Published in Proc Natl Acad Sci U S A on March 01, 1992
STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Acad Sci U S A (1994) 1.67
In vivo treatment of human leukemia in a scid mouse model with c-myb antisense oligodeoxynucleotides. Proc Natl Acad Sci U S A (1992) 1.67
Coordination of erythropoiesis by the transcription factor c-Myb. Blood (2006) 1.52
Block of AIDS-Kaposi's sarcoma (KS) cell growth, angiogenesis, and lesion formation in nude mice by antisense oligonucleotide targeting basic fibroblast growth factor. A novel strategy for the therapy of KS. J Clin Invest (1994) 1.21
c-Myb is required for pro-B cell differentiation. J Immunol (2009) 1.10
Facilitating oligonucleotide delivery: helping antisense deliver on its promise. Proc Natl Acad Sci U S A (1996) 0.97
Spontaneous malignant transformation of melanocytes explanted from Wf/Wf mice with a Kit kinase-domain mutation. Proc Natl Acad Sci U S A (1992) 0.96
A homeobox gene of the Antennapedia class is required for human adult erythropoiesis. Proc Natl Acad Sci U S A (1993) 0.95
Identification of antisense nucleic acid hybridization sites in mRNA molecules with self-quenching fluorescent reporter molecules. Nucleic Acids Res (2005) 0.92
Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells. Proc Natl Acad Sci U S A (1996) 0.90
Cancer treatment with kinase inhibitors: what have we learnt from imatinib? Br J Cancer (2004) 0.90
Expression of SCF splice variants in human melanocytes and melanoma cell lines: potential prognostic implications. Br J Cancer (2000) 0.83
A reappraisal of the role of insulin-like growth factor I in the regulation of human hematopoiesis. J Clin Invest (1994) 0.82
Nerve growth factor-beta induces mast-cell marker expression during in vitro culture of human umbilical cord blood cells. Immunology (2000) 0.80
Signal transduction of c-Kit receptor tyrosine kinase in CHRF myeloid leukemia cells. J Cancer Res Clin Oncol (2004) 0.76
Pre-clinical studies of gilteritinib, a next-generation FLT3 inhibitor. Blood (2016) 0.75
Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J (1987) 7.32
The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell (1988) 7.10
Hereditary anemias of the mouse: a review for geneticists. Adv Genet (1979) 6.91
Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J (1990) 5.08
A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family. Nature (1986) 4.90
The kit ligand: a cell surface molecule altered in steel mutant fibroblasts. Cell (1990) 4.43
A c-myb antisense oligodeoxynucleotide inhibits normal human hematopoiesis in vitro. Science (1988) 2.88
The dominant W42 spotting phenotype results from a missense mutation in the c-kit receptor kinase. Science (1990) 2.75
Steel locus defines new multipotent growth factor. Cell (1990) 2.31
An oligomer complementary to c-myb-encoded mRNA inhibits proliferation of human myeloid leukemia cell lines. Proc Natl Acad Sci U S A (1989) 1.98
G1/S transition in normal human T-lymphocytes requires the nuclear protein encoded by c-myb. Science (1989) 1.96
Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides. Science (1991) 1.93
Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism. Proc Natl Acad Sci U S A (1991) 1.81
Deletion of the c-kit protooncogene in the human developmental defect piebald trait. Proc Natl Acad Sci U S A (1991) 1.72
Monoclonal antibody YB5.B8 identifies the human c-kit protein product. Blood (1991) 1.40
Effect of murine mast cell growth factor (c-kit proto-oncogene ligand) on colony formation by human marrow hematopoietic progenitor cells. Blood (1991) 1.35
Normal and leukemic hematopoietic cells manifest differential sensitivity to inhibitory effects of c-myb antisense oligodeoxynucleotides: an in vitro study relevant to bone marrow purging. Proc Natl Acad Sci U S A (1991) 1.25
Stage-related proliferative activity determines c-myb functional requirements during normal human hematopoiesis. J Clin Invest (1990) 1.13
Lineage-specific requirement of c-abl function in normal hematopoiesis. Science (1989) 1.09
The expression of the proto-oncogene C-kit in the blast cells of acute myeloblastic leukemia. Leukemia (1989) 0.95
Modulation of c-kit mRNA and protein by hemopoietic growth factors. Mol Cell Biol (1991) 0.87
Interleukin 3 can compensate for the deficiency in erythroid burst-forming cells in anemic mice of genotype W/Wv. Exp Hematol (1990) 0.80
Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat Genet (1999) 6.61
Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood (2001) 3.90
Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. EMBO J (1997) 3.34
The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells. Leukemia (2000) 3.32
Real time detection of DNA.RNA hybridization in living cells. Proc Natl Acad Sci U S A (1998) 3.10
A c-myb antisense oligodeoxynucleotide inhibits normal human hematopoiesis in vitro. Science (1988) 2.88
