chem Biol (2000) 1.21
Implications of the three-dimensional structure of astacin for the structure and function of the astacin family of zinc-endopeptidases. Eur J Biochem (1993) 1.20
Structure of 2-keto-3-deoxy-6-phosphogluconate aldolase at 2 . 8 A resolution. J Mol Biol (1982) 1.19
Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics. J Mol Biol (1992) 1.18
Use of site-directed mutagenesis to investigate the basis for the specificity of hirudin. Biochemistry (1988) 1.18
The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition. J Biol Chem (2001) 1.17
Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7 A resolution and its comparison with other serpins. J Mol Biol (1991) 1.17
The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities. EMBO J (1996) 1.17
Effect of thrombomodulin on the kinetics of the interaction of thrombin with substrates and inhibitors. Biochem J (1986) 1.17
Site-directed mutagenesis of mouse dihydrofolate reductase. Mutants with increased resistance to methotrexate and trimethoprim. J Biol Chem (1988) 1.17
Structure of astacin with a transition-state analogue inhibitor. Nat Struct Biol (1996) 1.17
Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin. Biochemistry (1993) 1.16
Essential groups in synthetic agonist peptides for activation of the platelet thrombin receptor. Biochemistry (1992) 1.15
X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design. Eur J Biochem (1995) 1.15