Role of ribosome degradation in the death of starved Escherichia coli cells. J Bacteriol (1986) 2.86
Inhibition of cellular proliferation by antisense oligodeoxynucleotides to PCNA cyclin. Science (1988) 2.74
Genome instability in a region of human DNA enriched in Alu repeat sequences. Nature (1982) 2.60
Coding sequence and growth regulation of the human vimentin gene. Mol Cell Biol (1986) 2.34
Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis. Mol Cell Biol (1999) 2.17
Expression of cell-cycle-dependent genes in phytohemagglutinin-stimulated human lymphocytes. Proc Natl Acad Sci U S A (1985) 2.01
An oligomer complementary to c-myb-encoded mRNA inhibits proliferation of human myeloid leukemia cell lines. Proc Natl Acad Sci U S A (1989) 1.98
G1/S transition in normal human T-lymphocytes requires the nuclear protein encoded by c-myb. Science (1989) 1.96
Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides. Science (1991) 1.93
Antitumor effect of c-myc antisense phosphorothioate oligodeoxynucleotides on human melanoma cells in vitro and and in mice. J Natl Cancer Inst (1996) 1.74
Regulation of the proliferating cell nuclear antigen cyclin and thymidine kinase mRNA levels by growth factors. J Biol Chem (1988) 1.70
Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells. Blood (1995) 1.69
STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Acad Sci U S A (1994) 1.67
Presence of a highly repetitive and widely dispersed DNA sequence in the human genome. Proc Natl Acad Sci U S A (1981) 1.67
In vivo treatment of human leukemia in a scid mouse model with c-myb antisense oligodeoxynucleotides. Proc Natl Acad Sci U S A (1992) 1.67
Gfi-1 inhibits proliferation and colony formation of p210BCR/ABL-expressing cells via transcriptional repression of STAT 5 and Mcl-1. Leukemia (2012) 1.65
Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis. J Exp Med (1999) 1.61
TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis. EMBO J (1998) 1.60
Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb gene. Mol Cell Biol (1991) 1.58
Structure of the human gene for the proliferating cell nuclear antigen. J Biol Chem (1989) 1.56
Treatment of Philadelphia leukemia in severe combined immunodeficient mice by combination of cyclophosphamide and bcr/abl antisense oligodeoxynucleotides. J Natl Cancer Inst (1997) 1.47
p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107. Cancer Res (1994) 1.46
Binding, uptake, and intracellular trafficking of phosphorothioate-modified oligodeoxynucleotides. J Clin Invest (1995) 1.44
Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases. J Clin Invest (1997) 1.44
De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells. Proc Natl Acad Sci U S A (1995) 1.43
Autologous stem-cell transplant after conventional dose adjuvant chemotherapy for high-risk breast cancer: impact on the delivery of local-regional radiation therapy. Ann Oncol (1999) 1.40
Danazol treatment of myelodysplastic syndromes. Br J Haematol (1991) 1.39
Cooperative action of germ-line mutations in decorin and p53 accelerates lymphoma tumorigenesis. Proc Natl Acad Sci U S A (1999) 1.39
Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein. J Biol Chem (1986) 1.36
Structural and functional analysis of a growth-regulated gene, the human calcyclin. J Biol Chem (1987) 1.36
c-myb transactivates cdc2 expression via Myb binding sites in the 5'-flanking region of the human cdc2 gene. J Biol Chem (1993) 1.34
mRNA in human cells contains sequences complementary to the Alu family of repeated DNA. Proc Natl Acad Sci U S A (1981) 1.32
c-Myb and Bcl-x overexpression predicts poor prognosis in colorectal cancer: clinical and experimental findings. Am J Pathol (2001) 1.29
Molecular cloning of a cDNA for a human ADP/ATP carrier which is growth-regulated. J Biol Chem (1987) 1.27
Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells. Proc Natl Acad Sci U S A (1995) 1.26
Recent amplification of an alpha satellite DNA in humans. Nucleic Acids Res (1985) 1.25
Normal and leukemic hematopoietic cells manifest differential sensitivity to inhibitory effects of c-myb antisense oligodeoxynucleotides: an in vitro study relevant to bone marrow purging. Proc Natl Acad Sci U S A (1991) 1.25
Overexpression of the zinc finger protein MZF1 inhibits hematopoietic development from embryonic stem cells: correlation with negative regulation of CD34 and c-myb promoter activity. Mol Cell Biol (1995) 1.24
Resistance to apoptosis in CTLL-2 cells constitutively expressing c-Myb is associated with induction of BCL-2 expression and Myb-dependent regulation of bcl-2 promoter activity. Proc Natl Acad Sci U S A (1997) 1.24
Regulation of BALB/c 3T3 fibroblast proliferation by B-myb is accompanied by selective activation of cdc2 and cyclin D1 expression. Proc Natl Acad Sci U S A (1992) 1.23
Oligonucleotide N3'-->P5' phosphoramidates as antisense agents. Nucleic Acids Res (1996) 1.22
Sudden death among patients with acute promyelocytic leukemia treated with arsenic trioxide. Blood (2001) 1.22
Caspase cleavage enhances the apoptosis-inducing effects of BAD. Mol Cell Biol (2001) 1.21
The SH3 domain contributes to BCR/ABL-dependent leukemogenesis in vivo: role in adhesion, invasion, and homing. Blood (1998) 1.20
Control of hsp70 RNA levels in human lymphocytes. J Cell Biol (1987) 1.19
c-myc antisense oligodeoxynucleotides enhance the efficacy of cisplatin in melanoma chemotherapy in vitro and in nude mice. Cancer Res (1998) 1.19
Suppression of Philadelphia1 leukemia cell growth in mice by BCR-ABL antisense oligodeoxynucleotide. Proc Natl Acad Sci U S A (1994) 1.19
Inhibition of T-cell proliferation by a MYB antisense oligomer is accompanied by selective down-regulation of DNA polymerase alpha expression. Proc Natl Acad Sci U S A (1990) 1.18
Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity. Nucleic Acids Res (2001) 1.17
Expression of tumor-suppressor genes interferon regulatory factor 1 and death-associated protein kinase in primitive acute myelogenous leukemia cells. Blood (2001) 1.16
Prognostic value of FDG-PET scan imaging in lymphoma patients undergoing autologous stem cell transplantation. Bone Marrow Transplant (2006) 1.15
Blastic transformation of p53-deficient bone marrow cells by p210bcr/abl tyrosine kinase. Proc Natl Acad Sci U S A (1996) 1.15
Differentiation of human leukemias in response to 12-0-tetradecanoylphorbol-13-acetate in vitro. Blood (1980) 1.15
Inhibition of leukemia cell proliferation by receptor-mediated uptake of c-myb antisense oligodeoxynucleotides. Proc Natl Acad Sci U S A (1992) 1.14
Cell-cycle-specific genes differentially expressed in human leukemias. Proc Natl Acad Sci U S A (1985) 1.14
Stage-related proliferative activity determines c-myb functional requirements during normal human hematopoiesis. J Clin Invest (1990) 1.13
Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant. J Exp Med (1998) 1.13
Role of p53 in hematopoietic recovery after cytotoxic treatment. Blood (1998) 1.11
Direct transactivation of the anti-apoptotic gene apolipoprotein J (clusterin) by B-MYB. J Biol Chem (2000) 1.11
Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation. Oncogene (2000) 1.10
Correlation between E2F-1 requirement in the S phase and E2F-1 transactivation of cell cycle-related genes in human cells. Cancer Res (1994) 1.09
Expression of c-myc and other cell cycle-dependent genes in human colon neoplasia. Cancer Res (1985) 1.09
Lineage-specific requirement of c-abl function in normal hematopoiesis. Science (1989) 1.09
Oncogenes, protooncogenes, and tumor suppressor genes in acute myelogenous leukemia. J Pediatr Hematol Oncol (1995) 1.08
BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac. Proc Natl Acad Sci U S A (1998) 1.07
Altered expression of G1-specific genes in human malignant myeloid cells. Proc Natl Acad Sci U S A (1986) 1.07
Second auto-SCT is safe and effective salvage therapy for relapsed multiple myeloma. Bone Marrow Transplant (2008) 1.07
Activation of mitochondrial Raf-1 is involved in the antiapoptotic effects of Akt. Cancer Res (1999) 1.06
Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth. J Exp Med (1994) 1.06
Inhibition of proliferation by c-myb antisense oligodeoxynucleotides in colon adenocarcinoma cell lines that express c-myb. Cancer Res (1991) 1.05
Tumorigenic conversion of p53-deficient colon epithelial cells by an activated Ki-ras gene. J Clin Invest (1998) 1.05
Wild-type p53 gene expression induces granulocytic differentiation of HL-60 cells. Blood (1994) 1.05
Inhibition of human megakaryocytopoiesis in vitro by platelet factor 4 (PF4) and a synthetic COOH-terminal PF4 peptide. J Clin Invest (1989) 1.05
2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (2'F-ANA) modified oligonucleotides (ON) effect highly efficient, and persistent, gene silencing. Nucleic Acids Res (2006) 1.04
hIan5: the human ortholog to the rat Ian4/Iddm1/lyp is a new member of the Ian family that is overexpressed in B-cell lymphoid malignancies. Genes Immun (2004) 1.04
Biologic and therapeutic significance of MYB expression in human melanoma. Proc Natl Acad Sci U S A (1994) 1.04
Expression of B-myb in neuroblastoma tumors is a poor prognostic factor independent from MYCN amplification. Cancer Res (1999) 1.03
Evidence for a functional kit receptor in melanoma, breast, and lung carcinoma cells. Cancer Gene Ther (1997) 1.03
The Jun family members, c-Jun and JunD, transactivate the human c-myb promoter via an Ap1-like element. J Biol Chem (1992) 1.03
Activation of human B-MYB by cyclins. Proc Natl Acad Sci U S A (1997) 1.03
BCR-ABL prevents c-jun-mediated and proteasome-dependent FUS (TLS) proteolysis through a protein kinase CbetaII-dependent pathway. Mol Cell Biol (2000) 1.03
Versatility of BCR/ABL-expressing leukemic cells in circumventing proapoptotic BAD effects. Blood (2000) 1.02